In shift, Bloomberg offers ex-campaign staff health coverage
Michael Bloomberg will cover healthcare for ex-campaign staffers through November. His firing of staffers prompted lawsuits against the billionaire.
Michael Bloomberg will cover healthcare for ex-campaign staffers through November. His firing of staffers prompted lawsuits against the billionaire.
Kings captain Anze Kopitar says if the NHL can resume after the coronavirus pandemic subsides, it should continue the regular season and not go straight to the playoffs.
Sales are down at one of Orange County's most famous Vietnamese restaurants, but Brodard is adapting to survive
Quarantined in Riverside, novelist Susan Straight watches "Gunsmoke" and "Gentefied" and gives away Judy Blume and National Geographic.
In the resort city of Coronado, Padres pitcher Craig Stammen recently shelled out $3.7 million for a home right across the bay from Petco Park.
Times' critics Justin Chang and Kenneth Turan recommend "Parasite," "Knives Out," "The Invisible Man" and more as the best new releases to watch at home.
US campaign financing rules have been relaxed even further in recent years, making a worrying problem about the state of American democracy worse (because those with money have even more ability to try and buy votes or influence policy).
Media coverage of this issue, though it may pop up from time to time, seems quite limited. Perhaps because it is estimated that television stations this year could make as much as eight billion dollars from political campaigns.
The state of US mainstream media has unfortunately been lamentable for many years, and after the issues around hurricane Katrina, it was thought that the media would be rejuvenated. Unfortunately it does not seem that way.
This page has been updated with further information about campaign financing issues and how limits in the US have been lifted making the problem worse. Also added were notes on US press freedom, and an info graphic on media ownership concentration.
Read full article: Media in the United States
Keeping him in office prevents the left from destroying America with their socialistic ideology, a letter to the editor says.
Republican state Sen. Victoria Spartz had the biggest personal loan, giving her campaign $750,000 while raising under $10,000.
Republican state Sen. Victoria Spartz had the biggest personal loan, giving her campaign $750,000 while raising under $10,000.
A lawyer who served as legal counsel for Mother Teresa told Republican Chuck Dietzen to stop using Mother Teresa's name and image in ads.
Mike Pence will visit Kokomo Thursday to highlight the administration's response to the novel coronavirus pandemic.
Florida attorney Jim Towey, who represented Mother Teresa for over a decade, said he regrets using her image in a 2016 ad for a U.S. House candidate.
After a court acquittal former Labor Secretary, Ray Donovan, was famously quoted as saying, “Which office do I go to to get my reputation back?” I’ve chosen pursuits that have put me under a microscope for public scrutiny. I was an Army Officer and after leaving the service I got […]
The Members team ultimately fell 10-4 to the press team, despite valiant efforts from players such as 2020 presidential hopeful and team pitcher Kirsten Gillibrand.
Low-key no longer: The presidential candidate and his actress girlfriend appeared together at public events over the holiday weekend.
The rapper has been a supporter of the Democratic presidential candidate, and says she wants to help "a movement of young people to transform this country."
I am requesting that you publish this letter as a response to the article so that my side of the story can be heard in order to provide a balanced view.
Hear about travel to Ho Chi Minh City (Saigon), Vietnam as the Amateur Traveler talks to Jodi Ettenberg from legalnomads.com.
Fatty acid esters of hydroxy fatty acids (FAHFAs) are a newly discovered class of signaling lipids with anti-inflammatory and anti-diabetic properties. However, the endogenous regulation of FAHFAs remains a pressing but unanswered question. Here, using MS-based FAHFA hydrolysis assays, LC-MS–based lipidomics analyses, and activity-based protein profiling, we found that androgen-induced gene 1 (AIG1) and androgen-dependent TFPI-regulating protein (ADTRP), two threonine hydrolases, control FAHFA levels in vivo in both genetic and pharmacologic mouse models. Tissues from mice lacking ADTRP (Adtrp-KO), or both AIG1 and ADTRP (DKO) had higher concentrations of FAHFAs particularly isomers with the ester bond at the 9th carbon due to decreased FAHFA hydrolysis activity. The levels of other lipid classes were unaltered indicating that AIG1 and ADTRP specifically hydrolyze FAHFAs. Complementing these genetic studies, we also identified a dual AIG1/ADTRP inhibitor, ABD-110207, which is active in vivo. Acute treatment of WT mice with ABD-110207 resulted in elevated FAHFA levels, further supporting the notion that AIG1 and ADTRP activity control endogenous FAHFA levels. However, loss of AIG1/ADTRP did not mimic the changes associated with pharmacologically administered FAHFAs on extent of upregulation of FAHFA levels, glucose tolerance, or insulin sensitivity in mice, indicating that therapeutic strategies should weigh more on FAHFA administration. Together, these findings identify AIG1 and ADTRP as the first endogenous FAHFA hydrolases identified and provide critical genetic and chemical tools for further characterization of these enzymes and endogenous FAHFAs to unravel their physiological functions and roles in health and disease.
Fatty acid esters of hydroxy fatty acids (FAHFAs) are a newly discovered class of signaling lipids with anti-inflammatory and anti-diabetic properties. However, the endogenous regulation of FAHFAs remains a pressing but unanswered question. Here, using MS-based FAHFA hydrolysis assays, LC-MS–based lipidomics analyses, and activity-based protein profiling, we found that androgen-induced gene 1 (AIG1) and androgen-dependent TFPI-regulating protein (ADTRP), two threonine hydrolases, control FAHFA levels in vivo in both genetic and pharmacologic mouse models. Tissues from mice lacking ADTRP (Adtrp-KO), or both AIG1 and ADTRP (DKO) had higher concentrations of FAHFAs particularly isomers with the ester bond at the 9th carbon due to decreased FAHFA hydrolysis activity. The levels of other lipid classes were unaltered indicating that AIG1 and ADTRP specifically hydrolyze FAHFAs. Complementing these genetic studies, we also identified a dual AIG1/ADTRP inhibitor, ABD-110207, which is active in vivo. Acute treatment of WT mice with ABD-110207 resulted in elevated FAHFA levels, further supporting the notion that AIG1 and ADTRP activity control endogenous FAHFA levels. However, loss of AIG1/ADTRP did not mimic the changes associated with pharmacologically administered FAHFAs on extent of upregulation of FAHFA levels, glucose tolerance, or insulin sensitivity in mice, indicating that therapeutic strategies should weigh more on FAHFA administration. Together, these findings identify AIG1 and ADTRP as the first endogenous FAHFA hydrolases identified and provide critical genetic and chemical tools for further characterization of these enzymes and endogenous FAHFAs to unravel their physiological functions and roles in health and disease.
Fatty acid esters of hydroxy fatty acids (FAHFAs) are a newly discovered class of signaling lipids with anti-inflammatory and anti-diabetic properties. However, the endogenous regulation of FAHFAs remains a pressing but unanswered question. Here, using MS-based FAHFA hydrolysis assays, LC-MS–based lipidomics analyses, and activity-based protein profiling, we found that androgen-induced gene 1 (AIG1) and androgen-dependent TFPI-regulating protein (ADTRP), two threonine hydrolases, control FAHFA levels in vivo in both genetic and pharmacologic mouse models. Tissues from mice lacking ADTRP (Adtrp-KO), or both AIG1 and ADTRP (DKO) had higher concentrations of FAHFAs particularly isomers with the ester bond at the 9th carbon due to decreased FAHFA hydrolysis activity. The levels of other lipid classes were unaltered indicating that AIG1 and ADTRP specifically hydrolyze FAHFAs. Complementing these genetic studies, we also identified a dual AIG1/ADTRP inhibitor, ABD-110207, which is active in vivo. Acute treatment of WT mice with ABD-110207 resulted in elevated FAHFA levels, further supporting the notion that AIG1 and ADTRP activity control endogenous FAHFA levels. However, loss of AIG1/ADTRP did not mimic the changes associated with pharmacologically administered FAHFAs on extent of upregulation of FAHFA levels, glucose tolerance, or insulin sensitivity in mice, indicating that therapeutic strategies should weigh more on FAHFA administration. Together, these findings identify AIG1 and ADTRP as the first endogenous FAHFA hydrolases identified and provide critical genetic and chemical tools for further characterization of these enzymes and endogenous FAHFAs to unravel their physiological functions and roles in health and disease.
A UK general election has been called - polling day is on the 12th of December, and from now until then we’re going to be bringing you a weekly election-themed podcast. We want to help you make sense of the promises and pledges, claims and counter-claims, that are being made around healthcare and the NHS out on the campaign trail. This week has...
A UK general election has been called - polling day is on the 12th of December, and from now until then we’re going to be bringing you a weekly election-themed podcast. We want to help you make sense of the promises and pledges, claims and counter-claims, that are being made around healthcare and the NHS out on the campaign trail. This week...
A UK general election has been called - polling day is on the 12th of December, and from now until then we’re going to be bringing you a weekly election-themed podcast. We want to help you make sense of the promises and pledges, claims and counter-claims, that are being made around healthcare and the NHS out on the campaign trail. This week...
UK general election has been called - polling day is on the 12th of December, and from now until then we’re going to be bringing you a weekly election-themed podcast. We want to help you make sense of the promises and pledges, claims and counter-claims, that are being made around healthcare and the NHS out on the campaign trail. This week we're...
The UK general election is happening this week, and you’ve probably made your mind up which MP you’re voting for already - and maybe the NHS has influenced that decision. This year has seen an increase in the number of doctors running for parliament, and in this podcast we find out what motivates doctors to step away from clinical practice, and...
In its first year, the Trump administration moved to deliver on some of Donald Trump’s campaign promises on immigration, including ramping up enforcement in the U.S. interior and ending the Deferred Action for Childhood Arrivals (DACA) program. The administration also announced the termination of Temporary Protected Status (TPS) for nationals of some countries. This article explores some of the top policy changes.
Dr. Bettie R. McKaig, who served as the Association’s first vice president from 1998-99, died Feb. 3. She was 70.
The ADA is calling on dentists everywhere to contact their legislators today ahead of the Senate’s vote on the Coronavirus Aid, Relief and Economic Security Act.