““Travel is to discover everyone else is wrong about other countries””

-

Aldous Huxley (via preferred-destinations)

Researchers at Princeton University and the University of California-Los Angeles have found that the moon is at least 4.51 billion years old, or 40 million to 140 million years older than scientists previously thought. The findings — based on an analysis performed at Princeton on samples brought back from the moon in 1971 — provide an approximate date for the impact that could allow scientists to estimate when life on Earth began.

DALLAS – (Oct. 23, 2019) The U.S. Environmental Protection Agency (EPA) recently awarded the Louisiana Department of Environmental Quality (LDEQ) a grant of $476,539 to support underground storage tank programs.

BOSTON – The US Environmental Protection Agency (EPA) is awarding seven local New England organizations with recognition for their work keeping wasted food out of landfills and incinerators and putting it to better use.

DENVER (February 19, 2020) — Today, the U.S.

WASHINGTON (April 22, 2019) – Today, U.S.

WASHINGTON – Today, the U.S. Environmental Protection Agency (EPA) announced the 2019 winners of the national WasteWise awards. EPA is recognizing the outstanding accomplishments of 11 WasteWise partner organizations.

Every day should be Mother’s Day, because without mothers, none of us would exist. But today is the national holiday, designated 106 years ago by President Woodrow Wilson — a time when cards, flowers, chocolates and breakfast in bed typically accompany the kind words we send mom’s way.

Earth is heating up at a much higher level than expected.

Earth is heating up at a much higher level than expected.

At first, it was hard to hear what Turk Wendell was saying from atop his tractor.

At first, it was hard to hear what Turk Wendell was saying from atop his tractor.

At first, it was hard to hear what Turk Wendell was saying from atop his tractor.

Edwin Cabrera, a father of two, was unlocking his e-bike after dropping off a pizza on Fort George Hill near Fairview Ave. on May 3 when two suspects jumped out of the shadows and attacked him around 9 p.m.

Exclusive: 'As well as staggered working hours we need to stagger holidays,' says AA president Edmund King

Unilever is recalling Wall’s Mini Calippo (Orange and Lemon-Lime) multi-packs because they may contain small pieces of metal. The presence of metal makes this product unsafe to eat.

Visit CTVNews.ca for an interactive record of the COVID-19 outbreak in Canada.

Decision makers at Penske Entertainment are beginning to chart the course for a historic summer of racing at the Indianapolis Motor Speedway.

In the latest MOTD podcast the experts discussed the top 10 Ballon d'Or winners of the Premier League era - and here's how you ranked them.

The Tech Stuff You Use Everyday is Dirtier Than You Think!

The Tech Stuff You Use Everyday is Dirtier Than You Think!

Filed under: Skiing, North America, United States

• 16 Easy Ski Vacation Ideas from U.S. Cities
• 50 Ways to Ski in 50 States

Where to Ski In Every State and 16 Ski Vacations Near Big U.S. Cities originally appeared on Gadling on Thu, 05 Dec 2013 11:29:00 EST. Please see our terms for use of feeds.

• This week's most popular movies on Netflix include its original thriller "Dangerous Lies" and "Den of Thieves."
• Netflix introduced daily top lists of the most popular titles on the service in February.
• Streaming search engine Reelgood keeps track of the lists and provides Business Insider with a rundown of the week's most popular movies on Netflix every Friday.
• Visit Business Insider's homepage for more stories.

The Netflix action movie "Extraction" is pacing to be the streaming giant's biggest movie premiere ever, but it was dethroned this week as the service's most popular movie. Another Netflix original, "Dangerous Lies," stole the crown.

Netflix introduced daily top 10 lists of its most viewed movies and TV shows in February (it counts a view if an account watches at least two minutes of a title).

Every week, the streaming search engine Reelgood compiles for Business Insider a list of which movies have been most prominent on Netflix's daily lists that week. On Reelgood, users can browse Netflix's entire movie library and sort by IMDb or Rotten Tomatoes ratings.

This week's list also includes "Den of Thieves," another movie starring Gerard Butler after his "Angel Has Fallen" enjoyed a few weeks on the list.

But the real winner this week is Netflix itself, as five of the seven movies on the list are Netflix originals. 

SEE ALSO: Insiders say major questions hang over DC Universe as its parent company prepares to launch Netflix rival HBO Max

7. "The Willoughbys" (2020 — Netflix original)

Netflix description: "Four siblings with horribly selfish parents hatch a plan to get rid of them for good and form a perfectly imperfect family of their own."

Rotten Tomatoes critic score: 89%

What critics said: "Though the film-makers are indebted to Edward Gorey and Lemony Snicket — and pay musical homage to Mark Mothersbaugh's work on The Royal Tenenbaums — they find their own voice, when it counts." — London Evening Standard

6. "Murder to Mercy: The Cyntoia Brown Story" (2020 — Netflix original)

Netflix description: "After 16-year-old Cyntoia Brown is sentenced to life in prison, questions about her past, physiology and the law itself call her guilt into question."

Rotten Tomatoes critic score: 75%

What critics said: "A moving reflection of what criminal justice reform means in personal terms." — New York Times

5. "Arctic Dogs" (2019)

Netflix description: "When he stumbles upon evil Otto Von Walrus's scheme to melt the Arctic, ambitious delivery fox Swifty assembles a ragtag crew to protect the planet."

Rotten Tomatoes critic score: 13%

What critics said: "There's really not much to recommend about this film: the animation lacks texture, the score is overwrought, the plotting is scattershot, and the character design is uninspired." — AV Club

4. "Den of Thieves" (2018)

Netflix description: "A highly skilled crew of bank robbers plotting a heist at the supposedly impenetrable Federal Reserve faces off against an elite unit of L.A. cops."

Rotten Tomatoes critic score: 41%

What critics said: "It often resembles a men's rights bonding weekend more than it does a movie." — Guardian

3. "Extraction" (2020 — Netflix original)

Netflix description: "A hardened mercenary's mission becomes a soul-searching race to survive when he's sent into Bangladesh to rescue a drug lord's kidnapped son."

Rotten Tomatoes critic score: 68%

What critics said: "Illustrates an important principle in escapist entertainment: you don't have to one-up your predecessors. Sometimes, it's enough to replicate what made them successful." — Newsday

2. "All Day and a Night" (2020 — Netflix original)

Netflix description: "While serving life in prison, a young man looks back at the people, the circumstances and the system that set him on the path toward his crime."

Rotten Tomatoes critic score: 56%

What critics said: "'All Day and a Night' lingers and sometimes meanders in that gray zone, where the story can accrue texture and feeling and emerge as more than the sum of its plot mechanics." — Los Angeles Times

1. "Dangerous Lies" (2020 — Netflix original)

Netflix description: "A broke caregiver unexpectedly inherits her patient's estate, but dark secrets swirl around her newfound wealth, tangling her in deceit and danger."

Rotten Tomatoes critic score: 39%

What critics said: "Looks like it cost the amount of your monthly Netflix subscription and is as satisfying to watch as it is paying that particular bill." — Globe and Mail

Some kids took advantage of the opportunity to show their appreciation for their moms on Saturday afternoon at the Love You Mama event.

The PGA Tour's Memorial Tournament will use radio frequency identification chips in spectator badges to ensure fans maintain social distance.

American Justin Gaethje scored a surprise technical knockout victory over Tony Ferguson to win the interim lightweight title at UFC 249.

After six weeks of negotiating, the UN Security Council was close to agreeing on a resolution for a global ceasefire during the Covid-19 pandemic. Seems fair, right? Let's agree to stop killing each other for a while, so we can focus on the virus that's killing us instead?

China proposed that the text explicitly mention a commitment by member nations to support the efforts of the World Health Organization — who Donald Trump has blamed (without evidence) for withholding information on the coronavirus outbreak.

So the US looked at the resolution and said "LOL no," despite last minute efforts to reach a compromise. As The Guardian reports:

On Thursday night, French diplomats thought they had engineered a compromise in which the resolution would mention UN “specialized health agencies” (an indirect, if clear, reference to the WHO).

The Russian mission signaled that it wanted a clause calling for the lifting of sanctions that affected the delivery of medical supplies, a reference to US punitive measures imposed on Iran and Venezuela. However, most security council diplomats believed Moscow would withdraw the objection or abstain in a vote rather than risk isolation as the sole veto on the ceasefire resolution.

While everyone else seemed game to go along with these compromises, the US insisted it was one big Chinese trick. As one diplomat told CNN:  "This discussion has been taken hostage by issues that do not have to do with the real issues at stake. Instead it has been transformed into a fight between the US and China. Read the rest

6 March 2014

21 July 2016

captain_j03 posted a photo:

Wish me a happy mother's day and I'll slit your guts like a ripe melon.

My mood is not the best today - my sister woke me at 6 AM for said reason. On a sunday. And guess what - I am not even a mother.

Toy Project Day 1746

ridureyu1 posted a photo:

Wearing only the best hi-tech snail shell!

ridureyu1 posted a photo:

Too bad he's named after FDR and not Teddy.

β-1,3-d-Glucan is a ubiquitous glucose polymer produced by plants, bacteria, and most fungi. It has been used as a diagnostic tool in patients with invasive mycoses via a highly-sensitive reagent consisting of the blood coagulation system of horseshoe crab. However, no method is currently available for measuring β-1,6-glucan, another primary β-glucan structure of fungal polysaccharides. Herein, we describe the development of an economical and highly-sensitive and specific assay for β-1,6-glucan using a modified recombinant endo-β-1,6-glucanase having diminished glucan hydrolase activity. The purified β-1,6-glucanase derivative bound to the β-1,6-glucan pustulan with a KD of 16.4 nm. We validated the specificity of this β-1,6-glucan probe by demonstrating its ability to detect cell wall β-1,6-glucan from both yeast and hyphal forms of the opportunistic fungal pathogen Candida albicans, without any detectable binding to glucan lacking the long β-1,6-glucan branch. We developed a sandwich ELISA-like assay with a low limit of quantification for pustulan (1.5 pg/ml), and we successfully employed this assay in the quantification of extracellular β-1,6-glucan released by >250 patient-derived strains of different Candida species (including Candida auris) in culture supernatant in vitro. We also used this assay to measure β-1,6-glucan in vivo in the serum and in several organs in a mouse model of systemic candidiasis. Our work describes a reliable method for β-1,6-glucan detection, which may prove useful for the diagnosis of invasive fungal infections.

Multidrug resistance (MDR) in cancer arises from cross-resistance to structurally- and functionally-divergent chemotherapeutic drugs. In particular, MDR is characterized by increased expression and activity of ATP-binding cassette (ABC) superfamily transporters. Sphingolipids are substrates of ABC proteins in cell signaling, membrane biosynthesis, and inflammation, for example, and their products can favor cancer progression. Glucosylceramide (GlcCer) is a ubiquitous glycosphingolipid (GSL) generated by glucosylceramide synthase, a key regulatory enzyme encoded by the UDP-glucose ceramide glucosyltransferase (UGCG) gene. Stressed cells increase de novo biosynthesis of ceramides, which return to sub-toxic levels after UGCG mediates incorporation into GlcCer. Given that cancer cells seem to mobilize UGCG and have increased GSL content for ceramide clearance, which ultimately contributes to chemotherapy failure, here we investigated how inhibition of GSL biosynthesis affects the MDR phenotype of chronic myeloid leukemias. We found that MDR is associated with higher UGCG expression and with a complex GSL profile. UGCG inhibition with the ceramide analog d-threo-1-(3,4,-ethylenedioxy)phenyl-2-palmitoylamino-3-pyrrolidino-1-propanol (EtDO-P4) greatly reduced GSL and monosialotetrahexosylganglioside levels, and co-treatment with standard chemotherapeutics sensitized cells to mitochondrial membrane potential loss and apoptosis. ABC subfamily B member 1 (ABCB1) expression was reduced, and ABCC-mediated efflux activity was modulated by competition with nonglycosylated ceramides. Consistently, inhibition of ABCC-mediated transport reduced the efflux of exogenous C6-ceramide. Overall, UGCG inhibition impaired the malignant glycophenotype of MDR leukemias, which typically overcomes drug resistance through distinct mechanisms. This work sheds light on the involvement of GSL in chemotherapy failure, and its findings suggest that targeted GSL modulation could help manage MDR leukemias.

The report examines U.S. immigration and international development policies, which have unique objectives and respond to distinct political and administrative constraints, and points out that international development has never been a U.S. immigration policy objective; nonetheless, it is an unintended consequence.

Migration and development have emerged as a pressing policy priority on the global agenda. This report identifies critical lessons from the past decade of policy experimentation and offers recommendations for migration and development policy.

Declaring it has been “pained” by the Jodian Fearon situation, the embattled Andrews Memorial Hospital (AMH) is speaking out, saying it has never been approached for or rejected efforts at registration or certification since it began operating 76...

Losses within the entertainment industry are already estimated to be in the billions as the sector continues to reel from the impacts of COVID-19. Major events like Reggae Sumfest, which has already been cancelled this year, had an estimated...

At least 10 stores inside the Portmore Mall have fallen casualty to the economic chokehold brought on by the COVID-19 pandemic, with several others struggling to stay afloat as St Catherine businesses grapple with revenue losses. And with a 14-day...

This report focuses on the development of children of Black immigrants in the United States, comparing against the outcomes for their peers in native-born and other immigrant families. It also compares these U.S. children to those in the United Kingdom, where there is a large Black immigrant population but a notably different policy context of reception.

There is nothing average about Bishop Cleveland Mattis who uses the skills and knowledge he has acquired over the years, from varying areas, to be more relatable to the people he serves and transform lives through the teachings of the Holy Spirit...

This edited volume examines the development impact of diasporas in six critical areas: entrepreneurship, capital markets, "nostalgia" trade and "heritage" tourism, philanthropy, volunteerism, and advocacy.

This practical handbook highlights policies and programs that can magnify the resources, both human and financial, that emigrants and their descendants contribute to development. It gives concrete examples of policies and programs that have been effective, and pulls out both useful lessons and common challenges associated with the topics at hand.

This edited volume develops a pragmatic approach to the engagement of highly skilled members of the diaspora for the benefit of their countries of origin. The book, edited by a World Bank senior economist, is based on empirical work in middle-income and high-income economies.

A webinar showcasing MPI's profiles of unauthorized immigrants in the 94 U.S. counties with the largest populations potentially eligible for DACA or DAPA, and the implications of the data for implementation of the DACA and DAPA programs.

This interactive language access webinar, one in a series offered by the Migration Policy Institute's National Center on Immigrant Integration Policy, examines how New York and Illinois have broken down some of these barriers to proactively engage LEP communities to obtain workforce services.