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In shift, Bloomberg offers ex-campaign staff health coverage

Michael Bloomberg will cover healthcare for ex-campaign staffers through November. His firing of staffers prompted lawsuits against the billionaire.




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Kings' Anze Kopitar in favor of resuming regular season instead of going straight to playoffs

Kings captain Anze Kopitar says if the NHL can resume after the coronavirus pandemic subsides, it should continue the regular season and not go straight to the playoffs.




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Dwayne Johnson sends retiring teacher swag box and personal video after Twitter campaign

He’s teaching a class on how to be a good guy.




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Surviving the Shutdown: Brodard Restaurant keeps feeding Little Saigon

Sales are down at one of Orange County's most famous Vietnamese restaurants, but Brodard is adapting to survive




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What Susan Straight is reading, hearing and watching in quarantine

Quarantined in Riverside, novelist Susan Straight watches "Gunsmoke" and "Gentefied" and gives away Judy Blume and National Geographic.




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Padres pitcher Craig Stammen buys Coronado home close to Petco Park

In the resort city of Coronado, Padres pitcher Craig Stammen recently shelled out $3.7 million for a home right across the bay from Petco Park.




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'Straight Up' and our critics' 15 best choices to watch at home

Times' critics Justin Chang and Kenneth Turan recommend "Parasite," "Knives Out," "The Invisible Man" and more as the best new releases to watch at home.




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Media in the US: lax campaign financing bad for democracy but good for media companies

US campaign financing rules have been relaxed even further in recent years, making a worrying problem about the state of American democracy worse (because those with money have even more ability to try and buy votes or influence policy).

Media coverage of this issue, though it may pop up from time to time, seems quite limited. Perhaps because it is estimated that television stations this year could make as much as eight billion dollars from political campaigns.

The state of US mainstream media has unfortunately been lamentable for many years, and after the issues around hurricane Katrina, it was thought that the media would be rejuvenated. Unfortunately it does not seem that way.

This page has been updated with further information about campaign financing issues and how limits in the US have been lifted making the problem worse. Also added were notes on US press freedom, and an info graphic on media ownership concentration.

Read full article: Media in the United States




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Next James Bond odds: Tom Hardy OVERTAKES Richard Madden in race to replace Daniel Craig



NEXT JAMES BOND odds favourite Tom Hardy has overtaken Richard Madden in the race to replace Daniel Craig after No Time To Die.




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Stuart Lancaster interview: Leinster coach opens up on remarkable campaign - EXCLUSIVE



Stuart Lancaster spoke to Daily Express Chief Sports Writer about his season with Leinster.




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Brexit sabotage: David Cameron’s bid to derail Vote Leave campaign exposed



BREXIT was almost thwarted before it could even begin as former Prime Minister David Cameron planned legislation that could have significantly damaged Vote Leave's referendum campaign, a book claims.




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Brexit sabotage: David Cameron’s bid to derail Vote Leave campaign exposed



BREXIT was almost thwarted before it could even begin as former Prime Minister David Cameron planned legislation that could have significantly damaged Vote Leave's referendum campaign, a book claims.




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Next James Bond odds: Tom Hardy OVERTAKES Richard Madden in race to replace Daniel Craig



NEXT JAMES BOND odds favourite Tom Hardy has overtaken Richard Madden in the race to replace Daniel Craig after No Time To Die.




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Strictly can go on in September despite coronavirus, Craig says



STRICTLY star Craig Revel Horwood has revealed that the show can still go on in September despite coronavirus - but it will be Strictly Social Distancing.




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Letters: Trump keeps campaign promises by building a robust economy

Keeping him in office prevents the left from destroying America with their socialistic ideology, a letter to the editor says.

      




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Some 5th District candidates rely on personal loans for campaigns amid coronavirus

Republican state Sen. Victoria Spartz had the biggest personal loan, giving her campaign $750,000 while raising under $10,000.

       




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Varvel: Drawing campaign commercials

Watch Gary Varvel's time lapse video of of negative political campaign commercials.

      




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Cartoonist Gary Varvel: Negative campaign commercials

Many voters are turned off by political attacks.

      




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Brownsburg boys defeat Plainfield for third straight Hendricks County title

Brownsburg defeats Plainfield, 55-43

      




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Some 5th District candidates rely on personal loans for campaigns amid coronavirus

Republican state Sen. Victoria Spartz had the biggest personal loan, giving her campaign $750,000 while raising under $10,000.

       




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Mother Teresa attorney to 5th District candidate: stop using her name, image in campaign ads

A lawyer who served as legal counsel for Mother Teresa told Republican Chuck Dietzen to stop using Mother Teresa's name and image in ads.

       




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Biden campaign calls Pence visit to Indiana ventilator factory an undeserved victory lap

Mike Pence will visit Kokomo Thursday to highlight the administration's response to the novel coronavirus pandemic.

       




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'I was wrong': Mother Teresa lawyer addresses 2016 ad in dust-up with Indiana campaign

Florida attorney Jim Towey, who represented Mother Teresa for over a decade, said he regrets using her image in a 2016 ad for a U.S. House candidate.

       




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Thompson: Setting the Record Straight

After a court acquittal former Labor Secretary, Ray Donovan, was famously quoted as saying, “Which office do I go to to get my reputation back?” I’ve chosen pursuits that have put me under a microscope for public scrutiny. I was an Army Officer and after leaving the service I got […]




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Presidential hopefuls swap the campaign trail for the field at Congressional Women’s Softball Game

The Members team ultimately fell 10-4 to the press team, despite valiant efforts from players such as 2020 presidential hopeful and team pitcher Kirsten Gillibrand.




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Cory Booker and his ‘boo,’ Rosario Dawson, take their relationship on the campaign trail

Low-key no longer: The presidential candidate and his actress girlfriend appeared together at public events over the holiday weekend.




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Cardi B continues her support of Bernie Sanders by filming a campaign video together

The rapper has been a supporter of the Democratic presidential candidate, and says she wants to help "a movement of young people to transform this country."




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Donald Trump Jr.’s ‘Triggered’ reads like a campaign book for 2024




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News24.com | Former UKZN Maritzburg SRC president sets the record straight

I am requesting that you publish this letter as a response to the article so that my side of the story can be heard in order to provide a balanced view.




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AT#374 - Travel to Ho Chi Minh City (Saigon), Vietnam

Hear about travel to Ho Chi Minh City (Saigon), Vietnam as the Amateur Traveler talks to Jodi Ettenberg from legalnomads.com.




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Inside the Assad Regime’s Surreal “Summer in Syria” Campaign

The Assad government sought to promote regime-sponsored cultural events through a marketing campaign called "Summer in Syria," but the effort didn't exactly go as planned.




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Inside the Making of “Terror in Little Saigon”

A.C. Thompson and Richard Rowley’s search for answers into the killings of five Vietnamese-American journalists took them from cities like Houston and San Francisco, to the jungles of Southeast Asia, to the corridors of power in Washington.




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Terror in Little Saigon

From 1981 to 1990, five Vietnamese-American journalists were killed in what some suspected was a string of political assassinations. Why did the murders go unsolved?




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A Campaign of Disappearances in Syria Leaves Thousands Missing

At least 65,116 individuals have been "forcibly disappeared" by the Syrian government, according to a new report by Amnesty International.




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CBD Communiqué: Discovery Communications and the United Nations Announce Partnership to Celebrate International Year of Biodiversity: Awareness Campaign to Promote Biological Diversity.




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CBD Press Release: International Year of Biodiversity Wins the Green Award as Best Global Environmental Campaign.




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CBD News: To focus attention on the global extinction crises and advance implementation of the Aichi Biodiversity Targets, the LifeWeb initiative of the Convention on Biological Diversity (CBD) is launching the Zero Extinction Campaign.




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AIG1 and ADTRP are endogenous hydrolases of fatty acid esters of hydroxy fatty acids (FAHFAs) in mice [Metabolism]

Fatty acid esters of hydroxy fatty acids (FAHFAs) are a newly discovered class of signaling lipids with anti-inflammatory and anti-diabetic properties. However, the endogenous regulation of FAHFAs remains a pressing but unanswered question. Here, using MS-based FAHFA hydrolysis assays, LC-MS–based lipidomics analyses, and activity-based protein profiling, we found that androgen-induced gene 1 (AIG1) and androgen-dependent TFPI-regulating protein (ADTRP), two threonine hydrolases, control FAHFA levels in vivo in both genetic and pharmacologic mouse models. Tissues from mice lacking ADTRP (Adtrp-KO), or both AIG1 and ADTRP (DKO) had higher concentrations of FAHFAs particularly isomers with the ester bond at the 9th carbon due to decreased FAHFA hydrolysis activity. The levels of other lipid classes were unaltered indicating that AIG1 and ADTRP specifically hydrolyze FAHFAs. Complementing these genetic studies, we also identified a dual AIG1/ADTRP inhibitor, ABD-110207, which is active in vivo. Acute treatment of WT mice with ABD-110207 resulted in elevated FAHFA levels, further supporting the notion that AIG1 and ADTRP activity control endogenous FAHFA levels. However, loss of AIG1/ADTRP did not mimic the changes associated with pharmacologically administered FAHFAs on extent of upregulation of FAHFA levels, glucose tolerance, or insulin sensitivity in mice, indicating that therapeutic strategies should weigh more on FAHFA administration. Together, these findings identify AIG1 and ADTRP as the first endogenous FAHFA hydrolases identified and provide critical genetic and chemical tools for further characterization of these enzymes and endogenous FAHFAs to unravel their physiological functions and roles in health and disease.




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Biden holds remote campaign events with supporters

The presumptive Democratic presidential nominee Joe Biden campaigns virtually in his Delaware home; Fox News correspondent Peter Doocy reports.





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AIG1 and ADTRP are endogenous hydrolases of fatty acid esters of hydroxy fatty acids (FAHFAs) in mice [Metabolism]

Fatty acid esters of hydroxy fatty acids (FAHFAs) are a newly discovered class of signaling lipids with anti-inflammatory and anti-diabetic properties. However, the endogenous regulation of FAHFAs remains a pressing but unanswered question. Here, using MS-based FAHFA hydrolysis assays, LC-MS–based lipidomics analyses, and activity-based protein profiling, we found that androgen-induced gene 1 (AIG1) and androgen-dependent TFPI-regulating protein (ADTRP), two threonine hydrolases, control FAHFA levels in vivo in both genetic and pharmacologic mouse models. Tissues from mice lacking ADTRP (Adtrp-KO), or both AIG1 and ADTRP (DKO) had higher concentrations of FAHFAs particularly isomers with the ester bond at the 9th carbon due to decreased FAHFA hydrolysis activity. The levels of other lipid classes were unaltered indicating that AIG1 and ADTRP specifically hydrolyze FAHFAs. Complementing these genetic studies, we also identified a dual AIG1/ADTRP inhibitor, ABD-110207, which is active in vivo. Acute treatment of WT mice with ABD-110207 resulted in elevated FAHFA levels, further supporting the notion that AIG1 and ADTRP activity control endogenous FAHFA levels. However, loss of AIG1/ADTRP did not mimic the changes associated with pharmacologically administered FAHFAs on extent of upregulation of FAHFA levels, glucose tolerance, or insulin sensitivity in mice, indicating that therapeutic strategies should weigh more on FAHFA administration. Together, these findings identify AIG1 and ADTRP as the first endogenous FAHFA hydrolases identified and provide critical genetic and chemical tools for further characterization of these enzymes and endogenous FAHFAs to unravel their physiological functions and roles in health and disease.




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AIG1 and ADTRP are endogenous hydrolases of fatty acid esters of hydroxy fatty acids (FAHFAs) in mice [Metabolism]

Fatty acid esters of hydroxy fatty acids (FAHFAs) are a newly discovered class of signaling lipids with anti-inflammatory and anti-diabetic properties. However, the endogenous regulation of FAHFAs remains a pressing but unanswered question. Here, using MS-based FAHFA hydrolysis assays, LC-MS–based lipidomics analyses, and activity-based protein profiling, we found that androgen-induced gene 1 (AIG1) and androgen-dependent TFPI-regulating protein (ADTRP), two threonine hydrolases, control FAHFA levels in vivo in both genetic and pharmacologic mouse models. Tissues from mice lacking ADTRP (Adtrp-KO), or both AIG1 and ADTRP (DKO) had higher concentrations of FAHFAs particularly isomers with the ester bond at the 9th carbon due to decreased FAHFA hydrolysis activity. The levels of other lipid classes were unaltered indicating that AIG1 and ADTRP specifically hydrolyze FAHFAs. Complementing these genetic studies, we also identified a dual AIG1/ADTRP inhibitor, ABD-110207, which is active in vivo. Acute treatment of WT mice with ABD-110207 resulted in elevated FAHFA levels, further supporting the notion that AIG1 and ADTRP activity control endogenous FAHFA levels. However, loss of AIG1/ADTRP did not mimic the changes associated with pharmacologically administered FAHFAs on extent of upregulation of FAHFA levels, glucose tolerance, or insulin sensitivity in mice, indicating that therapeutic strategies should weigh more on FAHFA administration. Together, these findings identify AIG1 and ADTRP as the first endogenous FAHFA hydrolases identified and provide critical genetic and chemical tools for further characterization of these enzymes and endogenous FAHFAs to unravel their physiological functions and roles in health and disease.




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Covid-19: Campaigner calls for national guidance to stop DNR orders being made without discussion with patients and families




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Behind the campaign promises - GP numbers, and appointment slots

A UK general election has been called - polling day is on the 12th of December, and from now until then we’re going to be bringing you a weekly election-themed podcast. We want to help you make sense of the promises and pledges, claims and counter-claims, that are being made around healthcare and the NHS out on the campaign trail. This week has...




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Behind the campaign promises - Health and social care spending

A UK general election has been called - polling day is on the 12th of December, and from now until then we’re going to be bringing you a weekly election-themed podcast. We want to help you make sense of the promises and pledges, claims and counter-claims, that are being made around healthcare and the NHS out on the campaign trail. This week...




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Behind the campaign promises - Health beyond the NHS

A UK general election has been called - polling day is on the 12th of December, and from now until then we’re going to be bringing you a weekly election-themed podcast. We want to help you make sense of the promises and pledges, claims and counter-claims, that are being made around healthcare and the NHS out on the campaign trail. This week...




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Behind the campaign promises - what the NHS means for the election

UK general election has been called - polling day is on the 12th of December, and from now until then we’re going to be bringing you a weekly election-themed podcast. We want to help you make sense of the promises and pledges, claims and counter-claims, that are being made around healthcare and the NHS out on the campaign trail. This week we're...




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Behind the campaign promises - Doctors in parliament

The UK general election is happening this week, and you’ve probably made your mind up which MP you’re voting for already - and maybe the NHS has influenced that decision. This year has seen an increase in the number of doctors running for parliament, and in this podcast we find out what motivates doctors to step away from clinical practice, and...




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Trump Administration Makes Down Payment on Campaign Pledges to Address Illegal Immigration

In its first year, the Trump administration moved to deliver on some of Donald Trump’s campaign promises on immigration, including ramping up enforcement in the U.S. interior and ending the Deferred Action for Childhood Arrivals (DACA) program. The administration also announced the termination of Temporary Protected Status (TPS) for nationals of some countries. This article explores some of the top policy changes.




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Dr. Bettie McKaig, first female ADA vice president, dies

Dr. Bettie R. McKaig, who served as the Association’s first vice president from 1998-99, died Feb. 3. She was 70.




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ADA initiates grassroots campaign in response to CARES Act

The ADA is calling on dentists everywhere to contact their legislators today ahead of the Senate’s vote on the Coronavirus Aid, Relief and Economic Security Act.