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Deep roots: On the 2024 Physics Nobel Prize 

Physics Nobel Prize acknowledges the diverse foundations of AI




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Culture and society: On upholding Section 6A of the Citizenship Act

Supreme Court of India verdict on citizenship law for Assam helps avoid fresh problems




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Semisynthetic phytochemicals in cancer treatment: a medicinal chemistry perspective

RSC Med. Chem., 2024, 15,3345-3370
DOI: 10.1039/D4MD00317A, Review Article
Meghna Arora, Ankit Kumar Singh, Adarsh Kumar, Harshwardhan Singh, Prateek Pathak, Maria Grishina, Jagat Pal Yadav, Amita Verma, Pradeep Kumar
Semisynthetic phytochemicals in cancer treatment.
The content of this RSS Feed (c) The Royal Society of Chemistry




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A comprehensive apoptotic assessment of niloticin in cervical cancer cells: a tirucallane-type triterpenoid from Aphanamixis polystachya (Wall.) Parker

RSC Med. Chem., 2024, 15,3444-3459
DOI: 10.1039/D4MD00318G, Research Article
Anuja Gracy Joseph, Mohanan Biji, Vishnu Priya Murali, Daisy R. Sherin, Alisha Valsan, Vimalkumar P. Sukumaran, Kokkuvayil Vasu Radhakrishnan, Kaustabh Kumar Maiti
Niloticin, a triterpenoid from Aphanamixis polystachya, induces apoptosis in HeLa cells which is primarily validated through in silico analysis and subsequently in vitro apoptotic evaluation by modulating the apoptotic proteins.
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SLL-1A-16 suppresses proliferation and induces autophagy in non-small-cell lung cancer cells via the AKT/mTOR signaling pathway

RSC Med. Chem., 2024, 15,3460-3468
DOI: 10.1039/D4MD00405A, Research Article
Xiaoqin Luo, Jin Wang, Ruichang Wang, Jiabing Lian, Mengnan Guo, Hongrui Zhou, Mengxue Zhang, Zhe Yang, Xiaolong Li, Xianran He, Xiuli Bi
Schematic of proposed mechanism for the treatment of the SLL-1A-16 inhibiting the proliferation in NSCLC.
The content of this RSS Feed (c) The Royal Society of Chemistry




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Exploring apoptotic induction of malabaricone A in triple-negative breast cancer cells: an acylphenol phyto-entity isolated from the fruit rind of Myristica malabarica Lam.

RSC Med. Chem., 2024, 15,3558-3575
DOI: 10.1039/D4MD00391H, Research Article
Pothiyil S. Vimalkumar, Neethu Sivadas, Vishnu Priya Murali, Daisy R. Sherin, Madhukrishnan Murali, Anuja Gracy Joseph, Kokkuvayil Vasu Radhakrishnan, Kaustabh Kumar Maiti
Malabaricone A isolated from Myristica malabarica induces apoptosis in triple-negative breast cancer cells through intrinsic and extrinsic pathways, which is validated through in vitro and in silico studies and resembles a potent phyto-entity.
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Design, synthesis, and structure–activity relationship studies of 6H-benzo[b]indeno[1,2-d]thiophen-6-one derivatives as DYRK1A/CLK1/CLK4/haspin inhibitors

RSC Med. Chem., 2024, Advance Article
DOI: 10.1039/D4MD00537F, Research Article
Open Access
Abdelfattah Faouzi, Alexandre Arnaud, François Hallé, Jean Roussel, Mandy Aymard, Vincent Denavit, Cong Viet Do, Angélique Mularoni, Mohamed Salah, Ahmed ElHady, Thanh-Nhat Pham, Alexandre Bancet, Marc Le Borgne, Raphaël Terreux, Roland Barret, Matthias Engel, Thierry Lomberget
A series of sulfur-containing tetracycles was designed and evaluated for their ability to inhibit protein kinase DYRK1A, a target known to have several potential therapeutic applications including cancers, Down syndrome or Alzheimer's disease.
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Design and Synthesis of coumarin-based amphoteric antimicrobials with the biofilm interference and immunoregulation effects

RSC Med. Chem., 2024, Accepted Manuscript
DOI: 10.1039/D4MD00721B, Research Article
Qun Tang, Haiyang Zhang, Kasemsiri Chandarajoti, Zirui Jiao, Lianhua Nie, Sai Lv, Jiakun Zuo, Wen Zhou, Xiangan Han
Bacterial infections pose a threat to the health of animals and human being, and the biofilm formation exacerbates the microbial threat. New antimicrobial agents to address this challenge are much...
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Development, biological evaluation, and molecular modelling of some benzene-sulfonamide derivatives as protein tyrosine phosphatase-1B inhibitors for managing diabetes mellitus and associated metabolic disorders

RSC Med. Chem., 2024, Advance Article
DOI: 10.1039/D4MD00594E, Research Article
Nagat Ghareb, Khaled M. Darwish, Mohamed S. Nafie, Ranwa Elrayess, Noha M. Abourobe, Shaimaa A. Fattah, Reem M. Hazem, Eman T. Mehanna, Ranza Elrayess
One benzene-sulfonamide derivative exhibited potent protein tyrosine phosphatase-1B inhibition for managing diabetes mellitus and associated metabolic disorders.
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Correction: Anti-schistosomal activity and ADMET properties of 1,2,5-oxadiazinane-containing compound synthesized by visible-light photoredox catalysis

RSC Med. Chem., 2024, Advance Article
DOI: 10.1039/D4MD90044H, Correction
Open Access
  This article is licensed under a Creative Commons Attribution 3.0 Unported Licence.
Kennosuke Itoh, Hiroki Nakahara, Atsushi Takashino, Aya Hara, Akiho Katsuno, Yuriko Abe, Takaaki Mizuguchi, Fumika Karaki, Shigeto Hirayama, Kenichiro Nagai, Reiko Seki, Noriko Sato, Kazuki Okuyama, Masashi Hashimoto, Ken Tokunaga, Hitoshi Ishida, Fusako Mikami, Kofi Dadzie Kwofie, Hayato Kawada, Bangzhong Lin, Kazuto Nunomura, Toshio Kanai, Takeshi Hatta, Naotoshi Tsuji, Junichi Haruta, Hideaki Fujii
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Breaking boundaries in diabetic nephropathy treatment: design and synthesis of novel steroidal SGLT2 inhibitors

RSC Med. Chem., 2024, Advance Article
DOI: 10.1039/D4MD00645C, Research Article
Geetmani Singh Nongthombam, Semim Akhtar Ahmed, Kangkon Saikia, Sanjib Gogoi, Jagat Chandra Borah
Virtual screening and synthetic modification of natural product-derived steroidal precursors as potential SGLT2 inhibitors for the treatment of diabetic nephropathy.
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Medicinal chemistry-based perspective on thiophene and its derivatives: Exploring the structural insights to discover plausible druggable leads

RSC Med. Chem., 2024, Accepted Manuscript
DOI: 10.1039/D4MD00450G, Review Article
Shikha Thakur, Devendra Kumar, shivani jaiswal, Kapil Kumar Goel, Pramod Rawat, Vivek Srivastava, Sonia Dhiman, Hemant R Jadhav, Ashish Ranjan Dwivedi
Thiophene is a privileged pharmacophore in medicinal chemistry owing to its diversified biological attributes. The thiophene moiety has been ranked 4th in US FDA drug approval of small drug molecules,...
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Ligand-centred phenotype-driven development of potent kinase inhibitors against oesophageal cancer

RSC Med. Chem., 2024, Advance Article
DOI: 10.1039/D4MD00579A, Research Article
Open Access
Cecilia C. Ayala-Aguilera, Yang Ge, Álvaro Lorente-Macías, Benjamin N. Jones, Catherine Adam, Neil O. Carragher, Asier Unciti-Broceta
A ligand-centred strategy combined with phenotypic screening was used to develop novel antiproliferative inhibitors against oesophageal cancer and identified a lead compound that induces potent anticancer activity and inhibits Aurora kinase A.
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Design, synthesis, and biological evaluation of pyrazole–ciprofloxacin hybrids as antibacterial and antibiofilm agents against Staphylococcus aureus

RSC Med. Chem., 2024, Advance Article
DOI: 10.1039/D4MD00623B, Research Article
Ojaswitha Ommi, Priyanka Sudhir Dhopat, Shashikanta Sau, Madhu Rekha Estharla, Srinivas Nanduri, Nitin Pal Kalia, Venkata Madhavi Yaddanapudi
A series of pyrazole–ciprofloxacin hybrids were designed, synthesized, and tested for antibacterial activity against Staphylococcus aureus, Pseudomonas aeruginosa, and Mycobacterium tuberculosis, aiming to combat antibiotic resistance.
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meso-Substituted AB3-type phenothiazinyl porphyrins and their indium and zinc complexes photosensitising properties, cytotoxicity and phototoxicity on ovarian cancer cells

RSC Med. Chem., 2024, Advance Article
DOI: 10.1039/D4MD00601A, Research Article
Open Access
Brém Balázs, Bianca Stoean (Vasile), Éva Molnár, Eva Fischer-Fodor, Ovidiu Bălăcescu, Raluca Borlan, Monica Focsan, Adriana Grozav, Patriciu Achimaş-Cadariu, Emese Gál, Luiza Gaina
New meso-substituted AB3-type phenothiazinyl porphyrins and ferrocenylvinyl phenothiazinyl porphyrin were synthesised by Suzuki–Miyaura and Mizoroki–Heck cross-coupling reactions, respectively.
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Generation and capture of naphthoquinonynes: a new frontier in the development of trypanocidal quinones via aryne chemistry

RSC Med. Chem., 2024, Advance Article
DOI: 10.1039/D4MD00558A, Research Article
Laura P. R. Figueroa, Renato L. de Carvalho, Renata G. Almeida, Esther R. S. Paz, Emilay B. T. Diogo, Maria H. Araujo, Warley S. Borges, Victor F. S. Ramos, Rubem F. S. Menna-Barreto, James M. Wood, John F. Bower, Eufrânio N. da Silva Júnior
This article presents A-ring functionalized quinones via a modern and efficient new strategy involving the generation and capture of benzyne quinones and their evaluation against Trypanosoma cruzi.
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Light enhanced cytotoxicity and antitumoral effect of a ruthenium-based photosensitizer inspired from natural alkaloids

RSC Med. Chem., 2024, Advance Article
DOI: 10.1039/D4MD00600C, Research Article
Open Access
Gennaro Sanità, Maria Laura Alfieri, Barbara Carrese, Serena Damian, Vincenza Mele, Gaetano Calì, Brigida Silvestri, Sebastiano Marra, Susan Mohammadi, Giuseppina Luciani, Paola Manini, Annalisa Lamberti
Biological assays carried out on melanoma and breast cancer cells highlighted the role of light in boosting the cytotoxic effect of a ruthenium complex featuring a dihydroisoquinoline ligand suggesting applications in photodynamic therapy.
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Two doctors posted at Uppiliyapuram UPHC




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547: WordPress and GraphQL with Jason Bahl

Jason Bahl joins the show to talk about the GraphQL and WordPress connection, his work on WP GraphQL plugin, Faust and Atlas from WP Engine, Jamstack and Wordpress, and more.




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Diamonds are a UV photodetector’s best friend

How lab-grown rocks from Surat are set to power the development of high-performance electronics



  • Science and Technology

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Into the life of a billionaire-philanthropist

The book covers Wipro founder Azim Premji’s journey without pulling any punches




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Millennial prophet with a failed vision

A gripping account of WeWork founder Adam Neumann’s meteoric rise and precipitous crash




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Triumphs and travails of a consultant

The book is a detailed job description for anybody wanting to make consulting their career




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The Dhoni phenomenon

A record of Captain Cool’s exploits on the cricket field




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GlaxoSmithKline Pharma March quarter net at Rs. 106 cr.




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Mphasis Q4 net profit declines 13% to Rs. 155 crore




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RPG Life Sciences to sell biotech unit to Intas Pharma




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By 2021, India to have 810 m smartphone subscriptions




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Sun Pharma to focus on skincare to boost OTC business




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‘India is a bright spot in global smartphone scene’




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Dynamics of phase-separated microdroplets near the contact line of evaporating all-aqueous drops

Soft Matter, 2024, 20,8260-8266
DOI: 10.1039/D4SM01056F, Paper
Open Access
  This article is licensed under a Creative Commons Attribution 3.0 Unported Licence.
Rahul Rai, Maheshwar Gopu, Senthan Pugalneelam Parameswaran, Tapan Chandra Adhyapak, Dileep Mampallil
Evaporation of multicomponent drops can induce liquid–liquid phase separation and spatial reconfiguration of phases through complex dynamics near the contact line.
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Revisiting the density profile of the fuzzy sphere model for microgel colloids

Soft Matter, 2024, 20,8181-8184
DOI: 10.1039/D4SM01045K, Communication
Open Access
  This article is licensed under a Creative Commons Attribution 3.0 Unported Licence.
Frank Scheffold
Microgel density profiles evaluated with the complementary error function and the popular fuzzy sphere model are not compatible with each other.
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Stress amplification and relaxation imaging around cracks in nanocomposite gels using ultrasound elastography

Soft Matter, 2024, Advance Article
DOI: 10.1039/D4SM00909F, Paper
H. Le Blay, T. Deffieux, L. Laiarinandrasana, M. Tanter, A. Marcellan
Stress visualization around cracks in NC gels was performed using ultrasonic elastography. Temporal and spatial mapping are performed non-invasively. Over time, the stress gradient is erased by large-scale reorganization of the polymer network.
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Telephone cord blister formation in solvent swollen elastomer films

Soft Matter, 2024, Advance Article
DOI: 10.1039/D4SM01035C, Paper
Open Access
James S. Sharp, Nathaniel M. Roberts, Sam Walker
Telephone cord blister formation is studied in PDMS films swollen in four different solvents. Buckling and fracture mechanics theories are developed to interpret blister morphology and growth rates. A simple surface patterning method is introduced.
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Carboxymethyl cellulose-stabilized calcium phosphate particles for injectable hydrogel-based bone tissue engineering

Soft Matter, 2024, Advance Article
DOI: 10.1039/D4SM00670D, Paper
Piyaporn Srisura, Yuwaporn Pinyakit, Umphan Ngoensawat, Pongsakorn Yuntasiri, Khoiria Nur Atika Putri, Theerapat Chanamuangkon, Waranyoo Phoolcharoen, Varol Intasanta, Voravee P. Hoven
Carboxymethyl cellulose-stabilized calcium phosphate particles well-dispersed in aqueous solution can be integrated into an injectable hydrogel made of methacrylated hyaluronic acid which is a promising material for bone regeneration applications.
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Emulsifying mechanisms of phospholipids in high-pressure homogenization of perfluorocarbon nanoemulsions

Soft Matter, 2024, 20,8373-8384
DOI: 10.1039/D4SM00828F, Paper
Open Access
  This article is licensed under a Creative Commons Attribution 3.0 Unported Licence.
Larissa J. Lubitz, Harden Rieger, Gero Leneweit
An optimized PFC/W emulsion contains 1 mM lipid per 1% (v/v) dispersed phase for an emulsifying monolayer; higher ratios result in triple layers. Low viscosity ratios ηD/ηC ≤ 5 and low PFC volume fractions lead to smaller monodisperse droplets.
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Development of a coarse-grained molecular dynamics model for poly(dimethyl-co-diphenyl)siloxane

Soft Matter, 2024, 20,8480-8492
DOI: 10.1039/D4SM00875H, Paper
Weikang Xian, Amitesh Maiti, Andrew P. Saab, Ying Li
Polydimethylsiloxane and its copolymer systems have a wide range of application. We systematically develop a coarse-grained MD model for PDMS-co-PDPS system. The model preserves the structural and dynamic properties of the material quantitatively.
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The surface diffusivity of nanoparticles physically adsorbed at a solid–liquid interface

Soft Matter, 2024, 20,8446-8454
DOI: 10.1039/D4SM00992D, Paper
Troy Singletary, Nima Iranmanesh, Carlos E. Colosqui
This work proposes an analytical model considering the effects of hydrodynamic drag and energy barriers induced by liquid solvation forces to predict the in-plane translational diffusivity of a nanoparticle physically adsorbed on a wetted surface.
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Segregative phase separation of strong polyelectrolyte complexes at high salt and high polymer concentrations

Soft Matter, 2024, 20,8505-8514
DOI: 10.1039/D4SM00994K, Paper
Open Access
  This article is licensed under a Creative Commons Attribution 3.0 Unported Licence.
Conner H. Chee, Rotem Benharush, Lexi R. Knight, Jennifer E. Laaser
Complexes of strong polyelectrolytes prepared well above the binodal are shown to undergo hydrophobicity-driven segregative phase separation.
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Self-assembly of amphiphilic homopolymers grafted onto spherical nanoparticles: complete embedded minimal surfaces and a machine learning algorithm for their recognition

Soft Matter, 2024, 20,8385-8394
DOI: 10.1039/D4SM00616J, Paper
D. A. Mitkovskiy, A. A. Lazutin, A. L. Talis, V. V. Vasilevskaya
Amphiphilic macromolecules grafted onto spherical nanoparticles can self-assemble into morphological structures corresponding to the family of complete embedded minimal surfaces. They arise situationally, can coexist and transform into each other.
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Random field reconstruction of three-phase polymer structures with anisotropy from 2D-small-angle scattering data

Soft Matter, 2024, 20,8493-8504
DOI: 10.1039/D4SM00721B, Paper
Open Access
Stephen Kronenberger, Nitant Gupta, Benjamin Gould, Colin Peterson, Arthi Jayaraman
We present a computational method to analyze 2D small-angle scattering data from three-phase soft materials systems with structural anisotropy and output representative real-space structures of the three phases.
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Mechanical characterization of freestanding lipid bilayers with temperature-controlled phase

Soft Matter, 2024, 20,8524-8537
DOI: 10.1039/D4SM00706A, Paper
Open Access
  This article is licensed under a Creative Commons Attribution 3.0 Unported Licence.
Arash Yahyazadeh Shourabi, Roland Kieffer, Djanick de Jong, Daniel Tam, Marie-Eve Aubin-Tam
Lipid membranes formed in a microfluidic device are studied with temperature-controlled optical tweezers, revealing how mechanical properties of ripple phase and gel-fluid phase-separated membranes change when heated above the transition temperature.
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pH and glucose dual-responsive phenylboronic acid hydrogels for smart insulin delivery

Soft Matter, 2024, Advance Article
DOI: 10.1039/D4SM01004C, Paper
Keke Yang, Hou Bo, Dewei Ma, Mingwei Peng, Qinglong Liu, Ziwen Heng, Zhongwei Gu, Xuhan Liu, Siyuan Chen
Phenylboronic acid (PBA) is a widely exploited glucose-sensitive element for constructing glucose-responsive hydrogels to enable smart insulin delivery.
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Retraction: Self-assembled organic nanotubes embedding hydrophobic molecules within solid bilayer membranes

Soft Matter, 2024, Advance Article
DOI: 10.1039/D4SM90171A, Retraction
Open Access
  This article is licensed under a Creative Commons Attribution 3.0 Unported Licence.
Naohiro Kameta, Masumi Asakawa, Mitsutoshi Masuda, Toshimi Shimizu
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Linking local microstructure to fracture location in a two-dimensional amorphous solid under isotropic strain

Soft Matter, 2024, Advance Article
DOI: 10.1039/D4SM00486H, Paper
Open Access
  This article is licensed under a Creative Commons Attribution 3.0 Unported Licence.
Max Huisman, Axel Huerre, Saikat Saha, John C. Crocker, Valeria Garbin
Machine learning predicts possible crack location in experiments of a fracturing colloid monolayer, shown along with the actual crack path.
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Modeling nematic phase main-chain liquid crystal elastomer synthesis, mechanics, and thermal actuation via coarse-grained molecular dynamics

Soft Matter, 2024, Accepted Manuscript
DOI: 10.1039/D4SM00528G, Paper
Nicolas Herard, Raja Annapooranan, Todd Henry, Martin Kroger, Shengqiang Cai, Nicholas Boechler, Yelena Sliozberg
This paper presents a coarse-grained molecular dynamics simulation study of the synthesis, mechanics, and thermal actuation of nematic phase main-chain liquid crystal elastomers (LCEs), a type of soft, temperature-responsive, polymeric...
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Morphology and line tension of twist disclinations in a nematic liquid crystal

Soft Matter, 2024, Advance Article
DOI: 10.1039/D4SM01076K, Paper
Open Access
Yihao Chen, Mina Mandić, Charlotte G. Slaughter, Michio Tanaka, James M. Kikkawa, Peter J. Collings, A. G. Yodh
This work characterizes twist disclinations in nematic liquid crystals, using confocal microscopy to measure their 3D profile and test theoretical predictions, and using magnetic fields to deform the disclinations and measure their line tension.
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Hydrophobic fouling-resistant electrospun nanofiber membranes from poly(vinylidene fluoride)/polyampholyte blends

Soft Matter, 2024, 20,8654-8662
DOI: 10.1039/D4SM00817K, Paper
Anuja S. Jayasekara, Luca Mazzaferro, Ryan O’Hara, Ayse Asatekin, Peggy Cebe
This study reports the fabrication of non-woven fibrous membranes from electrospinning blended solutions of PVDF with a random polyampholyte amphiphilic copolymer (r-PAC) in N,N-dimethylformamide and methanol.
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Entropically and enthalpically driven self-assembly of a naphthalimide-based luminescent organic π-amphiphile in water

Soft Matter, 2024, 20,8684-8691
DOI: 10.1039/D4SM00986J, Paper
Sk Mursed Ali, Sujauddin Sk, Shuvajyoti Sarkar, Sayani Das, Nayim Sepay, Mijanur Rahaman Molla
Entropically and enthalpically favourable vesicular self-assembly of a naphthalimide based water soluble luminescent organic dipolar building block is reported.
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Extended kinetic theory applied to pressure-controlled shear flows of frictionless spheres between rigid, bumpy planes

Soft Matter, 2024, 20,8702-8715
DOI: 10.1039/D4SM00831F, Paper
Open Access
  This article is licensed under a Creative Commons Attribution 3.0 Unported Licence.
Dalila Vescovi, Astrid S. de Wijn, Graham L. W. Cross, Diego Berzi
We perform discrete simulations of steady, pressure-imposed, heterogeneous flows of frictionless spheres sheared between parallel bumpy planes, and use the results to test the predictions of the extended kinetic theory of granular gases.
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