Agents that specifically bind to an opioid receptor in a conformationally specific way can be used to induce a conformational change in the receptor. Such agents have therapeutic applications and can be used in X-ray crystallography studies of the receptor. Such agents can also be used to improve drug discovery via compound screening and/or structure-based drug design.

The present invention relates to VEGF-binding agents, DLL4-binding agents, VEGF/DLL4 bispecific binding agents, and methods of using the agents for treating diseases such as cancer. The present invention provides antibodies that specifically bind human VEGF, antibodies that specifically bind human DLL4, and bispecific antibodies that specifically bind human VEGF and/or human DLL4. The present invention further provides methods of using the agents to inhibit tumor growth. Also described are methods of treating cancer comprising administering a therapeutically effect amount of an agent or antibody of the present invention to a patient having a tumor or cancer.

A recombinant vector comprises simian adenovirus 36, simian adenovirus 42.1, simian adenovirus 42.2 and/or simian adenovirus 44 sequences and a heterologous gene under the control of regulatory sequences. A cell line which expresses one or more simian adenovirus-36, -42.1, -42.2 or -44 gene(s) is also described. Methods of using the vectors and cell lines are provided.

Described herein are methods and compositions for treatment of immune-related diseases or disorders by modulating DD1α activity, alone or in combination with modulation of PD-1 activity. In some embodiments, the methods and compositions described herein are directed to treatment of cancer and/or infections (e.g., bacterial infection, and/or fungal infection). In some embodiments, the methods and compositions described herein are directed to treatment of autoimmune diseases and/or inflammation. In some embodiments, the methods and compositions described herein are directed to treatment of asthma, and allergy. Methods for identifying patients who are more likely to be responsive to and benefit from an immunotherapy that targets DD1α and/or PD-1 activity or expression are also described herein.

The present invention is directed to recombinant thraustochytrids that grow on sucrose and cell cultures comprising the recombinant thraustochytrids as well as methods of producing cell cultures, biomasses, microbial oils, compositions, and biofuels using the recombinant thraustochytrids.

The present disclosure relates to methods and apparatuses for assembling diapers, each including a chassis connected with front and back elastic belts. As discussed in more detail below, opposing end regions of the chassis are connected with regions of the elastic belts where the elasticity of the elastic belts has been removed or deactivated. An elastic laminate may be formed by continuously bonding elastic strands between a first continuous substrate layer and a second continuous substrate layer such that the elastic strands are bonded to both the first substrate layer and the second substrate layer in heavy-bond regions. And the elastic strands are bonded to the first substrate layer and/or the second substrate layer with in light-bond regions. The elastic strands are then intermittently deactivated by cutting the strands into one or more discrete pieces in the light-bond regions. The discrete pieces retract and remain in the light-bond regions.

A method includes performing a patterning step on a layer using a process gas. When the patterning step is performed, a signal strength is monitored, wherein the signal strength is from an emission spectrum of a compound generated from the patterning step. The compound includes an element in the patterned layer. At a time the signal strength is reduced to a pre-determined threshold value, the patterning step is stopped.

An esteramide compound of the following formula (I): R1OOC-A-CONR2R3 (I) is described, wherein: A is a covalent bond or a methylene group —CH2—;R1 is an optionally substituted, saturated or unsaturated aliphatic or cycloaliphatic hydrocarbon group including from 5 to 36 carbon atoms,R2 and R3, either identical or different, are groups selected from a hydrogen atom, and optionally substituted hydrocarbon groups, preferably including from 1 to 36 carbon atoms, andR2 and R3 not being simultaneously hydrogen atoms. Also described, are applications for using the esteramide compound, notably as a solvent.

Methods and apparatuses for drying electronic devices are disclosed. Embodiments include methods and apparatuses that heat and decrease pressure within the electronic device. Some embodiments increase and decrease pressure while adding heat. Other embodiments include a desiccator for removing moisture from the air being evacuated from the electronic device prior to the air reaching an evacuation pump. Further embodiments detect humidity within the low-pressure chamber and determine when to increase and/or decrease pressure based on the humidity. Still further embodiments determine that the device is sufficiently dry to restore proper function based on the detected humidity, and in some embodiments based on the changes in humidity while pressure is being increased and/or decreased. Still further alternate embodiments automatically control some or all aspects of the drying of the electronic device. Additional embodiment disinfect the electronic device.

A vertical conveying channel is made of elastic fabric. The elastic fabric's latitude elastic deformation rate is 100˜450%, latitude resilience is 300˜2500N, and latitude elastic recovery rate is 70˜100%; preferably, the latitude elastic deformation rate is 120˜400%, the latitude resilience is 350˜2300N, and the latitude elastic recovery rate is 75˜98%; more preferably, the latitude elastic deformation rate is 140˜350%, the latitude resilience is 550˜2200N, and the latitude elastic recovery rate is 80˜96%; most preferably, the latitude elastic deformation rate is 170˜300%, the latitude resilience is 750˜2000N, and the latitude elastic recovery rate is 85˜94%. The vertical conveying channel can be used for vertical conveying of cargo or personnel, preferably used in the field of lifesaving, engineering or military.

An apparatus for producing a textile product generally includes a feeding section for providing a starting material to facilitate producing a textile product derived from the starting material; a drafting section operably coupled to the feeding section for gripping, pulling, stretching and breaking at least one strand of the starting material into at least one continuous and cohesive network of an intermediate product; and a spinning section operably coupled to the drafting section for winding and twisting the at least one continuous and cohesive network of an intermediate product onto a removable receiving member to form the textile product; the feeding section, the drafting section, and the spinning section are configured to form the textile product in a continuous operation.

Devices, cartridges, and method are described herein for emulating smoking wherein a device generates an aerosol for inhalation by a subject by heating a viscous material that can have a tactile response in the mouth or respiratory tract, while reducing Hoffman analytes and mutagenic compounds delivered to the user as compared to a common tobacco cigarette.

A system for producing porous masses may include a mold cavity disposed along the material path, at least one hopper before at least a portion of the mold cavity for feeding a matrix material to the material path, a heat source in thermal communication with at least a first portion of the material path, and a cutter disposed along the material path after the first portion of the material path.

An improved ladderway system 30 for an underground raise. The system comprises an elongate tube 32 made of a suitably rigid plastics material and adapted to be received in the raise. The tube has a series of steps 34 moulded into an interior side wall thereof so as to form a ladder extending substantially the full length of the tube 32.

A method is provided for a reading memory even if there is a threshold voltage in an overlapped threshold voltage (VTH) region between a first state distribution and a second state distribution. The method includes ramping a bias on a memory cell a first time to determine a first threshold voltage (VTH1) of the memory cell and determining whether the VTH1 is within the overlapped VTH region. Upon determination that the memory cell is within the overlapped VTH region, the method further includes applying a write pulse to the memory cell; ramping a bias on the memory cell a second time to determine a second threshold voltage (VTH2); and determining the state of the memory cell prior to receiving the write pulse based on a comparison between the VTH1 and the VTH2.

Root canal abutment devices and methods which facilitate the adjustment or removal of an oral appliance, e.g., a crown or bridge, from a reconfigurable abutment assembly are described. The adjustable abutment assembly may be secured within a pulp chamber of a pre-existing tooth. The abutment assembly has a projecting abutment portion with one or more shape memory alloy sleeves or plates or elements extending along the abutment. Each of the sleeves has a length with at least one curved or arcuate portion. Energy may be applied to the elements such that the arcuate portion flattens to allow for the oral appliance to be placed thereupon while removal of the energy allows the elements to reconfigure into its curved configuration thereby locking the oral appliance to the abutment. Removal of the oral appliance may be effected by reapplication of energy to the elements.

An air mattress apparatus includes an air mattress which comprised of an array of air bladder cells that are individually inflatable to quiescent pressure levels which provide comfortable support for the body of a human, and a pressure-pulse generator controlled by a wave sequence generator for introducing into ordered patterns of air bladder cells a wave-like time sequence of air pressure pulses which vary quiescent pressure levels in the cells, the pressure wave resulting in a traveling wave of support force variation which travels over the surfaces of the pulsed air bladder cells, thus inhibiting formation of bedsores. The wave pattern may optionally simulate water waves and/or rocking motions of a boat to produce relaxing effects.

Person support apparatuses with selectively coupled foot sections are disclosed. In one embodiment, the person support apparatus includes a base frame, a primary support frame supported on the base frame, and a foot section coupled to the primary support frame. The person support apparatus also includes a carriage that is freely translatable between a head end of the primary support frame and a foot end of the primary support frame, the carriage comprising a torso portion and a seat portion having a thigh segment and a gluteal segment. The person support apparatus further includes a selectable trunnion that selectively and severally couples the foot section to the primary support frame and the thigh segment of the seat portion.

Processes and apparatuses for co-processing pyrolysis effluent and a hydrocarbon stream in which a char produced by the catalytic cracking of the pyrolysis effluent is recovered and utilized to provide energy, such as heat to the catalytic cracking zone. The char can be burned in various combustion zones associated with the catalytic cracking zone. The char is produced from a renewable resource.

A fly blanket for laying atop a horse's rump behind a saddle comprising a mesh sheet having a generally rounded trapezoidal shape; two attachment components both for attaching the mesh sheet to a saddle ring disposed on the saddle; and stitched binding disposed along edges of the mesh sheet, wherein a weighted rope is disposed in all of or a portion of the stitched binding, wherein the weighted rope functions to help keep the fly blanket from flopping around while the horse is moving.

Compositions having a high metal content comprising a metal salt solution, a stabilizer and one or more optional additives, wherein the metal salt solution comprises a metal ion, a counter ion and a solvent. The compositions are useful for forming films on substrates in the manufacture of solid state and integrated circuit devices.

A method of preparing an electrochemical electrode which is partially or totally covered with a film that is obtained by spreading an aqueous solution comprising a water-soluble binder over the electrode and subsequently drying same. The production cost of the electrodes thus obtained is reduced and the surface porosity thereof is associated with desirable resistance values.

Aspects of the disclosure are directed to apparatuses and methods involving filters and detection of operation thereof. As may be consistent with one or more embodiments, an apparatus includes a fixture having mechanical components that hold a filter. Gas flow componentry operates with the fixture to eject particles from the filter by subjecting the filter to gas flow. A flow metering circuit meters the gas flow, and a particulate counter detects the ejected particles.

Methods and apparatuses are provided for detecting parameter. The method includes: acquiring at least one intake air quality parameter of an air intake area of an air purifier and at least one output air quality parameter of an air discharging area of the air purifier; determining a purification parameter corresponding to the intake air quality parameter of the air intake area and the output air quality parameter of the air discharging area; and outputting the purification parameter.

A mower carrying a rotary cutting deck has a height of cut system for adjusting the vertical position of the deck relative to the mower frame for changing or adjusting the height of cut. The height of cut system comprises a pair of parallel cross shafts that carry a plurality of pivotal suspension linkages that connect to the deck, the cross shafts and linkages pivoting jointly with one another and with a pivotal control lever. One of the cross shafts carries a torsion spring to counterbalance the weight of the deck. The control lever is maintained in a plurality of adjusted pivotal positions by a height selection bracket fixed to the frame with the height selection bracket being capable of having its position changed or adjusted relative to the frame by a single adjustment bolt. Each suspension linkage has its effective length adjusted by turning a threaded adjuster carried at the upper end of a connecting rod that is part of each linkage to allow the deck to be leveled relative to a reference plane. The adjustment of the height selection bracket is accomplished without affecting the length adjustments previously made to any of the suspension linkages.

A system for determining thickness variation values of a semiconductor substrate comprises a substrate vacuumed to a pedestal that defines a reference plane for measuring the substrate. A measurement probe assembly determines substrate CTV and BTV values, and defines a substrate slope angle. A thermal bonding assembly attaches a die to the substrate at a bonding angle congruent with the substrate slope angle. A plurality of substrates are measured using the same reference plane on the pedestal. Associated methods and processes are disclosed.

A hinge for transport cases, trunks, suitcases and the like, comprising two elements which are mutually articulated about a common axis and are both able to rotate with respect to the common axis. Each element is delimited by two parallel walls and has a total width that is equal to the width of the channel delimited between the stiffening ribs of the transport case, suitcase or trunk on which it will be installed. Each element is associable with the stiffening ribs of the respective transport case, once it is inserted between the ribs, without requiring any mechanical machining of the surfaces of the case.

A chemically-modified mixed fuel includes methane gas from at least two methane-production sources and can be utilized in any process that incorporates a Kellogg Primary Reformer. A method for producing the chemically-modified mixed fuel described herein includes providing a first methane-containing gas from a first methane-production source, providing a second methane-containing gas from a second methane-production source and blending the first methane-containing gas with the second methane-containing gas at a suitable pressure to form a chemically-modified mixed fuel. In some cases, at least one additional methane-containing gas can be provided from at least one additional methane-production source and blended with the chemically-modified fuel.

A gas generator and process for converting a fuel into an oxygen-depleted gas and/or hydrogen-enriched gas. The gas generator is preferably used for generating protection gas or reducing gas for start up, shut down or emergency shut down of a SOFC or SOEC. The process for converting fuel into oxygen-depleted gas and/or a hydrogen-enriched gas includes combusting the fuel in a primary catalytic burner with an oxygen-containing gas to produce a flue gas with oxygen, combusting or partially oxidizing the flue gas comprising oxygen with excess fuel in a secondary catalytic burner to produce a gas with hydrogen and carbon monoxide, and reducing the trace amounts of oxygen from the gas comprising traces of oxygen and obtaining an oxygen-depleted gas, or reducing the carbon monoxide present in the gas by conversion to carbon dioxide or methane to obtain a hydrogen-enriched gas.

Processes for the catalytic conversion of a carbonaceous composition into a gas stream comprising methane are provided. In addition, the processes provide for the generation of a hydrogen-enriched gas stream and, optionally, a carbon monoxide-enriched gas stream, which can be mixed or used separately as an energy source for subsequent catalytic gasification processes.

Various processes and apparatus are discussed for an ultra-high heat flux chemical reactor. A thermal receiver and the reactor tubes are aligned to 1) absorb and re-emit radiant energy, 2) highly reflect radiant energy, and 3) any combination of these, to maintain an operational temperature of the enclosed ultra-high heat flux chemical reactor. Particles of biomass are gasified in the presence of a steam carrier gas and methane in a simultaneous steam reformation and steam biomass gasification reaction to produce reaction products that include hydrogen and carbon monoxide gas using the ultra-high heat flux thermal energy radiated from the inner wall and then into the multiple reactor tubes. The multiple reactor tubes and cavity walls of the receiver transfer energy primarily by radiation absorption and re-radiation, rather than by convection or conduction, to the reactants in the chemical reaction to drive the endothermic chemical reaction flowing in the reactor tubes.

A solid feed system may comprise a supersonic nozzle, an isolated injection section having a port for injection of solid feedstock positioned downstream from the supersonic nozzle, and a supersonic diffuser positioned downstream from the isolated injection section. Additionally, a gasification system may comprise such a solid feed system and a reaction chamber downstream thereof. Furthermore, a method of reacting a solid feedstock under pressure may include directing a fluid flow through a supersonic nozzle to provide a supersonic flow stream, and directing the supersonic flow stream through an isolated injection section at a static pressure at least fifty percent (50%) lower than an operating pressure within a reaction chamber (e.g., at a static pressure near ambient pressure).

The present invention relates to substituted cellulose acetates and methods of use thereof. One embodiment of the present invention provides a coating having a substituted cellulose acetate having a polar substituent that has an oxygen atom covalently bonded to a nonmetal selected from the group of sulfur, phosphorus, and boron; wherein the nonmetal is present in at least about 0.01% by weight of the substituted cellulose acetate.

Card shuffler apparatuses include a card repositioner used to randomly reposition a plurality of cards on-edge over an aperture extending through a card support surface to allow cards to sequentially pass through the aperture in a random order. The apparatuses may be capable of continuously and sequentially forming playing card hands for use in a game. Shuffler apparatuses may be used to obtain a measurement relating to a thickness of the deck of cards. Methods involve the use of card shuffler apparatuses to form one or more playing card hands in a playing card game. Additional methods involve counting playing cards present within a stack of playing cards using a shuffler apparatus. In further methods, a number of shuffler apparatuses and a lesser number of shuffler activation devices are provided in a gaming establishment so as to preclude simultaneous use of all the shuffler apparatuses in the establishment.

The invention relates to a device for cooling hot gases generated by an internal arc in high voltage metal-enclosed switchgear and controlgear or prefabricated high voltage/low voltage stations. This device comprises a metal foam cooling filter having a honeycomb structure.

This invention relates to novel methods for affecting, controlling and/or directing various crystal formation, structure formation or phase formation/phase change reaction pathways or systems by exposing one or more components in a holoreaction system to at least one spectral energy pattern. In a first aspect of the invention, at least one spectral energy pattern can be applied to a crystallization reaction system. In a second aspect of the invention, at least one spectral energy conditioning pattern can be applied to a conditioning reaction system. The spectral energy conditioning pattern can, for example, be applied at a separate location from the reaction vessel (e.g., in a conditioning reaction vessel) or can be applied in (or to) the reaction vessel, but prior to other (or all) crystallization reaction system participants being introduced into the reaction vessel.

The present invention relates generally to processes for preparing agglomerated particulate low-rank coal feedstocks of a particle size suitable for reaction in certain gasification reactors and, in particular, for coal gasification. The present invention also relates to integrated coal gasification processes including preparing and utilizing such agglomerated particulate low-rank coal feedstocks.

A method of modulating oxygen saturation levels can include measuring oxygen saturation levels in a patient, administering inhaled nitric oxide, adjusting the dose of oxygen in real time to a second dose based on the inhaled nitric oxide.

The present document describes an electrophoretic tissue clearing chamber comprising an electrophoresis channel, configured to receive a clarification fluid therethrough; a first clarification fluid inlet, in fluid communication with the electrophoresis channel, configured to be connected to a source of the clarification fluid; a tissue sample holder in fluid communication with the electrophoresis channel, configured to receive a tissue sample to be clarified, and pressurize and homogenously apply the clarification fluid onto the tissue sample; a clarification fluid outlet, in fluid communication with the tissue sample holder, for exit of the clarification fluid from the electrophoretic tissue clearing chamber; and first and a second electrode, opposite one another in the electrophoresis channel, for transmission of an electric field therethrough.

In one aspect, a biological sequencing device comprising a cartridge configured to be removed from the instrument is disclosed. In various embodiments the cartridge can include one or more capillaries suitable for capillary electrophoresis, a reservoir and a pump. In various embodiments the reservoir can contain a separation matrix. In various embodiments the pump can load a capillary with separation matrix. In another aspect the biological sequencing device can include one or more capillaries and an integrated valve assembly. In various embodiments the integrated valve assembly can provide a polymer to the one or more capillaries.

Embodiments include apparatuses, systems, and methods including a switching converter having an output stage including a power switch or first switching device to convert an input switching signal to an output switching signal and a sensor stage including a second switching device and a third switching device. In embodiments, the sensor stage may be coupled to receive the output switching signal from the first switching device and to substantially replicate a condition of the first switching device to generate a continuous signal rather than a switched signal. In embodiments, the continuous signal may allow detection of a current level. In some embodiments, the current level may indicate an overcurrent event. A digital post-processing circuit may be coupled to the switching device to count a number of overcurrent events according to various embodiments. Other embodiments may also be described and claimed.

Methods and systems for monitoring an integrity of electrical connectivity between a repair patch and a parent structure include providing the repair patch with an embedded sensor configured to detect electrical conductivity. The repair patch includes a ply of conductive material that overlaps a portion of a conductive layer of the parent structure. A baseline set of sensor data is acquired from the sensor indicative of an electrical connectivity between the ply of conductive material of the repair patch and the conductive layer of the parent structure. One or more additional sets of data may be obtained from the sensor and compared to the baseline set of data to determine an integrity of the electrical connectivity between the ply of conductive material of the repair patch and the conductive layer of the parent structure.

Test measurements on a utility power device by a switch matrix apparatus and a common voltage source as separate devices is performed. Through the switch matrix apparatus, the common voltage source selectively sends a first high voltage signal via a first lead to a first terminal of the utility power device, measures a first corresponding signal returned via a second lead of the switch matrix apparatus from a second terminal of the utility power device. While the first lead and the second lead of the switch matrix apparatus remain electrically coupled to the first and the second terminal of the utility power device, a second high voltage signal is selectively sent via the second lead to the second terminal of the utility power device, and a second corresponding signal returned from the first terminal of the utility power device via the first lead of the switch matrix apparatus is measured.

A system comprising: a parent structure made of composite material and having a repair site; a repair patch made of composite material, the repair patch being bonded to the parent structure at the repair site; and a sensor embedded in the repair patch. The system may further comprise non-volatile memory and an interface unit embedded in the repair patch and electrically connected to the sensor. In one embodiment, the sensor is a loop-shaped sensor comprising an electrically conductive structure having an electrical conductivity that varies as a function of a pressure exerted on the repair patch. In another embodiment, the sensor comprises a sensor chip having nonvolatile memory. In a further embodiment, the sensor comprises an optical fiber that is sensitive to changes in pressure on or strain in the repair patch.

A process for fabricating an organic photodetector is presented. The process includes providing an array of thin film transistor assemblies, each thin film transistor assembly including a first electrode disposed on a thin film transistor; disposing an organic semiconductor layer on the array; disposing a second electrode layer including a first inorganic material on the organic semiconductor layer through a shadow mask to form a first etch stop layer; and removing portions of the organic semiconductor layer unprotected by the first etch stop layer using a dry etching process to form a multilayered structure. An organic photodetector, for example an organic x-ray detector fabricated by the process is further presented. An x-ray system including the organic x-ray detector is also presented.

A fluid analyzer includes an optical source and an optical detector defining an optical beam path through an interrogation region of a fluid flow cell. Flow-control devices conduct analyte and reference fluids through a channel and the interrogation region, and manipulate fluid flow in response to control signals to move a fluid boundary separating the analyte and reference fluids across the interrogation region. A controller generates control signals to (1) cause the fluid boundary to be moved across the interrogation region accordingly, (2) sample an output signal from the optical detector at a first interval during which the interrogation region contains more analyte fluid than reference fluid and at a second interval during which the interrogation region contains more reference fluid than analyte fluid, and (3) determine from samples of the output signal a measurement value indicative of an optically measured characteristic of the analyte fluid.

The present invention relates generally to processes for preparing agglomerated particulate low-rank coal feedstocks of a particle size suitable for reaction in a fluidized-bed reactor and certain other gasification reactors and, in particular, for coal gasification and combustion applications. The present invention also relates to integrated coal gasification and combustion processes including preparing and utilizing such agglomerated particulate low-rank coal feedstocks.

The invention concerns nucleic acids coding for mutated or truncated forms of the human parkin gene, or forms comprising multiplication of exons, and the corresponding proteins and antibodies. The invention also concerns methods and kits for identifying mutations of the parkin gene, and for studying compounds for therapeutic purposes.

An assay and a method for identifying a prebiotic to treat a subject in need thereof to promote intestinal barrier integrity or to blunt an inflammatory response are provided.