de Severe Hypoglycemia and Cognitive Function in Older Adults With Type 1 Diabetes: The Study of Longevity in Diabetes (SOLID) By care.diabetesjournals.org Published On :: 2020-02-20T11:55:29-08:00 OBJECTIVE In children with type 1 diabetes (T1D), severe hypoglycemia (SH) is associated with poorer cognition, but the association of SH with cognitive function in late life is unknown. Given the increasing life expectancy in people with T1D, understanding the role of SH in brain health is crucial. RESEARCH DESIGN AND METHODS We examined the association between SH and cognitive function in 718 older adults with T1D from the Study of Longevity in Diabetes (SOLID). Subjects self-reported recent SH (previous 12 months) and lifetime history of SH resulting in inpatient/emergency department utilization. Global and domain-specific cognition (language, executive function, episodic memory, and simple attention) were assessed. The associations of SH with cognitive function and impaired cognition were evaluated via linear and logistic regression models, respectively. RESULTS Thirty-two percent of participants (mean age 67.2 years) reported recent SH and 50% reported lifetime SH. Compared with those with no SH, subjects with a recent SH history had significantly lower global cognition scores. Domain-specific analyses revealed significantly lower scores on language, executive function, and episodic memory with recent SH exposure and significantly lower executive function with lifetime SH exposure. Recent SH was associated with impaired global cognition (odds ratio [OR] 3.22, 95% CI 1.30, 7.94) and cognitive impairment on the language domain (OR 3.15, 95% CI 1.19, 8.29). CONCLUSIONS Among older adults with T1D, recent SH and lifetime SH were associated with worse cognition. Recent SH was associated with impaired global cognition. These findings suggest a deleterious role of SH on the brain health of older patients with T1D and highlight the importance of SH prevention. Full Article
de Lactation Duration and Long-term Risk for Incident Type 2 Diabetes in Women With a History of Gestational Diabetes Mellitus By care.diabetesjournals.org Published On :: 2020-03-20T11:50:34-07:00 OBJECTIVE We examined the association of lactation duration with incident type 2 diabetes among women with a history of gestational diabetes mellitus (GDM). RESEARCH DESIGN AND METHODS We monitored 4,372 women with a history of GDM participating in the Nurses’ Health Study II for incident type 2 diabetes over 25 years up to 2017. Lactation history was obtained through follow-up questionnaires to calculate lactation duration. Follow-up blood samples were collected from a subset of these women at median age of 58 years through the Diabetes & Women’s Health Study. RESULTS We documented 873 incident cases of type 2 diabetes during 87,411 person-years of follow-up. Longer duration of lactation was associated with lower risk of type 2 diabetes for both total lactation (hazard ratio 1.05 [95% CI 0.83–1.34] for up to 6 months, 0.91 [0.72–1.16] for 6–12 months, 0.85 [0.67–1.06] for 12–24 months, and 0.73 [0.57–0.93] for >24 months, compared with 0 months; P-trend = 0.003) and exclusive breastfeeding (P-trend = 0.002) after adjustment for age, ethnicity, family history of diabetes, parity, age at first birth, smoking, diet quality, physical activity, and prepregnancy BMI. Longer duration of lactation was also associated with lower HbA1c, fasting plasma insulin, and C-peptide concentrations among women without type 2 diabetes at follow-up (all adjusted P-trend ≤0.04). CONCLUSIONS Longer duration of lactation is associated with a lower risk of type 2 diabetes and a favorable glucose metabolic biomarker profile among women with a history of GDM. The underlying mechanisms and impact on diabetes complications, morbidity, and mortality remain to be determined. Full Article
de Similar Breast Cancer Risk in Women Older Than 65 Years Initiating Glargine, Detemir, and NPH Insulins By care.diabetesjournals.org Published On :: 2020-03-20T11:50:34-07:00 OBJECTIVE To assess whether initiation of insulin glargine (glargine), compared with initiation of NPH or insulin detemir (detemir), was associated with an increased risk of breast cancer in women with diabetes. RESEARCH DESIGN AND METHODS This was a retrospective new-user cohort study of female Medicare beneficiaries aged ≥65 years initiating glargine (203,159), detemir (67,012), or NPH (47,388) from September 2006 to September 2015, with follow-up through May 2017. Weighted Cox proportional hazards regression was used to estimate hazard ratios (HRs) and 95% CIs for incidence of breast cancer according to ever use, cumulative duration of use, cumulative dose of insulin, length of follow-up time, and a combination of dose and length of follow-up time. RESULTS Ever use of glargine was not associated with an increased risk of breast cancer compared with NPH (HR 0.97; 95% CI 0.88–1.06) or detemir (HR 0.98; 95% CI 0.92–1.05). No increased risk was seen with glargine use compared with either NPH or detemir by duration of insulin use, length of follow-up, or cumulative dose of insulin. No increased risk of breast cancer was observed in medium- or high-dose glargine users compared with low-dose users. CONCLUSIONS Overall, glargine use was not associated with an increased risk of breast cancer compared with NPH or detemir in female Medicare beneficiaries. Full Article
de The Longitudinal Influence of Social Determinants of Health on Glycemic Control in Elderly Adults With Diabetes By care.diabetesjournals.org Published On :: 2020-03-20T11:50:34-07:00 OBJECTIVE This study aimed to understand the longitudinal relationship between financial, psychosocial, and neighborhood social determinants and glycemic control (HbA1c) in older adults with diabetes. RESEARCH DESIGN AND METHODS Data from 2,662 individuals with self-reported diabetes who participated in the Health and Retirement Study (HRS) were used. Participants were followed from 2006 through 2014. Financial hardship, psychosocial, and neighborhood-level social determinant factors were based on validated surveys from the biennial core interview and RAND data sets. All social determinant factors and measurements of HbA1c from the time period were used and treated as time varying in analyses. SAS PROC GLIMMIX was used to fit a series of hierarchical linear mixed models. Models controlled for nonindependence among the repeated observations using a random intercept and treating each individual participant as a random factor. Survey methods were used to apply HRS weighting. RESULTS Before adjustment for demographics, difficulty paying bills (β = 0.18 [95% CI 0.02, 0.24]) and medication cost nonadherence (0.15 [0.01, 0.29]) were independently associated with increasing HbA1c over time, and social cohesion (–0.05 [–0.10, –0.001]) was independently associated with decreasing HbA1c over time. After adjusting for both demographics and comorbidity count, difficulty paying bills (0.13 [0.03, 0.24]) and religiosity (0.04 [0.001, 0.08]) were independently associated with increasing HbA1c over time. CONCLUSIONS Using a longitudinal cohort of older adults with diabetes, this study found that financial hardship factors, such as difficulty paying bills, were more consistently associated with worsening glycemic control over time than psychosocial and neighborhood factors. Full Article
de Diabetic Neuropathy Is a Substantial Burden in People With Type 1 Diabetes and Is Strongly Associated With Socioeconomic Disadvantage: A Population-Representative Study From Scotland By care.diabetesjournals.org Published On :: 2020-03-20T11:50:34-07:00 OBJECTIVE To assess the contemporaneous prevalence of diabetic peripheral neuropathy (DPN) in people with type 1 diabetes (T1D) in Scotland and study its cross-sectional association with risk factors and other diabetic complications. RESEARCH DESIGN AND METHODS We analyzed data from a large representative sample of adults with T1D (N = 5,558). We assessed the presence of symptomatic neuropathy using the dichotomized (≥4) Michigan Neuropathy Screening Instrument Patient Questionnaire score. Logistic regression models were used to investigate associations between DPN and risk factors, as well as with other complications. RESULTS The burden of DPN is substantial with 13% prevalence overall. Adjusting for attained age, diabetes duration, and sex, the odds of DPN increased mainly with waist-to-hip ratio, lipids, poor glycemic control (odds ratio 1.51 [95% CI 1.21–1.89] for levels of 75 vs. 53 mmol/mol), ever versus never smoking (1.67 [1.37–2.03]), and worse renal function (1.96 [1.03–3.74] for estimated glomerular filtration rate levels <30 vs. ≥90 mL/min/1.73 m2). The odds significantly decreased with higher HDL cholesterol (0.77 [0.66–0.89] per mmol/L). Living in more deprived areas was associated with DPN (2.17 [1.78–2.65]) for more versus less deprived areas adjusted for other risk factors. Finally, individuals with prevalent DPN were much more likely than others to have other diabetes complications. CONCLUSIONS Diabetic neuropathy remains substantial, particularly affecting those in the most socioeconomically deprived groups. Those with clinically manifest neuropathy also have a higher burden of other complications and elevated levels of modifiable risk factors. These data suggest that there is considerable scope to reduce neuropathy rates and narrow the socioeconomic differential by better risk factor control. Full Article
de Watch: Driver accidentally reverses onto two parked cars outside Florida bank By www.upi.com Published On :: Wed, 06 May 2020 10:31:58 -0400 A Florida sheriff's office said a driver reversing out of a bank parking lot accidentally ended up backing up onto two other cars. Full Article
de Watch: Escaped bull goes wandering on Massachusetts highway By www.upi.com Published On :: Wed, 06 May 2020 10:47:28 -0400 A young bull went wandering on a Massachusetts highway after escaping from a trailer and was captured without causing any incidents, police said. Full Article
de Lottery winner's prankster past made wife skeptical of $250,000 jackpot By www.upi.com Published On :: Wed, 06 May 2020 16:07:33 -0400 A South Carolina man had extra trouble convincing his wife that his $250,000 lottery win was legitimate due to her memories of a past prank. Full Article
de Wallaby found wandering British countryside after zoo escape By www.upi.com Published On :: Thu, 07 May 2020 10:56:23 -0400 Police in Britain said a surprised jogger tipped officers off to the location of a wallaby that escaped from a zoo and went hopping through the countryside. Full Article
de Arizona firefighters rescue puppy from deep hole at construction site By www.upi.com Published On :: Thu, 07 May 2020 14:09:49 -0400 Firefighters in Arizona came to the rescue of a puppy that plunged into a 15-foot-deep hole at a construction site. Full Article
de Police, public works employees rescue deer from soccer net By www.upi.com Published On :: Fri, 08 May 2020 14:24:42 -0400 Police and public works employees in Wisconsin came to the rescue of a deer that found itself struggling to escape a soccer net. Full Article
de Look: Dangling raccoon rescued from under California highway on-ramp By www.upi.com Published On :: Fri, 08 May 2020 15:08:05 -0400 Animal rescuers in California said they reached over the side of a freeway on-ramp to rescue a raccoon seen dangling from a metal beam under the ramp. Full Article
de Despite Flurry of Actions, Trump Administration Faces Constraints in Achieving Its Immigration Agenda By www.migrationpolicy.org Published On :: Wed, 24 Apr 2019 10:39:18 -0400 Though it has achieved success in some areas, the Trump administration’s many efforts to stiffen immigration enforcement in the U.S. interior and at the Southwest border are being consistently stymied by court injunctions, existing laws and settlements, state and local resistance, congressional pushback, and migration pressures that are beyond the government’s ability to swiftly address, as this article explores. Full Article
de After Deportation, Some Congolese Returnees Face Detention and Extortion By www.migrationpolicy.org Published On :: Wed, 22 May 2019 17:22:03 -0400 This article explores post-deportation dynamics and challenges returnees face in the Democratic Republic of the Congo (DRC). Even as European countries focus on increasing returns of migrants deemed not to have a right to stay, little attention has been given to conditions at return—even to a country such as the DRC where allegations of serious human-rights violations against returned migrants have been reported for years. Full Article
de Migration, Development, and Global Governance: From Crisis toward Consolidation By www.migrationpolicy.org Published On :: Tue, 25 Jun 2019 18:12:58 -0400 Migration and development policy discussions have edged closer to each other on the international stage. The adoption of the Global Compact for Migration in December 2018 marks an important milestone. As all eyes turn toward the compact’s implementation, this brief examines some of the key topics states have pledged to work more closely on—from labor migration and migrants’ rights, to returns and reintegration. Full Article
de Democrats Under Pressure: Political Calendar Exposes Ideological Differences on Immigration By www.migrationpolicy.org Published On :: Wed, 24 Jul 2019 17:39:12 -0400 Ideological differences in the Democratic Party over immigration that were once masked by unity against President Trump’s border wall and immigration agenda are now being exposed as Democratic presidential candidates seek to stand out in a crowded field and amid controversy over an emergency border spending bill. As the 2020 electoral calendar accelerates, how the party navigates the gulf between its most liberal and conservative wings will become a greater challenge for its leaders. Full Article
de From Control to Crisis: Changing Trends and Policies Reshaping U.S.-Mexico Border Enforcement By www.migrationpolicy.org Published On :: Fri, 02 Aug 2019 12:09:41 -0400 How did the U.S. border enforcement picture go in the span of two years from the lowest levels of illegal immigration since 1971 to a spiraling border security and humanitarian crisis? This report draws on enforcement and other data as well as analysis of changing migration trends and policies to tell this story. The authors outline key elements for a new strategy that can succeed over the long term. Full Article
de Panthers' Derrick Brown to become first 2020 Round 1 pick to sign rookie deal By www.upi.com Published On :: Fri, 08 May 2020 20:02:40 -0400 Former Auburn defensive tackle Derrick Brown agreed to his rookie contract with the Carolina Panthers on Friday. Full Article
de Evidence-Informed Clinical Practice Recommendations for Treatment of Type 1 Diabetes Complicated by Problematic Hypoglycemia By care.diabetesjournals.org Published On :: 2015-06-01 Pratik ChoudharyJun 1, 2015; 38:1016-1029Type 1 Diabetes at a Crossroads Full Article
de Kidney Disease and Related Findings in the Diabetes Control and Complications Trial/Epidemiology of Diabetes Interventions and Complications Study By care.diabetesjournals.org Published On :: 2014-01-01 Ian H. de BoerJan 1, 2014; 37:24-30DCCT/EDIC 30th Anniversary Summary Findings Full Article
de Day and Night Home Closed-Loop Insulin Delivery in Adults With Type 1 Diabetes: Three-Center Randomized Crossover Study By care.diabetesjournals.org Published On :: 2014-07-01 Lalantha LeelarathnaJul 1, 2014; 37:1931-1937Emerging Technologies and Therapeutics Full Article
de Overnight Closed-Loop Insulin Delivery in Young People With Type 1 Diabetes: A Free-Living, Randomized Clinical Trial By care.diabetesjournals.org Published On :: 2014-05-01 Roman HovorkaMay 1, 2014; 37:1204-1211Advances in Artificial Pancreas Development Full Article
de Framingham, SCORE, and DECODE Risk Equations Do Not Provide Reliable Cardiovascular Risk Estimates in Type 2 Diabetes By care.diabetesjournals.org Published On :: 2007-05-01 Ruth L. ColemanMay 1, 2007; 30:1292-1293BR Cardiovascular and Metabolic Risk Full Article
de Glucagon-Like Peptide 1 Receptor Agonist or Bolus Insulin With Optimized Basal Insulin in Type 2 Diabetes By care.diabetesjournals.org Published On :: 2014-10-01 Michaela DiamantOct 1, 2014; 37:2763-2773Emerging Technologies and Therapeutics Full Article
de Consensus Development Conference on Insulin Resistance: 5-6 November 1997 By care.diabetesjournals.org Published On :: 1998-02-01 American Diabetes AssociationFeb 1, 1998; 21:310-314Consensus Development Conference Report Full Article
de Update on Cardiovascular Outcomes at 30 Years of the Diabetes Control and Complications Trial/Epidemiology of Diabetes Interventions and Complications Study By care.diabetesjournals.org Published On :: 2014-01-01 John M. LachinJan 1, 2014; 37:39-43DCCT/EDIC 30th Anniversary Summary Findings Full Article
de Lower Risk of Death With SGLT2 Inhibitors in Observational Studies: Real or Bias? By care.diabetesjournals.org Published On :: 2018-01-01 Samy SuissaJan 1, 2018; 41:6-10Perspectives in Care Full Article
de A Mathematical Model for the Determination of Total Area Under Glucose Tolerance and Other Metabolic Curves By care.diabetesjournals.org Published On :: 1994-02-01 Mary M TaiFeb 1, 1994; 17:152-154Short Report Full Article
de Depressive Symptoms in Children and Adolescents With Type 1 Diabetes: Association with diabetes-specific characteristics By care.diabetesjournals.org Published On :: 2006-06-01 Korey K. HoodJun 1, 2006; 29:1389-1389BR Epidemiology/Health Services/Psychosocial Research Full Article
de Neuropathy and Related Findings in the Diabetes Control and Complications Trial/Epidemiology of Diabetes Interventions and Complications Study By care.diabetesjournals.org Published On :: 2014-01-01 Catherine L. MartinJan 1, 2014; 37:31-38DCCT/EDIC 30th Anniversary Summary Findings Full Article
de Beneficial Effect of Low-Glycemic Index Diet in Overweight NIDDM Subjects By care.diabetesjournals.org Published On :: 1992-04-01 Thomas M S WoleverApr 1, 1992; 15:562-564Short Report Full Article
de Dietary Sugar and Body Weight: Have We Reached a Crisis in the Epidemic of Obesity and Diabetes?: Health Be Damned! Pour on the Sugar By care.diabetesjournals.org Published On :: 2014-04-01 George A. BrayApr 1, 2014; 37:950-956Current Concepts of Type 2 Diabetes Prevention Full Article
de Liraglutide, a Long-Acting Human Glucagon-Like Peptide-1 Analog, Given as Monotherapy Significantly Improves Glycemic Control and Lowers Body Weight Without Risk of Hypoglycemia in Patients With Type 2 Diabetes By care.diabetesjournals.org Published On :: 2007-06-01 Tina VilsbøllJun 1, 2007; 30:1608-1610BR Emerging Treatments and Technologies Full Article
de The Use of Areas Under Curves in Diabetes Research By care.diabetesjournals.org Published On :: 1995-02-01 David B AllisonFeb 1, 1995; 18:245-250Technical Article Full Article
de Insulinotropic Action of Glucagonlike Peptide-I-(7-37) in Diabetic and Nondiabetic Subjects By care.diabetesjournals.org Published On :: 1992-02-01 David M NathanFeb 1, 1992; 15:270-276Short Report Full Article
de Update on Prevention of Cardiovascular Disease in Adults With Type 2 Diabetes Mellitus in Light of Recent Evidence: A Scientific Statement From the American Heart Association and the American Diabetes Association By care.diabetesjournals.org Published On :: 2015-09-01 Caroline S. FoxSep 1, 2015; 38:1777-1803Scientific Statement Full Article
de Diabetes Prevention in the Real World: Effectiveness of Pragmatic Lifestyle Interventions for the Prevention of Type 2 Diabetes and of the Impact of Adherence to Guideline Recommendations: A Systematic Review and Meta-analysis By care.diabetesjournals.org Published On :: 2014-04-01 Alison J. DunkleyApr 1, 2014; 37:922-933Current Concepts of Type 2 Diabetes Prevention Full Article
de A Prospective Analysis of the HOMA Model: The Mexico City Diabetes Study By care.diabetesjournals.org Published On :: 1996-10-01 Steven M HaffnerOct 1, 1996; 19:1138-1141Short Report Full Article
de Relationship of Glucose Tolerance and Plasma Insulin to the Incidence of Coronary Heart Disease: Results from Two Population Studies in Finland By care.diabetesjournals.org Published On :: 1979-03-01 Kalevi PyöräläMar 1, 1979; 2:131-141Proceedings of the Kroc Foundation International Conference on Epidemiology of Diabetes and its Macrovascular Complications Full Article
de Coronary Heart Disease Incidence and Cardiovascular Mortality in Busselton with Reference to Glucose and Insulin Concentrations By care.diabetesjournals.org Published On :: 1979-03-01 T A WelbornMar 1, 1979; 2:154-160Proceedings of the Kroc Foundation International Conference on Epidemiology of Diabetes and its Macrovascular Complications Full Article
de The Diabetes Control and Complications Trial/Epidemiology of Diabetes Interventions and Complications Study at 30 Years: Overview By care.diabetesjournals.org Published On :: 2014-01-01 David M. NathanJan 1, 2014; 37:9-16DCCT/EDIC 30th Anniversary Summary Findings Full Article
de Prevalence and Determinants of Glucose Intolerance in a Dutch Caucasian Population: The Hoorn Study By care.diabetesjournals.org Published On :: 1995-09-01 Johanna M MooySep 1, 1995; 18:1270-1273Short Report Full Article
de Impact of Recent Increase in Incidence on Future Diabetes Burden: U.S., 2005-2050 By care.diabetesjournals.org Published On :: 2006-09-01 K.M. Venkat NarayanSep 1, 2006; 29:2114-2116BR Epidemiology/Health Services/Psychosocial Research Full Article
de Consensus Development Conference on the Diagnosis of Coronary Heart Disease in People With Diabetes: 10-11 February 1998, Miami, Florida By care.diabetesjournals.org Published On :: 1998-09-01 American Diabetes AssociationSep 1, 1998; 21:1551-1559Consensus Development Conference Report Full Article
de India police: Security forces kill top militant commander in Kashmir By www.upi.com Published On :: Wed, 06 May 2020 16:05:42 -0400 Police in India said security forces killed a top Hizbul Mujahideen commander amid a series of gunfights in the disputed Jammu and Kashmir region on Wednesday. Full Article
de Latin American business leaders optimistic about region’s post-pandemic economy By www.upi.com Published On :: Wed, 06 May 2020 18:44:51 -0400 Despite worrying economic projections, business leaders in Latin America remain optimistic about post-pandemic economy. Full Article
de Israeli High Court permits Benjamin Netanyahu to form government despite indictments By www.upi.com Published On :: Wed, 06 May 2020 18:59:47 -0400 A panel of 11 judges ruled that Israeli Prime Minister Benjamin Netanyahu can form a government after reaching a deal with rival Benny Gantz. Full Article
de Bank of England: British economy could decline 14 percent By www.upi.com Published On :: Thu, 07 May 2020 07:29:45 -0400 A Bank of England report said Thursday the British economy could fall as much as 14 percent this year, which would be its worst showing in more than 300 years. Full Article
de Digitizing financial services key to Africa's post-pandemic growth, experts say By www.upi.com Published On :: Thu, 07 May 2020 16:18:10 -0400 As the COVID-19 pandemic begins to take root in Africa, experts say that digitizing financial services could help keep the continent safe Full Article
de Moderate earthquake in Iran hits near Tehran; 2 dead By www.upi.com Published On :: Fri, 08 May 2020 07:48:58 -0400 At least two people died and more than a dozen were hurt Friday when a moderate earthquake struck in Iran's northern city of Damavand, near Tehran. Full Article
