The votive plaque was found amid the ruins of an ancient Roman fortress. Researchers think a temple dedicated to the mysterious deity may have stood nearby

The insect eggshell is a multifunctional structure with several important roles, including generating an entry point for sperm via the micropyle before oviposition, serving as an oviposition substrate attachment surface, and functioning as a protective layer during embryo development. Eggshell proteins play major roles in eggshell tanning and hardening following oviposition and provide molecular cues that define dorsal–ventral axis formation. Precise eggshell formation during ovarian follicle maturation is critical for normal embryo development and the synthesis of a defective eggshell often gives rise to inviable embryos. Therefore, simple and accurate methods for identifying eggshell proteins will facilitate our understanding of the molecular pathways regulating eggshell formation and the mechanisms underlying normal embryo development. This protocol describes how to isolate and enrich eggshells from mature oocytes of Aedes aegypti mosquitoes and how to extract their eggshell proteins for liquid chromatography with tandem mass spectrometry (LC–MS/MS) proteomic analysis. Although this methodology was developed for studying mosquito eggshells, it may be applicable to eggs from a variety of insects. Mosquitoes are ideal model organisms for this study as their ovarian follicle development and eggshell formation are meticulously regulated by blood feeding and their follicles develop synchronously throughout oogenesis in a time-dependent manner.

That Figure Skating Show recaps the men's program at the 2022 Canadian National Championships in Ottawa and discusses who likely made the Olympic team.

Volker (OM Montenegro) describes how their outdoor lessons for Roma kids were threatened by bad weather. Then God provided not only the solution - building a carport as a shelter - but also the funds and manpower needed to build it.

Roma pastors and leaders from across Eastern Europe and the Balkans gather together for a Roma conference.

This summer nearly 1,000 Roma children in Roma villages throughout Central and Eastern Europe heard the Gospel.

OM Albania partners in the Emmanuel Centre ministry to Roma street kids and their mothers during the holiday season.

Tears flowed on parting as Albanian Roma boys experienced genuine relationship during the one-week visit of an OM Transform team to Lushnje, Albania.

GEORGETOWN – Governor John Carney, Delaware State Housing Authority (DSHA) Director Anas Ben Addi, local legislators, town officials and members of the business community celebrated the grand opening of Splash Laundromat on Friday and presented a Downtown Development Districts (DDD) rebate check in the amount of $457,997 to owners Enrique and Veronica Nunez. The Nunezes […]

NASA's Roman Space Telescope has successfully integrated the Roman Coronagraph, a vital step in detecting planets far beyond our solar system. This tool will help block starlight, enabling the telescope to capture faint planetary light. The coronagraph marks a significant advancement in exoplanet detection, allowing the telescope to observe planets 100 million times fainter than their stars. The mission will provide insights into dark energy, exoplanets, and more, paving the way for future observatories like the Habitable Worlds Observatory.

Samsung Galaxy Ring’s availability has been expanded to several Gulf countries and eastern European markets, the company announced on Tuesday. The smart wearable is available in a total of nine sizes, three finishes, and boasts features such as AI-powered health tracking and sleep monitoring courtesy of various sensors. It is touted to deliver up to seven days of battery life on a single charge and runs on the Samsung Health platform.

Directed by Nikhil Advani, Kal Ho Naa Ho features Shah Rukh Khan as Aman Mathur, Saif Ali Khan as Rohit Patel and Preity Zinta as Naina Catherine Kapur

Read the in depth Review of Micromax In 1 Mobile Phones. Know detailed info about Micromax In 1 configuration, design and performance quality along with pros & cons, Digit rating, verdict based on user opinions/feedback.

Read the in depth Review of Micromax Canvas Nitro A310 Mobile Phones. Know detailed info about Micromax Canvas Nitro A310 configuration, design and performance quality along with pros & cons, Digit rating, verdict based on user opinions/feedback.

Read the in depth Review of Micromax Canvas Nitro 4G Mobile Phones. Know detailed info about Micromax Canvas Nitro 4G configuration, design and performance quality along with pros & cons, Digit rating, verdict based on user opinions/feedback.

Read the in depth Review of Micromax In 2c Mobile Phones. Know detailed info about Micromax In 2c configuration, design and performance quality along with pros & cons, Digit rating, verdict based on user opinions/feedback.

Check here each week to keep up with the latest from John MacArthur's pulpit at Grace Community Church.

Check here each week to keep up with the latest from John MacArthur's pulpit at Grace Community Church.

Check here each week to keep up with the latest from John MacArthur's pulpit at Grace Community Church.

Check here each week to keep up with the latest from John MacArthur's pulpit at Grace Community Church.

Check here each week to keep up with the latest from John MacArthur's pulpit at Grace Community Church.

Check here each week to keep up with the latest from John MacArthur's pulpit at Grace Community Church.

Check here each week to keep up with the latest from John MacArthur's pulpit at Grace Community Church.

Check here each week to keep up with the latest from John MacArthur's pulpit at Grace Community Church.

Furious about its government cowing to Russia and mishandling economic challenges, Ukrainian citizens have taken to the streets in record force.

Radiocarbon dating and DNA analysis have revealed that a complete skeleton found in a 2nd-century cemetery is made up of bones from many people spanning thousands of years – but we don’t know who assembled it or why

Analysis of pollen in sediment cores from a large lake in Greece shows that nomadic livestock herders took over the region after the collapse of the Western Roman Empire

An urn found in a tomb in Spain contained the cremated remains of a man, a gold ring and about 5 litres of liquid, which has been identified as now-discoloured white wine

The technologies introduced by the Romans after they conquered Britain led to the kind of economic growth seen in the industrial age

Radiocarbon dating and DNA analysis have revealed that a complete skeleton found in a 2nd-century cemetery is made up of bones from many people spanning thousands of years – but we don’t know who assembled it or why

Title: Promacta Approval Expanded to Kids With Rare Blood Disorder
Category: Health News
Created: 8/24/2015 12:00:00 AM
Last Editorial Review: 8/25/2015 12:00:00 AM

As a major type of structural variants, tandem duplication plays a critical role in tumorigenesis by increasing oncogene dosage. Recent work has revealed that noncoding enhancers are also affected by duplications leading to the activation of oncogenes that are inside or outside of the duplicated regions. However, the prevalence of enhancer duplication and the identity of their target genes remains largely unknown in the cancer genome. Here, by analyzing whole-genome sequencing data in a non-gene-centric manner, we identify 881 duplication hotspots in 13 major cancer types, most of which do not contain protein-coding genes. We show that the hotspots are enriched with distal enhancer elements and are highly lineage-specific. We develop a HiChIP-based methodology that navigates enhancer–promoter contact maps to prioritize the target genes for the duplication hotspots harboring enhancer elements. The methodology identifies many novel enhancer duplication events activating oncogenes such as ESR1, FOXA1, GATA3, GATA6, TP63, and VEGFA, as well as potentially novel oncogenes such as GRHL2, IRF2BP2, and CREB3L1. In particular, we identify a duplication hotspot on Chromosome 10p15 harboring a cluster of enhancers, which skips over two genes, through a long-range chromatin interaction, to activate an oncogenic isoform of the NET1 gene to promote migration of gastric cancer cells. Focusing on tandem duplications, our study substantially extends the catalog of noncoding driver alterations in multiple cancer types, revealing attractive targets for functional characterization and therapeutic intervention.

The neuronal nucleus houses a meticulously organized genome. Within this structure, genetic material is not simply compacted but arranged into a precise and functional 3D chromatin landscape essential for cellular regulation. This mini-review highlights the importance of this chromatin landscape in healthy neurodevelopment, as well as the diseases that occur with aberrant chromatin architecture. We discuss insights into the fundamental mechanistic relationship between histone modifications, DNA methylation, and genome organization. We then discuss findings that reveal how these epigenetic features change throughout normal neurodevelopment. Finally, we highlight single-gene neurodevelopmental disorders that illustrate the interdependence of epigenetic features, showing how disruptions in DNA methylation or genome architecture can ripple across the entire epigenome. As such, we emphasize the importance of measuring multiple chromatin architectural aspects, as the disruption of one mechanism can likely impact others in the intricate epigenetic network. This mini-review underscores the vast gaps in our understanding of chromatin structure in neurodevelopmental diseases and the substantial research needed to understand the interplay between chromatin features and neurodevelopment.

Exogenous substances, including drugs and chemicals, can transfer into human seminal fluid and influence male fertility and reproduction. In addition, substances relevant in the context of sports drug testing programs, can be transferred into the urine of a female athlete (after unprotected sexual intercourse) and trigger a so-called adverse analytical finding. Here, the question arises as to whether it is possible to distinguish analytically between intentional doping offenses and unintentional contamination of urine by seminal fluid. To this end, 480 seminal fluids from nonathletes were analyzed to identify concentration ranges and metabolite profiles of therapeutic drugs that are also classified as doping agents. Therefore, a screening procedure was developed using liquid chromatography connected to a triple quadrupole mass spectrometer, and suspect samples (i.e., samples indicating the presence of relevant compounds) were further subjected to liquid chromatography-high-resolution accurate mass (tandem) mass spectrometry. The screening method yielded 90 findings (including aromatase inhibitors, selective estrogen receptor modulators, diuretics, stimulants, glucocorticoids, beta-blockers, antidepressants, and the nonapproved proliferator-activated receptor delta agonist GW1516) in a total of 81 samples, with 91% of these suspected cases being verified by the confirmation method. In addition to the intact drug, phase-I and -II metabolites were also occasionally observed in the seminal fluid. This study demonstrated that various drugs including those categorized as doping agents partition into seminal fluid. Monitoring substances and metabolites may contribute to a better understanding of the distribution and metabolism of exogenous substances in seminal fluid that may be responsible for the impairment of male fertility.

Archaeologists have discovered a "remarkable" section of one of Britain's most important Roman roads in southeast London.

Its latest roadmap suggests that if you want white fans, you should wait for an announcement in Q1 2022.

The announcement was made in a video unveiled at Disney’s D23 event in Brazil, featuring the returning stars in a reveal

A lot of folks got into the SaGa series a long time ago through its many releases on prior console …

Continue reading "Romancing SaGa 2: Revenge of the Seven Interview With Game Producer Shinichi Tatsuke and Steam Deck Hands-On Preview"

Les fromages vendus en portions individuelles sont des plus pratiques pour l’école et le bureau.

My Chemical Romance teased a new project on social media. The Welcome to the Black Parade rockers — who broke up in 2013 before releasing new song The Foundations of Decay nine years later — have largely kept things quiet since their reunion tour ended in March 2023, besides a headline slot at When We Were Young Festival last month. On Monday (Nov 11), the band's official Instagram shared an image of a hazy skyline and confetti alongside Russian letters which translate to "TPK". The cryptic post was captioned: "If you could be anything, what would you be?" https://www.instagram.com/p/DCPw84izQkN/?utm_source=ig_web_copy_link&igsh=MzRlODBiNWFlZA== While there are no further hints about the message and what it could mean, fans have suggested it may refer to MCR's scrapped record The Paper Kingdom, which was ditched in 2013 and would have been their fifth album.

Ready to welcome a steady incoming flow of conference attendees, introduce the world to a host of new industry innovations and provide a full lineup of fun events all week long, ProMat 2023 opened its doors to the world at 10 a.m. CST this morning.

Radiocarbon dating and DNA analysis have revealed that a complete skeleton found in a 2nd-century cemetery is made up of bones from many people spanning thousands of years – but we don’t know who assembled it or why

In this week’s podcast episode, we’re looking at the glorious  ads and features for the October/November 1988 issue of RT Magazine. Thank you to Amy M. for this issue! You can also find all the RTRW content at our category page for Romantic Times Rewind.  If you want to listen and follow along with this entry, we have more detail in the audio, but you can click play and listen and read and absorb all … Continue reading Romantic Times Rewind: October 1988 Ads & Features →

Welcome to Book Beat! Book Beat aims to highlight other books that we may hear about through friends, social media, or other sources. We could see a gorgeous ad! Or find a new-to-us author on a list of underrated romances! Think of Book Beat as Teen Beat or Tiger Beat, but for books. And no staples to open to get the fold-out poster.