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connect-core5.c

Linux/ppc shellcode which connects /bin/sh to a host. connect-core5.s is appended.




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execve-core.c

execve /bin/sh shellcode for Linux PPC. execve-core.s is appended.




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readnexecppc-core.c

read(0,stack,1028); stack(); shellcode for Linux PPC. readnexecppc-core.s appended.




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JUNOS (Juniper) Flaw Exposes Core Routers To Kernel Crash




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ASP.NET Core 5-RC1 HTTP Header Injection

ASP.NET Core version 5.-RC1 suffers from an HTTP header injection vulnerability.




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Lotus Core CMS 1.0.1 Local File Inclusion

Lotus Core CMS version 1.0.1 suffers from a local file inclusion vulnerability.




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Apple's Corellium Lawsuit Causes Chilling Effect With Security Researchers




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Amiga Launches A $2,500 Quad-Core Lunchbox PC




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NanoCore Trojan Is Protected In Memory From Being Killed Off




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Zibo hopes to score investment goals

The eastern Chinese city of Zibo is recognised as the official birthplace of football. However, its local government is hoping it will soon be known for its excellence in the chemical, medical and manufacturing industries.




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UK Low-Carbon Contract Winners Revealed: Wind Scores, Solar Disappoints

The first round of the Contracts for Difference (CfD) programme — the UK scheme that is designed to support low-carbon generation and a capacity margin in the energy sector — has concluded. Contracts were offered to 27 renewable electricity projects with a total value of some £315 million (US$500 million), which include two offshore wind farms with a total planned capacity of more than 1.1 GW, 15 onshore wind projects and five solar projects. In total, more 2 GW of new low-carbon capacity (including renewables, nuclear and carbon capture and storage) could be built under the CfD scheme.




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2013 Draws to a Close: Clean Energy Scorecard

Global private capital renewable energy investments are still above $250 billion for 2013. While the final numbers are not in yet, 3rd quarter global renewable energy investments, according to Bloomberg New Energy Finance’s latest data on deals and projects, notes slightly lower global investment than in 2012 due faltering “political will to decarbonise energy mix.” They further note that the third quarter’s decline in investment will push the year’s overall investment in renewable energy and energy-smart technologies down below 2012's $281 billion. But $250+ billion ain’t shabby.




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Thailand score first World Cup goal in 5-1 loss to Sweden

NICE: A couple of seconds elapsed before a disbelieving Kanjana Sungngoen raised her arms in celebration.




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Didi boss Jean Liu says core business profitable, as China’s ride-hailing market recovers from Covid-19

Chinese ride-hailing giant Didi Chuxing’s core business has been profitable, president Jean Liu Qing said for the first time, as ride orders in its domestic market recover from the impact of the coronavirus pandemic.In a rare interview, Liu told the CNBC that Didi’s core business has been profitable, without providing specific figures or explaining how or when the company had measured its profitability. The company has no plans for job cuts or raising capital, Liu said in the interview that…




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Forum underscores need for counselling in sports as virus bites

“The crisis has helped us learn, react, engage and think deeper,” said Mutuku.




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Worsening climate emergency and tepid COP25 underscore need for urgent global action -- by Preety Bhandari

After a disappointing 2019 United Nations Climate Change Conference, there is a need to restore confidence that the intergovernmental process can deliver on mitigation, adaptation, and finance.




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Polygenic risk scores of several subtypes of epilepsies in a founder population

Objective

Polygenic risk scores (PRSs) are used to quantify the cumulative effects of a number of genetic variants, which may individually have a very small effect on susceptibility to a disease; we used PRSs to better understand the genetic contribution to common epilepsy and its subtypes.

Methods

We first replicated previous single associations using 373 unrelated patients. We then calculated PRSs in the same French Canadian patients with epilepsy divided into 7 epilepsy subtypes and population-based controls. We fitted a logistic mixed model to calculate the variance explained by the PRS using pseudo-R2 statistics.

Results

We show that the PRS explains more of the variance in idiopathic generalized epilepsy than in patients with nonacquired focal epilepsy. We also demonstrate that the variance explained is different within each epilepsy subtype.

Conclusions

Globally, we support the notion that PRSs provide a reliable measure to rightfully estimate the contribution of genetic factors to the pathophysiologic mechanism of epilepsies, but further studies are needed on PRSs before they can be used clinically.




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Accuracy of the Ottawa score in risk stratification of recurrent venous thromboembolism in patients with cancer-associated venous thromboembolism: a systematic review and meta-analysis

In patients with cancer-associated venous thromboembolism, knowledge of the estimated rate of recurrent events is important for clinical decision-making regarding anticoagulant therapy. The Ottawa score is a clinical prediction rule designed for this purpose, stratifying patients according to their risk of recurrent venous thromboembolism during the first six months of anticoagulation. We conducted a systematic review and meta-analysis of studies validating either the Ottawa score in its original or modified versions. Two investigators independently reviewed the relevant articles published from 1st June 2012 to 15th December 2018 and indexed in MEDLINE and EMBASE. Nine eligible studies were identified; these included a total of 14,963 patients. The original score classified 49.3% of the patients as high-risk, with a sensitivity of 0.7 [95% confidence interval (CI): 0.6-0.8], a 6-month pooled rate of recurrent venous thromboembolism of 18.6% (95%CI: 13.9-23.9). In the low-risk group, the recurrence rate was 7.4% (95%CI: 3.4-12.5). The modified score classified 19.8% of the patients as low-risk, with a sensitivity of 0.9 (95%CI: 0.4-1.0) and a 6-month pooled rate of recurrent venous thromboembolism of 2.2% (95%CI: 1.6-2.9). In the high-risk group, recurrence rate was 10.2% (95%CI: 6.4-14.6). Limitations of our analysis included type and dosing of anticoagulant therapy. We conclude that new therapeutic strategies are needed in patients at high risk for recurrent cancer-associated venous thromboembolism. Low-risk patients, as per the modified score, could be good candidates for oral anticoagulation. (This systematic review was registered with the International Prospective Registry of Systematic Reviews as: PROSPERO CRD42018099506).




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A post-stem cell transplant risk score for Philadelphia-negative acute lymphoblastic leukemia




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Activity of Imipenem-Relebactam against Carbapenem-Resistant Escherichia coli Isolates from the United States in Relation to Clonal Background, Resistance Genes, Coresistance, and Region [Epidemiology and Surveillance]

Imipenem-relebactam (I-R) is a recently developed carbapenem–beta-lactamase inhibitor combination agent that can overcome carbapenem resistance, which has now emerged in Escherichia coli, including sequence type 131 (ST131) and its fluoroquinolone-resistant H30R subclone, the leading cause of extraintestinal E. coli infections globally. To clarify the likely utility of I-R for carbapenem-resistant (CR) E. coli infections in the United States, we characterized 203 recent CR clinical E. coli isolates from across the United States (years 2002 to 2017) for phylogroup, clonal group (including ST131, H30R, and the CTX-M-15-associated H30Rx subset within H30R), relevant beta-lactamase genes, and broth microdilution MICs for I-R and 11 comparator agents. Overall, I-R was highly active (89% susceptible), more so than all comparators except tigecycline and colistin (both 99% susceptible). I-R’s activity varied significantly in relation to phylogroup, clonal background, resistance genotype, and region. It was greatest among phylogroup B2, ST131-H30R, H30Rx, Klebsiella pneumoniae carbapenemase (KPC)-positive, and northeast U.S. isolates and lowest among phylogroup C, New Delhi metallo-β-lactamase (NDM)-positive, and southeast U.S. isolates. Relebactam improved imipenem’s activity against CR isolates within each phylogroup—especially groups A, B1, and B2—and particularly against isolates containing KPC. I-R remained substantially active against isolates coresistant to comparator agents, albeit somewhat less so than against the corresponding susceptible isolates. These findings suggest that I-R should be useful for treating most CR E. coli infections in the United States, largely independent of coresistance, although this likely will vary in relation to the local prevalence of specific E. coli lineages and carbapenem resistance mechanisms.




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Prospective Association of Energy Balance Scores Based on Metabolic Biomarkers with Colorectal Cancer Risk

Background:

Energy balance–related factors, such as body mass index (BMI), diet, and physical activity, may influence colorectal cancer etiology through interconnected metabolic pathways, but their combined influence is less clear.

Methods:

We used reduced rank regression to derive three energy balance scores that associate lifestyle factors with combinations of prediagnostic, circulating levels of high-sensitivity C-reactive protein (hsCRP), C-peptide, and hemoglobin A1c (HbA1c) among 2,498 participants in the Cancer Prevention Study-II Nutrition Cohort. Among 114,989 participants, we verified 2,228 colorectal cancer cases. We assessed associations of each score with colorectal cancer incidence and by tumor molecular phenotypes using Cox proportional hazards regression.

Results:

The derived scores comprised BMI, physical activity, screen time, and 14 food groups, and explained 5.1% to 10.5% of the variation in biomarkers. The HR and 95% confidence interval (CI) for quartile 4 versus 1 of the HbA1c+C peptide–based score and colorectal cancer was 1.30 (1.15–1.47), the hsCRP-based score was 1.35 (1.19–1.53), and the hsCRP, C-peptide, and HbA1c-based score was 1.35 (1.19–1.52). The latter score was associated with non-CIMP tumors (HRQ4vsQ1: 1.59; 95% CI: 1.17–2.16), but not CIMP-positive tumors (Pheterogeneity = 0.04).

Conclusions:

These results further support hypotheses that systemic biomarkers of metabolic health—inflammation and abnormal glucose homeostasis—mediate part of the relationship between several energy balance–related modifiable factors and colorectal cancer risk.

Impact:

Results support cancer prevention guidelines for maintaining a healthful body weight, consuming a healthful diet, and being physically active. More research is needed on these clusters of exposures with molecular phenotypes of tumors.




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Circulating Biomarker Score for Visceral Fat and Risks of Incident Colorectal and Postmenopausal Breast Cancer: The Multiethnic Cohort Adiposity Phenotype Study

Background:

Visceral adipose tissue (VAT) may play a greater role than subcutaneous fat in increasing cancer risk but is poorly estimated in epidemiologic studies.

Methods:

We developed a VAT prediction score by regression equations averaged across 100 least absolute shrinkage and selection operator models in a cross-sectional study of 1,801 older adults in the Multiethnic Cohort (MEC). The score was then used as proxy for VAT in case–control studies of postmenopausal breast (950 case–control pairs) and colorectal (831 case–control pairs) cancer in an independent sample in MEC. Abdominal MRI–derived VAT; circulating biomarkers of metabolic, hormonal, and inflammation dysfunctions; and ORs for incident cancer adjusted for BMI and other risk factors were assessed.

Results:

The final score, composed of nine biomarkers, BMI, and height, explained 11% and 15% more of the variance in VAT than BMI alone in men and women, respectively. The area under the receiver operator curve for VAT >150 cm2 was 0.90 in men and 0.86 in women. The VAT score was associated with risk of breast cancer [OR (95% confidence interval [CI]) by increasing tertiles: 1.00, 1.09 (0.86–1.39), 1.48 (1.16–1.89); Ptrend = 0.002] but not with colorectal cancer (P = 0.84), although an association [1.00, 0.98 (0.68–1.39), 1.24 (0.88–1.76); Ptrend = 0.08] was suggested for this cancer after excluding cases that occurred within 7 years of blood draw (Pheterogeneity = 0.06).

Conclusions:

The VAT score predicted risks of postmenopausal breast cancer and can be used for risk assessment in diverse populations.

Impact:

These findings provide specific evidence for a role of VAT in breast cancer.




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Further Guidance in Implementing the Standardized 2018 World Cancer Research Fund/American Institute for Cancer Research (WCRF/AICR) Score

The 2018 World Cancer Research Fund/American Institute for Cancer Research (WCRF/AICR) Score was developed to establish a simple, standardized scoring system for researchers to quantify adherence to the 2018 WCRF/AICR Cancer Prevention Recommendations and assess its impact on cancer risk and other health-related outcomes. The aim of this commentary is to clarify potential points of ambiguity in its application, focusing on aspects related to specific subscore components (physical activity, fast foods, alcohol, and sugar-sweetened drinks), how to address different data needs due to varied data collection instruments, and future exploratory score approaches. Overall, we encourage researchers to utilize the standardized score to enhance comparability across populations and countries. Researchers who may adapt or augment the 2018 WCRF/AICR Score are strongly encouraged to provide detailed descriptions of their methods to promote transparency and reproducibility.




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RPGCast – Episode 391: “Hardcore Artbook”

While Chris tries to log into Pokémon Go, Anna Marie teaches Kelley about the finer points of Berserker rearing in Final Fantasy V. Johnathan still...




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RPGCast – Episode 471: “Your French Is As Good As Your Common Core Math”

Shenmue III is still accepting backers. Fallout 76 is still something we don't understand. And Utawarerumono is still unpronounceable.




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H&M tops 2020 fashion transparency index as 10 brands score zero

C&A, Adidas/Reebok, Esprit and M&S round out top five as average scores increase year on year, but Max Mara, Pepe Jeans and Tom Ford fall flat

The H&M Group, C&A, Adidas/Reebok, Esprit, Marks & Spencer and Patagonia are the world’s most transparent major fashion brands, according to the 2020 fashion transparency index from the campaign group Fashion Revolution.

The annual report, now in its fifth year, ranks the amount of information companies disclose about social and environmental policies, processes and effects within their operations and supply chains.

Continue reading...




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Fore, score and 18 holes ago...

Mark Twain once described golf as "a good walk spoiled." With all due respect, the father of American literature likely would have had a much different take had he joined me ...




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Man Utd fans DESPERATE for Alexis Sanchez to CELEBRATE if he scores against Arsenal

ALEXIS SANCHEZ returns to former club Arsenal tonight - and Manchester United fans are desperate to see him celebrate if he scores at the Emirates..




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Drake scores the Official UK Chart double with Dark Lane Demo Tapes and Toosie Slide

Congratulations to Drake, who scores the Official Chart double this week as his Dark Lane Demo Tapes mixtape and song Toosie Slide claim Number 1 on the Official Albums and Singles Charts.




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Chile v Israel - Davis Cup scores

REUTERS - Davis Cup world group first round scores between Chile and Israel in Coquimbo on Monday (* denotes new result).




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Wall Street Week Ahead: U.S. data deluge to underscore divide between roaring market, plunging economy

A week packed with U.S. economic data is likely to provide investors with more evidence of the extent to which the coronavirus pandemic has hit growth, sharpening the debate on whether a rebound in stocks has been justified amid an unprecedented slowdown.




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Billy Mitchell takes his Donkey Kong high-score cheating case to court

Newly revealed Twin Galaxies defamation suit has been quietly proceeding for months.




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Who is David Corenswet? Meet the actor who plays Jack Castello in Netflix's Hollywood

David Corenswet plays heartthrob Jack Castello in Ryan Murphy's new Netflix series




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Ethical at any size: the plus-size brands with sustainability at their core

Because every body deserves to be dressed well




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Why Arsenal will be confident in transfer race to sign Corentin Tolisso from Bayern

Arsenal and Manchester United have been linked with a move for Bayern Munich star Corentin Tolisso, but it is the Gunners who may have the transfer edge.




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What Ferran Torres would bring to Liverpool: 'Skilful, great one-on-one, quick... and scores goals'

Ferran Torres has the talent and temperament to succeed at Liverpool if he makes a move to the Premier League, according to a former Valencia chief.




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Lionel Messi scored his first Barcelona goal 15 years ago today

May 1, 2005 is a date for the history books – a day when everything changed for FC Barcelona as a 17-year-old Lionel Messi scored his first official goal for the Catalan club.




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Where are they now? Barcelona's starting XI the day Lionel Messi scored his first LaLiga goal

Friday marked 15 years since Lionel Messi hit his very first goal for Barcelona.




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Lionel Messi is not a natural goalscorer, argues Tim Sherwood

Tim Sherwood has suggested Lionel Messi is not a 'natural goalscorer', insisting talent in football can only be nurtured.




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Jeonbuk vs Suwon LIVE stream: K-League 2019-20 commentary, latest score, TV, prediction

Welcome to Standard Sport's LIVE coverage of the K-League openers between Jeonbuk Hyundai Motors and the Suwon Samsung Bluewings




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Melbourne City v Adelaide United, Sydney FC v Western Sydney Wanderers: A-League live scores, stats and commentary

The Sky Blues make it two from two with a against the Phoenix, following Melbourne City's 2-1 win over Adelaide United.




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Western United score comeback 3-2 win over Melbourne Victory in A-League derby

Western United come away with a 3-2 win in their Melbourne derby against the Victory despite trailing 2-0 after just seven minutes. Look back at that remarkable win and Western Sydney's 0-0 draw with Brisbane in our ScoreCentre.




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Razer's Blade 15 packs an 8-core Intel CPU and RTX 2080 Super

Razer has unveiled the 2020 Blade 15 Advanced with more gaming and content creation power, along with one long overdue addition. To start with, the Advanced model is the first Razer Blade with an 8-core CPU, namely the 10th-generation Intel Core i7-10875. That will make it useful for both content creation and gaming, particularly since you can clock it up to 5.1 GHz.




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Scientists discover microplastics in decade-old Antarctic ice core sample

Researchers melt an ice core taken from Antarctica 10 years ago and find dozens of microplastic particles, including polyethylene used to make plastic bags.




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Morning Break: Shingrix Gets CDC Blessing; Judge Won't Reinstate ACA Subsidies; Obamacare Fix Score

Health news and commentary from around the Web gathered by the ALLMedPage Today staff




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COVID-19 Core Formula

The U.S. Food and Drug Administration posted a photo:

This product is promoted with unapproved claims to prevent, treat, mitigate, or cure COVID-19. FDA warns consumers to avoid unproven and potentially unsafe products. See the Warning Letter for more information:

www.fda.gov/inspections-compliance-enforcement-and-crimin...

More information is available at www.fda.gov/consumers/health-fraud-scams/fraudulent-coron...

Photo by FDA's Office of Regulatory Affairs, Health Fraud Branch

This photo is free of all copyright restrictions and available for use and redistribution without permission. Credit to FDA's Office of Regulatory Affairs, Health Fraud Branch is appreciated but not required.




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Gilead's remdesivir scores emergency FDA nod in COVID-19 days after big data reveal

Days after U.S. officials reported the first positive controlled data for Gilead's remdesivir in COVID-19, the FDA has given the drug an emergency use authorization.




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AbbVie, Allergan score FTC approval for $63B merger with one final hurdle left to go

AbbVie and Allergan have waited for nearly a year for their much-discussed merger to pass muster. Finally, after pushback from consumer groups and tight scrutiny from regulators, the FTC has granted its green light. The partners face just one final hurdle to consummating their deal. 




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AstraZeneca's Farxiga scores landmark FDA nod in heart failure patients with or without diabetes

AstraZeneca has watched superstar SGLT2 diabetes med Farxiga nail trial after trial in highly coveted kidney and heart failure indications, with the FDA expediting reviews to back them up. The one thing AstraZeneca was missing? The agency taking Farxiga across the finish line. 




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Fourth Georgia Corections Officer Pleads Guilty in Inmate Beating Case

Today, the Civil Rights Division of the Justice Department and the U.S. Attorney for the Middle District of Georgia announced that Kadarius Thomas, a former member of the Correctional Emergency Response Team (CERT) and a former supervisor at Macon State Prison (MSP), in Oglethorpe, Ga., pleaded guilty to obstruction of justice.



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