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Neuroglia in neurodegenerative diseases / Alexei Verkhratsky, Margaret S. Ho, Robert Zorec, Vladimir Parpura, editors

Online Resource




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Online release: It’s film producers vs multiplexes

Multiplex players may boycott studios, actors if exclusive theatrical window not honoured




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Bihar govt denies outbreak of diseases

However, 900 cases of dengue have come to light in Bihar, of which 640 are in Patna alone




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Study finds method to diagnose Lyme disease within 15 minutes

Caused by Borrelia burgdorferi and transmitted by the bite of infected Ixodes ticks, Lyme disease if left untreated can cause serious neurologic, cardiac, and/or rheumatologic complications




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Antibody-based eye drop may treat dry eye disease: Study

Dry eye disease is caused by abnormalities in the tear fluid and results in dry areas over the cornea, the transparent outer layer of the eye, which can lead to disabling eye pain and sensitivity to light in severe cases




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80% of adolescents don't even spend an hour on physical activity, at risk of heart disease: WHO study

An alarming highlight in the study is the fact that India, along with Bangladesh and the United States (US), ranks the lowest in physical activity among boys.




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AYUSH releases immunity-boosting measures for self-care during COVID-19 pandemic: Here is what you can do

The advisory was issued by the Ministry of AYUSH to support the efforts of all as a measure towards enhancing immunity.




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Hydrogen sulfide increases copper-dependent neurotoxicity via intracellular copper accumulation

Metallomics, 2020, Advance Article
DOI: 10.1039/D0MT00015A, Paper
Norika Goto, Hirokazu Hara, Mao Kondo, Naomi Yasuda, Tetsuro Kamiya, Kensuke Okuda, Tetsuo Adachi
Copper (Cu) is an essential trace element and acts as a redox cofactor for many enzymes; however, excess Cu is toxic to cells.
To cite this article before page numbers are assigned, use the DOI form of citation above.
The content of this RSS Feed (c) The Royal Society of Chemistry




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Bis(ethylmaltolato)oxidovanadium(IV) inhibited the pathogenesis of Alzheimer's disease in triple transgenic model mice

Metallomics, 2020, 12,474-490
DOI: 10.1039/C9MT00271E, Paper
Zhijun He, Shuangxue Han, Chong Wu, Lina Liu, Huazhang Zhu, Ang Liu, Qiying Lu, Jingqiang Huang, Xiubo Du, Nan Li, Qinguo Xie, Lu Wan, Jiazuan Ni, Lingling Chen, Xiaogai Yang, Qiong Liu
BEOV activates PPARγ to affect JAK2/STAT3/SOCS1 signaling and eventually prevents Aβ generation. Meanwhile, BEOV inactivates PTP1B to affect PI3K/Akt/GSK3β signaling and finally reduces tau hyperphosphorylation.
The content of this RSS Feed (c) The Royal Society of Chemistry




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Correction: Bis(ethylmaltolato)oxidovanadium(IV) inhibited the pathogenesis of Alzheimer's disease in triple transgenic model mice

Metallomics, 2020, 12,631-631
DOI: 10.1039/D0MT90008G, Correction
Open Access
  This article is licensed under a Creative Commons Attribution 3.0 Unported Licence.
Zhijun He, Shuangxue Han, Chong Wu, Lina Liu, Huazhang Zhu, Ang Liu, Qiying Lu, Jingqiang Huang, Xiubo Du, Nan Li, Qingguo Xie, Lu Wan, Jiazuan Ni, Lingling Chen, Xiaogai Yang, Qiong Liu
The content of this RSS Feed (c) The Royal Society of Chemistry




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Diphenyl Diselenide Protects Caenorhabditis elegans Model for Huntington's Disease by Activation of Antioxidant Pathway and Decrease in Protein Aggregation

Metallomics, 2020, Accepted Manuscript
DOI: 10.1039/D0MT00074D, Paper
Fabiane Bicca Obetine Baptista, Marina Lopes Machado, Aline da Silva Franzen, Larissa Marafiga Cordeiro, Tassia da Silveira, Leticia Arantes, Félix A. A. Soares
Huntington’s disease (HD) is an autosomal dominant, progressive neurodegenerative disease with a distinct phenotype. It occurs due to a mutation in huntingtin (or IT19) gene with abnormal CAG repeat, leading...
The content of this RSS Feed (c) The Royal Society of Chemistry




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A liver-targeting Cu(I) chelator relocates Cu in hepatocytes and promotes Cu excretion in a murine model of Wilson’s disease

Metallomics, 2020, Accepted Manuscript
DOI: 10.1039/D0MT00069H, Paper
Marie Monestier, AnaÏS M. Pujol, Aline Lamboux, Martine Cuillel, Isabelle Pignot-Paintrand, Doris Cassio, Peggy Charbonnier, Khémary Um, Amélie Harel, Sylvain BOHIC, Christelle GATEAU, Vincent Balter, Virginie Brun, Pascale Delangle, Elisabeth Mintz
Copper chelation is the most commonly used therapeutic strategy nowadays to treat Wilson’s disease, a genetic disorder primarily inducing a pathological accumulation of Cu in the liver. The mechanism of...
The content of this RSS Feed (c) The Royal Society of Chemistry




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The study of levels from redox-active elements in cerebrospinal fluid of amyotrophic lateral sclerosis patients carrying disease-related gene mutations shows potential copper dyshomeostasis

Metallomics, 2020, Advance Article
DOI: 10.1039/D0MT00051E, Paper
Federica Violi, Nikolay Solovyev, Marco Vinceti, Jessica Mandrioli, Marianna Lucio, Bernhard Michalke
Gene-environment interaction is as a possible key factor in the development of ALS. The levels of redox species of Cu, Fe, and Mn were assessed in cerebrospinal fluid, showing a possible positive association between Cu and genetic ALS.
To cite this article before page numbers are assigned, use the DOI form of citation above.
The content of this RSS Feed (c) The Royal Society of Chemistry




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Evidence that levels of nine essential metals in post-mortem human-Alzheimer's-brain and ex vivo rat-brain tissues are unaffected by differences in post-mortem delay, age, disease staging, and brain bank location

Metallomics, 2020, Advance Article
DOI: 10.1039/D0MT00048E, Paper
Melissa Scholefield, Stephanie J. Church, Jingshu Xu, Sarah Kassab, Natalie J. Gardiner, Federico Roncaroli, Nigel M. Hooper, Richard D. Unwin, Garth J. S. Cooper
Metal findings in human Alzheimer brains are consistent despite differences in sample post-mortem delay, age, Braak stage and biobank location.
To cite this article before page numbers are assigned, use the DOI form of citation above.
The content of this RSS Feed (c) The Royal Society of Chemistry




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Maths formulae book released

Maths formulae book released




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NCI study finds long-term increased risk of cancer death following common treatment for hyperthyroidism

Findings from a new NCI study of patients who received radioactive iodine (RAI) treatment for hyperthyroidism show an association between the dose of treatment and long-term risk of death from solid cancers, including breast cancer.




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[ASAP] Comprehensive Insights into the Catalytic Mechanism of Middle East Respiratory Syndrome 3C-Like Protease and Severe Acute Respiratory Syndrome 3C-Like Protease

ACS Catalysis
DOI: 10.1021/acscatal.0c00110




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How the measles virus disables immunity to other diseases and a news roundup

Michael Mina discusses how measles destroys immunity to other infectious diseases and why the measles vaccine has led to disproportionate reductions in childhood mortality since its introduction 50 years ago, and David Grimm discusses daily news stories. Hosted by Susanne Bard. [Img: UNICEF Ethiopia/Creative Commons License BY-NC-ND 2.0, via flickr]




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3-parent gene therapy for mitochondrial diseases and a news roundup

Kimberly Dunham-Snary discusses the long-term health considerations of gene therapy for mitochondrial diseases and David Grimm talks about the smell of death, Mercury crashing, and animal IQ. Hosted by Susanne Bard. [Image credit: Ben Gracewood CC BY-NC 2.0, via flickr]




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Podcast: Pollution hot spots in coastal waters, extreme bees, and diseased dinos

News stories on bees that live perilously close to the mouth of a volcano, diagnosing arthritis in dinosaur bones, and the evolution of the female orgasm, with David Grimm.  From the magazine Rivers deliver water to the ocean but water is also discharged along the coast in a much more diffuse way. This “submarine groundwater discharge” carries dissolved chemicals out to sea. But the underground nature of these outflows makes them difficult to quantify.  Audrey Sawyer talks with Sarah Crespi about the scale of this discharge and how it affects coastal waters surrounding the United States.  [Image: Hilary Erenler/Music: Jeffrey Cook]




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Podcast: An ethics conundrum from the Nazi era, baby dinosaur development, and a new test for mad cow disease

This week, we chat about how long dinosaur eggs take—or took—to hatch, a new survey that confirms the world’s hot spots for lightning, and replenishing endangered species with feral pets with Online News Editor Catherine Matacic. Plus, Science’s Alexa Billow talks to Megan Gannon about the dilemma presented by tissue samples collected during the Nazi era. And Sarah Crespi discusses a new test for mad cow disease with Kelly Servick.   Listen to previous podcasts.   [Image: NASA/flickr; Music: Jeffrey Cook]




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Drug use in the ancient world, and what will happen to plants as carbon dioxide levels increase

Armed with new data, archaeologists are revealing that mind-altering drugs were present at the dawn of the first complex societies some 5000 years ago in the ancient Middle East. Contributing writer Andrew Lawler joins Sarah Crespi to discuss the evidence for these drugs and how they might have impacted early societies and beliefs. Sarah also interviews Sarah Hobbie of the University of Minnesota about the fate of plants under climate change. Will all that extra carbon dioxide in the air be good for certain types of flora? A 20-year long study published this week in Science suggests theoretical predictions have been off the mark. This week’s episode was edited by Podigy. Listen to previous podcasts. [Image: Public domain Music: Jeffrey Cook]




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How the appendix could hold the keys to Parkinson’s disease, and materials scientists mimic nature

For a long time, Parkinson’s disease was thought to be merely a disorder of the nervous system. But in the past decade researchers have started to look elsewhere in the body for clues to this debilitating disease—particularly in the gut. Host Meagan Cantwell talks with Viviane Labrie of the Van Andel Institute in Grand Rapids, Michigan, about new research suggesting people without their appendixes have a reduced risk of Parkinson’s. Labrie also describes the possible mechanism behind this connection. And host Sarah Crespi talks with Peter Fratzl of the Max Planck Institute of Colloids and Interfaces in Potsdam, Germany, about what materials scientists can learn from nature. The natural world might not produce innovations like carbon nanotubes, but evolution has forged innumerable materials from very limited resources—mostly sugars, proteins, and minerals. Fratzl discusses how plants make time-release seedpods that are triggered by nothing but fire and rain, the amazing suckerin protein that comprises squid teeth, and how cicadas make their transparent, self-cleaning wings from simple building blocks. Fratzl’s review is part of a special section in Science on composite materials. Read the whole package, including a review on using renewables like coconut fiber for building cars and incorporating carbon nanotubes and graphene into composites. This week’s episode was edited by Podigy. Download the transcript (PDF) Listen to previous podcasts. About the Science Podcast [Image: Roger Smith/Flickr; Music: Jeffrey Cook]




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A big increase in monkey research and an overhaul for the metric system

A new report suggests a big increase in the use of monkeys in laboratory experiments in the United States in 2017. Online News Editor David Grimm joins host Sarah Crespi to discuss which areas of research are experiencing this rise and the possible reasons behind it. Also this week, host Meagan Cantwell talks with staff writer Adrian Cho about a final push to affix the metric system’s measures to physical constants instead of physical objects. That means the perfectly formed 1-kilogram cylinder known as Le Grand K is no more; it also means that the meter, the ampere, and other units of measure are now derived using complex calculations and experiments.  This week’s episode was edited by Podigy. Download a transcript (PDF) Listen to previous podcasts. About the Science Podcast [Image: Peter Nijenhuis/Flickr; Music: Jeffrey Cook] 




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Race and disease risk and Berlin’s singing nightingales

Noncancerous tumors of the uterus—also known as fibroids—are extremely common in women. One risk factor, according to the scientific literature, is “black race.” But such simplistic categories may actually obscure the real drivers of the disparities in outcomes for women with fibroids, according to this week’s guest. Host Meagan Cantwell speaks with Jada Benn Torres, an associate professor of anthropology at Vanderbilt University in Nashville, about how using interdisciplinary approaches— incorporating both genetic and cultural perspectives—can paint a more complete picture of how race shapes our understanding of diseases and how they are treated. In our monthly books segment, book review editor Valerie Thompson talks with David Rothenberg, author of the book Nightingales in Berlin: Searching for the Perfect Sound, about spending time with birds, whales, and neuroscientists trying to understand the aesthetics of human and animal music. This week’s episode was edited by Podigy. Download the transcript (PDF) Listen to previous podcasts. About the Science Podcast [Image: Carlos Delgado/Wikipedia; Matthias Ripp/Flickr; Music: Jeffrey Cook]




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An app for eye disease, and planting memories in songbirds

Host Sarah Crespi talks with undergraduate student Micheal Munson from Baylor University in Waco, Texas, about a smartphone app that scans photos in the phone’s library for eye disease in kids.  And Sarah talks with Todd Roberts of the University of Texas Southwestern Medical Center in Dallas, Texas, about incepting memories into zebra finches to study how they learn their songs. Using a technique called optogenetics—in which specific neurons can be controlled by pulses of light—the researchers introduced false song memories by turning on neurons in different patterns, with longer or shorter note durations than typical zebra finch songs. This week’s episode was edited by Podigy. Ads on this week’s show: MOVA Globes; KiwiCo.com Download a transcript (PDF) Listen to previous podcasts. About the Science Podcast  




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Researchers flouting clinical reporting rules, and linking gut microbes to heart disease and diabetes

Though a law requiring clinical trial results reporting has been on the books for decades, many researchers have been slow to comply. Now, 2 years after the law was sharpened with higher penalties for noncompliance, investigative correspondent Charles Piller took a look at the results. He talks with host Sarah Crespi about the investigation and a surprising lack of compliance and enforcement. Also this week, Sarah talks with Brett Finlay, a microbiologist at the University Of British Columbia, Vancouver, about an Insight in this week’s issue that aims to connect the dots between noncommunicable diseases like heart disease, diabetes, and cancer and the microbes that live in our guts. Could these diseases actually spread through our microbiomes? This week’s episode was edited by Podigy. Listen to previous podcasts. About the Science Podcast Download a transcript (PDF). [Image: stu_spivack/Flickr; Music: Jeffrey Cook]




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Why some diseases come and go with the seasons, and how to develop smarter, safer chemicals

On this week’s show, host Joel Goldberg gets an update on the coronavirus pandemic from Senior Correspondent Jon Cohen. In addition, Cohen gives a rundown of his latest feature, which highlights the relationship between diseases and changing seasons—and how this relationship relates to a potential coronavirus vaccine. Also this week, from a recording made at this year’s AAAS annual meeting in Seattle, host Meagan Cantwell speaks with Alexandra Maertens, director of the Green Toxicology initiative at Johns Hopkins University, Baltimore, about the importance of incorporating nonanimal testing methods to study the adverse effects of chemicals. This week’s episode was produced with help from Podigy. Download a transcript (PDF) Listen to previous podcasts. About the Science Podcast [Image: Let Ideas Compete/Flickr; Music: Jeffrey Cook] 




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How COVID-19 disease models shape shutdowns, and detecting emotions in mice

On this week’s show, Contributing Correspondent Kai Kupferschmidt talks with host Sarah Crespi about modeling coronavirus spread and the role of forecasts in national lockdowns and other pandemic policies. They also talk about the launch of a global trial of promising treatments. See all of our News coverage of the pandemic here. See all of our Research and Editorials here. Also this week, Nadine Gogolla, research group leader at the Max Planck Institute of Neurobiology, talks with Sarah about linking the facial expressions of mice to their emotional states using machine learning. This week’s episode was produced with help from Podigy. Listen to previous podcasts. About the Science Podcast Download a transcript (PDF)




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Product :: Adobe Illustrator CC Classroom in a Book (2017 release), Web Edition




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Product :: Adobe Illustrator CC Classroom in a Book (2017 release)




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Product :: Adobe Illustrator CC Classroom in a Book (2017 release)




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Product :: Adobe Illustrator CC Classroom in a Book (2018 release)




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Product :: Adobe Illustrator CC Classroom in a Book (2018 release), Web Edition




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Product :: Adobe Illustrator CC Classroom in a Book (2018 release)




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Product :: Adobe Dimension CC Classroom in a Book (2019 Release) (Web Edition)




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Product :: Adobe Dimension CC Classroom in a Book (2019 Release)




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A deep learning approach to identify association of disease–gene using information of disease symptoms and protein sequences

Anal. Methods, 2020, 12,2016-2026
DOI: 10.1039/C9AY02333J, Paper
Xingyu Chen, Qixing Huang, Yang Wang, Jinlong Li, Haiyan Liu, Yun Xie, Zong Dai, Xiaoyong Zou, Zhanchao Li
Prediction of disease–gene association based on a deep convolutional neural network.
The content of this RSS Feed (c) The Royal Society of Chemistry




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Correction: Towards simultaneous quantification of protease inhibitors and inflammatory biomarkers in serum for people living with HIV

Anal. Methods, 2020, 12,2196-2196
DOI: 10.1039/D0AY90050H, Correction
Open Access
  This article is licensed under a Creative Commons Attribution 3.0 Unported Licence.
Pengyi Wang, Charles S. Venuto, Raymond Cha, Benjamin L. Miller
The content of this RSS Feed (c) The Royal Society of Chemistry




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Building a multimodal future: connecting real estate development and transportation demand management to ease gridlock / Justin B. Schor, Federico Tallis

Rotch Library - HE308.S36 2019




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[ASAP] Bifunctional Au@Pt/Au core@shell Nanoparticles As Novel Electrocatalytic Tags in Immunosensing: Application for Alzheimer’s Disease Biomarker Detection

Analytical Chemistry
DOI: 10.1021/acs.analchem.0c00760




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[ASAP] 27-Plex Tandem Mass Tag Mass Spectrometry for Profiling Brain Proteome in Alzheimer’s Disease

Analytical Chemistry
DOI: 10.1021/acs.analchem.0c00655




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Coronavirus: Tamil Nadu to ease lockdown restrictions in non-containment areas from Monday

The state has registered a huge increase in the number of coronavirus cases in the last few days.




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Positive Findings from Year 2 of the Centers for Medicare & Medicaid Services’ Million Hearts® Cardiovascular Disease Risk Reduction Model

Mathematica has released positive evaluation findings from Year 2 of the Million Hearts® model, just in time for American Heart Month this February.




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Powdery mildew disease of crucifers: biology, ecology and disease management / Govin Singh Saharan, Naresh K. Mehta, Prabhu Dayal Meena

Online Resource




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The Stockholm paradigm: climate change and emerging disease / Daniel R. Brooks, Eric P. Hoberg, and Walter A. Boeger

Dewey Library - QH543.B76 2019




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Sustainable management of phytoplasma diseases in crops grown in the tropical belt: biology and detection / Chrystel Y. Olivier, Tim J. Dumonceaux, Edel Pérez-López, editors

Online Resource




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Forest pest and disease management in Latin America: modern perspectives in natural forests and exotic plantations / Sergio A. Estay, editor

Online Resource




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Ocean outbreak: confronting the rising tide of marine disease / Drew Harvell

Hayden Library - QH541.5.S3 H37 2019




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Liposomal adhesion via electrostatic interactions and osmotic deflation increase membrane tension and lipid diffusion coefficient

Soft Matter, 2020, Advance Article
DOI: 10.1039/D0SM00416B, Paper
Atsushi Oda, Chiho Watanabe, Natsumi Aoki, Miho Yanagisawa
Liposome–liposome adhesion by electrostatic interactions and osmotic contraction increase membrane tension and the lipid diffusion coefficient compared to isolated liposomes.
To cite this article before page numbers are assigned, use the DOI form of citation above.
The content of this RSS Feed (c) The Royal Society of Chemistry