IBM today announced sweeping advances in its all-flash storage solutions and software to significantly drive down the costs of data and extend its solutions for hybrid and private cloud environments.

Twitter and IBM today announced a landmark partnership that will help transform how businesses and institutions understand their customers, markets and trends – and inform every business decision. The alliance brings together Twitter data that distinctively represents the public pulse of the planet with IBM’s industry-leading cloud-based analytics, customer engagement platforms, and consulting services.

El actual entorno tecnológico impulsa a las empresas a transformar sus modelos de negocio en un escenario en donde, según la Organización para la Cooperación y el Desarrollo Económicos (OCDE), el 25% de la economía mundial será digital en los próximos cinco años. De esta forma, el uso de nuevas tecnologías se vuelve la pieza clave para asegurar tanto competitividad, como su alto desempeño.

IBM anunció hoy la primera plataforma de servicios basada en IBM Watson y construida en IBM Cloud para aumentar la inteligencia humana y ayudar a mejorar las operaciones de los proveedores de servicios a través de tecnologías cognitivas.

El Grupo BBVA acaba de formalizar un acuerdo con IBM para que esta firma asuma la operación y transformación de la infraestructura tecnológica actual de BBVA y el procesamiento de datos en América Latina y EE.UU., actualmente gestionada por su filial ATA en México.

Como parte de su compromiso por contribuir con la tecnología más innovadora a la resolución de los desafíos y retos que enfrenta el mundo, IBM dio a conocer que seleccionó a CUCEA (Centro Universitario de Ciencias Económico y Administrativas) de la Universidad de Guadalajara (UdeG); a fin de poner en marcha en México la implementación del Programa IBM Skills Academy, con foco en competencias de tecnología de Nube.

IBM anuncia el lanzamiento de IBM Cloud Private, una plataforma de software creada para los clientes que requieren la flexibilidad y capacidad de una nube pública en un ambiente privado. IBM Cloud Private transforma los sistemas de TI (Tecnologías de la Información) en un ambiente de nube flexible para crear un puente hasta las nubes públicas y acelerar el desarrollo de aplicativos.

IBM (NYSE: IBM) reinventa hoy el correo electrónico empresarial con una nueva oferta de colaboración social freemium que utiliza la tecnología de analítica integrada para dar a los empleados una nueva forma de conversar, encontrar a las personas y la información correcta rápidamente, y hacer su trabajo de manera eficiente. IBM Verse es el resultado de una inversión de US$100 millones en diseño e innovación, y reúne las plataformas líderes cloud, analytics, social y de seguridad de la compañía para transformar el futuro del trabajo.

IBM today announced that Westpac New Zealand, part of one of the world’s largest financial services institutions, has selected IBM’s private cloud technology to support its goal to be New Zealand’s leading digital bank. The new five year agreement is part of an extensive services and technology contract which includes Westpac migrating some of its business critical IT systems into IBM’s state-of-the-art Auckland data centre, enabling enhanced customer service.

IBM dio a conocer que el Tecnológico de Monterrey está transformando la gestión del entorno laboral de todas sus unidades de negocios con su solución de gestión de talento, Kenexa. La solución permite a los profesionales de Talento y Cultura (Recursos Humanos) del Tecnológico de Monterrey, tomar decisiones estratégicas a fin de impulsar los resultados de negocio basadas en hechos, es decir, sobre la base del análisis de talento (reporteadores) de su tradicional encuesta de clima organizacional.

Diltex -empresa mexicana propietaria de las marcas Ilusión y Fiorentina, socios de Vanity Fair Brands y franquiciatarios de David's Bridal en México- e IBM, anunciaron que la compañía dedicada a la industria de la moda está mejorando la experiencia del cliente y fortaleciendo su producción, distribución y comercialización a través de su transformación digital.

CEMEX, S.A.B. de C.V. (BMV: CEMEXCPO), una de las compañías de materiales para la industria de la construcción líder en el mundo, e IBM (NYSE: IBM) anunciaron hoy que CEMEX llevará a cabo una importante transformación tecnológica diseñada para optimizar sus operaciones, mejorar notablemente la experiencia de sus clientes y aumentar la eficiencia del negocio.

Durante la cumbre Business Connect 2017 en la Ciudad de México, IBM presentó a la Transformación Digital como una de las áreas de mayor crecimiento para los negocios en 2017 y mostró cómo las soluciones cognitivas (de analítica avanzada, de nube, de engagement), están transformando la forma en la que trabajamos y vivimos.

Las estrategias de negocio con las que organizaciones líderes están transformando su negocio para obtener mayores eficiencias se basan en tecnologías para mejorar el manejo de la información, la interacción con clientes y modelos de negocio en la nube. Estas tecnologías son impulsadas por IBM, reconociendo las necesidades de las compañías mexicanas.

Tres proyectos que proponen mejorar la interacción y la experiencia de los jóvenes usuarios con servicios bancarios móviles, fueron reconocidos hoy por Banorte, IBM y el Tec de Monterrey como resultado del Reto Banorte en el marco de la Semana i, que la institución educativa llevó a cabo del 21 al 25 de septiembre en todo el país.

GIG Desarrollos Inmobiliarios dio a conocer que está utilizando una solución de analítica de datos de IBM para transformar el área de ventas inmobiliarias. La herramienta les ha permitido acelarar hasta 6 veces el tiempo dedicado al procesamiento de datos para el cálculo de comisiones.

IBM y VON DER HEIDE, compañía especializada en servicios de consultoría de Recursos Humanos, informan que han firmado una importante alianza para expandir su oferta de servicios de Employee Engagement y HR Analytics en toda América Latina. Por medio de las tecnologías de IBM, esta alianza le permitirá a VON DER HEIDE brindar a sus clientes una oferta de consultoría única en el mercado, para transformar estrategias de talento en resultados de negocio.

Vodafone New Zealand, a leading telecommunications services provider, and IBM (NYSE: IBM) today announced a partnership to deliver the Digital Vodafone 2021 program in New Zealand. The vision for Digital Vodafone 2021 is to create the most engaging digital customer experience by adopting agile as a way of working, embracing new technologies and simplifying business models. The program is supported by IBM iX, one of the world’s largest digital agencies and global business design partners.

IBM (NYSE: IBM) et SAP SE (NYSE: SAP) annoncent aujourd’hui des projets communs pour accompagner leurs clients dans la modernisation de leurs systèmes et processus afin d’accélérer leur présence dans l’économie numérique. Les deux compagnies envisagent particulièrement d’innover ensemble pour créer de nouvelles solutions qui augmentent la valeur ajoutée du client en s’appuyant sur des extensions cognitives, des expériences client et utilisateur renforcées ainsi que des fonctionnalités sectorielles. Tout ceci doté de la SAP® Business Suite, du logiciel 4 SAP HANA® (SAP S/4HANA) et disponible sur site et dans le Cloud.

Les deux sociétés s'unissent afin de redéfinir le travail quotidien de millions de personnes

@IBM et Hardis Group signent un accord mondial pour transformer la chaîne logistique à l'heure du #client connecté #smartercommerce

lior Banque annonce aujourd’hui avoir choisi l’application IBM MobileFirst sur iOS pour apporter une transformation fondamentale à la façon dont les clients en Pologne interagissent avec leur banque. A l’aide d’un iPad, les professionnels des services bancaires pourront fournir une expérience plus dynamique et personnalisée aux clients en tirant avantage de la puissance de l’analyse prédictive, et ce de façon sécurisée, facile, rapide et disponible 24h/24.

ANZ, Commonwealth Bank, IBM Scentre Group and Westpac have jointly launched a live pilot for Lygon, a new digital platform using blockchain technology to transform the way businesses obtain and manage bank guarantees that are often required as part of a retail property lease.

Icon Group first in Australia to adopt world-leading technology as part of its comprehensive cancer care offering

Einstein’s derivation of the Lorentz Transformation is purely theoretical. This study shows how it is related to the physical phenomenon of time dilation and length contraction. The Lorentz Transformation was first derived using the conditions of time dilation and length contraction. Later, Albert Einstein has given a different derivation of the Lorentz Transformation by using...

Without length contraction, time relativity transformation solves paradoxes and explains incongruent relativistic experiments, which allows us to build a transformation of coordinates without length contraction. For abscissa transformation, Figure 1 shows a spaceship in the frame of O1, its backend is at O1 and frontend at A1. At time zero the spaceship is stationary, from...

A discrepancy-free transformation of velocity is derived using the Time relativity transformation of coordinates because relativistic transformation of velocity creates a discrepancy. The relativistic transformation of velocity expresses the velocity u2 of an object q in frame 2 in terms of its velocity in frame 1. In frame 2 at time tq, the position of...

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Carmel and IU grad Sage Steele will co-host and star athletes like Drew Brees and Venus Williams will announce winners during the online broadcast.

The owner of FoxGardin in Fortville transformed himself into Joe Exotic to help his workers.

The owner of FoxGardin in Fortville transformed himself into Joe Exotic to help his workers.

Carmel and IU grad Sage Steele will co-host and star athletes like Drew Brees and Venus Williams will announce winners during the online broadcast.

• The storied investment bank is seeing leadership shakeups under CEO David Solomon and a slew of partner departures. 
• Goldman has been moving away from high-risk businesses like trading and is making pushes into more stable areas like consumer lending, wealth management, and transaction banking. 
• There have been big cultural changes, too. Solomon is looking to create a more transparent workplace, while new tech execs are taking cues from Silicon Valley heavy-hitters. 
• At Business Insider, we are closely tracking the latest developments at Goldman. You can read all of our Goldman coverage on BI Prime.

Storied Wall Street bank Goldman Sachs is going through some massive changes under CEO David Solomon.

It's taken big steps involving transparency and inclusion to change up its culture. It has seen a slew of partner departures — many in the securities division. And it's making big pushes into businesses like wealth management and transaction banking.  

The latest people moves

• Goldman Sachs just hired Kurt Hoffman, an expert in distressed situations and bankruptcy, to join a trading unit known for some of the bank's most lucrative deals
• Goldman Sachs' top tech exec explains how a fresh slew of senior hires are transforming the bank's approach to building products
• Read the full memo Goldman Sachs just sent naming 4 execs to lead its private-equity investments across the merchant-banking division

Culture and talent

• Read the full memo Goldman Sachs just sent to staff announcing its new head of regulatory affairs. The former White House counsel will be tasked with helping clean up the bank's 1MDB drama.
• Goldman Sachs just hired 2 senior recruiting execs focused on luring top talent from other firms —and it's a huge departure from the firm's traditional promote-from-within mentality
• Read the full memo David Solomon just sent to 38,000 Goldman Sachs employees explaining why he's moving his management team out of stuffy offices and into open seating
• Goldman Sachs CEO David Solomon and his management team are ditching their stuffy offices and moving to an open floor plan closer to the people so they can feel the buzz of New York headquarters
• Goldman Sachs just unveiled a new gender pronouns initiative as part of a broader inclusion push at the Wall Street firm
• Read the memo Goldman Sachs just sent to its employees unveiling a new pronouns initiative

Coronavirus response

• Inside a 38,000-person remote work rollout at Goldman Sachs: sleepless nights, assembly lines, and an Amazon-like hub on a Manhattan trading floor
• How a massive New York hospital secured 130,000 N95 masks from China with help from a senior partner at Goldman Sachs, private jets, and a call to Warren Buffett
• Goldman Sachs CEO David Solomon just sent a firm-wide voicemail about the coronavirus crisis. Here's what he told employees.
• Goldman Sachs and Bank of America just updated their WFH policies — again. Here's what they're telling employees about the latest steps aimed at combating the spread of coronavirus.
• Read the full memo Goldman Sachs top brass just sent detailing the firm's coronavirus contingency plans, including separating employees into 'blue' and 'white' teams to alternate working from the office and home

Consumer push, transaction banking, wealth management

• Goldman Sachs just announced its first partnership for transaction banking as it looks to build a new $1 billion business moving money around the world
• Goldman Sachs is sending much less mail to potential Marcus customers. A senior exec lays out the reason why.
• A Goldman Sachs exec explains why the bank isn't sweating concerns over the Apple Card's profitability
• A Wall Street firm crunched the numbers around how much Apple will make from its new credit card with Goldman Sachs
• Here's why Goldman Sachs just did its biggest deal in nearly 20 years as part of a pivot to less wealthy clients
• Goldman Sachs execs are opening up about their plans for Marcus, and they think it can do to banking what iTunes did to the music industry
• Goldman Sachs' partnership with Apple could move it a step closer to being 'a bank branch in your pocket'
• Human resources is the next battleground for Wall Street wealth advisers as Morgan Stanley and Goldman Sachs jockey over new turf
• Goldman Sachs has a novel method for predicting the next economic slump, and it's at the heart of its hot new business

Technology

• JPMorgan and Goldman Sachs are finally beginning to embrace fintech startups. Here's how they test the waters before committing to working with them.
• We talked to the execs behind Bloomberg's new data partnership with Goldman Sachs. Here's why they think it's a sign of Wall Street's future.
• Goldman Sachs is putting its own Marquee app on Amazon's cloud in a pitch to lure more fintech developers
• Goldman Sachs is embracing open-source code and its chief data officer says it's part of a "new world" of software
• Read the memo the new Goldman tech chief sent to the firm's 9,000-plus engineers where he urges them to ditch presentations in favor of Amazon's famous narratives
• A new Goldman Sachs tech exec hired from Amazon is taking a page from the Jeff Bezos playbook by urging engineers to ditch PowerPoint and write memos
• Goldman Sachs' new CTO shares his strategy for attracting outside developers to work more closely with the bank, giving a glimpse into the future of how Wall Street will work
• A Verizon executive is joining Goldman Sachs as chief technology officer as the Wall Street bank reshuffles its ranks
• Marty Chavez is retiring from Goldman Sachs. We chatted with him about the bank's tech transformation, why now is the right time for him to step down, and what he's planning next.
• Goldman Sachs tech guru Marty Chavez is retiring from the bank
• Goldman Sachs' CEO just warned that the bank's big tech bets might not pay off as quickly as people hope
• Goldman Sachs is scrapping a homegrown email app it once touted — and it's a sign the bank is moving away from building tech in house
• Goldman Sachs is exploring plans to create a Netflix for data, and it marks a new frontier for Wall Street
• Goldman Sachs' internal idea factory hatched a plan for the Google of Wall Street, and it's now looking for the next big thing to disrupt the bank
• Goldman Sachs' big bet on the future of Wall Street had a rocky start. Here's the inside story of the bank's struggle to grow its next business and an exclusive look at its plans

Trading

• Bank of America is shaking up its global markets division and poached a Goldman Sachs exec to fill a key new role
• Goldman Sachs' massive quant business now rivals AQR and Two Sigma. We talked to the bank's top quant about asset growth, finding data sources, and why critics of computerized trading are wrong.
• Goldman Sachs' CEO tells us the bank is winning over quant clients. That helped it outpace rivals like JPMorgan last quarter.
• Goldman Sachs is cutting about 5% of sales and trading staff after senior equities leaders delivered a tough town-hall talk
• Goldman Sachs is moving away from a tool championed by its former CFO as it pushes its traders to see clients where they once saw quick wins
• Goldman Sachs is shuffling its top stock trading executives as the business tries to claw back market share from Morgan Stanley and JPMorgan
• Goldman Sachs's bond trading unit is still trying to find its way — and it represents a key challenge for new CEO David Solomon

Alternatives

• Read the full memo Goldman Sachs just sent naming 4 execs to lead its private-equity investments across the merchant-banking division
• Goldman Sachs is making targeted hires for a 'storefront' for alternative investments that's modeled after firms like KKR and Blackstone
• Goldman Sachs' push into private equity is ruffling feathers at Blackstone — and it might be a sign of big client skirmishes to come
• Goldman Sachs execs are jockeying for control of the firm's lucrative private investing units after a plan to merge it — and the stakes couldn't be higher
• Meet the Goldman Sachs execs tasked with building the firms' new Blackstone-esque private-investing unit — and pumping up the bank's flagging stock price
• 'It's good to be Rich': Meet the Goldman Sachs banker who has built a private investing empire that goes head-to-head with Blackstone — and you've probably never heard of him
• Goldman Sachs is considering a shakeup of its alternative investing units as part of a plan to simplify the bank's strategy

Deals

• Goldman Sachs is assembling a team of senior bankers focused on middle-market private equity. Here are the key hires and the playbook they'll use to land new clients.
• Goldman Sachs unloaded some of its WeWork shares before its investment bankers pitched investors on what it once considered a $60 billion-plus IPO
• Goldman Sachs just revealed it sold part of its Uber stake to SoftBank and it helped boost a $4.5 billion business
• A senior Goldman Sachs fintech banker was about to join JPMorgan — but then got lured back —and it's another sign of the fierce battle for M&A talent
• Goldman just promoted a star tech banker close to Tesla and Microsoft to co-head one of its most profitable businesses, as incoming CEO Solomon makes his mark
• Goldman Sachs just announced a shakeup of its leadership — and it signals the rise of bankers over traders
• A tug-of-war between Goldman Sachs and JPMorgan over a top banker highlights Wall Street's $1 trillion battleground

Investor day 2020

• Inside Goldman Sachs' first investor day, where avocado toast and crab apples were served with tech talk, 3-year plans, and a surprising trading mea culpa
• Goldman Sachs just revealed a new wealth brand at its first-ever investor day. It shows how the bank is trying to reshape its strategy — and image.
• Goldman Sachs just unveiled hundreds of slides laying out the future of the company. Here are the 10 crucial slides that show how it plans to transform into a bank for everyone.
• Goldman Sachs is rethinking how it makes private-equity bets with its own money – and one analyst thinks that shift will be a big driver of its stock price

Careers 

• Goldman Sachs is now hiring high-school graduates for roles in Salt Lake City, one of the company's 'high value' locations
• Goldman Sachs has lost at least 54 partners since David Solomon became CEO. We're keeping a running list — and compiling details from insiders about how the exits are being celebrated.
• Read the full memo Goldman Sachs' top brass just sent to staff announcing 2 heads of the bank's private-investing arm are out as it's gearing up to raise billions
• 2 coheads of Goldman Sachs' private-investing business are retiring, in a blow to David Solomon's fundraising plans
• A Goldman Sachs partner who just resigned is leaving behind a job overseeing $2 billion for a London VC with a leading stake in neobank Revolut
• Read the memo announcing the departure of Adam Korn, the Goldman Sachs exec who was 'instrumental in building and championing' innovations like the bank's Marquee platform
• Another Goldman Sachs partner is out. HR chief Dane Holmes is the latest key player to leave the Wall Street bank in a matter of days.
• Goldman Sachs is offering buyouts to encourage partners to leave as CEO David Solomon works to shrink one of the most elite clubs on Wall Street
• Goldman Sachs is making renewable energy a big priority based on its hiring strategy. It's a sign that its ideas incubator is working.
• The David Solomon era at Goldman Sachs kicked off with 43 words Lloyd Blankfein would never say
• Goldman Sachs CEO David Solomon shares his best leadership advice
• Goldman Sachs is shaking up the way it stocks one of the most elite clubs on Wall Street — and it shows how banks are back to making money again
• Goldman Sachs' 1MDB problems are eating into employee morale, and insiders worry the firm will use its legal woes as an excuse to scrimp on bonuses
• Goldman Sachs is about to move dozens of jobs out of pricey New York to Utah as Wall Street turns to cheaper cities

Join the conversation about this story »

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The protein-tyrosine phosphatase SHP2 is an allosteric enzyme critical for cellular events downstream of growth factor receptors. Mutations in the SHP2 gene have been linked to many different types of human diseases, including developmental disorders, leukemia, and solid tumors. Unlike most SHP2-activating mutations, the T507K substitution in SHP2 is unique in that it exhibits oncogenic Ras-like transforming activity. However, the biochemical basis of how the SHP2/T507K variant elicits transformation remains unclear. By combining kinetic and biophysical methods, X-ray crystallography, and molecular modeling, as well as using cell biology approaches, here we uncovered that the T507K substitution alters both SHP2 substrate specificity and its allosteric regulatory mechanism. We found that although SHP2/T507K exists in the closed, autoinhibited conformation similar to the WT enzyme, the interactions between its N-SH2 and protein-tyrosine phosphatase domains are weakened such that SHP2/T507K possesses a higher affinity for the scaffolding protein Grb2-associated binding protein 1 (Gab1). We also discovered that the T507K substitution alters the structure of the SHP2 active site, resulting in a change in SHP2 substrate preference for Sprouty1, a known negative regulator of Ras signaling and a potential tumor suppressor. Our results suggest that SHP2/T507K's shift in substrate specificity coupled with its preferential association of SHP2/T507K with Gab1 enable the mutant SHP2 to more efficiently dephosphorylate Sprouty1 at pTyr-53. This dephosphorylation hyperactivates Ras signaling, which is likely responsible for SHP2/T507K's Ras-like transforming activity.

The protein-tyrosine phosphatase SHP2 is an allosteric enzyme critical for cellular events downstream of growth factor receptors. Mutations in the SHP2 gene have been linked to many different types of human diseases, including developmental disorders, leukemia, and solid tumors. Unlike most SHP2-activating mutations, the T507K substitution in SHP2 is unique in that it exhibits oncogenic Ras-like transforming activity. However, the biochemical basis of how the SHP2/T507K variant elicits transformation remains unclear. By combining kinetic and biophysical methods, X-ray crystallography, and molecular modeling, as well as using cell biology approaches, here we uncovered that the T507K substitution alters both SHP2 substrate specificity and its allosteric regulatory mechanism. We found that although SHP2/T507K exists in the closed, autoinhibited conformation similar to the WT enzyme, the interactions between its N-SH2 and protein-tyrosine phosphatase domains are weakened such that SHP2/T507K possesses a higher affinity for the scaffolding protein Grb2-associated binding protein 1 (Gab1). We also discovered that the T507K substitution alters the structure of the SHP2 active site, resulting in a change in SHP2 substrate preference for Sprouty1, a known negative regulator of Ras signaling and a potential tumor suppressor. Our results suggest that SHP2/T507K's shift in substrate specificity coupled with its preferential association of SHP2/T507K with Gab1 enable the mutant SHP2 to more efficiently dephosphorylate Sprouty1 at pTyr-53. This dephosphorylation hyperactivates Ras signaling, which is likely responsible for SHP2/T507K's Ras-like transforming activity.

13 March 2014 , Volume 90, Number 2

Jason M. Ridlon
Feb 1, 2006; 47:241-259
Reviews

Corporate Members Event Nominees Breakfast Briefing Partners and Major Corporates

Event participants

Christophe Bellmann, Associate Fellow, Hoffmann Centre for Sustainable Resource Economy, Chatham House

Carolyn Deere Birkbeck, Associate Fellow, Global Economy and Finance Department and Hoffmann Centre for Sustainable Resource Economy, Chatham House

N. Arcozzi, K. Domelevo and S. Petermichl
Proc. Amer. Math. Soc. 148 (2020), 2433-2446.
Abstract, references and article information

The protein-tyrosine phosphatase SHP2 is an allosteric enzyme critical for cellular events downstream of growth factor receptors. Mutations in the SHP2 gene have been linked to many different types of human diseases, including developmental disorders, leukemia, and solid tumors. Unlike most SHP2-activating mutations, the T507K substitution in SHP2 is unique in that it exhibits oncogenic Ras-like transforming activity. However, the biochemical basis of how the SHP2/T507K variant elicits transformation remains unclear. By combining kinetic and biophysical methods, X-ray crystallography, and molecular modeling, as well as using cell biology approaches, here we uncovered that the T507K substitution alters both SHP2 substrate specificity and its allosteric regulatory mechanism. We found that although SHP2/T507K exists in the closed, autoinhibited conformation similar to the WT enzyme, the interactions between its N-SH2 and protein-tyrosine phosphatase domains are weakened such that SHP2/T507K possesses a higher affinity for the scaffolding protein Grb2-associated binding protein 1 (Gab1). We also discovered that the T507K substitution alters the structure of the SHP2 active site, resulting in a change in SHP2 substrate preference for Sprouty1, a known negative regulator of Ras signaling and a potential tumor suppressor. Our results suggest that SHP2/T507K's shift in substrate specificity coupled with its preferential association of SHP2/T507K with Gab1 enable the mutant SHP2 to more efficiently dephosphorylate Sprouty1 at pTyr-53. This dephosphorylation hyperactivates Ras signaling, which is likely responsible for SHP2/T507K's Ras-like transforming activity.