Covid-19 is shining yet another spotlight on American systemic racism as African Americans face higher rates of death from coronavirus, as well as policing in the form of social distancing patrols, which are often racially disparate, inequitable, and aggressive. A majority of businesses have reduced operations or closed, but the NYPD has not slowed operations at all during the pandemic. Even in the midst of a historic crisis, the police oppression of Black and Brown communities perseveres. Earlier this week in New York City’s East Village, the violent arrest of a Black man allegedly defying social distancing orders was captured on camera by a witness. This was one of three arrests in the area that day by unmasked officers breaking the very social distancing rules they were ostensibly enforcing. All of these arrests have been condemned by the Legal Aid Society which is asking the NYPD to reconsider their selective social distancing enforcement. The NYPD is currently investigating the incident. In Philadelphia last month, mask requirements on public transportation led to the accosting of a Black bus rider by eight or nine police officers who then forced him off the bus instead of handing him a mask as they have […]

Embed from Getty Images It has been declared, rather dramatically, that this is a post-truth era. In making a case for this, people point to Trump lifting himself into the presidency on an unrelenting spew of untruths as well as …

Last year I traveled to Brazil to give a talk for a creative Facebook Conference. Before traveling I connected with Denise Faertes who offered to be my unofficial tour guide in Rio. Her family showed me the best time, driving around and listening to soul music, lunching at vegan spots around town, and playing dress up with items from her wonderful collection Fruto do Conde....

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The post Fruto Do Conde appeared first on Advanced Style.

The wildly influential singer and pianist established rock ’n’ roll as a genre with just one rule — there are no rules.

Our country is reeling under the dual onslaught of COVID-19 and runaway unemployment, but there’s one person who’s willing to give President Trump high marks for handing the situation: Donald Trump. “I think in a certain way, maybe our best work has been on what we’ve done with COVID-19,” he mused in an interview this week.

As much as Mayor de Blasio wants to pretend these arrests are just a drop in the bucket, from the point of view of those being constantly dropped in the bucket, the city’s heavy-handed coronavirus crackdown is just more of the same.Same profiling. Same brutality. Same disrespect.

The last suspect in the grisly gang-related Brooklyn murders of two men whose bodies were burned after they were tortured and killed pleaded guilty Friday.

The COVID-19 deaths included 22 paraprofessionals, 21 teachers, two administrators, two central office staffers, a facilities employee, a guidance counselor and a school food worker.

One Trump's smartest moves was to make Dr. Anthony Fauci a part of his coronavirus task force. Let's keep him there.

In America, the healthiest are by no coincidence also the wealthiest. The poor, the disabled and people of color get the short end of the stick.

As much as Mayor de Blasio wants to pretend these arrests are just a drop in the bucket, from the point of view of those being constantly dropped in the bucket, the city’s heavy-handed coronavirus crackdown is just more of the same.Same profiling. Same brutality. Same disrespect.

The wildly influential singer and pianist established rock ’n’ roll as a genre with just one rule — there are no rules.

In "The True History of the Kelly Gang," director Justin Kurzel's fourth and best feature, George MacKay stars as 19th-century Australian bushranger Ned Kelly.

MERVYN KING, the former governor of the Bank of England, once issued a brutal analysis of the global banking system and argued for its reinvention, it can be revealed as the Government fine-tunes its economic response to the coronavirus pandemic.

ON COUNTLESS occasions on this page I've argued forcefully for, and supported journalists in, pursuing the truth with a rigorous and forensic determination. That's what we're put on Earth to do: to sit at the back of the room staring quizzically and sometimes snorting derisively as those in power tell us the truth as they see fit to present it. Our role is straightforward: holding to account those in power, however uncomfortable or ugly the consequences might be.

Bipartisanship doesn't score you many points in politics these days. But it should, and Sen. Joe Donnelly is a perfect example of why.

The 86-year-old Supreme Court Justice repeated a regular clap back she's reserved for those who've counted her out. She isn't going anywhere.

The "notorious" Supreme Court justice posed for pictures with the actress, who was attending a performance of "Fiddler on the Roof" in New York.

The senator from Vermont and the rapper bantered and got into the issues in a new campaign video.

No, they aren’t going to pay for themselves.

Andreas Georgiou offered an honest accounting of Greece’s financial situation. He’s still paying for it.

We won’t get better outcomes with a government that repeatedly overpromises and underdelivers.

The Amateur Traveler talks to Jeremy from Palm Beach Gardens Florida who talks to use about cruising up the Norwegian coastline into the Arctic Circle on a Hurtigruten cruise. Jeremy lives someplace warm so when he and his wife travel they often travel someplace cold so cruising into the small fjords of Norway during the Winter appealed to them. Hurtigruten started as the boat that delivered the mail to the isolated villages on the coast of Norway (which it still does) but added passenger and ferry service also.

Video: Merlin Mann - "Time & Attention Talk (improvised)"

Audio (mp3): "Merlin Mann - 'Rutgers Time & Attention Talk'"

This is a talk I did at Rutgers earlier this month. I kinda like it, but for a weird reason. Something something, perfect storm of technology Ragnarok, and yadda yadda, I had to start the talk 20 minutes late with no slides. Nothing.

So, I riffed.

And, I ended up talking about a lot of the new stuff you can expect to see in the Inbox Zero book—work culture, managing expectations, the 3 deadly qualities of email, and one surprising reason email's not as much fun as Project Runway.

Some people liked it. I think. I liked it. I hope you do, too.

Here's the slides I would have shown. ;-)

Many thanks, again, to my great pal, Dr. Donald Schaffner, for bringing me in for this visit. I had a great time and met some fantastic, passionate people. Much appreciated.

update 2010-04-27_13-50-00

Apologies—my friends at Rutgers (inexplicably) have placed this video under lock and key. Fortunately, I have a lock-picker called Firefox. Samizdat video available soon...

update 2010-04-27_14-42-24

Yay, fixed! Many thanks to my hero, Jesse Schibilia.

Treatment of patients with chronic lymphocytic leukemia (CLL) with inhibitors of Bruton's tyrosine kinase (BTK), such as ibrutinib, is limited by primary or secondary resistance to this drug. Examinations of CLL patients with late relapses while on ibrutinib, which inhibits BTK's catalytic activity, revealed several mutations in BTK, most frequently resulting in the C481S substitution, and disclosed many mutations in PLCG2, encoding phospholipase C-γ2 (PLCγ2). The PLCγ2 variants typically do not exhibit constitutive activity in cell-free systems, leading to the suggestion that in intact cells they are hypersensitive to Rac family small GTPases or to the upstream kinases spleen-associated tyrosine kinase (SYK) and Lck/Yes-related novel tyrosine kinase (LYN). The sensitivity of the PLCγ2 variants to BTK itself has remained unknown. Here, using genetically-modified DT40 B lymphocytes, along with various biochemical assays, including analysis of PLCγ2-mediated inositol phosphate formation, inositol phospholipid assessments, fluorescence recovery after photobleaching (FRAP) static laser microscopy, and determination of intracellular calcium ([Ca2+]i), we show that various CLL-specific PLCγ2 variants such as PLCγ2S707Y are hyper-responsive to activated BTK, even in the absence of BTK's catalytic activity and independently of enhanced PLCγ2 phospholipid substrate supply. At high levels of B-cell receptor (BCR) activation, which may occur in individual CLL patients, catalytically-inactive BTK restored the ability of the BCR to mediate increases in [Ca2+]i. Because catalytically-inactive BTK is insensitive to active-site BTK inhibitors, the mechanism involving the noncatalytic BTK uncovered here may contribute to preexisting reduced sensitivity or even primary resistance of CLL to these drugs.

18 December 2019

Research Event

Event participants

Mathematics has helped investigators in several major cases of human rights abuses and election fraud. Among them: The 2009 election in Iran. A mathematical result known as Benford's Law states that the leading digits of truly random numbers aren't distributed uniformly, as might be expected. Instead, smaller digits, such as 1's, appear much more frequently than larger digits, such as 9's. Benford's Law and other statistical tests have been applied to the 2009 election and suggest strongly that the final totals are suspicious. Ethnic cleansing. When Slobodan Milosevic went on trial, it was his contention that the mass exodus of ethnic Albanians from Kosovo was due to NATO bombings and the activities of the Albanian Kosovo Liberation Army rather than anything he had ordered. A team collected data on the flow of refugees to test those hypotheses and was able to refute Milosevic's claim in its entirety. Guatemalan disappearances. Here, statistics is being used to extract information from over 80 million National Police archive pages related to about 200,000 deaths and disappearances. Sampling techniques give investigators an accurate representation of the records without them having to read every page. Families are getting long-sought after proof of what happened to their relatives, and investigators are uncovering patterns and motives behind the abductions and murders. Tragically, the people have disappeared. But because of this analysis, the facts won't. For More Information: Killings and Refugee Flow in Kosovo, March-June 1999, Ball et al., 2002.

Mathematics has helped investigators in several major cases of human rights abuses and election fraud. Among them: The 2009 election in Iran. A mathematical result known as Benford's Law states that the leading digits of truly random numbers aren't distributed uniformly, as might be expected. Instead, smaller digits, such as 1's, appear much more frequently than larger digits, such as 9's. Benford's Law and other statistical tests have been applied to the 2009 election and suggest strongly that the final totals are suspicious. Ethnic cleansing. When Slobodan Milosevic went on trial, it was his contention that the mass exodus of ethnic Albanians from Kosovo was due to NATO bombings and the activities of the Albanian Kosovo Liberation Army rather than anything he had ordered. A team collected data on the flow of refugees to test those hypotheses and was able to refute Milosevic's claim in its entirety. Guatemalan disappearances. Here, statistics is being used to extract information from over 80 million National Police archive pages related to about 200,000 deaths and disappearances. Sampling techniques give investigators an accurate representation of the records without them having to read every page. Families are getting long-sought after proof of what happened to their relatives, and investigators are uncovering patterns and motives behind the abductions and murders. Tragically, the people have disappeared. But because of this analysis, the facts won't. For More Information: Killings and Refugee Flow in Kosovo, March-June 1999, Ball et al., 2002.

Treatment of patients with chronic lymphocytic leukemia (CLL) with inhibitors of Bruton's tyrosine kinase (BTK), such as ibrutinib, is limited by primary or secondary resistance to this drug. Examinations of CLL patients with late relapses while on ibrutinib, which inhibits BTK's catalytic activity, revealed several mutations in BTK, most frequently resulting in the C481S substitution, and disclosed many mutations in PLCG2, encoding phospholipase C-γ2 (PLCγ2). The PLCγ2 variants typically do not exhibit constitutive activity in cell-free systems, leading to the suggestion that in intact cells they are hypersensitive to Rac family small GTPases or to the upstream kinases spleen-associated tyrosine kinase (SYK) and Lck/Yes-related novel tyrosine kinase (LYN). The sensitivity of the PLCγ2 variants to BTK itself has remained unknown. Here, using genetically-modified DT40 B lymphocytes, along with various biochemical assays, including analysis of PLCγ2-mediated inositol phosphate formation, inositol phospholipid assessments, fluorescence recovery after photobleaching (FRAP) static laser microscopy, and determination of intracellular calcium ([Ca2+]i), we show that various CLL-specific PLCγ2 variants such as PLCγ2S707Y are hyper-responsive to activated BTK, even in the absence of BTK's catalytic activity and independently of enhanced PLCγ2 phospholipid substrate supply. At high levels of B-cell receptor (BCR) activation, which may occur in individual CLL patients, catalytically-inactive BTK restored the ability of the BCR to mediate increases in [Ca2+]i. Because catalytically-inactive BTK is insensitive to active-site BTK inhibitors, the mechanism involving the noncatalytic BTK uncovered here may contribute to preexisting reduced sensitivity or even primary resistance of CLL to these drugs.

(Rutgers University) Rutgers Professor Gregory W. Moore, a renowned physicist who seeks a unified understanding of the basic forces and fundamental particles in the universe, has been elected to the prestigious National Academy of Sciences.

Treatment of patients with chronic lymphocytic leukemia (CLL) with inhibitors of Bruton's tyrosine kinase (BTK), such as ibrutinib, is limited by primary or secondary resistance to this drug. Examinations of CLL patients with late relapses while on ibrutinib, which inhibits BTK's catalytic activity, revealed several mutations in BTK, most frequently resulting in the C481S substitution, and disclosed many mutations in PLCG2, encoding phospholipase C-γ2 (PLCγ2). The PLCγ2 variants typically do not exhibit constitutive activity in cell-free systems, leading to the suggestion that in intact cells they are hypersensitive to Rac family small GTPases or to the upstream kinases spleen-associated tyrosine kinase (SYK) and Lck/Yes-related novel tyrosine kinase (LYN). The sensitivity of the PLCγ2 variants to BTK itself has remained unknown. Here, using genetically-modified DT40 B lymphocytes, along with various biochemical assays, including analysis of PLCγ2-mediated inositol phosphate formation, inositol phospholipid assessments, fluorescence recovery after photobleaching (FRAP) static laser microscopy, and determination of intracellular calcium ([Ca2+]i), we show that various CLL-specific PLCγ2 variants such as PLCγ2S707Y are hyper-responsive to activated BTK, even in the absence of BTK's catalytic activity and independently of enhanced PLCγ2 phospholipid substrate supply. At high levels of B-cell receptor (BCR) activation, which may occur in individual CLL patients, catalytically-inactive BTK restored the ability of the BCR to mediate increases in [Ca2+]i. Because catalytically-inactive BTK is insensitive to active-site BTK inhibitors, the mechanism involving the noncatalytic BTK uncovered here may contribute to preexisting reduced sensitivity or even primary resistance of CLL to these drugs.

18 December 2019

Research Event

Event participants

Mayor, Thomas -- Travel -- Australia.

Senses and sensation.

London : Health Education Council, 1985.

Over four years in Eugene, Ruthy Hebard has made a name for herself with reliability and dynamic play. She's had many memorable moments in a Duck uniform. But her career day against Washington State (34 points), her moment reaching 2,000 career points and her NCAA record for consecutive made FGs (2018) tops the list. Against the Trojans, she set the record (30) and later extended it to 33.

Pac-12 Networks' Ashley Adamson speaks with Oregon stars Sabrina Ionescu, Ruthy Hebard and Satou Sabally to hear how special their recent Naismith Starting 5 honor was, as the Ducks comprise three of the nation's top five players. Ionescu (point guard), Sabally (small forward) and Hebard (power forward) led the Ducks to a 31-2 record in the 2019-20 season before it was cut short.

Pac-12 Networks' Ashley Adamson catches up with Oregon's "Big 3" of Sabrina Ionescu, Ruthy Hebard and Satou Sabally to hear how they're adjusting to the new world without sports while still preparing for the WNBA Draft on April 17. They also share how they're staying hungry for basketball during the hiatus.

Ruthy Hebard, who ranks 2nd in Oregon history in points (2,368) and 3rd in rebounds (1,299), prepares to play in the WNBA following four years in Eugene. Hebard is the Oregon and Pac-12 all-time leader in career field-goal percentage (65.1) and averaged 17.3 points per game and a career-high 9.6 rebounds per game as a senior.

Learn how Oregon stars Sabrina Ionescu and Ruthy Hebard developed a lasting bond as college freshmen and carried that through storied four-year careers for the Ducks. Watch "Our Stories Unfinished Business: Sabrina Ionescu and Ruthy Hebard" debuting Wednesday, April 15 at 7 p.m. PT/ 8 p.m. MT on Pac-12 Network.

Ruthy Hebard and Sabrina Ionescu have had a remarkable four years together in Eugene, rewriting the history books and pushing the Ducks into the national spotlight. Catch the debut of "Our Stories Unfinished Business: Sabrina Ionescu and Ruthy Hebard" at Wednesday, April 15 at 7 p.m. PT/ 8 p.m. MT on Pac-12 Network.