The invention provides diagnostic and therapeutic targets for pulmonary disease, in particular, fibrotic lung disease. The inventors have found that a genetic variant MUC5B gene is associated with increased expression of the gene, increased risk of developing a pulmonary disease, and an improved prognosis and survival among those developing the pulmonary disease.

A fabric covered button comprising a button head having a peripheral groove for receiving a locking ring. The fabric is secured to the button head and the marginal edge thereof is retained within the groove by the locking ring.

Apparatus for assembling covered buttons in which a first die assembly including a first punch carrying a first sleeve which sequentially receives a piece of covering material and the button shell with its flange extending toward the open end of the sleeve. A second assembly including a second sleeve having a bore one end of which is formed with a first cam surface extending axially inwardly of the above. The second sleeve is spring loaded to an extended position on a supporting post having a centrally located button back fastener receiving cavity in the end thereof with a second cam surface extending inwardly from the outer edge of the end to the bottom of a recess surrounding the cavity. An annular boss at the inner edge of the recess around the cavity is elevated to allow the material and the shell flange to curl inwardly under the button back. In the retracted position of the second sleeve on the post, the second cam surface forms a continuation of the first. In operation, when the first assembly carrying the covering piece and the shell moves toward the second assembly, the first sleeve stops against the spring loaded bottom sleeve and the punch continues forcing the material down so that the material is tucked inward by the beveled or curved surface of the second sleeve. Upon continued relative movement of the assemblies, the shell flange acts on the cam surface of the second sleeve to force the sleeve to its retracted position and the shell flange is moved inwardly of the back wall under the continued action of the first post, the extent of the inward movement of the shell flange being determined by the thickness of the material of the covering piece, as well as the height of the shell and the type of back used.

A button system and method of manufacturing the same are provided for identifying fiber from which an article of apparel is manufactured. Initially, an article of apparel manufactured with a predetermined fiber is identified. Next, indicia indicative of the predetermined fiber is selected. Next, at least one button is manufactured with the indicia thereon for identifying the fiber from which the article of apparel is manufactured.

A method for forming a multi-colored cap part of a snap button including the steps of forming a design portion of the cap part of snap button using a first group of molds, which includes a first female mold, a first male mold, and a plate-shaped middle mold, and a slide-plate mold adapted to movably assembled to the first male mold and having a plurality of mold cavities for forming the design portion; removing the slide-plate mold having the design portion molded therein from the first male mold; movably positioning the slide-plate mold into a second female mold included in a second group of molds for forming a body portion of the cap part of snap button; positioning a post for the cap part of snap button in a second male mold of the second group of molds; and forming the body portion.

A reaction arm for use with a torque generating device, the reaction arm including a reaction bar, and a body portion having a first internal diameter, and having formed on an internal surface thereof a female spline having a second internal diameter and a guide bushing having a third internal diameter, the first, second, and third internal diameter being distinctly sized.

A geared socket wrench hand tool is disclosed. The socket wrench is a clickless wrench allowing for more precise movement of the socket. The socket wrench, through a series of gears, can rotate in infinitesimally small rotations.

A wireless small motor driver, in which power consumption is decreased by adjusting a gear ratio, the efficiency of an operation is increased due to a high torque, and the safety of a worker at night is ensured using an illumination lamp. The wireless small motor driver includes a driver case inside of which a motor is provided. A driver bit has a predetermined length in a bilateral direction, the driver bit being replaceable, with one or both ends thereof conforming to the shape of a bolt, and has a fixing projection. A socket is coupled to an end portion of the driver case, the driver bit being fastened to the socket. A rotation reduction gear is coupled to the motor, the rotation reduction gear transmitting rotary force to the socket and increasing a torque. A USB and a battery for supplying uniform power to the motor are added.

An active anvil assembly for use in forming a looped suture is provided. The active anvil assembly includes an anvil member, a first sensor operably connected to the anvil member, and a control assembly. The first sensor is configured for measuring at least one of force, torque, and distance feedback. Also provided are systems and methods for forming a looped suture including an active anvil assembly.

The present invention provides a method for bonding two substrates using a UV radiation curing-redox curing adhesive system having a shadow area and a transparent area, comprising: bonding the shadow area of the substrates using a redox curing adhesive system, and bonding the transparent area of the substrates using a liquid optically clear adhesive containing UV initiators.

An electrical ground (36) of an RF impedance matching network (33) is connected to a connection area (50) on the grounded chamber cover (18) of a plasma chamber. The connection area is offset away from the center of the chamber cover toward a workpiece passageway (20). Alternatively, an RF power supply (30) has an electrically grounded output (32) that is connected to a connection area (52) on the chamber cover having such offset. Alternatively, an RF transmission line (37) has an electrically grounded conductor (39) that is connected between a grounded output of an RF power supply and a connection area (52) on the chamber cover having such offset.

An engineered soilless plant cultivation medium for potting applications includes specific balanced amounts of nutrient additives. Major nutrient cations (Ca, Mg, K, Na, H) are balanced according to optimal base saturation percentage ranges. Nutrient levels, namely, the amount of major nutrient cations, major nutrient anions and minor nutrients satisfy desired ranges for both standard Mehlich III soil extraction tests and saturated paste tests.

Provided is a high-value added fertilizer using a microorganism or a component of a microorganism and especially a fertilizer capable of promoting the bearing of fruit trees and fruit vegetables. A reducing fertilizer obtained by subjecting a mixture of a microorganism or a component of a microorganism with phosphoric acid component and/or potassium component to a hydrothermal reaction treatment is capable of promoting the growth the roots, especially, the root hairs of fruit trees and also promoting the enlargement of their fruits. In particular, because of the reducing characteristic, the reducing fertilizer of the present invention has an excellent affinity for cells constituting the roots, and enables phosphoric acid component and potassium component, which are useful fertilizer components, to be absorbed effectively.

An engineered topsoil for use in soil reclamation and a method of producing the same are disclosed that seek to replicate undisturbed native reference topsoil from near the site in need of land reclamation. The engineered topsoil is formed from a base amount of subsoil and amendment comprised of an effective amount of surrogate humin material sufficient to replicate the estimated humin organic carbon content of the native reference topsoil, and an effective amount of plant residue material sufficient to replicate the estimated non-humin organic carbon content of the native reference topsoil.

A navigation system includes at least one inertial sensor configured to detect motion of the system and generate inertial data; at least one aiding device configured to generate aiding device measurement data; at least one processing unit configured to generate an un-smoothed navigation solution inclusive of navigation state variable error resets based on the inertial data and the aiding device measurement data; wherein the at least one processing unit is further configured to sum the state variable error resets into a cumulative sum of the state variable error resets; wherein the at least one processing unit is further configured to high pass filter the cumulative sum of the state variable error resets; and wherein the at least one processing unit is further configured to subtract the high pass filtered cumulative sum of the state variable error resets from the un-smoothed navigation solution to generate a smoothed navigation solution.

Described herein are methods and systems for generating shared collaborative maps for planting or harvesting operations. A method of generating a collaborative shared map between machines includes generating a first map for a first machine based on a first set of data and generating a second map for a second machine based on a second set of data. The method further includes generating at least one shared collaborative map for at least one of the first and second machines based on the first and second maps.

The present invention provides a manually powered drive assembly for a vehicle. A foot crank winds a helical torsion spring through a system of shafts and sprockets in a first direction. By releasing a brake applied to a wheel, or wheels, of the vehicle, the wound spring transfers a rotational movement from a spring shaft to a freewheel sprocket coaxially aligned with the axle supporting a wheel, so that the rotational movement upon the wheel assists a user in manually moving the vehicle. The drive assembly may be advantageously used with a wheelbarrow to assist in building up momentum for moving heavy loads.

When a rotational shaft of a gear speed reducer is rotated, a small-diameter gear of a first gear is held in mesh with first internal teeth of a fixed gear and a large-diameter gear of the first gear is held in mesh with second internal teeth of a second gear. The first gear and the second gear comprise cycloidal gears, respectively, and transmit rotational drive power to the second gear. The rotational drive power is output from an output shaft of the second gear. The gear speed reducer has a default mechanism for holding the output shaft at a predetermined angular position when an electric signal applied to an actuator is interrupted, and a self-lock function for preventing drive power applied from the output shaft from being transmitted to the actuator.

This application includes a number of embodiments of a spring powered toothbrush for cleaning teeth. A wind-up spring is located in the base of the toothbrush which spring provides power for a gear train including a drive shaft assembly that is designed to bring about rapid movement of the brush portion of the toothbrush to aid in cleaning the teeth. The drive mechanism is controlled by a spring biased push button in the toothbrush housing. In one version the brush portion of the toothbrush includes a rotatable brush section that is gear driven by the drive shaft. In another version the upper portion of the toothbrush is vibrated by an offset weight connected to the drive shaft and in a third version the drive shaft includes an offset weight that acts to oscillate a movable brush section by intermittent engagement between the; weight and brush section.

Water heaters are described that are user-powered, such that external sources of power are unnecessary. The water heaters include a heating device and a generator coupled to a crank such that power is generated as the crank is rotated, which can be used to power the heating device.

An energy storing device is disclosed. In the energy storing device of the present invention, energy from an energy generating unit is stored in the form of spring torsion and then is output steadily. The energy storing device of the present invention includes a plurality of cog-wheels, a plurality of torsion magnitude limiting units, a plurality of single-directional input bearings, a plurality of energy storing units and a plurality of speed enhancing cog-wheels. Each of the energy storing units includes at least two end rotational disc portions, which are connected with each other co-axially. A leaf spring unit is provided between each pair of rotational disc portions and one end of the leaf spring unit is bent in an opposite direction. In addition, the energy storing units may be connected in series or in parallel to increase the efficiencies in energy storage and energy output.

Gravity powered electrical energy generators, particularly for producing lighting is disclosed. The apparatus has a support frame (1, 30) in which a series of gears and a gear-driven generator (20) are mounted. The power to drive the most upstream gear (2) is provided by a weight suspended from a point to one side of the axis of rotation of gear (2). The drive gear of the furthest downstream gear has no teeth so that the final contact between the drive gear and the shaft of the generator (20) is frictional. The gear ratio of the final downstream gear is at least 25. When used for lighting, the apparatus may include one or more high brightness LEDs (40) mounted on the housing (30). By suitable choice of gear ratios, the device may produce thirty minutes of illumination while allowing a 10 kilogram weight to fall through a distance of 1.8 meters.

Provided is a cleaning solution used for cleaning an ink containing a resin in an amount of 5 percent by mass or greater, the cleaning solution including a mixture solvent containing water and a solvent, wherein a hydrogen bond term of a Hansen solubility parameter of the mixture solvent is 7.0 (cal/cm3)1/2 or less.

A piece of luggage has a body with a surface. A weight scale has a top surface and is disposed in the body of the luggage. The top surface of the weight scale is coplanar with the surface of the body of the luggage. The weight scale determines a weight of the piece of luggage when in an operating state. When the weight scale is in a non-operating state it is stored safely within the body of the luggage. Most importantly the weight scale does not stick out from the body of the luggage so as to be susceptible to damage during transport of the luggage.

The present invention provides a new and useful apparatus for charging battery powered electronic devices using a rolling means. The rolling means transfers mechanical energy from a plurality of wheels to a generator by way of a gear ratio. The generator in turn yields electrical energy that is later transformed via integrated circuitry into viable power for the purposes of charging an optional internal batter or that of an attached device. This apparatus does not limit the user's mobility and can be used in everyday settings. The apparatus can be an integral part of a piece of luggage or added to an existing hand cart. Additionally, the apparatus can have a connection for a DC input to charge the internal battery when the apparatus is not in motion.

Apparatus configured detect a physical quantity, for example a density, of a flowing fluid, the apparatus including: a sensor body (2) configured to extend into the flowing fluid, the sensor body comprising a fiber Bragg grating (FBG) of a fiber Bragg grating sensor (3, 7, FBG), for generating a detector signal relating to vibration of at least part (2B) of the sensor body (2); anda processing unit, configured to process the detector signal, and to determine the physical quantity based on detected vibration at a mechanical eigenfrequency of the flexible part (2B) of the sensor body (2).

A freeze dryer processes bulk powder products. The freeze dryer freezes the product by mixing an atomized spray of product with sterile liquid nitrogen. The resultant powder is freeze dried in a vessel, and the vessel contents is agitated to maintain product contact with heated vessel wall and to prevent agglomeration.

Partially formed earth-boring rotary drill bits comprise a first less than fully sintered particle-matrix component having at least one recess, and at least a second less than fully sintered particle-matrix component disposed at least partially within the at least one recess. Each less than fully sintered particle-matrix component comprises a green or brown structure including compacted hard particles, particles comprising a metal alloy matrix material, and an organic binder material. The at least a second less than fully sintered particle-matrix component is configured to shrink at a slower rate than the first less than fully sintered particle-matrix component due to removal of organic binder material from the less than fully sintered particle-matrix components in a sintering process to be used to sinterbond the first less than fully sintered particle-matrix component to the first less than fully sintered particle-matrix component. Earth-boring rotary drill bits comprise such components sinterbonded together.

Described herein are methods for training a machine learning-based predictor of affective response to stimuli. The methods involve receiving samples comprising temporal windows of token instances to which a user was exposed, and target values representing affective response annotations of the user in response to the temporal windows of token instances. This data is used for the training of the predictor along with values indicative of the number of the token instances in the temporal windows of token instances, which are used to compensate for non-linear effects resulting from saturation of the user.

The present invention is directed to an explosive composition comprised of heavy ANFO and expanded polymeric beads that have a density that is less than the density of the heavy ANFO. The expanded polymeric beads have a size that is determined or based on the size of ammonium nitrate prills used in the heavy ANFO portion of the composition. In one embodiment, the expanded polymeric beads that are utilized in the composition are at least 70% of the lower limit of the mesh size of the predominant ammonium nitrate prill mesh size. In another embodiment, the expanded polymeric beads are at least 70% of the a size that is related to the average mesh size of the ammonium nitrate prills.

A heating appliance including a metal substrate, at least a part of which is covered with a self-cleaning coating including at least one oxidation catalyst selected from the platinoid oxides, and at least one dopant of said oxidation catalyst selected from the rare-earth oxides. The self-cleaning coating is a bilayer coating including: an inner layer at least partially covering the metal substrate and including the dopant; and an outer layer in contact with the ambient air and including the oxidation catalyst. Also provided is a method for producing such a heating appliance.

One illustrative method disclosed herein includes forming a plurality of spaced-apart trenches in a semiconducting substrate to thereby define a fin structure for the device, forming a local isolation region within each of the trenches, forming a sacrificial gate structure on the fin structure, wherein the sacrificial gate structure comprises at least a sacrificial gate electrode, and forming a layer of insulating material above the fin structure and within the trench above the local isolation region. In this example, the method further includes performing at least one etching process to remove the sacrificial gate structure to thereby define a gate cavity, after removing the sacrificial gate structure, performing at least one etching process to form a recess in the local isolation region, and forming a replacement gate structure that is positioned in the recess in the local isolation region and in the gate cavity.

A yarn object which, even though made of ultra-high-molecular-weight polyethylene, can be satisfactorily prevented from color fading caused by contact with other objects or the like, can be produced easily at low cast, and can maintain high strength. The yarn object is colored with a colorant. The yarn object includes a core yarn 2 colored with a predetermined colorant and an outer-layer yarn 3 disposed on the periphery of the core yarn. The outer-layer yarn 3 is disposed in such a manner that the core yarn 2 is prevented from contacting with other objects. The outer-layer yarn 3 includes a transparent filament and a space 4 is formed between the outer-layer yarns 3. The color applied to the core yarn 2 is externally visible through the transparent outer-layer yarn 3 and the space therebetween 4.

Intermittently colored yarns having an intermittent and random dye spacing pattern, and systems and methods of making the same, are disclosed. Such intermittently colored yarns exhibit higher quality and lower manufacturing costs over the known intermittently colored yarns. The intermittent coloring takes place while the yarn is in caterpillar form. Carpets made from such intermittently colored yarns exhibit enhanced aesthetics over carpets made from known intermittently colored yarns. Alternatively, a stain resist, colorless base dye, or bleaching agent can be applied in the same intermittent and random spacing pattern to the intermittently colored yarns prior to subsequent dyeing. This creates a mirror image like color effect to the resulting yarn.

A metal cord (C-1) having two layers (Ci, Ce) of 3+N construction, rubberized in situ, comprising an inner layer (Ci) formed from three core wires (10) of diameter d1 wound together in a helix with a pitch p1 and an outer layer (Ce) of N wires (11) N varying from 6 to 12, of diameter d2, which are wound together in a helix with a pitch p2 around the inner layer (Ci), said cord being characterized in that it has the following characteristics (d1, d2, p1 and p2 being in mm): 0.08

A method of reducing an initial stress on a cable includes stretching the cable to a first length to thereby define the initial stress. The cable has a central longitudinal axis, and includes a plurality of wires each twisted around the axis and formed from a shape memory alloy transitionable in response to a signal between a first state wherein each of the wires has a first temperature-dependent length, and a second state wherein each of the wires has a second temperature-dependent length that is less than the first. After stretching, the method includes activating the alloy by exposing the alloy to the signal such that the alloy transitions from the first to the second temperature-dependent state. Concurrent to activating, the method includes elongating the cable to a second length that is greater than the first to define a second stress on the cable that is less than the first.

Composite yarns, comprising one or more elastomeric fibers and hard yarns, are formed by adhering the elastomeric fibers and hard yarns together using a size material. The size-covered composite yarn can be used in weaving and knitting to make stretch fabrics with desired garment characteristics. The size material may be removed by subsequent wet fabric processing.

An automated variable speed control system for a cutter head of a dredging cutter has a cutter head and a pump. The pump pumps cuttings from the cutter head through a cuttings discharge line. A sensor monitors amperage draw of the pump. A controller controls speed of movement of the cutter head based upon data received from the sensor. The controller increases a speed of movement of the cutter head through the materials when the amperage draw of the pump falls below the determined amperage range and the controller decreases the speed of movement of the cutter head through the materials when the amperage draw of the pump exceeds the determined amperage range.

Two genes, A622 and NBB1, can be influenced to achieve a decrease of nicotinic alkaloid levels in plants. In particular, suppression of one or both of A622 and NBB1 may be used to decrease nicotine in tobacco plants.

A process and apparatus for shredding tobacco sheets, especially tobacco sheets formed of reconstituted tobacco particles with guar and sugar comprises rotating opposing sets of cutter discs in a partially overlapping relation so as to establish a nip. The cutter discs have notches at spaced locations along a peripheral portion of the cutter discs. Adjacent pairs of cutter discs are spaced apart by a spacer disc with a stripper plate interposed between adjacent pairs of spaced apart cutter discs. A tobacco sheet which is fed into the nip of the sets of cutter discs is shredded by the discs.

An oral pouch product includes a dual layer pouch wrapper and an inner botanical filling material contained within the pouch wrapper. The pouch wrapper includes an inner web, an outer web and a coating, such as a water soluble flavorant containing coating therebetween.

A device for filling cigarette tubes that can be designed and used manually, partially automatically, or, fully automatically for packing cigarette tubes with a metered, precise amount of tobacco that leads to a consistent filling of the tube to an even and complete density such that the burning rate and continuity are consistently the same, regardless of the cut of tobacco being used, or of moisture content of the tobacco, and, independent of operator control variables.

An improved apparatus for treating a fire in a multi-floored building where the fire is located on an upper floor vertically displaced from a lower floor from which the fire is treated, and where the upper and lower floors each have a selectively openable environmental access along an external wall of the multi-floored building. The improved apparatus includes a tubular structure having an inlet, an intermediate portion, and an outlet and a bracing system. The bracing system has a frame, a first pivot point, and a second pivot point. The frame provides support against a sturdy surface. The tubular structure is supported on the first pivot point and rotates thereon to elevate or hoist the outlet towards the upper floor environmental access. The tubular structure is further supported on a second pivot point and further rotates thereon to elevate the outlet.

Apparatus and methods are disclosed, such as a method that includes precharging channel material of a string of memory cells in an unselected sub-block of a block of memory cells to a precharge voltage during a first portion of a programming operation. A programming voltage can then he applied to a selected memory cell in a selected sub-block of the block of memory cells during a second portion of the programming operation. The selected memory cell is coupled to a same access line as an unselected memory cell in the unselected sub-block. Additional methods and apparatus are disclosed.

According to one embodiment, a first well of the first conductivity type which is formed in a substrate. a second well of a second conductivity type which is formed in the first well. The plurality of memory cells, the plurality of first bit line select transistors, and the plurality of second bit line select transistors are formed in the second well, and the plurality of first bit line select transistors and the plurality of second bit line select transistors are arranged on a side of the sense amplifier with respect to the plurality of memory cells of the plurality of bit lines.