The present invention relates to CX3CR1-binding polypeptides, in particular polypeptides comprising specific immunoglobulin domains. The invention also relates to nucleic acids encoding such polypeptides; to methods for preparing such polypeptides; to host cells expressing or capable of expressing such polypeptides; to compositions comprising such polypeptides; and to uses of such polypeptides or such compositions, in particular for prophylactic, therapeutic and diagnostic purposes.

A composition having proanthocyanidin compounds having an average degree of polymerization of at least about 6. A method of administering to an immunosuppressed patient or a patient diagnosed with sepsis or septic shock a composition having a proanthocyanidin. A method of administering to a patient diagnosed with a gram negative bacterial infection a composition having proanthocyanidin compounds having an average degree of polymerization of at least about 6.

The present application relates to antigen-binding proteins that are capable of binding to mammalian IgG. The frame-work regions of the antigen-binding proteins of the application preferably correspond to those of antibodies naturally that are devoid of light chains as may e.g. be found in camelids. The application further relates to nucleic acids that encode such antigen-binding proteins, to immunoadsorbent materials that comprise such proteins, to the uses of such immunoadsorbent materials for the purification of mammalian IgG antibodies and for therapeutic apheresis.

The invention relates to improved variants of the anti-serum albumin immunoglobulin single variable domain DOM7h-11, as well as ligands and drug conjugates comprising such variants, compositions, nucleic acids, vectors and hosts.

Antigen binding proteins with T cell receptor-like paratopes, that is, with an antigen binding region specific for an human leukocyte antigen-A2 restricted peptide are disclosed. The antigen binding proteins encompass antibodies in a variety of forms, including full-length antibodies, substantially intact antibodies, Fab fragments, F(ab')2 fragments, and single chain Fv fragments. Fusion proteins, such as scFv fusions with immunoglobulin or T-cell receptor domains, incorporating the specificity of the antigen binding region for each peptide are also contemplated by the invention. Furthermore, immunoconjugates may include antibodies to which is linked a radioisotope, fluorescent or other detectable marker, cytotoxin, or other molecule are also encompassed by the invention. Among other things, immunoconjugates can be used for delivery of an agent to elicit a therapeutic effect or to facilitate an immune effector function.

A perpendicular magnetic recording disk has a graded-anisotropy recording layer (RL) formed of at least two ferromagnetically exchange coupled CoPtCr-oxide magnetic layers (MAG1 and MAG2) with two nucleation films (NF1 and NF2) between the magnetic layers. NF1 is a metal film, preferably Ru or a Ru-based alloy like RuCr, sputter deposited on MAG1 at low pressure to a thickness between about 0.1-1.5 nm. NF2 is a metal oxide film, preferably an oxide of Ta, sputter deposited on NF1 at high pressure to a thickness between about 0.2-1.0 nm. MAG2 is sputter deposited over NF2. NF1 and NF2 provide a significant reduction in average grain size in the RL from a graded-anisotropy RL without nucleation films between MAG1 and MAG2, while also assuring that MAG1 and MAG2 are strongly exchange coupled.

Provided is a zinc-plated steel sheet for hot pressing having outstanding surface characteristics, comprising: a steel foundation plate comprising a metal surface diffusion layer of which the Gibbs free energy reduction per mole of oxygen during oxidation is less than that of Cr; an aluminum-rich layer containing at least 30 wt. % of aluminum formed on the surface diffusion layer, and a zinc plating layer formed on the aluminum-rich layer. In this way, a metal having a low affinity for oxygen is coated to an effective thickness prior to annealing and thus the creation of annealing oxides at the surface of the steel sheet is suppressed and a uniform zinc plating layer is formed, and alloying of the zinc plating layer is promoted during press-processing heat treatment. Cracking in the steel foundation plate during hot press molding is prevented.

Systems and methods for improving operation of a hybrid vehicle are presented. In one example, an electrical load may be automatically activated to consume electrical energy produced during driveline braking so that driveline braking may be extended. The electrical load may be a windscreen heater or other device.

Disclosed herein are polypeptides, polynucleotides encoding, cells and organisms comprising novel DNA-binding domains, including TALE DNA-binding domains. Also disclosed are methods of using these novel DNA-binding domains for modulation of gene expression and/or genomic editing of endogenous cellular sequences.

IL4/IL13-binding proteins comprise binding domains, which inhibit IL4/IL13 binding to IL4Ralpaha and common gamma chain complexes (Type 1) and inhibit IL4 binding to IL4Ralpha and IL13Ralpha1 complexes (Type 2), and IL13 binding to IL13Ralpha1 and/or IL13Ralpha2, are useful in the treatment of cancer, inflammatory, and other pathological conditions, such as allergic or fibrotic conditions, especially pulmonary conditions.

Provided is a method for shutting down an indirect internal reforming SOFC, in which a hydrocarbon-based fuel is reliably reformed, and the oxidative degradation of the anode can be prevented by a reformed gas. A method for shutting down an indirect internal reforming SOFC including a reformer; an SOFC; a combustion region for combusting the anode off-gas of the SOFC; and an enclosure for housing the reformer, the SOFC, and the combustion region, wherein the method includes causing the flow rate of a fuel supplied to the reformer to become FE from FS; and stopping the supply of the fuel to the reformer when an anode temperature becomes lower than the oxidative degradation temperature, where FE represents a flow rate of the fuel supplied to the reformer in a state in which the anode temperature is steady and lower than the oxidative degradation temperature, in which in the reformer the fuel is reformed and a reformed gas with a composition suitable to be supplied to an anode is produced, and in which an amount of the reformed gas produced is equal to or more than the requisite minimum flow rate for preventing the oxidative degradation of the anode when the anode temperature is a temperature equal to or higher than the oxidative degradation temperature, and FS represents a flow rate of the fuel supplied to the reformer at the start of the shutdown method. Also provided is an indirect internal reforming SOFC appropriate for this method.

A bookbinding structure for binding a stack of sheets including an elongated substrate having a first surface on which a first, heat activated, adhesive matrix is disposed and a second surface on which a second, pressure activated adhesive is disposed. The first adhesive matrix will be used to binding an edge of the stack so as to form a bound book with no cover. The second adhesive matrix includes first and second spaced-apart segments which extend along the length of the substrate. First and second release liners are disposed over the first and second adhesive segments, with the release liners remaining in place until the stack of sheets have been bound with the bookbinding structure. One of the release liners is manually removed from the bound stack and the stack is positioned in a cover assembly with the edge of the stack being positioned opposite a spine section of the cover assembly. The remaining release liner prevents the cover assembly from prematurely attaching to the stack thereby enabling the user to more easily positioned the stack with in the assembly. The user then forces the cover assembly against the exposed adhesive segment thereby securing part of the cover assembly to the stack. The second release liner is then removed and pressure is applied to that part of the cover assembly opposite the exposed segment thereby completing the binding sequence.

In contrast to slot-type gaming machines with their preset paylines designating predetermined array positions, the paylines of this novel wagering game are unknown until the indicia in the array have been selected. The indicia are selected from a variety of indicium types, each having a different number of members for identifying adjacent indicia. The randomly selected indicia determine the paylines, if any, in the array. Conditions may be imposed that limit the size and geometry of the paylines in this wagering game.

A flexible cable assembly (FCA) has a stiffener layer positioned in electrical contact with an electrical ground feature of the FCA, and a head stack assembly (HSA) may include a suspension tail electrically connected to the stiffener layer of the FCA, thus providing a robust ground path between the read/write head and the arm or E-block of the HSA. Additional efficient grounding techniques may include directly electrically connecting the suspension tail to the arm via a conductive adhesive, directly electrically connecting the FCA stiffener layer to the arm via a conductive screw, and/or directly electrically connecting the ground feature and the stiffener layer of the FCA to the arm using a ground post or screw.

The present disclosure generally relates to a HAMR head and a method for fabrication thereof. The HAMR head has a write head with a waveguide extending therethrough. A laser diode is coupled to a submount that is bonded to the write head using an adhesion layer, a solder structure, and a self-propagating multilayer alloying stack.

The present disclosure provides for a magnetic writer pole for use in a hard drive. The magnetic writer pole comprises a first bevel formed by a non-magnetic layer, the first bevel formed at a first angle and extending to a first throat height. The magnetic writer pole further comprises a second bevel formed by the non-magnetic layer and extending distally from the first bevel at a second angle that is greater than the first angle and extending to a second throat height. The magnetic writer pole further comprises a third bevel formed by the non-magnetic layer and extending distally from the second bevel at a third angle that is greater than the second angle.

A magnetic recording medium including a substrate, and at least one magnetic layer formed on the substrate. The magnetic layer is formed from an alloy containing Cobalt, and Platinum (Pt). The magnetic layer is also formed from grain boundary segregation materials comprising Manganese Oxide and at least one of Silicon Oxide, Chromium Oxide, and Cobalt Oxide (CoO).

A two-dimensional magnetic recording (TDMR) read head has upper and lower read sensors wherein the lower read sensor has its magnetization biased by side shields of soft magnetic material. The center shield between the lower and upper sensors may be an antiparallel structure (APS) with two ferromagnetic layers separated by an antiparallel coupling (APC) layer. The center shield has a central region and two side regions, but there is no antiferromagnetic (AF) layer in the central region. Instead the two side regions of the upper ferromagnetic layer in the APS are pinned by AF tab layers that are electrically isolated from the upper sensor. The upper ferromagnetic layer and the APC layer in the APS may also be located only in the side regions. The thickness of the center shield can thus be made thinner, which reduces the free layer to free layer spacing.

A device for suspending a turbojet casing, the device including a shouldered pin extending through aligned orifices of two lugs of a clevis secured to the casing. A protection piece for providing protection against wear is mounted on each lug of the clevis and has the shouldered pin passing therethrough, the protection piece being prevented from moving in rotation on the lug by co-operating shapes.

An information output device includes a first processor configured to execute a process to determine a type of notification information which is outputted from a computer and which notifies a state of the computer; and a second processor configured to execute a process to create a chart, in which a first coordinate axis represents time when the notification information is outputted from the computer, a second coordinate axis represents the type of the notification information, and the notification information is drawn at a corresponding position, and output the chart.

Methods and systems of monitoring events occurring in a computer system are provided. An event monitoring instruction including a condition is parsed, the event monitoring instruction expressed using syntax defined in source code, the parsing resulting in an event channel to monitor and the condition. Then execution of an application is paused. The event channel is monitored until an event occurs on the event channel. Then an event handler for the event is run in response to the event occurring on the event channel. The condition is evaluated to determine whether the condition is satisfied. Execution of the application is resumed in response to the condition being satisfied.

A grinding attachment for highways and similar surfaces is disclosed for grinding operations closer to adjacent obstacles than is possible with existing equipment using a straddle-type centrally mounted grinding drum. The grinding attachment assembly comprises at one end a stub axle, which engages the grinding drum via a head extension. The stub axle is attached to a shroud which is in turn supported by a mounting assembly, which in operation attaches to a vehicle or machine able to drive the grinding attachment. The grinding drum can thereby operate proximal obstacles adjacent a grinding surface by virtue of arrangement of the stub axle, shroud and mounting assembly.

An air guide element (10) for an aircraft air conditioning system comprises a housing (12), which has an air inlet opening (14) and an air outlet opening (16). The air inlet opening (14) and the air outlet opening (16) are disposed in such a way and the housing (12) is shaped in such a way that air that is fed to the air guide element (10) through the air inlet opening (14), as it flows through the air guide element (10), is deflected at an angle of ca. 45° to 135° relative to the direction of the air flow through the air inlet opening (14). A cross-sectional area of flow of the housing (12) that is disposed at right angles to the direction of the air flow through the air outlet opening (16) is subdivided into at least two regions (18a, 18b, 18c). In each of said regions (18a, 18b, 18c) an easily accessible, removable and exchangeable calibrating element (20a, 20b, 20c) is disposed, which is designed to generate, in the air flow passing through a region (18a, 18b, 18c) that is associated with a respective calibrating element (20a, 20b, 20c), a pressure loss that is constant over said region (18a, 1b, 18c).

A system for air-conditioning an aircraft cabin includes an air conditioning unit connected to a central mixer, a first recirculation system designed to remove exhaust air from a first aircraft cabin region and connected to the central mixer, and a second recirculation system designed to remove exhaust air from a second aircraft cabin region and connected to a local mixer. A control device is designed to control the second recirculation system to reduce an air volume flow being removed from the second aircraft cabin region when shifting from a first operating state (e.g., normal operation) to a second operating state (e.g., defined operating situations such as when quick cooling is desired). The air volume being removed from the first aircraft cabin region may be increased accordingly in the second operating state.

An installation for cooling an electronic device includes an air conditioner having an air outlet for blowing cooling air to a room; a first detector adjacent to the air outlet of the air conditioner, for detecting a temperature of the cooling air; a rack accommodating the electronic device, the rack having an air inlet for receiving the cooling air from the air conditioner and an air outlet for exhausting air to the room; a second detector adjacent to the air inlet of the rack, for detecting a temperature of air received through the air inlet of the rack; and a controller for acquiring the temperatures detected by the first and the second detectors, and controlling a quantity of the cooling air blown from the air outlet of the air conditioner so as to decrease a difference between the temperatures detected by the first and the second detectors.

An outdoor unit for an air conditioner according to an exemplary embodiment of the disclosure, comprising: a case forming shape and having a suction port suctioning outside air and a discharge port discharging the suctioned air; a heat exchanger accommodated inside the case; a fan that is accommodated inside the case and forcibly circulate air; and a louver assembly revolvably mounted in the case so as to selectively open and close the discharge port.

An air conditioning apparatus has, a first domed door comprising a first pivot and a first sealing surface, and a second domed door comprising a second pivot and a second sealing surface, wherein, said second pivot is positioned different from said second pivot. With the above structure, the radial gap between the first sealing surface and the second sealing surface is varied when at least one of the two domed doors is moved. Accordingly, the air conditioning apparatus described above does not have to set the constant small radial gap or constant wide radial gap for the sake of reducing unintentional air leaking or preventing said friction.

A register for air-conditioning includes a tubular register having an air passage and a blowoff opening and register fins 2 for regulating the wind direction of conditioned air blowing out from the blowoff opening. The register fin 2 includes a plate-like fin main body 3 and a pair of plate-like fin covers 4 and 5 assembled so as to sandwich the fin main body 3 from both sides of the fin main body 3 with the end face of the fin main body 3 on the vehicle cabin side being exposed. The fin main body 3 is provided with a plurality of engaging holes 31. The fin covers 4 and 5 are provided, at the positions corresponding to the engaging holes 31, with a plurality of engaging claws (41) and 51 protruding in the thickness direction from the surfaces facing the fin main body 3. The fin main body 3 and the fin covers 4 and 5 are assembled by engaging the engaging holes 31 with the engaging claws (41) and 51.

An embodiment includes a first space, a second space, a first damper, a second damper, and a third damper. The first space is connected to a cold space, having cold air reside therein to send to the cold space. The second space has return air reside therein, as it is discharged from a hot space. The first damper has an opening adjusted under control of a controller to take in outdoor air to the first space, and is operable to have an open state in an emergency with a server being supplied with power. The second damper has an opening adjusted under control of the controller to discharge return air in the second space, outside thereof, and is operable to have an open state in the emergency. The third damper has an opening adjusted under control of the controller to recirculate return air in the second space to the first space.

In the air conditioner, determination is made whether or not a “3-Dimensional Swing” or a “Left/Right Swing” relating to movement of a left/right flap is set (step S2). When it is determined that the “3-Dimensional Swing” or “Left/Right Swing” is set (step S2: Yes), a determination is made whether or not the swing range of the left/right flap is set to a part of the movable range (step S3). When it is determined in step S3 that the swing range of the left/right flap is set (step S3: Yes), the left/right flap is once returned to the reference position (step S4), and then reciprocation of the left/right flap within the swing range is started (step S5).

A bicycle rack for arrangement on the rear end of a motor vehicle in an extendible fashion is provided. The bicycle rack includes a carrying frame, a slide-in element that is displaceably arranged in the carrying frame, and a carrier element that is pivotably arranged on the side-in element.

The present invention relates to an aluminum extrusion heat sink structure and a corresponding backlight module. The aluminum extrusion heat sink structure comprises a light source connecting portion, a back plate connecting portion and a light guide plate support portion. The manufacture cost of the aluminum extrusion heat sink structure is lower, and the heat dissipation effect is better, so as to solve the technology problem that the volume of a traditional aluminum extrusion heat sink structure is larger caused the cost of the aluminum extrusion heat sink structure and the corresponding backlight module is higher.

Computationally implemented methods and systems are described herein that are designed to, among other things, receiving a level-one encrypted output of a surveillance device; encrypting at least a part of the level-one encrypted output of the surveillance device with a level-two encryption key whose decryption key is inaccessible by a level-two encryption entity; and transmitting a level-two encrypted output of the surveillance device.

A method and system of providing conditional access to encrypted content includes receiving unsolicited multiply encrypted video content and first decryption data over a broadcast network. Partially decrypted video content is obtained by decrypting a first layer of encryption of the encrypted video content using the first decryption data. The partially decrypted video content is stored. A request for viewing the encrypted video content is transmitted and second decryption data is received. A second layer of encryption of the encrypted video content is decrypted using the second decryption data.

A part fixturing system for securing a workpiece includes an expanding clamping device and a work holding device. The expanding clamping device includes a clamp base portion, first and second traversing wedge blocks, an actuation screw, and a clamp plate portion. The clamp base portion comprises a longitudinal recess, and the traversing wedge blocks are located inside the longitudinal recess, each block including an inclined contact surface and a threaded aperture. The actuation screw passes through the longitudinal recess of the clamp base portion and the threaded apertures of the traversing wedge blocks. The clamp plate portion comprises first and second declined contact surfaces. The work holding device comprises first and second support columns that define a longitudinal loading envelope. The expanding clamping device is positioned inside the longitudinal loading envelope of the work holding device and couples the workpiece to the first and second support columns.

The bonding apparatus is capable of effectively increasing temperature of a substrate and reducing occurrence of position gaps and poor connection in a process of flip-chip-bonding semiconductor devices to the substrate. The bonding apparatus comprises: a supporting unit for supporting the substrate, on which the semiconductor devices have been adhered by a non-conductive; and a heating/pressing unit for heating and pressing the substrate, the heating/pressing unit having a built-in heat source and a clamping face, onto which the substrate supported by the supporting unit is pressed. The substrate supported by the supporting unit is moved toward the clamping face of the heating/pressing unit so as to preheat the substrate and the semiconductor devices by radiation heat. Then, the semiconductor devices are pressed onto the clamping face of the heating/pressing unit so as to cure the non-conductive adhesive and bond bumps of the semiconductor devices to terminal sections of the substrate.

A support structure for supporting a semiconductor device during a bonding operation is provided. The support structure comprises a body portion defining an upper surface configured to support a semiconductor device during a bonding operation. The upper surface defines a constraining feature for constraining at least a portion of the semiconductor device during the bonding operation.

There are provided a substrate for an inkjet head and an inkjet head wherein in a case where a protection layer of heating resistors is energized, an electrical connection with portions around the protection layer is more reliably cut. A first protection layer provided for the substrate for an inkjet head includes individual sections provided at positions corresponding to the plurality of heating resistors and a common section which commonly connects the plurality of individual sections. The individual sections and the common section are connected via connect sections which are eluted and connect in a case where an electrochemical reaction occurs between the connect sections and ink when electricity flow therethrough, so that an electrical connection between the individual sections and the common section is cut.

A power conditioner for a feeding system which stabilizes a load of active power is provided. A power conditioner for a feeding system comprises a first AC-DC and DC-AC converter for performing conversion between AC power and DC power; and a nickel-metal hydride battery disposed between and connected to a high-voltage cable at DC side of the first AC-DC and DC-AC converter and a low-voltage cable at the DC side of the first AC-DC and DC-AC converter.

An inductive power outlet for providing power to an electric load via an inductive power receiver includes at least one primary inductive coil wired to a power supply via a driver configured to provide a driving voltage across the primary inductive coil such that a secondary voltage is induced in a secondary inductive coil associated with the inductive power receiver. The driver may include a controller configured to receive feedback control signals from the inductive power receiver indicating if more or less power is required. The controller may be further configured to adjust the driving voltage according to the control signals.

A transfer switch configured to detect a ground current is configured to selectively connect a first power source or a second power source to a load. Each of the power sources includes at least one “hot” lead and one neutral lead, and the transfer switch is configured to switch both the “hot” and the neutral leads. If the neutral switching portion of the transfer switch fails, current may be supplied to the load via the “hot” lead of one of the power sources and return from the load via a ground conductor and the neutral lead of the other power source. The transfer switch includes a current sensor, detecting current on the ground conductor, in order to detect such a condition. The signal from the current sensor is provided to a control circuit, which, in turn, activates an indicator if the current on the ground conductor exceeds a predefined level.

Methods and systems for a go/no-go Landing Decision Point (LDP) are disclosed. The methods and systems provide a graphical LDP on a cockpit display that pilots can use to determine whether to continue the landing or execute a go-around. The methods and systems may be implemented in embodiments having an onboard portion, an off-board portion, or both operatively coupled to provide an LDP in a preview/planning mode and real time mode.

A system for electrical braking of a vehicle comprises a power bus coupled to a first driver associated with a first electromechanical actuator (EMA). The power bus is also coupled to a second driver associated with a second EMA, and the first EMA and the second EMA are associated with a wheel of the vehicle. The power bus provides braking power to the first EMA via the first driver and to the second EMA via the second driver. A normal braking command interface provides a first braking signal to the first driver and a second braking signal to the second driver. An emergency/park brake interface bypasses the normal braking command interface and sends a first emergency/park braking signal to the first driver and a second emergency/park braking signal to the second driver. A sensor measures a current at a single location of the power bus that is proportional to a braking force exerted on the wheel.

Boom drive apparatus for substrate transport systems and methods are described. The boom drive apparatus is adapted to drive one or more multi-arm robots rotationally mounted to the boom to efficiently put or pick substrates. The boom drive apparatus has a boom including a hub, a web, a first pilot above the web, and a second pilot below the web, a first driving member rotationally mounted to the first pilot, a second driving member rotationally mounted to the second pilot, a first driven member rotationally mounted to the boom above the a web, a second driven member rotationally mounted to the boom below the a web, and a first and second transmission members coupling the driving members to driven members located outboard on the boom. Numerous other aspects are provided.

A front loader is provided with an indicator device. The indicator device is configured to indicate that the work implement is in an identical posture irrespective of a height position of the work implement, by aligning a rear end of the indicator rod with a rear end of the guide tube.

A system and method are described for receiving a NOTAM and storing information relating to the distance of a temporarily displaced threshold for a runway. When that runway is selected for approach and landing, the temporarily displaced threshold and new aiming point are automatically displayed. The change made to the display using NOTAM data can be indicated to the pilot by distinct symbology or particular color, or by using an icon or an annunciation.

A method of determining a turbulent condition in an aircraft with a handheld device where the handheld device has at least one of a gyroscope, seismometer, and an accelerometer where the method includes receiving an output from the at least one of the gyroscope, seismometer, and accelerometer while the handheld device is located within the aircraft and providing an indication of a turbulent condition.

Disclosed are polyvalent macromolecules, compositions comprising the macromolecules, and methods of use. The polyvalent macromolecules have a polymer backbone and pendent groups attached to the polymer backbone. Some or all of the pendent groups have optionally a linker, a surface-seeking group capable of binding strongly to a metal surface, and a spectroscopically detectable chromophore detectable.

The invention provides a binding layer comprising a polysaccharide substituted by carboxylic groups or derivatives thereof exhibiting high performance in the binding of ligand molecules and in the interaction thereof with analyte molecules. A method for the preparation of the binding layer and for the assaying of various analyte molecules is also provided.

A dual function binding machine for making journal notebooks at home includes a hole punching mechanism and a binding mechanism. A punch die includes a plurality of rectangular punch teeth in a graduated configuration to minimize the amount of force required to penetrate through the journal book materials. A guide provides different positions for punching through covers, inner pages and continuous punching of both. This allows the perfect alignment and fit of the outside covers with the inside pages. A spring biased lever operates the punch die in a horizontal direction. The binding mechanism included in the same machine has a vertical outer vise wall that is horizontally movable to compress the binding material to the pages and covers of the journal notebook.