A state full of parents who, having been suddenly forced to help homeschool youngsters, have by the millions grown more appreciative of the work of professional teachers in actual classrooms, had reason to worry when they heard how Gov. Cuomo trotted out plans for a Gates Foundation reinvention of public education statewide.

COVID-19 has killed at least 19,000 New Yorkers and dealt a body blow with lasting consequences to the city. Two paths lie ahead. If pandemics become common, then not only New York City but all of America’s service-based economy faces a bleak future. If this terrible plague is a unique event, then things will eventually get almost back to normal. To save both the nation’s biggest and most productive metropolis and tens of millions of service jobs across the county, we must invest enormously to prevent future pandemics.

The McFarland-Tessitore MNF experiment is over after two years.

The Ride of Your Life is raising money for the construction of a new bike park in Yellowknife.
( Photos: 15, Comments: 7 )

Tahnée Seagrave provides some insight into her thought process during the 2018 Val di Sole World Cup.
( Comments: 4 )

Norbert Elliott, who served as associate track and field and cross country coach, succeeds Lonnie Greene as head coach.

From Notre Dame to the Monon Bell. We rank Indiana's top 50 college football games in 2018.

A low-pressure trough pushing into Northern California from the Pacific will bring widespread showers to the part of the state most in need of rain.

Lockdown words of love and comfort across Ireland and the globe during the Covid-19 pandemic.

Google Chromebook Now Available for $299

Google Chromebook Now Available for $299

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Continue reading London, Rome, Paris Top TripAdvisor's Most-Reviewed Cities List

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• This week's most popular movies on Netflix include its original thriller "Dangerous Lies" and "Den of Thieves."
• Netflix introduced daily top lists of the most popular titles on the service in February.
• Streaming search engine Reelgood keeps track of the lists and provides Business Insider with a rundown of the week's most popular movies on Netflix every Friday.
• Visit Business Insider's homepage for more stories.

The Netflix action movie "Extraction" is pacing to be the streaming giant's biggest movie premiere ever, but it was dethroned this week as the service's most popular movie. Another Netflix original, "Dangerous Lies," stole the crown.

Netflix introduced daily top 10 lists of its most viewed movies and TV shows in February (it counts a view if an account watches at least two minutes of a title).

Every week, the streaming search engine Reelgood compiles for Business Insider a list of which movies have been most prominent on Netflix's daily lists that week. On Reelgood, users can browse Netflix's entire movie library and sort by IMDb or Rotten Tomatoes ratings.

This week's list also includes "Den of Thieves," another movie starring Gerard Butler after his "Angel Has Fallen" enjoyed a few weeks on the list.

But the real winner this week is Netflix itself, as five of the seven movies on the list are Netflix originals. 

SEE ALSO: Insiders say major questions hang over DC Universe as its parent company prepares to launch Netflix rival HBO Max

7. "The Willoughbys" (2020 — Netflix original)

Netflix description: "Four siblings with horribly selfish parents hatch a plan to get rid of them for good and form a perfectly imperfect family of their own."

Rotten Tomatoes critic score: 89%

What critics said: "Though the film-makers are indebted to Edward Gorey and Lemony Snicket — and pay musical homage to Mark Mothersbaugh's work on The Royal Tenenbaums — they find their own voice, when it counts." — London Evening Standard

6. "Murder to Mercy: The Cyntoia Brown Story" (2020 — Netflix original)

Netflix description: "After 16-year-old Cyntoia Brown is sentenced to life in prison, questions about her past, physiology and the law itself call her guilt into question."

Rotten Tomatoes critic score: 75%

What critics said: "A moving reflection of what criminal justice reform means in personal terms." — New York Times

5. "Arctic Dogs" (2019)

Netflix description: "When he stumbles upon evil Otto Von Walrus's scheme to melt the Arctic, ambitious delivery fox Swifty assembles a ragtag crew to protect the planet."

Rotten Tomatoes critic score: 13%

What critics said: "There's really not much to recommend about this film: the animation lacks texture, the score is overwrought, the plotting is scattershot, and the character design is uninspired." — AV Club

4. "Den of Thieves" (2018)

Netflix description: "A highly skilled crew of bank robbers plotting a heist at the supposedly impenetrable Federal Reserve faces off against an elite unit of L.A. cops."

Rotten Tomatoes critic score: 41%

What critics said: "It often resembles a men's rights bonding weekend more than it does a movie." — Guardian

3. "Extraction" (2020 — Netflix original)

Netflix description: "A hardened mercenary's mission becomes a soul-searching race to survive when he's sent into Bangladesh to rescue a drug lord's kidnapped son."

Rotten Tomatoes critic score: 68%

What critics said: "Illustrates an important principle in escapist entertainment: you don't have to one-up your predecessors. Sometimes, it's enough to replicate what made them successful." — Newsday

2. "All Day and a Night" (2020 — Netflix original)

Netflix description: "While serving life in prison, a young man looks back at the people, the circumstances and the system that set him on the path toward his crime."

Rotten Tomatoes critic score: 56%

What critics said: "'All Day and a Night' lingers and sometimes meanders in that gray zone, where the story can accrue texture and feeling and emerge as more than the sum of its plot mechanics." — Los Angeles Times

1. "Dangerous Lies" (2020 — Netflix original)

Netflix description: "A broke caregiver unexpectedly inherits her patient's estate, but dark secrets swirl around her newfound wealth, tangling her in deceit and danger."

Rotten Tomatoes critic score: 39%

What critics said: "Looks like it cost the amount of your monthly Netflix subscription and is as satisfying to watch as it is paying that particular bill." — Globe and Mail

While the phased-in reopening of schools in South Africa in the midst of Covid-19 remains provisional and sensitive, the Western Cape Education Department has advised principals and school management teams to wait a few more days before returning.

A Canadian department store chain is calling it quits after more than a century in business.

Wera, a four-year-old terrier cross, has found her way home to a Calgary-care organization after fraudsters tricked the dog's foster family.

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The following article, NYC Nurse Steals Credit Card From 70-Yr-Old Dying COVID-19 Patient On Ventilator, was first published on 100PercentFedUp.com.

"She is a despicable human being"

Continue reading: NYC Nurse Steals Credit Card From 70-Yr-Old Dying COVID-19 Patient On Ventilator ...

The following article, Witness Tampering? Asst. HHS Secretary Releases Threatening Text Messages From Dem Rep. Eric Swalwell: “In clear violation of House Ethics rules “, was first published on 100PercentFedUp.com.

Now that Michael Caputo, who was previously a target of the Mueller investigation, has been cleared, he has released some pretty damning text messages from the virulently anti-Trump lawmaker from California, Rep. Eric Swalwell (D). The text messages appear to prove that Swalwell, who has spent the last 3 1/2 years calling for Trump’s impeachment, […]

Continue reading: Witness Tampering? Asst. HHS Secretary Releases Threatening Text Messages From Dem Rep. Eric Swalwell: “In clear violation of House Ethics rules “ ...

Elizabeth Spiers wrote about an incident where Jared Kushner used the memorial of an employee to congratulate himself for success.

"I think it's always important to think about suicide as individual vulnerabilities and context," Eric Caine said.

Actinobacillus pleuropneumoniae (App) is the etiological agent of acute porcine pneumonia and responsible for severe economic losses worldwide. The capsule polymer of App serotype 1 (App1) consists of [4)-GlcNAc-β(1,6)-Gal-α-1-(PO4-] repeating units that are O-acetylated at O-6 of the GlcNAc. It is a major virulence factor and was used in previous studies in the successful generation of an experimental glycoconjugate vaccine. However, the application of glycoconjugate vaccines in the animal health sector is limited, presumably because of the high costs associated with harvesting the polymer from pathogen culture. Consequently, here we exploited the capsule polymerase Cps1B of App1 as an in vitro synthesis tool and an alternative for capsule polymer provision. Cps1B consists of two catalytic domains, as well as a domain rich in tetratricopeptide repeats (TPRs). We compared the elongation mechanism of Cps1B with that of a ΔTPR truncation (Cps1B-ΔTPR). Interestingly, the product profiles displayed by Cps1B suggested processive elongation of the nascent polymer, whereas Cps1B-ΔTPR appeared to work in a more distributive manner. The dispersity of the synthesized products could be reduced by generating single-action transferases and immobilizing them on individual columns, separating the two catalytic activities. Furthermore, we identified the O-acetyltransferase Cps1D of App1 and used it to modify the polymers produced by Cps1B. Two-dimensional NMR analyses of the products revealed O-acetylation levels identical to those of polymer harvested from App1 culture supernatants. In conclusion, we have established a protocol for the pathogen-free in vitro synthesis of tailored, nature-identical App1 capsule polymers.

Lens proteins become increasingly cross-linked through nondisulfide linkages during aging and cataract formation. One mechanism that has been implicated in this cross-linking is glycation through formation of advanced glycation end products (AGEs). Here, we found an age-associated increase in stiffness in human lenses that was directly correlated with levels of protein–cross-linking AGEs. α-Crystallin in the lens binds to other proteins and prevents their denaturation and aggregation through its chaperone-like activity. Using a FRET-based assay, we examined the stability of the αA-crystallin–γD-crystallin complex for up to 12 days and observed that this complex is stable in PBS and upon incubation with human lens–epithelial cell lysate or lens homogenate. Addition of 2 mm ATP to the lysate or homogenate did not decrease the stability of the complex. We also generated complexes of human αA-crystallin or αB-crystallin with alcohol dehydrogenase or citrate synthase by applying thermal stress. Upon glycation under physiological conditions, the chaperone–client complexes underwent greater extents of cross-linking than did uncomplexed protein mixtures. LC-MS/MS analyses revealed that the levels of cross-linking AGEs were significantly higher in the glycated chaperone–client complexes than in glycated but uncomplexed protein mixtures. Mouse lenses subjected to thermal stress followed by glycation lost resilience more extensively than lenses subjected to thermal stress or glycation alone, and this loss was accompanied by higher protein cross-linking and higher cross-linking AGE levels. These results uncover a protein cross-linking mechanism in the lens and suggest that AGE-mediated cross-linking of α-crystallin–client complexes could contribute to lens aging and presbyopia.

Contact between inflammatory cells and endothelial cells (ECs) is a crucial step in vascular inflammation. Recently, we demonstrated that the cell-surface level of endomucin (EMCN), a heavily O-glycosylated single-transmembrane sialomucin, interferes with the interactions between inflammatory cells and ECs. We have also shown that, in response to an inflammatory stimulus, EMCN is cleared from the cell surface by an unknown mechanism. In this study, using adenovirus-mediated overexpression of a tagged EMCN in human umbilical vein ECs, we found that treatment with tumor necrosis factor α (TNF-α) or the strong oxidant pervanadate leads to loss of cell-surface EMCN and increases the levels of the C-terminal fragment of EMCN 3- to 4-fold. Furthermore, treatment with the broad-spectrum matrix metalloproteinase inhibitor batimastat (BB94) or inhibition of ADAM metallopeptidase domain 10 (ADAM10) and ADAM17 with two small-molecule inhibitors, GW280264X and GI254023X, or with siRNA significantly reduced basal and TNFα-induced cell-surface EMCN cleavage. Release of the C-terminal fragment of EMCN by TNF-α treatment was blocked by chemical inhibition of ADAM10 alone or in combination with ADAM17. These results indicate that cell-surface EMCN undergoes constitutive cleavage and that TNF-α treatment dramatically increases this cleavage, which is mediated predominantly by ADAM10 and ADAM17. As endothelial cell-surface EMCN attenuates leukocyte–EC interactions during inflammation, we propose that EMCN is a potential therapeutic target to manage vascular inflammation.

The report examines U.S. immigration and international development policies, which have unique objectives and respond to distinct political and administrative constraints, and points out that international development has never been a U.S. immigration policy objective; nonetheless, it is an unintended consequence.

THE LAST two months have been two of the worst in the life of former national netball star Nichala Gibson. She lives in New York City, the epicentre for the COVID-19 virus in the United States. Gibson and her sister suffered, then recovered from...

For drummer Conroy Gordon, the hardest part of being locked away day after day in the narrow confines of a stranded cruise ship is his inability to tell his two daughters when Daddy will be home. For the past month, he has been battling this...

Brutal. Horrific. Tragic. Choose your ­description. The April jobs report showed, in harrowing ­detail, just how terribly the coronavirus outbreak has pummelled the United States economy. Most obviously, there’s the 14.7 per cent unemployment rate...

Jamaica is now two cases shy of 500 confirmed COVID-19 infections with the confirmation of eight new cases in the past 24 hours.  The new infections bring the total number to 498 confirmed COVID-19 cases.  In a release a short while...

The common questions that many are asking today in relation to the COVID-19 pandemic are: Why has this befallen us? Why is there so much death and dying from this disease? Where is God in all of this? If God exists, why doesn’t He intervene and...

At this release event in Washington, DC, co-sponsored by MPI, the Chicago Council on Global Affairs, and ImmigrationWorks USA, the Chicago Council's independent task force on immigration released its report, U.S. Economic Competitiveness at Risk: A Midwest Call to Action on Immigration Reform.

New research shows that a genetic mutation associated with schizophrenia alters the process of cellular differentiation, disturbing the balance of neurons and glia in the brain

Stem cells obtained from patients with schizophrenia carry a genetic mutation that alters the ratio of the different type of nerve cells they produce, according to a new study by researchers in Japan. The findings, published today in the journal Translational Psychiatry, suggest that abnormal neural differentiation may contribute to the disease, such that fewer neurons and more non-neuronal cells are generated during the earliest stages of brain development.

Schizophrenia is a debilitating mental illness that affects about 1 in 100 people. It is known to be highly heritable, but is genetically complex: so far, researchers have identified over 100 rare genetic variations and dozens of mutations associated with increased risk of developing the disease.

Related: Brain’s immune cells hyperactive in schizophrenia

Related: Turning urine into brain cells | Mo Costandi

Is this some sort of properties for fractions? I know how to arrive at step 1 from step 2 but not step 1 to step 2.

yesterday night i had come from the cold and i was freezing!. i immediately got into a hot shower - i don't know why but i started feeling dizzy: my vision started going and i was confused then my ears started ringing and i was scared. i shouted for someone and my brother came: he asked if i was ok but i said i felt dizzy and i couldn't really see him at all. i said i felt faint and he said sit down slowly - so i did. eventually i closed my eyes and it helped; i feel better now but why did it happen?!.

Testimony of Delia Pompa, Senior Fellow in Education Policy, before the Senate Committee on Health, Education, Labor and Pensions for the February 23, 2016 hearing on the implementation of the Every Student Succeeds Act (ESSA).

Correctional Service of Canada says an inmate, who escaped from an Edmonton facility in 2018, was arrested by police in Saskatoon on Saturday morning.

Hermance Cormier grew up in a big Acadian family in New Brunswick and came to Halifax in the 1950s not speaking a word of English. She is among those who died from COVID-19 at Northwood.

Tesla CEO Elon Musk threatened Saturday to pull the company's factory and headquarters out of California and sued local officials who have stopped the company from reopening its electric vehicle factory.

From watching Ramayan to dancing to Bollywood music, Nurvi's quarantine time looks fun! - entertainment  Mid-Day

Belen, 20, discovers she doesn't need to wait to serve God in missions when He sends her to Africa for six weeks.

Twenty students graduate OM Russia’s Discipleship programme with a heart for missions.

OM Russia’s Business for Transformation ministry supports eight projects that empower locals through employment, while impacting the kingdom.

Through people like Arayk, locals have started to listen to God's word and are responding to it in a small town.

Nineteen boys and girls graduated from Fishport Kids Tutorial Club's day care programme in Manila, Philippines, this month.

In 2008, the Greek Evangelical Church in Athens opened a community centre, in a suburb where many Albanians live. OM worker Martha describes how she and other staff are reaching out with God's love to local young people.