Five different business models for mobile fare payment apps are examined, as the world of apps used by transit agencies in the United States and Canada continues to steadily grow. The TRB Transit Cooperative Research Program's TCRP Synthesis 148: Business Models for Mobile Fare Apps documents current practices and experiences of transit agencies that offer mobile fare payment applications to transit riders. The report includes case examples from six cities: Santa Monica, Denver, Austin, Chicago, Dallas, ...

“Pavement condition data” are essential inputs to the process of managing airport pavements and ensuring safe operations. The technology available today to collect pavement condition data is considerably different from that available even 20 years ago, and new technologies are being developed and introduced into practice at a rapid pace. ACRP Research Report 203: Guidelines for Collecting, Applying, and Maintaining Pavement Condition Data at Airports provides guidance on the collection, use, maintenance,...

Barriers, berms, buildings, and natural terrain may affect the propagation of aircraft noise by shielding or reflecting sound energy. If terrain and manmade structures obstruct the line‐of‐sight between the source and the receiver, then sound energy will be attenuated at the receiver. This attenuation increases with the terrain and structures’ size and proximity to either the source or the receiver. If gaps exist in the terrain or structures, then the potential benefits of acoustical shielding will be su...

The first edition of this report, in 2009, provided a comprehensive industry reference for the management of airport deicing runoff. The second edition has been wholly updated to reflect the latest industry practices. The TRB Airport Cooperative Research Program's ACRP Research Report 14: Deicing Planning Guidelines and Practices for Stormwater Management Systems, second edition , explores a wide array of practices designed to provide for the practical, cost-effective control of runoff from aircraft and ...

TRB’s Airport Cooperative Research Program (ACRP) Report 39: Recommended Guidelines for the Collection and Use of Geospatially Referenced Data for Airfield Pavement Management offers recommended guidelines for the collection and use of geospatially referenced data for airfield pavement management. The guidelines provide a data schema, data collection methods, data quality requirements, and other relevant information required for developing specifications and standards for integrating geospatial data into...

Руководитель Delivery Club Гюванч Донмез считает, что пандемия ускорила выполнение планов компании

EPA announces the availability of the All-Ages Lead Model (AALM), Version 2 software with updated supporting documentation (External Review Draft). The AALM Model is scheduled to undergo an independent peer review by EPA's Science Advisory Board in October 2019. For more information related to scheduling and peer reviewers for this new tool, please visit the SAB AALM Project website. [Federal Register Notice Sep 24, 2019]

EPA announced the availability of the Guidelines for Human Exposure Assessment (hereafter "Guidelines"). The Guidelines present the current policies and practices of exposure assessors across the Agency and supersede the 1992 Guidelines for Exposure Assessment Edition.

The September 2015 issue of TRB’s Airport Cooperative Research Program (ACRP) Impacts on Practice explores how Philadelphia International Airport, Fort Lauderdale-Hollywood International Airport, and Changi Airport in Singapore applied guidance from ACRP Report 52 : Wayfinding and Signing Guidelines for Airport Terminals and Landside to help passengers find their way in and around an airport.

Upcoming Models No applications have been received since the last update. Finished Models No finished forms have been received since the last update. Moved Models No moved forms have been received since the last update. Closed Models (Open for application) No closed forms have been received since the last update. Report Forms: None. Overdue Models: […]

Australia bit barn outfit NEXTDC adds classic film reference to usual mix of resilience, connectivity and security

Australian serial entrepreneur Bevan Slattery has revealed that he told the architects of a data centre he funded to make it resemble the sets used in classic submarine flick The Hunt for Red October.…

Enterprise demand set to soften, offset tier-two cloud, telco sales

Global server shipments reached an industry record-breaking 3.3 million units in the first quarter of 2020, marking a 30 per cent year-on-year growth, Omdia analysts estimated this week.…

'Extra time for you to test,' you lucky, lucky developers

Google has applied the brakes to Android 11, pushing things out by a month as it grapples with a world that is much changed since planning for the release began.…

Россия якобы пытается переписать или представить однобоко историю Второй мировой войны. А строительство Россией АЭС в Белоруссии — лишь геополитический проект. Глава МИД Литвы Линас Линкявичюс отвечает на вопросы Delfi, активно используя антироссийскую риторику.

Эстонское издание провело опрос студентов к 9 мая, подведя под него антироссийскую риторику. Празднование 75-й годовщины окончания Второй мировой войны и победы над фашизмом для многих — довольно неоднозначный политический момент, считает автор.

We previously established that global deletion of the enhancer of trithorax and polycomb (ETP) gene, Asxl2, prevents weight gain. Because proinflammatory macrophages recruited to adipose tissue are central to the metabolic complications of obesity, we explored the role of ASXL2 in myeloid lineage cells. Unexpectedly, mice without Asxl2 only in myeloid cells (Asxl2ΔLysM) were completely resistant to diet-induced weight gain and metabolically normal despite increased food intake, comparable activity, and equivalent fecal fat. Asxl2ΔLysM mice resisted HFD-induced adipose tissue macrophage infiltration and inflammatory cytokine gene expression. Energy expenditure and brown adipose tissue metabolism in Asxl2ΔLysM mice were protected from the suppressive effects of HFD, a phenomenon associated with relatively increased catecholamines likely due to their suppressed degradation by macrophages. White adipose tissue of HFD-fed Asxl2ΔLysM mice also exhibited none of the pathological remodeling extant in their control counterparts. Suppression of macrophage Asxl2 expression, via nanoparticle-based siRNA delivery, prevented HFD-induced obesity. Thus, ASXL2 controlled the response of macrophages to dietary factors to regulate metabolic homeostasis, suggesting modulation of the cells’ inflammatory phenotype may impact obesity and its complications.

Seizures often herald the clinical appearance of gliomas or appear at later stages. Dissecting their precise evolution and cellular pathogenesis in brain malignancies could inform the development of staged therapies for these highly pharmaco-resistant epilepsies. Studies in immunodeficient xenograft models have identified local interneuron loss and excess glial glutamate release as chief contributors to network disinhibition, but how hyperexcitability in the peritumoral microenvironment evolves in an immunocompetent brain is unclear. We generated gliomas in WT mice via in utero deletion of key tumor suppressor genes and serially monitored cortical epileptogenesis during tumor infiltration with in vivo electrophysiology and GCAMP7 calcium imaging, revealing a reproducible progression from hyperexcitability to convulsive seizures. Long before seizures, coincident with loss of inhibitory cells and their protective scaffolding, gain of glial glutamate antiporter xCT expression, and reactive astrocytosis, we detected local Iba1+ microglial inflammation that intensified and later extended far beyond tumor boundaries. Hitherto unrecognized episodes of cortical spreading depolarization that arose frequently from the peritumoral region may provide a mechanism for transient neurological deficits. Early blockade of glial xCT activity inhibited later seizures, and genomic reduction of host brain excitability by deleting MapT suppressed molecular markers of epileptogenesis and seizures. Our studies confirmed xenograft tumor–driven pathobiology and revealed early and late components of tumor-related epileptogenesis in a genetically tractable, immunocompetent mouse model of glioma, allowing the complex dissection of tumor versus host pathogenic seizure mechanisms.