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Repurposing existing drugs for COVID-19 offers a more rapid alternative to a vaccine

Repurposing existing medicines focused on known drug targets is likely to offer a more rapid hope of tackling COVID-19 than developing and manufacturing a vaccine, argue an international team of scientists in the British Journal of Pharmacology today.

Since the emergence of the SARS-CoV-2 virus in late 2019, more than 3.5 million people are known to have been infected, leading to over 240,000 deaths worldwide from COVID-19, the disease caused by the novel coronavirus.




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Firms ready RNAi candidate for COVID-19 development

A collaboration in COVID-19 between immunology specialist Vir Biotechnology and Alnylam Pharmaceuticals…



  • Alnylam Pharmaceuticals/Anti-virals/Biotechnology/Cell and Gene Therapy/Coronavirus/Focus On/Public health/Research/USA/Vir Biotechnology/VIR-2703

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Journal Watch (Holiday 2019)

Closing out another year at BiotechDueDIligence, thank you for following along! Enjoy another round-up of scientific and medical journal articles driving the conversation and newsflow in biotech.There's lots of great #immunology in @sciencemagazine this week! @JSRustenhoven & @jonykipnis (@kipnislab @UVA) author a fascinating Perspective on how immune cells bypass the blood–brain barrier!https://t.co/6QjcNxU0p6 pic.twitter.com/njjnrn9Yej— Seth Thomas Scanlon (@ImmunoEditor) December 20, [...]




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Journal Watch (January 2020)

Important paper out on #Wuhan #nCoV2019 via @biorxivpreprint96% sequence identity to a bat #coronavirus~80% sequence identity to SARS~95% AA sequence identity in 7 conserved replicase domains to SARSuses the same cell entry receptor, ACE2, as SARShttps://t.co/iwaHTsDGJN pic.twitter.com/dGEjBvGx4j— Andy Biotech (@AndyBiotech) January 23, 2020This is major progress in understanding #Parkinsons disease biology!~ #LRRK2 atomic resolution #cryoEM structure~ Switch between active / inactive conforma [...]




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California Man Sentenced to 18 Months in Community Correctional Facility in Connection with Scheme to Defraud First International Bank and Export-Import Bank

Carlos Serrano, 64, of Glendale, Calif., was sentenced to 18 months in a community correctional facility in connection with a $1.3 million scheme to defraud the First International Bank of Connecticut (FIB) and the Export-Import Bank of the United States (Ex-Im Bank). In addition to his prison sentence, Serrano was placed on five years of probation and ordered to pay restitution of $924,569 to the Ex-Im Bank.



  • OPA Press Releases

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Five Defendants Convicted of International Sex Trafficking for Forcing Central American Girls and Women into Prostitution

Five defendants, all members or associates of an extended family, face potential life sentences after being found guilty of sex trafficking for participating in a scheme that lured young Central American women and girls into the Los Angeles area and forced them into prostitution. The defendants, four Guatemalan nationals and one Mexican citizen, were convicted on Feb. 11, 2009, of conspiracy; sex trafficking by force, fraud or coercion; and importation of aliens for purposes of prostitution.



  • OPA Press Releases

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Miami Man Found Guilty in $13.5 Million International Money Laundering Scheme

Rodrigo Molina, 33, a Brazilian national who resided in Miami, was found guilty by a federal jury on 11 of 16 charged counts related to a $13.5 million money laundering conspiracy. Molina was found guilty on Feb. 25, 2009, following a seven-day jury trial in U.S. District Court for the Southern District of Florida.



  • OPA Press Releases

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International Criminal Figure Pleads Guilty to $138 Million Fuel Tax Scheme After Nearly 13 Years as a Fugitive

After nearly 13 years as a fugitive, a former New Jersey resident has been returned to the United States, and pleaded guilty today to conspiring to committing one of the nation’s largest known motor fuel excise tax schemes. Aaron Misulovin a/k/a Albert Friedman, a/k/a Valery Vibornov, pleaded guilty before U.S. District Judge Joseph E. Irenas in Camden, N.J., to one count of conspiracy, three counts of wire fraud, three counts of money laundering and three counts of tax evasion.



  • OPA Press Releases

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Five Defendants Sentenced for Participation in International Child Exploitation Enterprise

Five U.S. defendants convicted for their activity in a global child pornography trafficking enterprise were sentenced today in the Northern District of Florida. The defendants had pled to multiple charges, including engaging in a child exploitation enterprise; conspiracy to advertise, transport, ship, receive and possess child pornography; advertising child pornography; transporting child pornography; and receiving child pornography.



  • OPA Press Releases

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U.S. Department of Justice Promotes International Network to Combat Intellectual Property Crime

Building upon the successes of earlier efforts, the Department today announced the opening in Bangkok of a regional conference of approximately 100 key law enforcement and industry officials from more than a dozen nations with the goal of strengthening international cooperation in fighting large-scale intellectual property crimes.



  • OPA Press Releases

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Iranian Man and His Company Charged in International Scheme to Supply Iran with Sensitive U.S. Technology

An Iranian citizen and his Tehran business have been charged with purchasing helicopter engines and advanced aerial cameras for fighter bombers from U.S. firms and illegally exporting them to Iran using companies in Malaysia, Ireland and the Netherlands. Among the alleged recipients of these U.S. goods was an Iranian military firm that has since been designated by the United States for being owned or controlled by entities involved in Iran’s nuclear and ballistic missile program.



  • OPA Press Releases

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Partner at Major International Accounting Firm Charged with Tax Crimes

A Newark, N.J., federal grand jury has returned an indictment charging Stephen A. Favato, a resident of Point Pleasant Beach, N.J., and a partner at a major international accounting firm, with tax charges for attempting to assist one of his clients evade income taxes. Favato, a partner in the accounting firm’s Woodbridge, N.J., office, was charged with tax evasion regarding the federal income taxes of Daniel Funsch and his spouse.



  • OPA Press Releases

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Three International Airline Companies Agree to Plead Guilty to Price Fixing on Air Cargo Shipments

Three international airline companies—Luxembourg-based Cargolux Airlines International S.A., Japan-based Nippon Cargo Airlines Co. Ltd. (NCA), and Korea-based Asiana Airlines Inc.—have each agreed to plead guilty and pay criminal fines totaling $214 million for conspiring to fix prices in the air cargo industry. In addition, Asiana was charged with fixing the passenger fares charged on flights from the United States to Korea.



  • OPA Press Releases

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Six Defendants Sentenced for Participation in International Child Exploitation Enterprise

WASHINGTON and PENSACOLA, Fla. – Six U.S. defendants convicted for their activity in a global child pornography trafficking enterprise were sentenced today in the Northern District of Florida, Acting Assistant Attorney General of the Criminal Division Rita M. Glavin, U.S. Attorney for the Northern District of Florida Thomas F. Kirwin and FBI Executive Assistant Director J. Stephen Tidwell announced.



  • OPA Press Releases

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Dupont and Lucite International Agree to Pay $2 Million for Clean Air Act Violations

DuPont and Lucite International Inc. have agreed to pay a $2 million civil penalty to settle Clean Air Act violations at a sulfuric acid plant in Belle, W. Va. The sulfuric acid plant is located on a 100-acre chemical manufacturing complex along the Kanawha River. The plant is owned by Lucite and operated by DuPont. The companies will pay $1 million to the United States and $1 million to the state of West Virginia.



  • OPA Press Releases

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Defendant Sentenced to Life for Participation in International Child Exploitation Enterprise

James Freeman of Santa Rosa Beach, Fla., was sentenced to life in prison today for his activity in a global child pornography trafficking enterprise. Freeman, a registered sex offender, was found guilty following a six-day trial in January 2009 of six counts relating to his criminal activities as a member of the child exploitation enterprise.



  • OPA Press Releases

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Chinese Baby Furniture Company Pleads Guilty to Smuggling Internationally Protected Wood

Style Craft Furniture Co. Ltd., pleaded guilty today in U.S. District Court in Camden, N.J., to one count of smuggling cribs containing internationally protected wood known as “ramin.”



  • OPA Press Releases

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Christine A. Varney to Participate in Eighth Annual International Competition Network Conference in Zurich, Switzerland

Christine A. Varney, Assistant Attorney General in charge of the Department’s Antitrust Division, will participate in the eighth annual International Competition Network (ICN) conference in Zurich, Switzerland, from June 3-5, 2009. At the conference, senior government antitrust officials, private-sector antitrust experts from around the world, and representatives from intergovernmental organizations will meet to discuss competition issues.



  • OPA Press Releases

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International Competition Network Adopts Recommended Practices to Improve Merger Analysis and Presents Reports on Unilateral Conduct Issues

At the eighth annual International Competition Network (ICN) conference in Zurich, Switzerland, the ICN adopted new Recommended Practices for substantive merger analysis and presented two new reports on the analysis of tying and bundled discounting and loyalty discounts and rebates under unilateral conduct laws.



  • OPA Press Releases

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Attorney General Holder at the Announcement of the National Southwest Border Counternarcotics Strategy

"By focusing on increased cooperation between the U.S. and Mexican governments as well as enhanced communication within U.S. law enforcement agencies, the National Southwest Border Counternarcotics Strategy we introduce today provides an effective way forward that will crack down on cartels and make our country safer."




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Defendant Sentenced to Life in Prison for Participation in International Child Exploitation Enterprise

Warren Mumpower of Spokane, Wash., was sentenced to life in prison today for his activity in a global child pornography trafficking enterprise.



  • OPA Press Releases

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Alleged International Hacker Indicted for Massive Attack on U.S. Retail and Banking Networks

Albert Gonzalez, 28, of Miami, Fla., was indicted today for conspiring to hack into computer networks supporting major American retail and financial organizations, and stealing data relating to more than 130 million credit and debit cards. Among the corporate victims named in the indictment are Heartland Payment Systems, a New Jersey-based card payment processor; 7-Eleven Inc., a Texas-based nationwide convenience store chain; and Hannaford Brothers Co. Inc., a Maine-based supermarket chain.



  • OPA Press Releases

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International Arms Dealer Arrested for Conspiracy to Supply U.S. Fighter Jet Engines to Iran

Jacques Monsieur, a Belgian national and resident of France suspected of international arms dealing for decades, has been arrested on charges alleging that he conspired to illegally export F-5 fighter jet engines and parts from the United States to Iran.



  • OPA Press Releases

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U.S. Citizen Arraigned on Charges of International Sex Tourism

Richard David Mitchell was arraigned yesterday on sex tourism charges in the U.S. District Court for the District of Hawaii, after being deported from Cambodia.



  • OPA Press Releases

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International Hacker Pleads Guilty for Massive Hacks of U.S. Retail Networks

An international computer hacker pleaded guilty today to multiple charges relating to hacking activity and credit card fraud. More than 40 million credit and debit card numbers were stolen from major U.S. retailers as a result of the hacking activity. Albert Gonzalez, 28, of Miami, pleaded guilty today to 19 counts of conspiracy, computer fraud, wire fraud, access device fraud and aggravated identity theft relating to hacks into numerous major U.S. retailers.



  • OPA Press Releases

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Attorney General Eric Holder Speaks at the International Association of Chiefs of Police (IACP) Conference

"Talk alone isn’t going to keep crime rates down. Talk alone isn’t going to protect innocent victims. Talk alone isn’t going to stop rival gangs from shooting up our streets, or drug dealers from peddling dope in our schools, or terrorists from attacking our cities. Indeed, we all know that the best ideas in the world are worth little without the resources to implement them."




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Alleged International Hacking Ring Caught in $9 Million Fraud

Sergei Tsurikov, 25, of Tallinn, Estonia; Viktor Pleshchuk, 28, of St. Petersburg, Russia; Oleg Covelin, 28, of Chisinau, Moldova; and a person known only as "Hacker 3;" have been indicted by a federal grand jury in Atlanta, Ga., on charges of hacking into a computer network operated by the Atlanta-based credit card processing company RBS WorldPay, which is part of the Royal Bank of Scotland.



  • OPA Press Releases

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Former Willbros International Consultant Pleads Guilty to $6 Million Foreign Bribery Scheme

A former consultant for Willbros International Inc. (WII), a subsidiary of Houston-based Willbros Group Inc. (Willbros), pleaded guilty today to engaging in a conspiracy to pay more than $6 million in bribes to government officials of the Federal Republic of Nigeria and officials from a Nigerian political party.



  • OPA Press Releases

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New Jersey Man Sentenced on International Sex Tourism and Child Pornography Charges

Wayne Nelson Corliss, 60, of Union City, N.J., was sentenced to 235 months in prison today in Newark, N.J., on three charges of traveling in foreign commerce with the intent to engage in illicit sexual conduct and a single count each of producing and possessing child pornography.



  • OPA Press Releases

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Justice Department Requires Divestitures in Cameron International Corp.’s Acquisition of NATCO Group Inc.

The Department said that the deal as originally proposed would substantially lessen competition in the manufacture of refinery desalters in the United States.



  • OPA Press Releases

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Two Foreign Nationals Sentenced for Roles in International Money Laundering Scheme Involving Online Sales

Two Bulgarian nationals have been sentenced in U.S. District Court in the District of Columbia for their roles as money launderers for a transnational criminal group based in Eastern Europe, announced Assistant Attorney General Lanny A. Breuer of the Criminal Division.



  • OPA Press Releases

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U.S. Settles with Itochu Corp. and Itochu International Regarding Defective Bullet-Proof Vests

The United States has reached a $6.75 million settlement with Itochu Corp. of Japan and its American subsidiary, Itochu International Inc., to resolve claims under the False Claims Act in connection with the companies’ importation and sale of defective Zylon fiber used as the key ballistic material in bullet-proof vests purchased by the United States for federal, state, local and tribal law enforcement agencies.



  • OPA Press Releases

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Credit Suisse Agrees to Forfeit $536 Million in Connection with Violations of the International Emergency Economic Powers Act and New York State Law

The forfeiture is the largest ever entered against an entity for IEEPA violations.



  • OPA Press Releases

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Major International Hacker Pleads Guilty for Massive Attack on U.S. Retail and Banking Networks

Albert Gonzalez pleaded guilty to conspiracy to gain unauthorized access to the payment card networks operated by, among others, Heartland Payment Systems, 7-Eleven and Hannaford Brothers Co. Inc.



  • OPA Press Releases

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Former Willbros International Executives Sentenced to Prison for Their Roles in $6 Million Foreign Bribery Scheme

Two former executives of Willbros International Inc. (WII), a subsidiary of Houston-based Willbros Group Inc. (Willbros), were sentenced today for their roles in a conspiracy to pay more than $6 million in bribes to government officials of the Federal Republic of Nigeria and officials from a Nigerian political party.



  • OPA Press Releases

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Assistant Attorney General Thomas E. Perez Speaks at the Opening of the International Civil Rights Center and Museum

"We need this Civil Rights Museum so that we remember our history, however painful it may be," said Assistant Attorney General Perez.




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Man Pleads Guilty to International Child Sex Tourism

Isidro Hinojosa Benavides, 77, a U.S. citizen extradited from Argentina, pleaded guilty today to engaging in illicit sexual conduct in foreign places.



  • OPA Press Releases

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Resident of India Pleads Guilty in International Online Brokerage “Hack, Pump and Dump” Scheme

Jaisankar Marimuthu, a native of Chennai, India, pleaded guilty to one count of conspiracy to commit wire fraud, securities fraud, computer fraud and aggravated identity theft, and to one count of aggravated identity theft.



  • OPA Press Releases

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Italian Subsidiary of U.S.-Based Company Agrees to Plead Guilty for Participating in International Price-Fixing Conspiracy

Parker ITR S.r.l. has agreed to plead guilty and to pay a $2.29 million criminal fine for participating in a conspiracy to rig bids, fix prices and allocate market shares of marine hose.



  • OPA Press Releases

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Key Member of International Human Trafficking Ring Sentenced to Twenty Years

Francisco Cortes-Meza, 26, of Mexico, was sentenced today by U.S. District Judge Richard W. Story in the Northern District of Georgia for sex trafficking in an organization that targeted young Mexican women.



  • OPA Press Releases

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Learning Tree International Inc. Agrees to Pay $4.5 Million to Settle Allegations of Improper Billing Practices and Retention of Federal Funds

Learning Tree International Inc. has agreed to pay the United States $4.5 million to resolve allegations that it violated the False Claims Act when it improperly invoiced federal agencies in advance for information technology training courses and kept federal funds for training courses that were never actually provided.



  • OPA Press Releases

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More Than $40 Million Worth of Gold, Silver and Jewelry Forfeited in International Money Laundering Case

“This forfeiture of more than $40 million in jewelry should remind criminals around the globe that they will be found, prosecuted and stripped of assets that are not theirs to keep,” said Assistant Attorney General Lanny A. Breuer.



  • OPA Press Releases

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Christine Varney to Participate in Ninth Annual International Competition Network Conference in Istanbul, Turkey

Christine Varney, Assistant Attorney General in charge of the Antitrust Division, will participate in the ninth annual International Competition Network (ICN) conference in Istanbul, Turkey, from April 27-29, 2010.



  • OPA Press Releases

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Indian National Sentenced to 81 Months in Prison for Role in International Online Brokerage “Hack, Pump and Dump” Scheme

An Indian national was sentenced today to 81 months in prison on conspiracy and aggravated identity theft charges arising from an international fraud scheme to "hack" into online brokerage accounts in the United States and use those accounts to manipulate stock prices.



  • OPA Press Releases

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Medicare Fraud Fugitive Taken into Custody at Miami International Airport and Ordered Held in Pre-trial Detention Pending Trial

Jose Garcia, 55, who has been a fugitive since 2008, was taken into federal custody yesterday at Miami International Airport.



  • OPA Press Releases

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Foreign National Pleads Guilty for Role in International Money Laundering Scheme Involving More Than $1.4 Million in Losses to Victims

A Bulgarian national pleaded guilty today in U.S. District Court in the District of Columbia for his role in laundering money for a transnational criminal group based in Eastern Europe.



  • OPA Press Releases

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Bulgarian National Extradited from Poland to the United States to Face Charges Related to Alleged Role in International Money Laundering Scheme

Georgi Vasilev Pletnyov, 49, of Svishtov, Bulgaria, was extradited from Poland to the United States on Friday, May 21, 2010. 



  • OPA Press Releases

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Final U.S. Defendant to Face Charges Related to International Child Pornography Conspiracy Case

Edward Oedewaldt, 47, was arrested in Arcadia, La., on April 23, 2010, after an extensive search involving assistance from law enforcement in the United States and abroad.



  • OPA Press Releases

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Nantucket Man Arrested and Charged with Operating International Online “Phishing” Scheme to Steal Income Tax Refunds

Mikalai Mardakhayeu, a Belarusian national residing in Nantucket, Mass., was arrested Wednesday night and charged for his alleged participation in an international online “phishing” scheme to steal income tax refunds intended for U.S. taxpayers around the country.



  • OPA Press Releases

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Five Defendants Sentenced for Child Pornography Crimes Uncovered as a Result of International Investigation

Four defendants were sentenced today in connection with their participation in an online child pornography conspiracy, while a fifth defendant was sentenced for receiving child pornography.



  • OPA Press Releases