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5 College Degrees that Help with Business

Think you need an MBA in order to be a successful entrepreneur? Think again. There are many aspects to founding a successful business, and a foundation based on business (which is highly subjective) is just one of them. In fact, almost any degree you can imagine can bolster small business success if you look at it from the right angle.

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5 Industries Without a Dominant Market Leader

When launching a startup, it always helps if the industry you're breaking into does not have a juggernaut with the power to crush the competition.

While almost every sector has incumbent market leaders and new rising stars, certain industries are fragmented to the point where no single player has a major stranglehold.

As a part of Inc.s annual look at the best industries for starting a business, we decided to highlight the niche sectors that are projected to grow during the next few years and that do not have an industry leader dominating the market.

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To Succeed With Your Small Business Avoid These 5 Mistakes

At one time or another, virtually everyone thinks about starting a business. The allure of being your own boss can be strong, but it is important to remember that launching a new business is risky: According to a recent SBA report, [about 50% of all small businesses will fail within just five years.

Managing a startup can be a minefield, especially when the pull of entrepreneurship clouds your decision-making – and when you go it alone with no business experience.

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How to Travel With Your Cell Phone Without Breaking the Bank

All major wireless operators available in the U.S. offer some international roam, but the volume varies by network. To get an understanding of how your network will fare abroad, or to understand which carrier to choose if you are a regular traveler, you should first understand the two basic major technologies that wireless operators use.

How to Travel With Your Cell Phone Without Breaking the Bank




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Big Data: How To Boost Your Marketing With Analytics

Is big data just for big business? For several years, larger corporations have been gathering informative insights from this next-generation approach to data analysis. But now small businesses are finding ways to leverage this comprehensive data analysis for marketing insights.

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The Basics of How I Built a Seven-Figure Business Without Employees

There is a lot to be said for those rare few that possess the ability to create huge companies with hundreds or thousands of employees that are all just ecstatic to be at work. It is exceptionally difficult and equally as impressive, which is why they end up taking up space on the front page of a major magazine or journal.

Although it appears flashy and glamorous, particularly with the amount of celebrity that todays super entrepreneurs wield, there is a tremendous amount of flexibility that is lost, almost by default, once you pass a certain size. Now, not only am I not one of those few, but I really do not want to be.

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How to Manage People (Without Making Them Hate You)

How to Manage People (Without Making Them Hate You) - video

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Is the Honeymoon Over? 6 Ways to Fall in Love Again With Your Small Business

Starting a business is a bit like falling in love for the first time: it is exciting, exhilarating, and new. You want to savor each moment and be your very best every minute of every day.

After the adrenaline rush subsides, however, reality sets in and you may discover that not everything about running a business is so wonderful. There will be tasks you don’t like to do, activities you find stale and boring, technical difficulties to test your patience, and clients and vendors who might challenge you.

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5 Ways to Cut Small Business Expenses with Tech

For initial, up-front investment or a low-cost monthly subscription fee, there are great tech products and services that can save you money in the long run on common business expenses. Here are a few tips for small businesses with fewer than 10 employees.

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Disrupt With These Ideas

There are 28 million small businesses in the country, and they provide most of Americas jobs and sales. According to the Small Business Administration, large companies have cut four million jobs since 1990, while small businesses have created eight million. Most small businesses want to become big businesses, so a new dog-walking service is probably not going to turn into the next Uber (though you never know! Dream big!).

Here are some of the top, best, most promising industries you might want to consider where businesses are growing. They are also ripe for disruption.

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How To Deal With Stress: Tips For Small Business Owners

Despite the potential for physical, emotional, and mental stress, you can learn to lead a sustainable and healthy lifestyle as an entrepreneur.

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How to Avoid Double Taxation with an S Corporation

Paying taxes is unavoidable, yet that does not mean you need to pay more than necessary. You can make smart decisions to minimize your tax burden, without running afoul of the IRS.

For small businesses and entrepreneurs, business structure impacts how you pay taxes, and potentially how much you pay as well. The biggest difference is whether the business is its own entity responsible for paying taxes or whether the business’ profits are passed along to the owners’ individual taxes.

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Build a Following for Your Business with Facebook Watch

A Look at Facebook Watch

The Facebook Watch platform, which will be accessible on mobile, desktop and in Facebooks TV apps, will focus on shows that have episodes that fit into a theme or storyline. And users can follow their favorites so that they never miss episodes. There will also be features to help users discover new shows that fit with their interests or that their friends are talking about.

To start, Facebook Watch will only be available to a limited number of publishers while Facebook grows the platform. But the company plans to roll it out slowly to more users in the coming weeks.

Build a Following for Your Business with Facebook Watch




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To Be Successful, Be Patient With Your Imperfections

Even though I’m learning and growing daily, life is still challenging. The more I learn, grow and become better, new challenges present themselves to me.

I am learning, over and over again, that being challenged, making mistakes and not knowing what I am doing is part of life. And there is nothing wrong with that.

To Be Successful, Be Patient With Your Imperfections




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4 Things Smart People Do When They Are Tasked With a New Project (Other Than Panic)

Recently, I was asked to take over an existing project. And, like most people, my first inclination was to feel completely intimidated and overwhelmed.

This assignment -- along with its longstanding processes and its related team members -- was all brand new to me. And, if that wasn't enough to have me breathing into a paper bag, managing this project also required me to branch out and exercise some skills that I had previously left untapped.

My chest gets tight at the very thought. Can you relate? Being asked to take on a new work endeavor is a great thing (hey, you must be doing something right!). But, it can also plant plenty of seeds of self-doubt.

Fortunately, this recent experience opened my eyes to some better, more productive things you can do when you're tasked with a new project -- aside from just panicking.

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4 High-Tech Industries (and a Really Low-Tech One) That Are Booming With No End In Sight

The beginning of the new year is when the worlds top investors make their predictions of industries to keep an eye on. Innovative technologies and ways of doing business are creating growth in certain industries. For those looking for something new to invest time or money in, take a look at these five industries that experts predict to have an increase in growth in 2018.

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10 Helpful Insights to Help You Make Use of Video and Better Communicate with Customers

Video is a medium that gives your small business lots of different options for communicating and sharing information with customers. But it can be sort of overwhelming for some small businesses. Arielle Kimbarovsky of CrowdSpring offers some suggestions for businesses looking to make the most of video in a recent post.

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Google Spent a Decade Researching What Makes a Great Boss. They Came Up With These 10 Things

Those are the types of questions Google set out to answer. In 2008, they began research into what makes a good manager, code-named Project Oxygen. They originally identified eight behaviors that were common among their highest performing managers, and began training all managers to develop those behaviors. Over time, Google saw a marked improvement in key metrics such as employee turnover, satisfaction, and performance.

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Organize Your Small-Business Finances With These 7 Steps

Going into business for yourself is a big deal. There is always a long to-do list and you will find yourself wearing many different hats from time to time. Your business is more of a hobby if you are not making money. Properly managing and organizing your small-business finances can contribute to the success of your business and make sure you’re hitting your profit goals. Like personal finance, there are plenty of ways to organize your small-business finances depending on what your goals are.

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The Biggest Reason Why the U.S. Needs Small Businesses to Thrive Has Nothing to Do With Taxes or the Economy

Despite recent stock market turmoil, everywhere you looked this year someone was heralding the strength of the economy, which grew at 3.5 percent in the third quarter. However, not all economic growth favors small businesses, and some even detracts from it. The Inc. Entrepreneurship Index, which measures the quarterly health of the U.S. startup economy, currently sits at 83 out of 100 for the third quarter of 2018. This is down two points from the second quarter and a full nine points from the first quarter of 2017, when our Index peaked. Our indicator sees one factor in particular still dragging like an anchor on the startup economy: job growth.

Even though overall economic conditions have been largely favorable, small businesses have hit a growth ceiling as larger companies--bolstered by generally strong market conditions, favorable tax policies, support from local governments, and easing federal regulations--have been gobbling up talent. This is why, for the past year, the Index has shown a startup economy that is strong but slowing.

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Americas Love Affair With Small Business Rekindled

Bloom Brewery is the kind of Main Street business that shut its doors a generation ago when shopping malls lured customers to their mega-buildings with well-lit parking lots, extended hours and everything imaginable under one roof.

The brewery, which offers 24 artisanal beers on tap, sits near the Great Allegheny Passage, a 335-mile bike trail that has connected Washington, D.C., to Pittsburgh since 2013. And with it, a new kind of customer is being drawn through its doors, seeking comfort and community instead of big-box discount deals.

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How to Handle Late Paying Clients with Ease Using These Tips

The holidays puts everyone in a celebratory mood — or almost everyone. For small business owners, the celebration may be tempered by stress over unpaid invoices. My business is lucky: Lots of our clients are scrambling to issue payments before year-end to finish off their fiscal years. But for other small businesses, freelancers and entrepreneurs in the B2B world, getting paid this time of year is an ongoing struggle.

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Air Force to Host First Small Business Pitch Day with $40 Million Up For Grabs

Like departments and agencies throughout government, the Air Force is tuning its acquisition methods to get closer the speed of technology, and will be holding its first live pitch day in March, with an available funding pool of $40 million.

The Air Forces Small Business Innovation Research program has issued a call to start-ups and small businesses—those with fewer than 500 employees—to offer pitches on innovative technologies for secure communications, down-range battlefield operations and digital technologies.

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4 Lucrative Careers You Can Move Into Without Getting Another Degree

Switching careers can feel intimidating, but you have got to make some moves if you’re spinning your wheels at your current job. Tech industry jobs are hot right now, and you can make great money once you’ve got the know-how to compete with other tech candidates. Here’s a breakdown of the fields with the best opportunities.

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Google Spent 2 Years Researching What Makes a Great Remote Team. It Came Up With These 3 Things

There can come days, however, when it all feels the same and very old.

That is when we steel ourselves and insist on being creative.

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More Than 150,000 U.S. Small-Business Websites Could Be Infected With Malware at Any Given Moment

Small-business owners were victims in 43 percent of data breaches tracked between Nov. 1, 2017, and Oct. 31, 2018, according to a 2019 Verizon report. The report tracked security incidents across all industries, but the most vulnerable sectors this year were retail, accommodation and healthcare.

What does the issue look like on a national scale? If we take the sample size of infected sites SiteLock said they found in 2018 -- approximately 47,244 out of 6,056,969 checked -- and apply that percentage to the country’s estimated 30.2 million small-businesses websites, minus the estimated 36 percent that do not have one, then we can loosely estimate the amount of infected small-business websites to be around 150,757.

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Seven Ways To Save Time With Small Business Automation

Running a small business may not seem too challenging from a distance. After all, it is a small business, so how much operational and management work could there be? But since I started my own agency, I’ve realized that running a small business or firm is not as easy as it looks.

The good news is that there are plenty of best practices small businesses can follow to save time and manage their tasks more efficiently with the help of automation.

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Company Emerges to Help Small Businesses Compete with Amazons Same-Day Delivery—But With Green Cred

As companies like Amazon, Walmart, and Target begin to dazzle us with the growing possibility of same-day delivery, it’s becoming harder for small businesses to compete in ways that provide the same speedy delivery without relying on high-emission forms of commercial storage or transportation options like renting space in large warehouses and air delivery.

That is all now changing thanks to an organization called Ohi—a US-based warehousing and delivery service that allows small businesses to offer speedy, sustainable delivery options.

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Get Motivated Going Into the New Year With These Top Small Business Stories

The first weekly roundup of 2020 starts with some motivational quotes to get you up and running for the new year.

Once you are all pumped up, an article about the economy should also get you excited. The report says all 50 states have improved their GDP since the 2016 election. And if the rally of the stock market on January 2, 2020 is an indicator of things to come you can expect even better numbers.

The optimism for the coming year is also being shared by business leaders. Over two thirds or 76% of them say they see similar or more profits in 2020. The data comes as part of a survey that polled 940 business owners in this article.

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Small Business Grapples with Uncertainty

Small business challenges for 2020 will not be easy as more than eight of ten owners indicate attracting new customers is their biggest problem, and nearly six out of ten report hiring or trying to hire qualified applicants has become frustrating. Overall, small business optimism during 2019 was a roller coaster ride for many, as potential threats, such as the on-again off-again trade war with China, potential trade wars with India and Europe, has made it nearly impossible to set long-term plans. Compounding the frustration is the potential impact of the upcoming national elections.

While the Republicans have loosened regulations for small businesses, the consequences of the ill advised 2017 corporate and wealthy tax cuts are beginning to bite, thus producing a walk back in 2020.

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Half of Small Businesses May Close Within 2 Weeks

Fifty-four percent of U.S. small businesses have either closed or expect to close temporarily over the next 14 days, according to a new Chamber of Commerce survey.

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15 Steps to start a business from scratch with (almost) no money

Coming up with a business idea and starting a business can seem overwhelming and complicated. There are so many things you have to consider from coming up with an excellent idea to registering a company, all the way to business planning, fundraising and much more.

That is why we have put together this in-depth guide to take you by step by step through how you can start a business.

More info - https://entrepreneurhandbook.co.uk/starting-a-business/




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6 Ways to Come Back From the Pandemic With a Stronger Team

Working from home has accelerated innovative team-building trends. How to make traits like agility, collaboration, and candor a permanent part of our management process.

The future of work arrived out of nowhere, on the back of a once-in-a-century pandemic. Team dynamics got challenged as members dealt with illness, trauma, and crisis. We've all been forced to rapidly and radically adapt to new working norms. The Ferrazzi Greenlight Research Institute has spent more than 15 years studying high-performing teams, but I've never seen entrepreneurs rise to the occasion as they have this year. When the crisis subsides, the temptation will be to turn back that progress and retreat into old behaviors.




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Small business ideas: 5 steps on how to go digital with your business

Arguably the most critical aspect of digital transformation, digital payments ensure that small merchants or kiranas can continue to accept or send money and preserve cash flow in an increasingly contactless world.




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Why Small Business Owners Need to Reconnect With Their Mission

Pivoting has become one of those hot topics in mainstream business media. When an economic crisis arises, countless think pieces are written about how to pivot your business to respond to the external environment. But pivoting is a huge gamble, requiring deep resources and the ability to fail with minimal consequences (hence why the term is often associated with venture-backed startups). And, one must ask oneself if there’s even a solid reason to pivot.

As a small business owner, while you might feel pressure to look anywhere and everywhere to increase your top line, resist the urge to pivot. Instead, focus on your mission.  

Define your mission
In the college admissions space, disruption is something we are used to. While high-profile recruiting scandals and a renewed focus on racial inequities have dominated headlines recently, a larger cultural shift was quietly occurring.




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A business owner who spent nearly $46 million on Facebook advertising says he has been booted from the platform without explanation

A business owner who spent nearly $46 million over the years on Facebook ads said he got booted from the platform without warning.

Jordan Nabigon, the CEO of the Ottawa, Ontario, content-curation site Shared, said Facebook deleted his companys main Facebook page without warning in October, and without providing an explanation. He shared a Medium post detailing his experience, which has received more than 400 claps from readers.

Nabigon spent $45,870,181 on Facebook advertising between 2006 and 2020 for Shared and his other company Freebies, according to expense reports reviewed by Business Insider. Shared employees three people full-time and 12 contract writers, Nabigon said.

Facebook increased its use of artificial intelligence to oversee advertising and other content during the COVID-19 pandemic, and Nabigon is among hundreds of business owners who said they suffered from Facebook's crackdown on ad policies.




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With Shopify, Small Businesses Strike Back at Amazon

In a world in which e-commerce has become a necessity for nearly every retailer, it can seem they have only two options: list their goods on marketplaces run by giant companies, or sell to consumers directly, hoping they will make more on each transaction despite fewer sales. In other words, either join a dominant marketplace like eBay , Walmart or Amazon —which by itself represents 38% of U.S. online sales, according to Digital Commerce 360—or hope they can find customers through advertising and word of mouth.

For many small- and medium-size sellers, a third option has emerged, embodied by the rising star of e-commerce, Shopify . This approach gives merchants access to cloud-based third-party services such as payments and fulfillment, but lets them maintain more control of their branding and customer relationships than the biggest marketplaces offer. Shoppers might not even know they’re buying something from a Shopify-powered retailer, and that’s the point.

In addition to making goods available on sellers’ own sites, these software companies—which also include BigCommerce and Magento—can perform the laborious task of listing merchandise on the giants marketplaces. By becoming hubs for managing sales through multiple channels, including social-media platforms, they represent real competition for Amazon and its ilk, potentially giving merchants more leverage when dealing with those entrenched giants.




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Flu Shots Lag in States With Low COVID Vaccine Uptake

Title: Flu Shots Lag in States With Low COVID Vaccine Uptake
Category: Health News
Created: 6/16/2022 12:00:00 AM
Last Editorial Review: 6/16/2022 12:00:00 AM




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Before We Get On With the Day...

...I'd just like to note three things: The new site is pretty much done. The CSS needs adjusting to make...




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An Evening With Neil Gaiman

I start touring 6 weeks from now. It's the first time I've done something like this since before Covid -- get out there every night, read stories and poems and suchlike, answer questions and generally try to interact with a living, breathing audience. I'm a bit nervous, to be honest. Still, the idea of interacting with living, breathing human beings seems wonderful.

Here's the list of places I'll be appearing, with links to get tickets. Right now there are tickets available to all of the venues except Madison Wisconsin. If you are sad I'm not going to be somewhere near to you, I also am probably sad about this too.

(There are different Covid regulations at different venues, please check your venue for their protocol.)

And I'll see you there, I hope...


Thursday, April 28, 2022

Schenectady, NY

Proctor’s Theatre. 7:30 PM

https://tickets.proctors.org/TheatreManager/95/tmEvent/tmEvent13763.html

 

Friday, April 29, 2022

Boston, MA

Emerson Colonial Theatre. 8 PM

https://www.emersoncolonialtheatre.com/Online/default.asp?doWork::WScontent::loadArticle=Load&BOparam::WScontent::loadArticle::article_id=D8EA3E70-5B3E-474C-949D-98ED0073B67E

 

Sunday, May 1, 2022

Seattle, WA

Venue: Benaroya Hall 7:30 PM

https://www.seattlesymphony.org/en/benaroyahall/bh-calendar/benaroya-hall-events/neil-gaiman

 

Monday, May 2, 2022

Eugene OR

Venue: Hult Center for the Performing Arts / 7:30 PM

Link: https://tickets.hultcenter.org/971/972?_ga=2.26526261.902947090.1628807551-307867051.1626909133

 

Tuesday, May 3, 2022  

San Francisco, CA

Sydney Goldstein Theater / City Arts & Lectures / 7:30 PM

Link: https://www.cityarts.net/event/an-evening-with-neil-gaiman/

 

Thursday, May 5, 2022  

San Diego, CA

Venue: Balboa Theatre   8:00 PM

https://artpower.ucsd.edu/event/an-evening-with-neil-gaiman/

 

Sunday, May 8, 2022

Austin, TX

Venue: Dell Hall, Long Center   7:30 PM

https://bit.ly/NeilGaimanAU

 

 

Monday, May 9, 2022

Denver, CO

Venue: Paramount Theatre   7:30 PM

https://www.ticketmaster.com/neil-gaiman-denver-colorado-05-09-2022/event/1E005B63DDA12DA5

 

Wednesday, May 11, 2022

Hartford CT

The Bushnell Performing Arts Center. 7:30 PM

https://bushnell.org/shows-concerts/an-evening-with-neil-gaiman

 

Thursday, May 12, 2022

Philadelphia, PA

Merriam Theatre : 7:30 PM

https://www.kimmelculturalcampus.org/events-and-tickets/202122/kcp/neil-gaiman/

 

Friday, May 13, 2022   

Chicago IL

Auditorium Theatre 8 PM

https://mytickets.auditoriumtheatre.org/overview/3019?queueittoken=e_presaleneilgaiman~q_8f2b69c0-de3a-45c1-9688-d97522585888~ts_1636660722~ce_true~rt_safetynet~h_16adf9e6a35024c0d734c9c67136c1fc0c92bef38b10b630f2b0c7073fe03c25

 

Sunday, May 15, 2022

Madison, WI

Venue: Orpheum Theater 8PM

https://madisonorpheum.com/event/an-evening-with-neil-gaiman/

(This one is sold out, I'm afraid.)

 

Monday, May 16, 2022

Indianapolis IN

Clowes Auditorium at Butler University  7:30 PM

https://butlerartscenter.org/performance/neil-gaiman/

 

Tuesday, May 17, 2022

Cleveland OH

Playhouse Square  7:30 PM

Link: https://tickets.playhousesquare.org/online/default.asp?doWork::WScontent::loadArticle=Load&BOparam::WScontent::loadArticle::article_id=ACAD824C-ED50-471B-8438-87A341A602C6

 

Wednesday, May 18, 2022

Columbus OH 

Palace Theatre. 7:30 PM

https://my.cbusarts.com/3190

 

Friday, May 20, 2022 

Dallas, TX 

AT & T Performing Arts Center. 8:00PM


https://www.attpac.org/on-sale/2022/an-evening-with-neil-gaiman/


 

Sunday, May 22, 2022

Houston TX

Jones Hall / Society for the Performing Arts. 8 PM

https://spahouston.org/events/neil-gaiman/

 

 

Monday, May 23, 2022

Los Angeles CA

The Theatre at Ace Hotel. 8:00 PM

https://www.axs.com/events/403235/neil-gaiman-tickets

 

Thursday, May 26, 2022

Pittsburgh PA

Carnegie Music Hall   7:30 PM

https://www.ticketmaster.com/event/16005B64C93844CE



All the details are also over at https://www.neilgaiman.com/where/



  • An evening with Neil Gaiman

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Photoacoustic Imaging Industry Worth $105 million by 2029, with a CAGR of 5.5%

(EMAILWIRE.COM, October 26, 2024 ) The global Photoacoustic Imaging Market, projecting growth from USD 80 million in 2024 to USD 105 million by 2029, with a CAGR of 5.5%. Key drivers include rising investments in imaging systems and strategic partnerships. Challenges include high system costs and...




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The Near Field Communication (NFC) India Market witnesses’ integration with IoT, as per Maximize Market Research.

(EMAILWIRE.COM, October 27, 2024 ) Near Field Communication (NFC) India Market overview NFC technology is integrated with IoT devices for seamless interactions. Mobile payments are advancing with NFC for convenience. Security enhancements are prioritized for trust in NFC solutions. Near Field...




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Digital Instrument Cluster Market Growth Accelerates with Rising Demand in Automotive Sector, as per Maximize Market Research.

(EMAILWIRE.COM, November 01, 2024 ) The global Digital Instrument Cluster market is witnessing rapid growth, fueled by increasing demand for advanced automotive displays and enhanced in-car experiences. Driven by advancements in digital interfaces, these clusters provide customizable, high-resolution...




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23 Butanediol Market Sees Expansion with Increased Demand in Chemical Manufacturing, as per Maximize Market Research

(EMAILWIRE.COM, November 03, 2024 ) The Global 23 Butanediol Market is experiencing growth due to its rising demand in the chemical and industrial sectors. Used widely as an intermediate in the production of plastics, textiles, and pharmaceuticals, 23 Butanediol is essential in high-performance material...




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Aluminum Flat Rolled Products Market Sees Strong Growth with Demand from Automotive and Construction Sectors, as per Maximize Market Research

(EMAILWIRE.COM, November 04, 2024 ) The Aluminum Flat Rolled Products Market is set for expansion as demand rises in automotive, construction, and packaging industries. Aluminum’s lightweight and corrosion-resistant properties make it ideal for use in energy-efficient vehicles and sustainable buildings....




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Agricultural Tractors Market Expands with Demand for Precision Farming, as per Maximize Market Research

(EMAILWIRE.COM, November 04, 2024 ) The Global Agricultural Tractors Market is growing, fueled by a demand for precision farming and advanced agricultural machinery. Modern tractors equipped with GPS, AI, and automation technology are transforming farm efficiency, reducing labor, and increasing yield....




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Apron Bus Market Grows with Expanding Air Travel and Airport Operations, as per Maximize Market Research

(EMAILWIRE.COM, November 04, 2024 ) The Global Apron Bus Market is expanding, supported by the growth in air travel and the need for efficient airport ground operations. Apron buses transport passengers between terminals and aircraft, ensuring smooth and timely boarding. Key manufacturers are innovating...




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Exoskeleton Market Poised for Growth with Demand in Healthcare and Industrial Sectors, as per Maximize Market Research

(EMAILWIRE.COM, November 05, 2024 ) The Exoskeleton Market is projected to grow rapidly, driven by applications in healthcare rehabilitation and industrial productivity. Exoskeletons enhance mobility for those with disabilities and improve worker efficiency and safety in industries such as manufacturing...




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Biomarkers Industry worth $93.8 billion in 2029, with a CAGR of 10.2%

(EMAILWIRE.COM, November 05, 2024 ) Biomarkers Market in terms of revenue was estimated to be worth $57.7 billion in 2024 and is poised to reach $93.8 billion by 2029, growing at a CAGR of 10.2% from 2024 to 2029 according to a new report by MarketsandMarkets™. The growing significance of biomarkers...