al Dynamically configuring and verifying routing information of broadcast networks using link state protocols in a computer network By www.freepatentsonline.com Published On :: Tue, 26 May 2015 08:00:00 EDT A technique dynamically configures and verifies routing information of broadcast networks using link state protocols in a computer network. According to the novel technique, a router within the broadcast network receives a link state protocol routing information advertisement from an advertising router, e.g., a designated router or other adjacent neighbor. The router learns of a next-hop router (“next-hop”) to reach a particular destination from the advertisement, and determines whether the next-hop is located within the same broadcast network (e.g., subnet) as the designated router. If so, the router further determines whether the next-hop is directly addressable (i.e., reachable), such as, e.g., by checking for link adjacencies to the next-hop or by sending request/reply messages (e.g., echo messages or “ping” messages) to the next-hop. In the event the next-hop for the destination is not directly addressable by the router (e.g., no adjacency or reply), the router installs a route to the destination via the designated router. Otherwise, the router installs a route to the destination via the next-hop. Full Article
al Virtual local area network (vlan) coordinator providing access to vlans By www.freepatentsonline.com Published On :: Tue, 26 May 2015 08:00:00 EDT A virtual computer system includes virtualization software, and one or more physical network interfaces for connecting to one or more computer networks. The virtualization software supports one or more virtual machines (VMs), and exports one or more virtual network interfaces to the VM(s) to enable the VM(s) to access the computer network(s) through the physical network interface(s). The virtualization software modifies and filters network data frames from the VM(s) and from the physical network interface(s) to restrict one or more VMs to one or more virtual local area networks (VLANs) that are implemented within a VLAN topology. Restricting a VM to a VLAN limits the broadcast domain to which the VM belongs, which may reduce security risks facing the VM. Implementing the VLAN functionality within the virtualization software provides the functionality to every VM in the computer system, without requiring every VM to provide the functionality. Full Article
al Quality of service application controller and user equipment application profiler By www.freepatentsonline.com Published On :: Tue, 04 Aug 2015 08:00:00 EDT Various topologies of a quality of service application controller and related techniques to optimize the communications performance an application executing on a device participating in a communications environment are disclosed. The communications environment may include a cellular network, an unlicensed spectrum network, or a combination of the two. The quality of service application controller observes one or more key performance indicators of the communications network, and retrieves a policy from a policy store specific to the application. The quality of service application controller then modifies the execution of the application and/or the configurable aspects of the communications environment to optimize the communications performance of the application. For example, the application's data throughput may be increased, the power draw of the application may be minimized, data requested by the application may be minimized, or the apparent response time of the application's response to a web service may be minimized. Full Article
al Channel-sounding method using a plurality of antennas, and apparatus for same By www.freepatentsonline.com Published On :: Tue, 23 Feb 2016 08:00:00 EST The present invention relates to a wireless communication system. More particularly, the present invention relates to a method and to an apparatus for transmitting an SRS in a multi-antenna system. The method comprises the steps of: acquiring specific information for discriminating a first antenna group and a second antenna group from among a plurality of antennas, wherein said first antenna group includes one or more antennas which are set to a turned-on state to perform communication with a base station, and said second antenna group includes one or more other antennas which are set to a turned-off state; transmitting an SRS to the base station if a predetermined condition is satisfied, under the condition that the second antenna group is set to the turned-off state; and setting the second antenna group to a turned-off state after the transmission of the SRS. Full Article
al Mobile user terminal, mobile communication system, base station, and communication method By www.freepatentsonline.com Published On :: Tue, 03 May 2016 08:00:00 EDT A mobile user terminal, which communicates with a base station in an intermittent fashion, the mobile user terminal includes a radio transmitter which transmits downlink channel quality information indicating downlink channel quality and an uplink pilot signal to a base station in an intermittent fashion; and a transmit time controller which synchronizes transmit time of the downlink quality information and transmit time of the uplink pilot signal relative to each other, such that the downlink quality information and the uplink pilot signal are sent in adjacent different timings in a period corresponding to a state of intermittent communicate. Full Article
al Treadle-drive eccentric wheel transmission wheel series with periodically varied speed ratio and having inward packing auxiliary wheel By www.freepatentsonline.com Published On :: Tue, 31 Mar 2015 08:00:00 EDT In the present invention, one or both of an active wheel or a passive wheel is composed of an eccentric transmission wheel and is combined with a synchronous transmission belt for forming an eccentric wheel transmission wheel series, so that when the feet input forces at different angles from the treadle shafts of the treadles to an active wheel shaft combined on the active wheel through cranks, the active wheel forms different transmission speed ratios relative to the passive wheel according to the treadle angle, and random inward packing is performed to the transmission belt (100) of the engage end of the eccentric passive wheel (413) during the transmission for stabling the operation. Full Article
al Vehicle energy harvesting device having a continuous loop of shape memory alloy By www.freepatentsonline.com Published On :: Tue, 14 Apr 2015 08:00:00 EDT An energy harvesting system comprises a first region having a first temperature and a second region. A conduit is located at least partially within the first region. A heat engine configured for converting thermal energy to mechanical energy includes a shape memory alloy forming at least one generally continuous loop. The shape memory alloy is disposed in heat exchange contact with the first region and the second region. The shape memory alloy is driven to rotate around at least a portion of the conduit by the response of the shape memory alloy to the temperature difference between the first region and the second region. At least one pulley is driven by the rotation of the shape memory alloy, and the at least one pulley is operatively connected to a component to thereby drive the component. Full Article
al Seal arrangement and hinge of a chain with the seal arrangement By www.freepatentsonline.com Published On :: Tue, 14 Apr 2015 08:00:00 EDT A sealing arrangement used to create a seal between a first part of a chain and a second part of the chain, wherein the second part can at least be pivoted in relation to the first part, includes a sealing ring with an annular sealing lip for sealing a lubricant area between parts which can be pivoted towards each other, and an elastic ring which is adapted to be fixed to one of the parts and which is adapted to exert pressure in the sealing ring. In addition, a supporting ring is arranged between the sealing ring and the elastic ring. Full Article
al Method for joining structural elements onto a shaft By www.freepatentsonline.com Published On :: Tue, 21 Apr 2015 08:00:00 EDT A method for joining structural elements onto a shaft may include generating at least one projection at a respective joining position on the shaft, sliding at least one of the structural elements over at least one projection and maintaining the structural elements in at least on projection. Full Article
al Recirculating ball screw assembly By www.freepatentsonline.com Published On :: Tue, 05 May 2015 08:00:00 EDT Ball screws are described that may be incorporated into other devices such as a pulley assembly or a differential device. The ball screws include a threaded shaft defining a central longitudinal axis with a threaded nut threadedly coupled thereto to define at least one track in between them. Each track forms a continuous loop around an infield protrusion and is filled with a plurality of rolling elements filling. Each rolling element has the same radius from the central longitudinal axis such that the nut can rotate at higher speeds without the rolling elements locking up as a result of centripetal force. Full Article
al Secondary assembly drive of an internal combustion engine and method for operating same By www.freepatentsonline.com Published On :: Tue, 19 May 2015 08:00:00 EDT A secondary assembly drive of an internal combustion engine and a method for operating same are provided. The secondary assembly drive includes: a first drive wheel (1) which can be rotatably connected to a crank shaft (CR) of the internal combustion engine, an electric machine which can be operated either as a generator (AL) of as a motor (M) and a second drive wheel (2) which can be rotatably connected to the electric machine (AL, M), an air-conditioning compressor (A/C) and a third drive wheel (3) which can be rotatably connected to the air-conditioning compressor, a traction element (4) which rotates infinitely and which wraps around the drive wheels, and an actuable clutch (7) for disconnecting the drive of the electric machine and of the air-conditioning compressor from the crankshaft when necessary. In addition, the air-conditioning compressor is designed for operation in both rotational directions, and a reversal of the rotational direction between the generator operating mode and the motor operating mode of the electric machine is provided. Full Article
al Method for electronically controlling a bicycle gearshift and electronically servo-assisted bicycle gearshift By www.freepatentsonline.com Published On :: Tue, 19 May 2015 08:00:00 EDT A method for electronically controlling a bicycle gearshift comprising at least one derailleur is disclosed, comprising the sequential steps of: a) imparting a movement on the derailleur of the gearshift until the derailleur is in an intended position;b) waiting for a predetermined time period,c) performing a check whether the derailleur is in the intended position, within a possible predetermined tolerance,d) in case said check has a negative outcome, imparting a movement on the derailleur of the gearshift until the derailleur is in the intended position. A derailleur and an electronically servo-assisted bicycle gearshift comprising control electronics comprising modules adapted to carry out the method outlined above are also disclosed. Full Article
al Secondary assembly drive of an internal combustion engine and method for operating same By www.freepatentsonline.com Published On :: Tue, 26 May 2015 08:00:00 EDT A secondary assembly drive of an internal combustion engine and a method for operating same are provided. The secondary assembly drive includes, in two drive planes, an assembly drive (2) and a starter drive (12) and permits, in addition to a normal operating mode, the following operating modes: —starting of the internal combustion engine, —boosting of the internal combustion engine, —air-conditioning, and —deactivation of the assembly drive (2). Full Article
al Treadle-drive eccentric wheel transmission wheel series with periodically varied speed ratio By www.freepatentsonline.com Published On :: Tue, 26 May 2015 08:00:00 EDT The present invention is structured by using one or both of an active wheel and a passive wheel being composed of an eccentric transmission wheel and being combined with a synchronous transmission belt for forming an eccentric wheel transmission wheel series, so that in the reciprocal treadle performed by the human's feet, when the feet input forces at different angles from the treadle shafts of the treadles to an active wheel shaft combined on the active wheel through cranks, the active wheel forms different transmission speed ratios relative to the passive wheel according to the treadle angle. Full Article
al Modalities for the treatment of degenerative diseases of the retina By www.freepatentsonline.com Published On :: Tue, 26 May 2015 08:00:00 EDT This invention relates to methods for improved cell-based therapies for retinal degeneration and for differentiating human embryonic stem cells and human embryo-derived into retinal pigment epithelium (RPE) cells and other retinal progenitor cells. Full Article
al Nonhuman mammal whose mtDNA is from a nonhuman mammal resistant to a selected disease or disorder and whose nDNA is from a nonhuman donor mammal more susceptible to the selected disease or disorder By www.freepatentsonline.com Published On :: Tue, 26 May 2015 08:00:00 EDT Provided herein are mitochondrial-nuclear exchanged cells and animals comprising mitochondrial DNA (mtDNA) from one subject and nuclear DNA (nDNA) from a different subject. Methods for producing a mitochondrial-nuclear exchanged animal and animals made by the methods are provided. Also provided are methods of screening for agents useful for treating a disease or disorder using mitochondrial-nuclear exchanged animals or cells, tissues or organs thereof. Full Article
al Osteospermum and Dimorphoteca plants having an altered flower phenotype By www.freepatentsonline.com Published On :: Tue, 26 May 2015 08:00:00 EDT The present invention relates to an Osteospermum and Dimorphoteca plant, seed, variety, and hybrid. Another aspect of the present invention relates to an Osteospermum and Dimorphoteca plant having a mutant allele designated KLEDF which results in an altered flower phenotype. The invention also relates to crossing Osteospermum and Dimorphoteca plants containing the KLEDF mutant allele with other Osteospermum and Dimorphoteca plants lacking the KLEDF mutant allele to produce intergeneric and interspecific hybrids. This invention further relates to specific lines of Osteospermum varieties exhibiting the altered-flowering phenotype. Furthermore, the invention relates to pollen, seed, and sexual, as well as asexual progeny of such plants with altered flowers. In addition, the invention relates to methods for propagating said plants and to uses of said plants. Full Article
al Genetically modified mice that produce hybrid antibodies By www.freepatentsonline.com Published On :: Tue, 21 Jun 2016 08:00:00 EDT A method for engineering and utilizing large DNA vectors to target, via homologous recombination, and modify, in any desirable fashion, endogenous genes and chromosomal loci in eukaryotic cells. These large DNA targeting vectors for eukaryotic cells, termed LTVECs, are derived from fragments of cloned genomic DNA larger than those typically used by other approaches intended to perform homologous targeting in eukaryotic cells. Also provided is a rapid and convenient method of detecting eukaryotic cells in which the LTVEC has correctly targeted and modified the desired endogenous gene(s) or chromosomal locus (loci) as well as the use of these cells to generate organisms bearing the genetic modification. Full Article
al Mixing device for creating an output mixture by mixing a first material and a second material By www.freepatentsonline.com Published On :: Tue, 14 Apr 2015 08:00:00 EDT A mixing device for mixing a first and second material together to create an output mixture. The device includes a first chamber containing the first material coupled to a mixing chamber defined between a rotor and a stator. The rotor is disposed inside the stator and rotates therein about an axis of rotation. The first chamber houses an internal pump configured to pump the first material from the first chamber into the mixing chamber. The pump may be configured to impart a circumferential velocity into the first material before it enters the mixing chamber. At least one of the rotor and stator have a plurality of through-holes through which the second material is provided to the mixing chamber. Optionally, a second chamber is coupled to the mixing chamber. The second chamber may house an internal pump configured to pump the output material from the mixing chamber into the second chamber. Full Article
al Method and an apparatus/universal combine for agitation of liquids By www.freepatentsonline.com Published On :: Tue, 21 Apr 2015 08:00:00 EDT A method of mixing together liquids or liquid/solid combinations, and mixing apparatus/universal combine utilizing a vertical spinning container or vessel having a rib, or a cross rib in its bottom wall. The container is spun about a vertical axis with no wobbling component to the motion. Meshed elements are used for high shear mixing. Start/stop routines, and variable acceleration/speed values are used, to facilitate complete mixing. Use of ‘impeller’ blade stirrers is completely eliminated. Full Article
al Sequential start clutch for a material mixing machine By www.freepatentsonline.com Published On :: Tue, 21 Apr 2015 08:00:00 EDT A mixer system includes a mixing chamber with a drive panel, open top, discharge opening in a side of the mixing chamber, and door configured to open and close the discharge opening. A first mixing auger is disposed inside the mixing chamber, and a first auger drive is disposed on another side of the drive panel and connected to the first auger through the drive panel and connected to a driveline. A second mixing auger is disposed inside the mixing chamber on the first side of the drive panel, and another auger drive is connected to the second auger through the drive panel. A clutch is connected between the second auger drive and the driveline and configured to mechanically connect and disconnect the second auger drive from the driveline based on an input. A method of sequentially starting different augers within a mixing chamber is provided. Full Article
al Apparatus, system and method for mixing and dispensing dental impression materials By www.freepatentsonline.com Published On :: Tue, 21 Apr 2015 08:00:00 EDT An apparatus, system and method for mixing and dispensing dental impression materials is described. A dental impression material mixing machine comprises a water dispenser fluidly coupled to a hollow mixing axle, the mixing axle extending through a pulley, wherein an inner circumference of the hollow mixing axle forms a water conduit and an outer circumference of the hollow mixing axle forms a hub connector, a closeable valve inserted at a water entrance to the water conduit and electronically coupled to a water pump, an electronically commutated motor rotatably coupled to the pulley, wherein the hub connector receives a tubular rotatable hub of a disposable mixing vessel comprising dry dental impression powder, and wherein water is dispensed from the water dispenser into the disposable mixing vessel through the water conduit and hub orifice. Full Article
al Mixing and kneading machine for continual compounding and method of implementing continual compounding by means of a mixing and kneading machine By www.freepatentsonline.com Published On :: Tue, 05 May 2015 08:00:00 EDT A mixing and kneading machine (1) for continual compounding comprises a screw shaft (3) rotating in a casing (2) and simultaneously moving axially translationally. To sustainably enhance the efficiency of the machine as regards its material thruput per unit of time the screw shaft (3) comprises at least four groups of radial screw vanes (4a, 4b, 4c, 4d) evenly distributed circumferentially, each group consisting of a plurality of screw vanes in axial sequence. The outer diameter (Da) of the screw shaft ranges from 400 to 800 millimeters. The rotary speed of the screw shaft (3) ranges from 30 to 80 rpm. A mixing and kneading machine (1) engineered as such is particularly suitable for compounding an anodic mass in the production of electrodes—anodes—for the aluminum industry. Full Article
al Treatment element for treating material in a multi-shaft worm machine and multi-shaft worm machine By www.freepatentsonline.com Published On :: Tue, 05 May 2015 08:00:00 EDT A treatment element to treat material in a multi-shaft worm machine has an outer contour with at least one outer contour portion, the associated evolute of which is a quantity of at least three points, each of the points lying outside the longitudinal axis and within the outer radius of the treatment element and two respective adjacent points having a spacing from one another, which is less than half the core radius. The treatment element ensures high flexibility during the adjustment of shear and/or extensional flows on the material to be treated. Full Article
al Seal ring By www.freepatentsonline.com Published On :: Tue, 12 May 2015 08:00:00 EDT A seal ring is provided which allows the interior of a cylinder 1 of a screw extruder to be maintained at elevated temperature and elevated pressure, thus suppressing a variation in the pressure in the cylinder 1. In a special seal ring 300 attached to a screw shaft 7 in the cylinder of the screw extruder so as to be rotatable integrally with the screw shaft 7, thus restraining a material to be treated from being fed from upstream to downstream in the cylinder, a lead groove 317 extending in an axial direction of the shaft 7 is formed in an outer circumferential surface 316 opposing with a predetermined gap to an inner circumferential surface 1a of the cylinder. The lead groove 317 serves to disturb the flow of the material to be treated passing between the outer circumferential surface 316 and the inner wall surface 1a of the cylinder 1 to complex the flow. This stabilizes feeding resistance to suppress a variation in the pressure in the cylinder 1. Full Article
al Method and apparatus for high intensity ultrasonic treatment of baking materials By www.freepatentsonline.com Published On :: Tue, 12 May 2015 08:00:00 EDT The present invention discloses a high intensity ultrasonic treatment method and apparatus that is used in conjunction with an existing commercial dough or batter mixer to enhance the rheological, aeration and textural properties of the dough or batter. This change in properties is a result of the phenomenon of acoustic cavitation induced in the dough or batter by treatment with high intensity ultrasonic waves. The present invention discloses a mixing bowl (20) of an existing mixer system that is preloaded with dough or batter, the bowl (20) is located at the center of an ultrasonic bath tank (101) filled with a working fluid. The effect of ultra-sonic waves with power levels above 1 kW can be observed over the entire or partial mixing period of the dough or batter. The ultra-sonic waves of the present invention are generated by a plurality of ultrasonic wave generators (104A, 104B) and piezoelectric transducers (1) mounted on a stainless steel tank (101). The electrical energy received in each transducer (1) will be converted into appropriate mechanical expansion and contractions in the piezoelectric ceramics of the transducer (1) thus leading to pressure waves being transmitted to the dough or batter to be mixed. The generation and transmission of high intensity ultrasonic waves to the dough or batter affects its rheological, aeration and textural properties. Full Article
al Mixing rotor and internal mixer By www.freepatentsonline.com Published On :: Tue, 19 May 2015 08:00:00 EDT A mixing rotor includes: a rotor shaft portion that includes a cooling passageway formed therein, and a mixing blade portion that is formed in an outer circumferential portion of the rotor shaft portion, wherein each of the long blades of the mixing blade portion includes a land portion as an end surface of the long blade facing a radially outside of the mixing rotor, a length of each of the long blades in the axis direction is set to be 0.6 times or more as large as a length of the mixing blade portion in the axis direction, a biting angle of each of the long blades is set to an angle equal to or smaller than 31°, and a center angle with respect to a land width as a width of the land portion in the cross-section of each of the long blades orthogonal to the axis direction is set to an angle equal to or larger than 7°. Full Article
al Dinitroxide-type biradical compounds optimized for dynamic nuclear polarization (DNP) By www.freepatentsonline.com Published On :: Tue, 19 May 2015 08:00:00 EDT The present invention relates to the field of organic chemistry and in particular to organic free radicals used as polarizing agents in the technique of Dynamic Nuclear Polarization (DNP), which involves transferring the polarization of electron spins to the nuclei of a compound whose Nuclear Magnetic Resonance (NMR) is being observed. It concerns Dinitroxide-type Biradical polarizing agents characterized by a rigid linkage between the aminoxyl groups of said nitroxide units. This particular structure enables, at low temperatures and high fields, optimal transfer of polarization and optimal enhancement of NMR/MAS signals of the polarized nuclei of the compound studied. Full Article
al Dihydroethidine analogues and uses thereof By www.freepatentsonline.com Published On :: Tue, 19 May 2015 08:00:00 EDT Tracers for imaging distribution of reactive oxygen species (ROS) are disclosed. The tracers include radiolabeled dihydroethidine (DHE) analogues. Further disclosed are uses of the compounds, including methods of imaging tissue distribution of ROS in vivo by positron emission tomography (PET). Methods of synthesizing the compounds are also disclosed. Full Article
al Process for preparing a compound useful for producing an optically active diazabicyclooctane compound By www.freepatentsonline.com Published On :: Tue, 19 May 2015 08:00:00 EDT A process for preparing the compound of the following formula (E): wherein Bn represents a benzyl group, and tBu represents a tert-butyl group, the process including: (a) subjecting the following compound (B) to trifluoroacetylation, wherein tBu represents a tert-butyl group to produce the following compound (C): wherein tBu represents a tert-butyl group, and TFA represents a trifluoroacetyl group; (b) reacting the compound (C) with benzyloxyamine in the presence of a hydroxyl group activating agent to produce the following compound (D): wherein Bn represents a benzyl group, tBu represents a tert-butyl group, and TFA represents a trifluoroacetyl group; and (c) subjecting the compound (D) to detrifluoroacetylation. Full Article
al Phosphorus-containing metal complexes By www.freepatentsonline.com Published On :: Tue, 26 May 2015 08:00:00 EDT The present invention relates, inter alia, to metal complexes having improved solubility, to processes for the preparaion of the metal complexes, to devices comprising these metal complexes and to the use of the metal complexes. Full Article
al Alpha adrenergic receptor modulators By www.freepatentsonline.com Published On :: Tue, 26 May 2015 08:00:00 EDT Compounds are described herein useful for treating diseases and conditions by modulation of one or more alpha adrenergic receptor. The compounds can include a naphthalene, a quinoline, a benzoimidazole or an isoquinoline as a core structure. Methods of making, using and formulating these compounds are described. Full Article
al Oxime-substituted-quinoxaline-type piperidine compounds as ORL-1 modulators By www.freepatentsonline.com Published On :: Tue, 26 May 2015 08:00:00 EDT The present disclosure relates to Oxime-Substituted Quinoxaline-Type Piperidine Compounds, such as those of Formula (I): and the pharmaceutically acceptable salts and solvates thereof, wherein R1, R2, R3, R4, R20, R21, Q, Y1, Z, A, B, and a are as defined herein; compositions comprising an effective amount of an Oxime-Substituted Quinoxaline-Type Piperidine Compound, and methods to treat or prevent a condition, such as pain, comprising administering to an animal in need thereof an effective amount of an Oxime-Substituted Quinoxaline-Type Piperidine Compound. Full Article
al Small molecule inhibitors of polynucleotide kinase/phosphatase, poly(ADP-ribose) polymerase and uses thereof By www.freepatentsonline.com Published On :: Tue, 26 May 2015 08:00:00 EDT The present invention generally relates to use of compounds and compositions as a chemosensitizers and/or radiosensitizers and/or inhibitors of PNKP phosphatase activity. The present invention provides pharmaceutical combinations and/or a pharmaceutically acceptable salt thereof, kits containing such compounds and/composition and methods of using such compounds and/or compositions. Full Article
al Solid forms of nematocidal sulfonamides By www.freepatentsonline.com Published On :: Tue, 26 May 2015 08:00:00 EDT Disclosed are solid forms of 8-chloro-N-[(2-chloro-5-methoxyphenyl)sulfonyl]-6-(trifluoromethyl)-imidazo[1,2-a]pyridine-2-carboxamide (Compound 1). Methods for the preparation of solid forms of Compound 1 and for the conversion of one solid form of Compound 1 into another are disclosed. Disclosed are nematocidal compositions comprising a nematocidally effective amount of a solid form of Compound 1 and at least one additional component selected from the group consisting of surfactants, solid diluents and liquid carriers. Compositions comprising a mixture of a solid form of Compound 1 and at least one other nematicide, insecticide and/or fungicide are also disclosed.Also disclosed are methods for protecting a plant from nematodes comprising applying to the plant, or portion, or seed thereof, or to the growing medium of the plant, a nematocidally effective amount of Compound 1 comprising the polymorph Form A. Full Article
al Dual inhibitors of farnesyltransferase and geranylgeranyltransferase I By www.freepatentsonline.com Published On :: Tue, 26 May 2015 08:00:00 EDT Many GTPases such as Ras, Ral and Rho require post-translational farnestylation or geranylgeranylation for mediating malignant transformation. Dual farnesyltransferase (FT) (FTI) and geranylgeranyltransferase-I (GGT-1) inhibitors (GGTI) were developed as anticancer agents from based on an ethylenediamine scaffold. On the basis of a 4-fold substituted ethylenediamine scaffold, the inhibitors are structurally simple and readily derivatized, facilitating extensive structure-activity relationship studies. The most potent inhibitor is compound exhibited an in vitro hFTase IC50 value of 25 nM and a whole cell H-Ras processing IC50 value of 90 nM. Several of the inhibitors proved highly selective for hFTase over the related prenyltransferase enzyme geranylgeranyltransferase-I (GGTase-I). A crystal structure of an inhibitor cocrystallized with farnesyl pyrophosphate in the active site of rat FTase illustrates that the para-benzonitrile moiety is stabilized by a π-π stacking interaction with the Y361β residue, suggesting an importance of this component of the inhibitors. Full Article
al Bicyclic thiazoles as allosteric modulators of mGluR5 receptors By www.freepatentsonline.com Published On :: Tue, 26 May 2015 08:00:00 EDT The present invention relates to novel bicyclic thiazoles which are positive allosteric modulators of the metabotropic glutamate receptor subtype 5 (“mGluR5”) and which are useful for the treatment or prevention of disorders associated with glutamate dysfunction and diseases in which the mGluR5 subtype of receptors is involved. The invention is also directed to pharmaceutical compositions comprising such compounds, to processes for preparing such compounds and compositions, and to the use of such compounds and compositions for the prevention and treatment of disorders in which mGluR5 is involved. Full Article
al Pesticidal compounds By www.freepatentsonline.com Published On :: Tue, 26 May 2015 08:00:00 EDT A compound of formula (I) wherein R1 to R4 are, for example, each hydrogen, R5 is pyridyl, which has two or more substituents selected, for example, from halogen, C1-C4-alkyl, C1-C4-haloalkyl, C1-C4-alkoxy, C1-C4-haloalkoxy, and cyano; R6 is, for example, hydrogen; R7 is, for example, hydrogen, cyano, hydroxyl, formyl, C1-C4-alkyl, C1-C4-alkoxy, C2-C4-alkenyl, or C2-C4-alkynyl; and A1 to A5 are, independently selected, from, for example, N, and C—H; and its use as a pesticidal agent. Full Article
al Method and device for manufacturing fastenings or fasteners with radial outer contours, especially screws or threaded bolts By www.freepatentsonline.com Published On :: Tue, 26 Feb 2013 08:00:00 EST A method of manufacturing fastenings or fasteners with radial outer contours, especially screws or threaded bolts, made of solid metal is performed by a device. The method manufactures the fastenings or fasteners preferably on a multi-stage press. Several recesses running in an axial direction at a fixed radial distance are formed in the shank-shaped section of a blank. The prefabricated blank with the recesses is inserted into a multi-part split mold within a multi-stage press, whose die stocks have an inner profiling forming the outer contour, and are opened in the starting position, that at the places where the die stocks are opened, there are the recesses. During the closing movement of the die stocks, at least one radial outer contour is pressed on the shank-shaped section of the blank by radial action of forces, with the recesses preventing material from getting between the die stocks during the pressing process. Full Article
al Nut, female thread machining device and female thread machining method By www.freepatentsonline.com Published On :: Tue, 16 Apr 2013 08:00:00 EDT There is provided a nut having a thread portion having a female thread, a metallic plate portion having a base segment, and a hardness gradient portion provided between the thread portion and the metallic plate portion. The thread portion, metallic plate portion and the hardness gradient portion are monolithic each other, a metallographic structure of the metallic plate portion differs from a metallographic structure of the thread portion and a hardness of the hardness gradient portion is lower than a hardness of the thread portion and lowers from the thread portion toward the metallic plate portion. Full Article
al Sealed end t-nut By www.freepatentsonline.com Published On :: Tue, 16 Jul 2013 08:00:00 EDT A fastener includes a t-nut having a barrel and a flange. The flange includes an opening which leads to a threaded barrel. The threaded barrel extends from the opening in the flange to a distal end portion thereof. An end cap has an annular recess on a first side thereof and has a raised annular ridge on a second side thereof. The raised annular ridge of the end cap is affixed to the flange of the t-nut by welding the end cap to the flange. Dirt, water and moisture cannot enter the barrel because the end cap is sealed to the flange. Additionally, the barrel may be relatively short as it is fully threaded prior to the affixation of the end cap to the flange. Full Article
al Form tap having a plurality of lobes By www.freepatentsonline.com Published On :: Tue, 10 Dec 2013 08:00:00 EST A form tap for tapping an article may include a longitudinal shank having a mounting end opposite a tip, the shank having a shank length, and a thread portion with a plurality of threads for engaging a surface of the article. The thread portion includes a first region, a second region and a third region. The form tap includes a plurality of lobes extending though the first and second regions from the tip to the second region end, the lobes being spaced circumferentially around the shank and lying on a crest circumference. Each lobe may be disposed between respective first and second convex relief portions and each relief portion may be spaced radially inward from the crest circumference. Each lobe has a lobe width, the lobe width at the second region end being greater than the lobe width at the tip. The third region is free of lobes. Full Article
al Hollow bolt comprising a longitudinal bore By www.freepatentsonline.com Published On :: Tue, 28 Jan 2014 08:00:00 EST A process for producing hollow bolts including a longitudinal bore with the hollow bolts being provided with circumferential notches. The hollow bolts are provided with longitudinal grooves extending between elevations determining the bolt diameter, wherein circumferential notches are rolled onto the hollow bolts provided with the longitudinal grooves and the elevations, the longitudinal grooves being of such cross-section that some of the material displaced during rolling-on of the notches flows into the longitudinal grooves. Full Article
al Spiral fluted tap and method for manufacturing the same By www.freepatentsonline.com Published On :: Tue, 29 Apr 2014 08:00:00 EDT A spiral fluted tap is provided which includes a threaded portion having an external thread corresponding to an internal thread to be cut and a cutting edge formed along a spiral flute formed to divide the external thread, and being screwed into a prepared hole that is provided on a workpiece to cut an internal thread by the cutting edge on an inner circumferential surface of the prepared hole with discharging chips toward a shank via the spiral flute, the spiral flute having a stepped portion at a rear end of a chamfer portion or in a portion on a shank side from the rear end of the chamfer portion in the threaded portion, and a flute bottom diameter on a distal end side of the spiral fluted tap from the stepped portion being smaller than a flute bottom diameter on a shank side from the stepped portion. Full Article
al Self-sealing fastener By www.freepatentsonline.com Published On :: Tue, 28 Oct 2014 08:00:00 EDT A fastener suitable for use in airplane manufacture or repair that is coated with a pre-mixed moisture cure sealant. The sealant layer is coated with a frangible moisture barrier that will break apart when the fastener is installed, thus exposing the sealant to atmospheric moisture. Once exposed to moisture, the sealant will begin to cure. Preferred embodiments also provide a moisture indicator that provides a visual indication that the outer moisture resistant layer has been damaged. Full Article
al Mobile abrasive blasting material separation device and method By www.freepatentsonline.com Published On :: Tue, 05 May 2015 08:00:00 EDT The process and apparatus for mobile separation and recovery of used contaminants abrasive blasting material from a work site. Entrained contaminants within used blast material are removed by a self-contained mobile platform process using multiple stage cleaning system including dual cyclonic separation, multiple stage dust filters with large debris magnetic drum, airwash and vibratory separation in a flow through containment and blast media separation process. Full Article
al Abrasive tool for use as a chemical mechanical planarization pad conditioner By www.freepatentsonline.com Published On :: Tue, 05 May 2015 08:00:00 EDT An abrasive tool including a CMP pad conditioner having a substrate including a first major surface, a second major surface opposite the first major surface, and a side surface extending between the first major surface and the second major, wherein a first layer of abrasive grains is attached to the first major surface and a second layer of abrasive grains is attached to the second major surface. The conditioner further includes a first sealing member extending in a peripheral direction along a portion of the side surface of the substrate. Full Article
al Pressurized dual fluid jet system By www.freepatentsonline.com Published On :: Tue, 12 May 2015 08:00:00 EDT A dual capability ultra high pressure (UHP) fire attack system includes a fluid jet assembly and an UHP attack line system. The fluid jet assembly and the UHP attack line system are coupled to a high pressure fluid source. The fluid is discharged from both the fluid jet assembly and the UHP attack line system as a mist having a droplet diameter of approximately 150 microns. When infused with an abrasive material, the fluid jet assembly may be used to cut through structural surfaces, so that a fire may be “knocked down” before the fuel source is attacked. Full Article
al Abrasive article for shaping of industrial materials By www.freepatentsonline.com Published On :: Tue, 12 May 2015 08:00:00 EDT An abrasive article including a base having an annular shape defining a central opening; and a mounting assembly coupled to the base, wherein a portion of the mounting assembly is under a compressive force, and a grinding segment coupled to the mounting member. Full Article
al Method and apparatus for reconditioning digital discs By www.freepatentsonline.com Published On :: Tue, 26 May 2015 08:00:00 EDT An automated method for reconditioning a plurality of digital discs within a reconditioning apparatus is disclosed. The method comprises holding the digital discs in a load area, and then transferring each of the digital discs from the load area to at least one workstation with a disc transfer mechanism. The method also comprises reconditioning each of the digital discs transferred to the workstation with at least one worktool operable to remove a portion of the protective coating of each of the digital discs without removal of the data underlying the protective coating. The method further comprises transferring each of the digital discs from the workstation to an unload area with the disc transfer mechanism, and then holding the digital discs in the unload area for manual retrieval. Advantageously, the digital discs may be automatically reconditioned within the reconditioning apparatus without manual manipulation of the digital discs during the reconditioning process. Various exemplary embodiments of the reconditioning apparatus and associated method are provided. Full Article