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An SDS-PAGE based method for the quantification of carbon black in biological samples

Analyst, 2020, 145,3370-3375
DOI: 10.1039/D0AN00046A, Paper
Keyang Liu, Bin Wan
Quantification of Carbon Black (CB) in bio-samples was made available through SDS-PAGE gel electrophoresis.
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The fingerprint of essential bio-oils by Fourier transform ion cyclotron resonance mass spectrometry

Analyst, 2020, 145,3414-3423
DOI: 10.1039/C9AN02492A, Paper
Claudia X. Ramírez, Diana Catalina Palacio Lozano, Hugh E. Jones, Rafael Cabanzo Hernández, Mark P. Barrow, Enrique Mejia-Ospino
Six essential oils were analyzed by Fourier transform ion cyclotron resonance mass spectrometry coupled to negative electrospray ionization (ESI(–)/FT-ICR MS).
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Removing interference-based effects from infrared spectra – interference fringes re-revisited

Analyst, 2020, 145,3385-3394
DOI: 10.1039/D0AN00062K, Paper
Thomas G. Mayerhöfer, Susanne Pahlow, Uwe Hübner, Jürgen Popp
Substantial refractive index mismatches between substrate and layers lead to undulating baselines and changes of band intensity, shape and position. For proper spectrum interpretation, all of these effects must be removed.
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Selective ratiometric red-emission detection of In3+ in aqueous solutions and in live cells using a fluorescent peptidyl probe and metal chelating agent

Analyst, 2020, Advance Article
DOI: 10.1039/D0AN00288G, Paper
Joohee Park, Hyeongseok Yu, See-Hyoung Park, Keun-Hyeung Lee
A ratiometric fluorescent detection method for In3+ in aqueous buffered solution, ground water, and live cells was developed.
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FRET based fluorescent ratiometric probes for rapid detection of endogenous hydrogen sulphide in living cells

Analyst, 2020, Accepted Manuscript
DOI: 10.1039/D0AN00531B, Paper
Yuming Zhang, Yuncong Chen, Bai Yang, Xueling Xue, Weijiang He, Zijian Guo
Real time monitor of hydrogen sulphide (H2S) level change is of crucial importance for the study of its complicated roles in physiology. Herein, we developed a FRET strategy for designing...
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An electrochemical biosensor based on methylene blue-loaded nanocomposites as signal-amplifying tags to detect pathogenic bacteria

Analyst, 2020, Advance Article
DOI: 10.1039/D0AN00470G, Paper
Shengjun Bu, Kuiyu Wang, Zhongyi Li, Chengyu Wang, Zhuo Hao, Wensen Liu, Jiayu Wan
Synthesis of new methylene blue–magainin I organic–inorganic nanocomposites as electrochemical signal labels for the detection of bacteria.
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Naked-Eye Sensing of Phytic Acid at Sub-Nanomolar Level in 100% Water Medium by Charge Transfer Complex Derived from off-the-shelf Ingredients

Analyst, 2020, Accepted Manuscript
DOI: 10.1039/D0AN00671H, Paper
Nilanjan Dey
Naked-eye sensing of phytic acid, one of the most abundant antinutrients, was achieved in 100% water medium using charge transfer complex, comprised of pyranine and methyl viologen. Since both the...
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A homogeneous photoelectrochemical hydrogen sulfide sensor based on the electronic transfer mediated by tetrasulfophthalocyanine

Analyst, 2020, Advance Article
DOI: 10.1039/D0AN00302F, Paper
Xinyang Wang, Huanan Zhao, Zhonghui Chen, Fang Luo, Longhua Guo, Bin Qiu, Zhenyu Lin, Jian Wang
A homogeneous photoelectrochemical sensor for H2S detection based on the electronic transfer mediated by [Fe(III)PcS4]+ was developed with an un-modified photoelectrode.
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Scientific workflow managers in metabolomics: an overview

Analyst, 2020, Advance Article
DOI: 10.1039/D0AN00272K, Critical Review
Aswin Verhoeven, Martin Giera, Oleg A. Mayboroda
Metabolomics workflows for data processing reproducibility and accelerated clinical deployment.
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Tetrahedral DNA Nanostructure-decorated Electrochemical Platform for Simple and Ultrasensitive EGFR Genotyping of Plasma ctDNA

Analyst, 2020, Accepted Manuscript
DOI: 10.1039/D0AN00591F, Paper
Xuyao Wang, Jianping Wu, Weilin Mao, Xia He, Liming Ruan, Junlan Zhu, Peng Shu, Zhenqi Zhang, Bitao Jiang, Xingguo Zhang
Genotyping of the epidermal growth factor receptor (EGFR) mutation status is of great importance in the screening of appropriate advanced non-small cell lung carcinoma (NSCLC) patients to receive superior tyrosine...
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A Simple and Ubiquitous Device for Picric Acid Detection in Latent Fingerprints using Carbon Dots

Analyst, 2020, Accepted Manuscript
DOI: 10.1039/D0AN00750A, Paper
Arunkumar Kathiravan, Annasamy Gowri, Srinivasan Venkatesan, Trevor Smith, Muthpandian Ashokkumar, Asha Jhonsi Mariadoss
This work addresses the synthetic optimization of carbon dots (CDs) and their application in sensing picric acid from latent fingerprint by exploiting a smartphone-based RGB tool. The optimization in the...
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[ASAP] A Coculture Based Tyrosine-Tyrosinase Electrochemical Gene Circuit for Connecting Cellular Communication with Electronic Networks

ACS Synthetic Biology
DOI: 10.1021/acssynbio.9b00469




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[ASAP] Efficient and Reproducible Multigene Expression after Single-Step Transfection Using Improved BAC Transgenesis and Engineering Toolkit

ACS Synthetic Biology
DOI: 10.1021/acssynbio.9b00457




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[ASAP] SCRaMbLEing of a Synthetic Yeast Chromosome with Clustered Essential Genes Reveals Synthetic Lethal Interactions

ACS Synthetic Biology
DOI: 10.1021/acssynbio.0c00059




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[ASAP] Genome-Wide CRISPRi-Based Identification of Targets for Decoupling Growth from Production

ACS Synthetic Biology
DOI: 10.1021/acssynbio.9b00143




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[ASAP] A Synthetic Genetic Circuit Enables Precise Quantification of Direct Repeat Deletion in Bacteria

ACS Synthetic Biology
DOI: 10.1021/acssynbio.9b00256




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[ASAP] MAPPS: A Web-Based Tool for Metabolic Pathway Prediction and Network Analysis in the Postgenomic Era

ACS Synthetic Biology
DOI: 10.1021/acssynbio.9b00397




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[ASAP] A Chemical Switch System to Modulate Chimeric Antigen Receptor T Cell Activity through Proteolysis-Targeting Chimaera Technology

ACS Synthetic Biology
DOI: 10.1021/acssynbio.9b00476




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[ASAP] Multiplex Generation, Tracking, and Functional Screening of Substitution Mutants Using a CRISPR/Retron System

ACS Synthetic Biology
DOI: 10.1021/acssynbio.0c00002




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[ASAP] Bacteriophage Inspired Growth-Decoupled Recombinant Protein Production in <italic toggle="yes">Escherichia coli</italic>

ACS Synthetic Biology
DOI: 10.1021/acssynbio.0c00028






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[ASAP] Imidazo[1,2-<italic toggle="yes">a</italic>]pyridine Derivatives as Aldehyde Dehydrogenase Inhibitors: Novel Chemotypes to Target Glioblastoma Stem Cells

Journal of Medicinal Chemistry
DOI: 10.1021/acs.jmedchem.9b01910




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[ASAP] Pyridine-Embedded Phenothiazinium Dyes as Lysosome-Targeted Photosensitizers for Highly Efficient Photodynamic Antitumor Therapy

Journal of Medicinal Chemistry
DOI: 10.1021/acs.jmedchem.0c00280




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[ASAP] Treating Cancer by Spindle Assembly Checkpoint Abrogation: Discovery of Two Clinical Candidates, BAY 1161909 and BAY 1217389, Targeting MPS1 Kinase

Journal of Medicinal Chemistry
DOI: 10.1021/acs.jmedchem.9b02035




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[ASAP] Bioisosteric Discovery of NPA101.3, a Second-Generation RET/VEGFR2 Inhibitor Optimized for Single-Agent Polypharmacology

Journal of Medicinal Chemistry
DOI: 10.1021/acs.jmedchem.9b01336




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[ASAP] Triazolo-Peptidomimetics: Novel Radiolabeled Minigastrin Analogs for Improved Tumor Targeting

Journal of Medicinal Chemistry
DOI: 10.1021/acs.jmedchem.9b01936




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[ASAP] Dual-Target Inhibitors Based on HDACs: Novel Antitumor Agents for Cancer Therapy

Journal of Medicinal Chemistry
DOI: 10.1021/acs.jmedchem.0c00491




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[ASAP] Computational Chemistry on a Budget: Supporting Drug Discovery with Limited Resources<subtitle>Miniperspective</subtitle>

Journal of Medicinal Chemistry
DOI: 10.1021/acs.jmedchem.9b02126




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[ASAP] Degradation versus Inhibition: Development of Proteolysis-Targeting Chimeras for Overcoming Statin-Induced Compensatory Upregulation of 3-Hydroxy-3-methylglutaryl Coenzyme A Reductase

Journal of Medicinal Chemistry
DOI: 10.1021/acs.jmedchem.0c00339




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[ASAP] Targeting ALK2: An Open Science Approach to Developing Therapeutics for the Treatment of Diffuse Intrinsic Pontine Glioma

Journal of Medicinal Chemistry
DOI: 10.1021/acs.jmedchem.0c00395




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[ASAP] p62/SQSTM1, a Central but Unexploited Target: Advances in Its Physiological/Pathogenic Functions and Small Molecular Modulators

Journal of Medicinal Chemistry
DOI: 10.1021/acs.jmedchem.9b02038




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[ASAP] Structural Fingerprints of an Intact Monoclonal Antibody Acquired under Formulated Storage Conditions via <sup>15</sup>N Direct Detection Nuclear Magnetic Resonance

Journal of Medicinal Chemistry
DOI: 10.1021/acs.jmedchem.0c00231




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[ASAP] Discovery of Potent Inhibitors against P-Glycoprotein-Mediated Multidrug Resistance Aided by Late-Stage Functionalization of a 2-(4-(Pyridin-2-yl)phenoxy)pyridine Analogue

Journal of Medicinal Chemistry
DOI: 10.1021/acs.jmedchem.0c00337




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[ASAP] Discovery of a Silicon-Containing Pan-Genotype Hepatitis C Virus NS5A Inhibitor

Journal of Medicinal Chemistry
DOI: 10.1021/acs.jmedchem.0c00082




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[ASAP] Ruthenium(II) Complex Containing a Redox-Active Semiquinonate Ligand as a Potential Chemotherapeutic Agent: From Synthesis to <italic toggle="yes">In Vivo</italic> Studies

Journal of Medicinal Chemistry
DOI: 10.1021/acs.jmedchem.0c00431




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[ASAP] Progress in the Field of Aldehyde Dehydrogenase Inhibitors: Novel Imidazo[1,2-<italic toggle="yes">a</italic>]pyridines against the 1A Family

ACS Medicinal Chemistry Letters
DOI: 10.1021/acsmedchemlett.9b00686




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[ASAP] Therapeutic Potential of Targeted Nanoparticles and Perspective on Nanotherapies

ACS Medicinal Chemistry Letters
DOI: 10.1021/acsmedchemlett.0c00075




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[ASAP] Design, Synthesis, and Pharmacological Evaluation of Second Generation EZH2 Inhibitors with Long Residence Time

ACS Medicinal Chemistry Letters
DOI: 10.1021/acsmedchemlett.0c00045




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[ASAP] Escaping from Flatland: Substituted Bridged Pyrrolidine Fragments with Inherent Three-Dimensional Character

ACS Medicinal Chemistry Letters
DOI: 10.1021/acsmedchemlett.0c00039




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[ASAP] Rationally Designed Covalent BCL6 Inhibitor That Targets a Tyrosine Residue in the Homodimer Interface

ACS Medicinal Chemistry Letters
DOI: 10.1021/acsmedchemlett.0c00111




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[ASAP] Pharmacophore-Based Virtual Screening for Identification of Negative Modulators of GLI1 as Potential Anticancer Agents

ACS Medicinal Chemistry Letters
DOI: 10.1021/acsmedchemlett.9b00639




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[ASAP] Novel Dithiolane-Based Ligands Combining Sigma and NMDA Receptor Interactions as Potential Neuroprotective Agents

ACS Medicinal Chemistry Letters
DOI: 10.1021/acsmedchemlett.0c00129




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[ASAP] Selective Covalent Targeting of Mutated EGFR(T790M) with Chlorofluoroacetamide-Pyrimidines

ACS Medicinal Chemistry Letters
DOI: 10.1021/acsmedchemlett.9b00574




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[ASAP] Design and Synthesis of Tetrazole- and Pyridine-Containing Itraconazole Analogs as Potent Angiogenesis Inhibitors

ACS Medicinal Chemistry Letters
DOI: 10.1021/acsmedchemlett.9b00438




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[ASAP] Potential Cancer Treatment by Agonists of the Stimulator of Interferon Genes

ACS Medicinal Chemistry Letters
DOI: 10.1021/acsmedchemlett.0c00117




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[ASAP] Complete Regression of Carcinoma via Combined C-RAF and EGFR Targeted Therapy

ACS Medicinal Chemistry Letters
DOI: 10.1021/acsmedchemlett.0c00159




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[ASAP] Discovery of an Atropisomeric PI3Kß Selective Inhibitor through Optimization of the Hinge Binding Motif

ACS Medicinal Chemistry Letters
DOI: 10.1021/acsmedchemlett.0c00095




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[ASAP] PROTAC Compounds Targeting a-Synuclein Protein for Treating Neurogenerative Disorders: Alzheimer’s and Parkinson’s Diseases

ACS Medicinal Chemistry Letters
DOI: 10.1021/acsmedchemlett.0c00192




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[ASAP] Development of Selective Steroid Inhibitors for the Glucose-6-phosphate Dehydrogenase from <italic toggle="yes">Trypanosoma cruzi</italic>

ACS Medicinal Chemistry Letters
DOI: 10.1021/acsmedchemlett.0c00106