Title: Climate Change May Prolong Smog Season in Southeast U.S.
Category: Health News
Created: 8/23/2016 12:00:00 AM
Last Editorial Review: 8/23/2016 12:00:00 AM

Title: Use of Cancer-Linked Fibroid Device Declines After FDA Warning
Category: Health News
Created: 8/23/2016 12:00:00 AM
Last Editorial Review: 8/24/2016 12:00:00 AM

Title: Breast-Feeding Rates Climb, But Many Moms Quit Early: CDC
Category: Health News
Created: 8/23/2016 12:00:00 AM
Last Editorial Review: 8/24/2016 12:00:00 AM

Title: Animal Research Yields Clues to Sexual Spread of Zika
Category: Health News
Created: 8/25/2016 12:00:00 AM
Last Editorial Review: 8/26/2016 12:00:00 AM

Title: Serious Problems at Florida Stem Cell Clinic
Category: Health News
Created: 8/29/2017 12:00:00 AM
Last Editorial Review: 8/29/2017 12:00:00 AM

Title: Harvey's Health Hazards Will Continue During Cleanup
Category: Health News
Created: 9/1/2017 12:00:00 AM
Last Editorial Review: 9/1/2017 12:00:00 AM

Title: Will Climate Change Bring More Highway Deaths?
Category: Health News
Created: 8/31/2017 12:00:00 AM
Last Editorial Review: 9/1/2017 12:00:00 AM

Title: Brain Scans Offer Clues to Why Some Teens Pile on Pounds
Category: Health News
Created: 8/31/2017 12:00:00 AM
Last Editorial Review: 9/1/2017 12:00:00 AM

Title: New Clues to Why Yawns Are Contagious
Category: Health News
Created: 8/31/2017 12:00:00 AM
Last Editorial Review: 9/1/2017 12:00:00 AM

Title: School Kids Need Supervision After Classes End
Category: Health News
Created: 8/26/2018 12:00:00 AM
Last Editorial Review: 8/27/2018 12:00:00 AM

Title: College Grades Low? Try a Different Seat in the Classroom
Category: Health News
Created: 8/24/2018 12:00:00 AM
Last Editorial Review: 8/27/2018 12:00:00 AM

Title: Is Climate Change Draining Nutrients From Crops?
Category: Health News
Created: 8/27/2018 12:00:00 AM
Last Editorial Review: 8/28/2018 12:00:00 AM

Title: STD Rates Continue to Climb in U.S.
Category: Health News
Created: 8/28/2018 12:00:00 AM
Last Editorial Review: 8/29/2018 12:00:00 AM

Title: Climate Change Hiking Danger of Flesh-Eating Bacteria Infections
Category: Health News
Created: 8/23/2019 12:00:00 AM
Last Editorial Review: 8/26/2019 12:00:00 AM

Title: Climate Change Raises Athletes' Risk of Heat Illness
Category: Health News
Created: 8/27/2019 12:00:00 AM
Last Editorial Review: 8/27/2019 12:00:00 AM

Title: Every Sudden Infant Death Deserves a Closer Look: Report
Category: Health News
Created: 8/26/2019 12:00:00 AM
Last Editorial Review: 8/27/2019 12:00:00 AM

Title: Men Should be Included in Breast Cancer Clinical Trials: FDA
Category: Health News
Created: 8/26/2019 12:00:00 AM
Last Editorial Review: 8/27/2019 12:00:00 AM

Title: Millions of Contigo Kids Cleanable Water Bottles Recalled
Category: Health News
Created: 8/28/2019 12:00:00 AM
Last Editorial Review: 8/28/2019 12:00:00 AM

Title: OxyContin Maker Purdue Offering Up to $12 Billion to Settle Opioid Claims
Category: Health News
Created: 8/27/2019 12:00:00 AM
Last Editorial Review: 8/28/2019 12:00:00 AM

Title: Regular Vaccines Advised With Multiple Sclerosis
Category: Health News
Created: 8/28/2019 12:00:00 AM
Last Editorial Review: 8/29/2019 12:00:00 AM

Title: For Muslim Pilgrimage, Climate Change Poses Health Risks
Category: Health News
Created: 8/28/2019 12:00:00 AM
Last Editorial Review: 8/29/2019 12:00:00 AM

Title: There Is No 'Gay Gene,' Major Study Concludes
Category: Health News
Created: 8/29/2019 12:00:00 AM
Last Editorial Review: 8/30/2019 12:00:00 AM

Title: AHA News: Preeclampsia May Double a Woman's Chances for Later Heart Failure
Category: Health News
Created: 8/24/2020 12:00:00 AM
Last Editorial Review: 8/25/2020 12:00:00 AM

Title: Clues to Why COVID-19 Hits Men Harder Than Women
Category: Health News
Created: 8/26/2020 12:00:00 AM
Last Editorial Review: 8/27/2020 12:00:00 AM

Title: Parents, Look Out for Mental Health Issues as College Kids Return to Class
Category: Health News
Created: 8/24/2021 12:00:00 AM
Last Editorial Review: 8/24/2021 12:00:00 AM

Title: Recent COVID-19 Raises Odds for Clots After Surgery by 90%
Category: Health News
Created: 8/25/2021 12:00:00 AM
Last Editorial Review: 8/25/2021 12:00:00 AM

Title: As Classes Resume, Some Health Tips From the CDC
Category: Health News
Created: 8/27/2021 12:00:00 AM
Last Editorial Review: 8/27/2021 12:00:00 AM

Title: Deepwater Horizon Oil Spill Cleanup Put Workers at Risk for Asthma
Category: Health News
Created: 8/22/2022 12:00:00 AM
Last Editorial Review: 8/22/2022 12:00:00 AM

Title: Can Stress Cause Multiple Sclerosis (MS)?
Category: Diseases and Conditions
Created: 6/18/2020 12:00:00 AM
Last Editorial Review: 7/26/2022 12:00:00 AM

Title: Scleritis
Category: Diseases and Conditions
Created: 1/5/2012 12:00:00 AM
Last Editorial Review: 7/27/2022 12:00:00 AM

Title: AHA News: Obstacles Didn't Stop This Heart Defect Survivor From Competing on 'American Ninja Warrior
Category: Health News
Created: 8/12/2022 12:00:00 AM
Last Editorial Review: 8/15/2022 12:00:00 AM

Title: What Is the Life Expectancy of Someone With CLOVES Syndrome?
Category: Diseases and Conditions
Created: 8/26/2022 12:00:00 AM
Last Editorial Review: 8/26/2022 12:00:00 AM

Title: Monkeypox Cases May Finally Be Ebbing, With Declines Seen in Europe, WHO Says
Category: Health News
Created: 8/25/2022 12:00:00 AM
Last Editorial Review: 8/25/2022 12:00:00 AM

Title: Torn ACL (Anterior Cruciate Ligament Tear)
Category: Diseases and Conditions
Created: 11/4/2010 12:00:00 AM
Last Editorial Review: 8/15/2022 12:00:00 AM

Title: Want to Maintain Muscle? Frequency of Workouts Is Key
Category: Health News
Created: 8/22/2022 12:00:00 AM
Last Editorial Review: 8/22/2022 12:00:00 AM

Title: Lamisil (terbinafine) vs. Lotrimin (clotrimazole)
Category: Medications
Created: 6/10/2019 12:00:00 AM
Last Editorial Review: 8/10/2022 12:00:00 AM

Title: Nerve Block Plus Lidocaine Clears Psoriasis in Small Study
Category: Health News
Created: 8/15/2022 12:00:00 AM
Last Editorial Review: 8/16/2022 12:00:00 AM

Title: Ketoconazole cream vs. clotrimazole cream
Category: Medications
Created: 5/29/2019 12:00:00 AM
Last Editorial Review: 8/25/2022 12:00:00 AM

Title: Shorter Menstrual Cycles May Affect Timing of Menopause
Category: Health News
Created: 8/25/2022 12:00:00 AM
Last Editorial Review: 8/25/2022 12:00:00 AM

Title: When Should I Start Cleaning My Baby’s Mouth?
Category: Diseases and Conditions
Created: 11/9/2020 12:00:00 AM
Last Editorial Review: 8/11/2022 12:00:00 AM

Title: Changes in Menstrual Cycle Can Come After COVID Shot
Category: Health News
Created: 7/18/2022 12:00:00 AM
Last Editorial Review: 7/18/2022 12:00:00 AM

Title: MS (Multiple Sclerosis) vs. ALS (Amyotrophic Lateral Sclerosis)
Category: Diseases and Conditions
Created: 6/16/2017 12:00:00 AM
Last Editorial Review: 8/4/2022 12:00:00 AM

Title: Who Fares Worse After Multiple Sclerosis Strikes?
Category: Health News
Created: 8/11/2022 12:00:00 AM
Last Editorial Review: 8/12/2022 12:00:00 AM

Title: New Multiple Sclerosis Treatment Shows Promise in Trial
Category: Health News
Created: 8/25/2022 12:00:00 AM
Last Editorial Review: 8/26/2022 12:00:00 AM

Title: Cyclobenzaprine vs. Xanax (alprazolam)
Category: Medications
Created: 6/6/2019 12:00:00 AM
Last Editorial Review: 8/25/2022 12:00:00 AM

The COVID-19 pandemic has highlighted the critical role of genomic surveillance for guiding policy and control. Timeliness is key, but sequence alignment and phylogeny slow most surveillance techniques. Millions of SARS-CoV-2 genomes have been assembled. Phylogenetic methods are ill equipped to handle this sheer scale. We introduce a pangenomic measure that examines the information diversity of a k-mer library drawn from a country's complete set of clinical, pooled, or wastewater sequence. Quantifying diversity is central to ecology. Hill numbers, or the effective number of species in a sample, provide a simple metric for comparing species diversity across environments. The more diverse the sample, the higher the Hill number. We adopt this ecological approach and consider each k-mer an individual and each genome a transect in the pangenome of the species. Structured in this way, Hill numbers summarize the temporal trajectory of pandemic variants, collapsing each day's assemblies into genome equivalents. For pooled or wastewater sequence, we instead compare days using survey sequence divorced from individual infections. Across data from the UK, USA, and South Africa, we trace the ascendance of new variants of concern as they emerge in local populations well before these variants are named and added to phylogenetic databases. Using data from San Diego wastewater, we monitor these same population changes from raw, unassembled sequence. This history of emerging variants senses all available data as it is sequenced, intimating variant sweeps to dominance or declines to extinction at the leading edge of the COVID-19 pandemic.

The transcription factor (TF) cone-rod homeobox (CRX) is essential for the differentiation and maintenance of photoreceptor cell identity. Several human CRX variants cause degenerative retinopathies, but most are variants of uncertain significance. We performed a deep mutational scan (DMS) of nearly all possible single amino acid substitutions in CRX using a cell-based transcriptional reporter assay, curating a high-confidence list of nearly 2000 variants with altered transcriptional activity. In the structured homeodomain, activity scores closely aligned to a predicted structure and demonstrated position-specific constraints on amino acid substitution. In contrast, the intrinsically disordered transcriptional effector domain displayed a qualitatively different pattern of substitution effects, following compositional constraints without specific residue position requirements in the peptide chain. These compositional constraints were consistent with the acidic exposure model of transcriptional activation. We evaluated the performance of the DMS assay as a clinical variant classification tool using gold-standard classified human variants from ClinVar, identifying pathogenic variants with high specificity and moderate sensitivity. That this performance could be achieved using a synthetic reporter assay in a foreign cell type, even for a highly cell type-specific TF like CRX, suggests that this approach shows promise for DMS of other TFs that function in cell types that are not easily accessible. Together, the results of the CRX DMS identify molecular features of the CRX effector domain and demonstrate utility for integration into the clinical variant classification pipeline.

We propose a paper that provides education on commonly used long-acting injectable antipsychotics (LAIs) to improve primary care based mental health interventions in patients with severe mental illnesses (SMIs) such as schizophrenia, schizoaffective disorder, and bipolar disorders. With the expanding interface of primary care and psychiatry across all healthcare settings, it has become increasingly important for primary care clinicians to have a broader understanding of common psychiatric treatments, including LAIs. Long-acting injectable antipsychotics have been shown to be helpful in significantly improving treatment adherence, preventing disease progression, improving treatment response, decreasing readmission rates, and reducing social impairment. We discuss evidence-based indications and guidelines for use of long-acting injectable antipsychotics. We provide an overview of the treatment of SMI with LAIs, mainly focusing on the most commonly used long-acting injectable antipsychotics, advantages and disadvantages of each, along with outlining important clinical pearls for ease of practical application. Equipped with increased familiarity and understanding of these essential therapies, primary care clinicians can better facilitate early engagement with psychiatric care, promote more widespread use, and thus significantly improve the wellbeing and quality of life of patients with severe mental illness.

Purpose:

Providing medication abortion in the primary care setting is a promising way to increase access to abortion, a threatened service in many States. This study aimed to characterize primary care clinicians’ interest in prescribing medication abortion, what barriers they face in adding this service, and what support they need.

Background:

Continuous glucose monitoring (CGM) for patients with type 1 and type 2 diabetes is associated with improved clinical, behavioral, and psychosocial patient health outcomes and is part of the American Diabetes Association’s Standards of Medical Care. CGM prescription often takes place in endocrinology practices, yet 50% of adults with type 1 diabetes and 90% of all people with type 2 diabetes receive their diabetes care in primary care settings. This study examined primary care clinicians’ perceptions of barriers and resources needed to support CGM use in primary care.