Disclosed in this specification is a drip filter coffee maker that includes features to improve the taste of the brewed coffee and to enhance to ease of use. In one embodiment, an integral plate burr grinder sends coffee ground down a coffee chute that feeds the filter cone. A chute door at the end of the coffee chute prevents vapors or condensation from entering the coffee chute. In another embodiment, the eject tray that carries the filter cone may be coupled with a dampened spring biasing mechanism which moderates the eject motion. Further, a pivot float may be provided within the carafe so that the user may read the carafe fill level easily.

A grill is provided with a removable storage basket assembly for providing a conveniently accessible receptacle or storage platform for articles such as seasonings, cooking tools, towels, or other articles. The storage basket assembly includes a frame having a basket or tray that can be mounted thereto, and a handle. The handle is configured to be received within a recess formed in a shelf of the grill for removably but stably mounting the storage basket assembly on the grill.

A cookware system includes a microwaveable metal collecting pan, configured in a bowl shape with a plurality of elongated slots disposed thereon. The collector pan is positioned in a supporting bowl to catch dripping fluids and to provide a basin to hold water during steam cooking. A food item can be placed inside the pan, which is in turn placed inside the bowl and covered with a lid.

A coffee machine comprises a frothing device, wherein an internal milk channel leading to a frothing chamber is provided into which opens a bypass air inlet for operable air supply to the frothing device. A flexible milk suction line connects the frothing device with a milk supply container. Means are provided for cleaning the frothing device and the milk suction line with rinsing water from a continuous-flow water heater of the coffee machine. A controlled valve arrangement is provided which feeds rinsing water from the continuous-flow water heater to the bypass air inlet of the frothing device. A milk suction end of the milk suction line is directly or indirectly, fluid-conductively connectable with a residual water pan of the coffee machine prior to feeding rinsing water to the bypass air inlet.

The present invention relates to a cooking control method performed by a cooking apparatus for a food item. The method comprises obtaining a unique identifier and cooking data for the food item, and checking for a record of the unique identifier in a memory of the cooking apparatus. If a record of the unique identifier is located in the memory, then the cooking apparatus will not cook the food item. Otherwise a cooking process based on the cooking data to cook the food item is performed. Accordingly, cooking data for a given instance of a food item can only be used once in order to activate a cooking process performed by the cooking apparatus. The present invention also features product recall as well as the ability to track food item sales via a cooking data communications system.

The invention relates to a human Interleukin-2 (hIL-2) specific monoclonal antibody (mAb), or antigen binding fragment thereof, the binding of which to hIL-2 inhibits binding of hIL-2 to CD25 and the antibody is characterized by any of the parameters: the variable chain of the mAb comprises the amino acid sequence of SEQ ID NO 005 or SEQ ID NO 006; the binding to hIL-2 is characterized by a dissociation constant (KD)≦7.5 nmol/L; the binding to hIL-2 is characterized by an off-rate (Koff)≦1×10−4 s−1 and/or the antibody displays no measurable cross-reactivity to murine IL-2.

Provided are methods of generating chimeric antigen receptors (CAR). In some embodiments, library screening of CAR is performed by generating a vector encoding the CAR from random attachment of vectors from libraries of vectors encoding antigen-binding domains (e.g., scFv regions), hinge regions, and endodomains. In some embodiments, the vectors contain a transposon.

The present invention provides compositions and methods relating to or derived from antigen binding proteins capable of inducing B-Klotho, and or FGF21-like mediated signaling. In embodiments, the antigen binding proteins specifically bind to a complex comprising β-Klotho and at least one of (i) FGFR1c, (ii) FGFR2c and (iii) FGFR3c. In some embodiments the antigen binding proteins induce FGF21-like signaling. In some embodiments, an antigen binding protein is a fully human, humanized, or chimeric antibodies, binding fragments and derivatives of such antibodies, and polypeptides that specifically bind to a complex comprising β-Klotho and at least one of (i) FGFR1c, (ii) FGFR2c and (iii) FGFR3c. Other embodiments provide nucleic acids encoding such antigen binding proteins, and fragments and derivatives thereof, and polypeptides, cells comprising such polynucleotides, methods of making such antigen binding proteins, and fragments and derivatives thereof, and polypeptides, and methods of using such antigen binding proteins, fragments and derivatives thereof, and polypeptides, including methods of treating or diagnosing subjects suffering from type 2 diabetes, obesity, NASH, metabolic syndrome and related disorders or conditions.

The invention provides compositions and methods for treating leukemia, for example, acute myeloid leukemia (AML) and B-cell acute lymphoid leukemia (B-ALL). The invention also relates to at least one chimeric antigen receptor (CAR) specific to CD123, vectors comprising the same, and recombinant T cells comprising the CD123 CAR. The invention also includes methods of administering a genetically modified T cell expressing a CAR that comprises a CD123 binding domain. The invention also includes methods of bone marrow ablation for use in treatments necessitating bone marrow reconditioning or transplant.

The invention provides diagnostic and therapeutic targets for pulmonary disease, in particular, fibrotic lung disease. The inventors have found that a genetic variant MUC5B gene is associated with increased expression of the gene, increased risk of developing a pulmonary disease, and an improved prognosis and survival among those developing the pulmonary disease.

Provided herein are methods for the prognosis of prostate cancer progression in a patient by analyzing the gene expression in a tumor sample obtained from the patient the prognosis of prostate cancer progression in a patient by analyzing the gene expression in a tumor sample obtained from the patient. In particular, gene expression levels of GCOM1, MEX3D, TRPM4, ATPAF1, PTRF, GLYATL1, FLNA, OBSCN, STRA13, WHSCl, ARFGAP3, KDM2A, FAM83H, CLDN7, CNOT6, and B3GNT9 are measured. Kits containing means for the measurement of gene expression as described herein and methods for treatment of prostate cancer are also provided.

This disclosure relates to methods, computer products, computer-implemented methods, and systems for predicting the probability or risk of prostate cancer recurrence and tumor aggressiveness in a patient. The method is based, in part, on the patient's risk profile that includes the presence/degree of specific copy number variations and predictive clinical factors. The methods and systems can be used to aid in treatment selection.

Fibrous structures that exhibit a novel combination of properties and to methods for making such fibrous structures are provided.

This invention relates to novel monoclonal antibodies that specifically bind to the alpha-folate receptor. In some embodiments, the antibodies inhibit a biological activity of folate receptor-α (FR-α). The antibodies are useful in the treatment of certain cancers, particularly cancers that have increased cell surface expression of the alpha-folate receptor (“FR-α”), such as ovarian, breast, renal, colorectal, lung, endometrial, or brain cancer. The invention also relates to cells expressing the monoclonal antibodies, antibody derivatives, such as chimeric and humanized monoclonal antibodies, antibody fragments, and methods of detecting and treating cancer using the antibodies, derivatives, and fragments.

The present invention provides methods for assessing whether a subject is at risk of developing a neurological disorder, diagnosing or confirming whether a subject is afflicted with a neurological disorder, assessing whether PD has progressed in a subject afflicted with PD, assessing whether a neurological disorder is developing in a subject who has been identified as being at risk of developing the neurological disorder, assessing whether a subject afflicted with a neurological disorder is likely to benefit from a therapy, assessing whether a subject afflicted with a neurological disorder has benefited from a therapy, treating a subject afflicted with a neurological disorder, and prophylactically treating a subject who has been identified as being at risk of developing a neurological disorder. The present invention also provides epitopes, compounds and compositions relating to these methods.

Portions of a pin-on button are cut and assembled as a result of a plurality of operations in a machine having a vertical press. Cutter and work deforming tools are displaced by a single press ram to cut blanks and deform the blanks onto a button top placed in one of two die assemblies positioned in alignment below the work deforming tool on the lower end of the ram.

Apparatus for the manufacture of a laminated button comprising a metallic backing plate having a transverse peripheral edge and an outwardly extending flange, an illustrated paper sheet and a protective acetate covering. The apparatus comprises a pneumatically operated press which receives the plate, illustrated sheet and covering, and, with a single downward movement, causes the sheet to conform to the plate and be crimped between the transverse edge and flange.

A machine for the manufacture of buckles, buttons or the like which comprises an upper tool and a lower tool. The lower tool has an outer, spring-mounted frame and an inner core piece displaceable vertically with respect to the surrounding frame. The lower tool is adapted to support the assembled button after the opening stroke of the upper tool. A device is provided for lifting the core piece of the lower tool relative to the surrounding frame up to about the height of a transversely directed stream of blast air serving for discharging the product from the lower tool.

An improved method of forming and assembling two-part merchandise display hooks, including new design features of the hook itself, enable two-part hooks to be manufactured and assembled at extremely low cost. Wire from a continuous length is gripped and bent to form the outer portion of the hook. The wire is then severed and bent in a single operation to form a hook-mounting portion. While the severed wire remains gripped by its shaped outer end, a preoriented and guided base member is applied over the just-formed mounting portion of the wire. A retractable bend-forming member is withdrawn when the base member is applied to the wire, to enable the bent portion to be fully received within the plastic base. Major manufacturing economies are realized.

Disclosed is a wireless surround sound speaker system wherein a transmitter broadcasts a variety of FM signals that correspond to the individual speaker channels commonly found in a surround sound system. Receivers, individually equipped with signal receiving, conditioning and amplification components, are configured to receive any one of the broadcast signals in a remote location and are used to drive a conventional loudspeaker in that location. Powered by wall socket or via DC battery packs, the receivers, used in conjunction with the transmitter, provide surround sound capabilities without the need for complex and difficult wiring.

A machine manufactures buttons having coplanar shell flanges in a two-stroke operation. The machine comprises a crimp die having different resistances to advancement of a ram. The first resistance enables a metal shell margin to partially bend under a flat back that is placed on a first surface of the crimp die. The second resistance enables the shell wall to completely bend against a second surface of the crimp die so as to form flanges that lie in a single plane. Both round and rectangular buttons are manufacturable using the same basic machine. The rectangular machine uses a shifter cage on the ram that rotates in response to indexing a die table on which the crimp die and a pickup die are attached. The round machine uses a rotatable frame on the ram. With the rectangular machine, the shell is initially bent during a pickup stroke of the ram.

A button making device capable of simply exchanging a first pressed mold, a second pressed mold, and a pressing mold so as to produce buttons of different sizes; a polygonal button whose front surface plate is dome-wise curved and has its shape fixed; and such a button making device, are provided. The button making device has a sliding platform, two pressed molds, a fixed member, a pressing shaft, a pressing mold, and an operation mechanism. The pressed molds are provided on an attachment member which is removably attached to the sliding platform. The pressing mold is removably attached to a lower end of the pressing shaft using magnetic force. The present invention can be used for a button making device which can easily form a metal button by press processing which can be used as an accessory adhered to clothes or the like by a pin or the like.

A shelf-stable snack product having visibly impactful vegetable inclusions, a composite dough for forming the shelf-stable snack product, and method of manufacture is disclosed herein. The shelf-stable snack product includes masa and a fresh vegetable ingredient, and a final moisture content in the range of about 1.7-2.5 weight percent. Additionally, the shelf-stable snack product has an l-value no less than a corresponding l-value of a plain version of the shelf-stable snack product lacking the vegetable inclusions.

A salad making device is able to be used to make a handheld salad for easier consumption instead of the typical salad in a bowl. A wrapper is able to be used to secure the compacted salad materials.

The present invention relates to a plant-based wrapping paper for wrapping food. The plants (raw materials) may be fruits, herbs, medicinal plants, tea, vegetables and/or spices. The invention further relates to a method for producing said wrapping paper, its use for wrapping food or its use as packaging material.

The invention relates to a capsule for the preparation of a beverage in a beverage preparation device. The capsule has a flange which is partially made of paper and partially made of polymer. The polymer is essentially arranged on the flange to cover at least partially the paper part and so to improve the inside tightness of the capsule, in particular, to prevent air enters inside the capsule via folds and creases.

A cup comprises a container having a flat bottom wall pierceable by a needle, a filter has a flat filter bottom supported on or sufficiently close to the flat bottom to allow the needle to push part of the flat filter bottom upwards to form a beverage collection chamber, a lid having an outer sidewall and a sloped inner sidewall to transform the brewing pressure in the cup into radial outward force acting on the outer sidewall to impart rigidity to the lid during brewing, and a pressure sensitive adhesive O-ring between the horizontal wall of the lid and the container rim. The cup may comprise a pressurization chamber enclosed by the outer sidewall, inner sidewall and a top film and adapted to become pressurized and expanded when hot water is injected into the cup, thereby imparting rigidity to the lid and improving the seal to the container.

Pancake mixes comprising at least one type of whole grain flour, at least one natural sweetener, at least one fat and a leavening system are provided herein. Packaged food products comprising single-serving containers containing said pancake mixes, as well as methods of preparing pancakes, are also provided. The pancakes described herein are preferably 100% whole grain and free from preservatives and/or artificial colorings.

A composition and process for making pet food treats is described herein. Auxiliary ingredients are combined to form a plant mixture. The plant mixture is formed into portions. The portions of plant mixture are positioned on a chew stick that comprises rawhide. The pet treat gives the appearance of a grilled shish kabob, where the plant portions are meant for initial taste, while the chew stick will provide the dog with a longer-lasting chewing portion.

A process for making pet food treats including a base material, the treats themselves and a processing system for making the treats. The auxiliary ingredients are combined to form a foodstuffs mixture. Portions of the foodstuffs mixture are formed. The portions of foodstuffs mixture are positioned on a chew stick that comprises pizzle stick. The pet treat gives the appearance of a grilled shish kabob, where the meat portions are meant for initial taste, while the chew stick will take provide the dog with a longer-lasting chewing portion.

A brew basket is described that has a handle and a body attached to the handle. The body provides an upper chamber and a lower chamber. A top opening to the upper chamber is substantially circular with a center C. A floor of the upper chamber provides a shelf for initially supporting a beverage medium filter pack above the lower chamber. When viewed from above, the shelf is substantially rectangular. A discharge port is located at a bottom of the lower chamber and is offset from the center C when viewed from above.

The present invention is directed to recombinant thraustochytrids that grow on sucrose and cell cultures comprising the recombinant thraustochytrids as well as methods of producing cell cultures, biomasses, microbial oils, compositions, and biofuels using the recombinant thraustochytrids.

The present invention relates to a shock absorbing hammer whose head has housings filled with pellet assembly inside. The pellet assembly includes both rigid pellets and soft pellets to absorb shock from external striking force impacted on the head of the main frame.

A geared socket wrench hand tool is disclosed. The socket wrench is a clickless wrench allowing for more precise movement of the socket. The socket wrench, through a series of gears, can rotate in infinitesimally small rotations.

A socket includes a body and a sleeve. The body is made of metal and includes first and second coupling ends for respectively coupling with a fastener and a driving tool. The first coupling end includes an outer periphery having a first protruded section, a second protruded section, and an engagement section extending between the first and second protruded sections. The sleeve is made of metal having a hardness greater than a hardness of the body. The sleeve includes an inner periphery extending between first and second end faces of the sleeve. The inner periphery of the sleeve includes an engagement portion engaged with the engagement section of the body, with the sleeve not contacting the first and second protruded sections.

Pliers include upper structure including an upper jaw and handle extending therefrom, and lower structure including a lower jaw and handle. The lower jaw may pivot relative to the upper jaw, and the lower handle may pivot relative to the lower jaw. An overcenter linkage operatively connects between the upper and lower structure, biasing the lower handle and jaw away from the upper handle and jaw, respectively, when in a jaw-opening position, and enabling the lower jaw and handle to be retained in a closed configuration when the linkage is in a jaw-closing position. A lock member is movable between a locking configuration preventing pivoting of the lower handle from the closed configuration and retaining the jaws in a closed position, and a release configuration enabling the lower handle to be moved away from the closed configuration, allowing the jaws to move to an open position.

A socket wrench with a positioning device contains: a body including an accommodating cavity, a first face, and a second face. A toothed holder is accommodated in the accommodating cavity and has a polygonal groove, a first circular portion, a second circular portion, and a ratchet protrusion between the first circular portion and the second circular portion. The first circular portion is inserted to the first face, the second circular portion is inserted to the second face, and the ratchet protrusion engages with a ratchet device. A positioning device includes at least one retaining element disposed on the first circular portion and horizontally moving in the polygonal groove. The first circular portion has a resilient element and a pressing loop which are fitted on the first circular, and the pressing loop has a recess defined on an inner face thereof to correspond to the at least one retaining element.

One embodiment of the present invention relates to a machine for sewing, embroidering, quilting and/or the like. Another embodiment of the present invention relates to a method for sewing, embroidering, quilting and/or the like. In one example, the present invention may be applied (e.g., as a machine and/or method) to a multi-needle machine or method. In another example, the present invention may provide for automatic lower (or bottom) thread cutting. In another example, the present invention may provide for automatic lower (or bottom) thread cutting by utilizing the phase (that is, movement phase) of a return of a looper (or hook) to cut the lower (or bottom) thread.

The invention comprises using a fabric cut into several pieces which are further assembled together by stitches, the stitches being made using a sewing machine comprising at least two needles (A', B') operating in-line one behind the other so that the sewing stitch of the second needle (B') is made on the threads of the sewing stitch made by the first needle (A') in order to cover the perforation made by the first needle and so that the perforation made by the second needle (B') is made through said thread (11), thereby filling said perforation with said thread (11).

An apparatus for thread-stitching a book block includes a thread tensioning device configured to store and tension a binding thread. A single actuator, including a servo drive, drives the thread tensioning device. The method includes storing a length of binding thread; in a separate step, tensioning the binding thread; and thread-stitching the book block.

Systems and methods for creating quilt blocks are provided. In one embodiment, a method for creating a quilt block with a computerized embroidery machine includes sewing placement stitching on a backing according to a placement stitching pattern provided by instructions for at least partially creating a quilt block comprised of one or more pieces, providing directions for placing one or more pieces of the quilt block on a corresponding portion of the placement stitching on the backing, and sewing the one or more pieces to the backing in accordance with the instructions.

A set of sewing disks for controlling the movement of a piece of fabric over the free arm and under the needle of a sewing or quilting machine. Each disk is flat and has an oval or circular configuration and comprises three registered, stacked adhesively attached layers—a first contact layer made of open cell foam, a semi-rigid intermediate stiffener member, and a second contact layer made of closed cell foam. When each disk is placed over a piece of fabric with the lower contact layer is placed adjacent thereto, the individual's fingers are exposed at all times and placed over the opposite contact layer. The intermediate stiffener layer spreads and evenly dissipates the forces exerted by the fingers to the top contact layer to the lower contact layer. Because the finger tips are not in contact with the fabric, soiling of the fabric by the finger tips is prevented.

A embroidery clamp for thick fabric includes a movable clamping window support that is pivotally connected to a frame and extends around a pivotal axis. An actuating system applies a force to the end of the clamping window support and rotates the support around to pivotal axis to move clamping windows together. The clamping window supports have resilient properties and are configured for flexure.

A bus seat for use in a bus comprises a frame and a seat back secured to a portion of the frame. The bus seat further comprises a seat cushion secured to another portion of the frame. The bus seat also comprises a removable two piece cover arranged over the seat back, wherein the cover pieces are secured to one another with a zipper. The zippered two piece seat back cover allows for easy installation, removal or replacement of any damaged or worn portions of the seat back trim cover.

A method for fabricating a repair laminate for a composite part having an exposed surface includes applying a bonding material to the exposed surface and forming an uncured ply stack assembly on the bonding material. The uncured ply stack assembly is formed by forming and compacting a series of uncured ply stacks. The ply stack assembly and bonding material are then cured.

A method for making a water-degradable paper sheet involves the following: providing at least one strip of a water-soluble binding material in the form of a dry film; providing at least two strips each made of at least one ply of cellulose wadding; placing the strip of water-soluble binding material between the two strips of cellulose wadding; humidifying, assembling and pressing the three strips; and drying the complex strip thus obtained. The sheet thus obtained can be used for making a roll carrier mandrel by helically winding one or more strips from the sheet about a cylinder. Articles produced from the sheet can particularly be used in the field of products for sanitary or domestic use.