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The ProteoRed MIAPE web toolkit: A user-friendly framework to connect and share proteomics standards [Technology]

The development of the HUPO-PSI's (Proteomics Standards Initiative) standard data formats and MIAPE (Minimum Information About a Proteomics Experiment) guidelines should improve proteomics data sharing within the scientific community. Proteomics journals have encouraged the use of these standards and guidelines to improve the quality of experimental reporting and ease the evaluation and publication of manuscripts. However, there is an evident lack of bioinformatics tools specifically designed to create and edit standard file formats and reports, or embed them within proteomics workflows. In this article, we describe a new web-based software suite (The ProteoRed MIAPE web toolkit) that performs several complementary roles related to proteomic data standards. Firstly, it can verify the reports fulfill the minimum information requirements of the corresponding MIAPE modules, highlighting inconsistencies or missing information. Secondly, the toolkit can convert several XML-based data standards directly into human readable MIAPE reports stored within the ProteoRed MIAPE repository. Finally, it can also perform the reverse operation, allowing users to export from MIAPE reports into XML files for computational processing, data sharing or public database submission. The toolkit is thus the first application capable of automatically linking the PSI's MIAPE modules with the corresponding XML data exchange standards, enabling bidirectional conversions. This toolkit is freely available at http://www.proteored.org/MIAPE/.




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How images frame China's role in African development

7 May 2020 , Volume 96, Number 3

George Karavas

Political leaders, policy-makers and academics routinely refer to development as an objective process of social change through the use of technical, value-free terms. Images of poverty and inequality are regularly presented as evidence of a world that exists ‘out there’ where development unfolds. This way of seeing reflects the value of scientific forms of knowledge but also sits in tension with the normative foundations of development that take European modernization and industrialization as the benchmark for comparison. The role images play in this process is often overlooked. This article argues that a dominant mode of visuality based on a Cartesian separation between subject and object, underpinning the ascendance of European hegemony and colonialism, aligns with the core premises of orthodox development discourse. An example of how visual representations of development matter is presented through images of Africa–China relations in western media sources. Using widely circulated images depicting China's impact on African development in western news media sources as an example of why visual politics matters for policy-making, the article examines how images play a role in legitimizing development planning by rendering associated forms of epistemological and structural violence ‘invisible to the viewer’.




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Online Disinformation and Political Discourse: Applying a Human Rights Framework

6 November 2019

Although some digital platforms now have an impact on more people’s lives than does any one state authority, the international community has been slow to hold to account these platforms’ activities by reference to human rights law. This paper examines how human rights frameworks should guide digital technology.

Kate Jones

Associate Fellow, International Law Programme

2019-11-05-Disinformation.jpg

A man votes in Manhattan, New York City, during the US elections on 8 November 2016. Photo: Getty Images.

Summary

  • Online political campaigning techniques are distorting our democratic political processes. These techniques include the creation of disinformation and divisive content; exploiting digital platforms’ algorithms, and using bots, cyborgs and fake accounts to distribute this content; maximizing influence through harnessing emotional responses such as anger and disgust; and micro-targeting on the basis of collated personal data and sophisticated psychological profiling techniques. Some state authorities distort political debate by restricting, filtering, shutting down or censoring online networks.
  • Such techniques have outpaced regulatory initiatives and, save in egregious cases such as shutdown of networks, there is no international consensus on how they should be tackled. Digital platforms, driven by their commercial impetus to encourage users to spend as long as possible on them and to attract advertisers, may provide an environment conducive to manipulative techniques.
  • International human rights law, with its careful calibrations designed to protect individuals from abuse of power by authority, provides a normative framework that should underpin responses to online disinformation and distortion of political debate. Contrary to popular view, it does not entail that there should be no control of the online environment; rather, controls should balance the interests at stake appropriately.
  • The rights to freedom of thought and opinion are critical to delimiting the appropriate boundary between legitimate influence and illegitimate manipulation. When digital platforms exploit decision-making biases in prioritizing bad news and divisive, emotion-arousing information, they may be breaching these rights. States and digital platforms should consider structural changes to digital platforms to ensure that methods of online political discourse respect personal agency and prevent the use of sophisticated manipulative techniques.
  • The right to privacy includes a right to choose not to divulge your personal information, and a right to opt out of trading in and profiling on the basis of your personal data. Current practices in collecting, trading and using extensive personal data to ‘micro-target’ voters without their knowledge are not consistent with this right. Significant changes are needed.
  • Data protection laws should be implemented robustly, and should not legitimate extensive harvesting of personal data on the basis of either notional ‘consent’ or the data handler’s commercial interests. The right to privacy should be embedded in technological design (such as by allowing the user to access all information held on them at the click of a button); and political parties should be transparent in their collection and use of personal data, and in their targeting of messages. Arguably, the value of personal data should be shared with the individuals from whom it derives.
  • The rules on the boundaries of permissible content online should be set by states, and should be consistent with the right to freedom of expression. Digital platforms have had to rapidly develop policies on retention or removal of content, but those policies do not necessarily reflect the right to freedom of expression, and platforms are currently not well placed to take account of the public interest. Platforms should be far more transparent in their content regulation policies and decision-making, and should develop frameworks enabling efficient, fair, consistent internal complaints and content monitoring processes. Expertise on international human rights law should be integral to their systems.
  • The right to participate in public affairs and to vote includes the right to engage in public debate. States and digital platforms should ensure an environment in which all can participate in debate online and are not discouraged from standing for election, from participating or from voting by online threats or abuse.




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Kenya's Emerging Oil and Gas Sector: Fostering Policy Frameworks for Effective Governance

Research Event

8 October 2014 - 12:00pm to 1:30pm

Chatham House, London

Event participants

Charles Wanguhu, Coordinator, Kenya CSO Platform on Oil and Gas
Ndanga Kamau, Oil and Gas Policy Adviser, Oxfam Kenya
John Ochola, Chairman, Kenya CSO Platform on Oil and Gas / EcoNews Africa
Simon Thompson, Chairman, Tullow Oil

ChairAlex Vines, Research Director, Area Studies and International Law; Head, Africa Programme, Chatham House 

In 2012, Kenya joined the swathe of East African countries with recent significant oil and gas discoveries. Long-established as a regional leader in terms of economic growth, foreign investment and technological innovation, Kenya's leaders are now assessing how to establish an effective policy framework to manage oil revenues while at the same time managing the expectations of its citizens.  

At this event, the panel will discuss how transparency and accountability can be strengthened as Kenya moves to become an oil-producing nation. This event will mark the UK launch of a report by the Kenyan Civil Society Platform on Oil and Gas, entitled Setting the Agenda for the Development of Kenya's Oil and Gas Resources.

LIVE STREAM: This event will be live streamed. The live stream will be made available at 12:00 BST on Wednesday 8 October 2014.

THIS EVENT IS NOW FULL AND REGISTRATION IS CLOSED.

Event attributes

Livestream

Christopher Vandome

Research Fellow, Africa Programme
+44 (0) 20 7314 3669




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Balancing Acts: Policy Frameworks for Migrant Return and Reintegration

In recent years, questions of whether, when, and how to return failed asylum seekers and other migrants to their origin countries have dominated migration debates in many countries. These issues were also taken up in the negotiation of the Global Compact for Safe, Orderly, and Regular Migration, moving the discussion beyond the typical bilateral one. This policy brief outlines how states might more constructively work together on returns and reintegration programs.




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Side-by-Side Comparison of the 2013 Senate Immigration Framework with 2006 and 2007 Senate Legislation

MPI has completed an analysis of the major provisions in the 2013 framework, comparing them to provisions of the legislation the Senate considered in 2006 and 2007. 

This fact sheet is formatted as a chart comparing the framework of comprehensive immigration reform outlined in the 2013 Senate immigration bill against provisions included in bills considered by the Senate in 2006 and 2007.




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A Strategic Framework for Creating Legality and Order in Immigration

This report analyzes how governments ought to best allocate their resources to address the risks associated with migration—the "immigration harms" that undermine the positive economic and social benefits of immigration—including choosing which threats to tackle and where to prioritize enforcement efforts. Immigration policymakers can learn from other public policy regulation efforts to ensure that regulatory actions advance the public interest.




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Commonwealth child safe framework / Department of the Prime Minister and Cabinet, National Office for Child Safety.

This publication outlines the Commonwealth Child Safe Framework requirements and guidance for its implementation.The primary audience for this publication is Commonwealth entities. This publication has been developed to assist entities to understand and implement the requirements of the Commonwealth Child Safe Framework.




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Review of the Australian Qualifications Framework : final report 2019.




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Stigma & Resilience Framework : (National strategic framework to address HIV stigma and build resilience capacity for people living with HIV) / written and edited by Brent Allan and Kirsten Machon.

"The HIV resilience framework will be of relevance to a wide range of people involved at all levels of the HIV response. We hope it provides encouragement for government decision makers and policy developers to pursue consistent and enabling policy and legislative environments and work cooperatively between jurisdictions and across departments to achieve best practice. Our consultation suggests that consistent legislation with the goal of supporting strong health outcomes, making disclosure safe, and eliminating stigmatising laws is crucial to creating environments in which people with HIV feel safe to access testing, treatment, and care. The HIV resilience framework also contains valuable insights for those who have responsibility for HIV health program management and service delivery, providing guidance to help ensure that programs, services, interventions or strategies supporting people living with HIV are developed and delivered in a way that is mindful of the interlinked twin goals of building personal resilience and eliminating stigma and discrimination." --President's message (page 6).




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A reproducible framework for 3D acoustic forward modelling of hard rock geological models with Madagascar / Andrew Squelch, Mahyar Madadi, Milovan Urosevic.

"A special challenge of hard rock exploration is to identify targets of interest within complex geological settings. Interpretation of the geology can be made from direct geological observations and knowledge of the area, and from 2D or 3D seismic surveys. These interpretations can be developed into 3D geological models that provide the basis for predictions as to likely targets for drilling and/or mining. To verify these predictions we need to simulate 3D seismic wave propagation in the proposed geological models and compare the simulation results to seismic survey data. To achieve this we convert geological surfaces created in an interpretation software package into discretised block models representing the different lithostratigraphic units, and segment these into discrete volumes to which appropriate density and seismic velocity values are assigned. This approach allows us to scale models appropriately for desired wave propagation parameters and to go from local to global geological models and vice versa. Then we use these digital models with forward modelling codes to undertake numerous 3D acoustic wave simulations. Simulations are performed with single shot and with exploding reflector (located on extracted geological surface) configurations" -- Summary.




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Gun control : what Australia got right (and wrong) / Tom Frame.

Gun control -- Australia.




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Elements of pathology and therapeutics being the outlines of a work, intended to ascertain the nature, causes, and most efficacious modes of prevention and cure, of the greater number of the diseases incidental to the human frame : illustrated by numerous

Bath : And sold by Underwood, London, 1825.




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Expectation Propagation as a Way of Life: A Framework for Bayesian Inference on Partitioned Data

A common divide-and-conquer approach for Bayesian computation with big data is to partition the data, perform local inference for each piece separately, and combine the results to obtain a global posterior approximation. While being conceptually and computationally appealing, this method involves the problematic need to also split the prior for the local inferences; these weakened priors may not provide enough regularization for each separate computation, thus eliminating one of the key advantages of Bayesian methods. To resolve this dilemma while still retaining the generalizability of the underlying local inference method, we apply the idea of expectation propagation (EP) as a framework for distributed Bayesian inference. The central idea is to iteratively update approximations to the local likelihoods given the state of the other approximations and the prior. The present paper has two roles: we review the steps that are needed to keep EP algorithms numerically stable, and we suggest a general approach, inspired by EP, for approaching data partitioning problems in a way that achieves the computational benefits of parallelism while allowing each local update to make use of relevant information from the other sites. In addition, we demonstrate how the method can be applied in a hierarchical context to make use of partitioning of both data and parameters. The paper describes a general algorithmic framework, rather than a specific algorithm, and presents an example implementation for it.




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A Unified Framework for Structured Graph Learning via Spectral Constraints

Graph learning from data is a canonical problem that has received substantial attention in the literature. Learning a structured graph is essential for interpretability and identification of the relationships among data. In general, learning a graph with a specific structure is an NP-hard combinatorial problem and thus designing a general tractable algorithm is challenging. Some useful structured graphs include connected, sparse, multi-component, bipartite, and regular graphs. In this paper, we introduce a unified framework for structured graph learning that combines Gaussian graphical model and spectral graph theory. We propose to convert combinatorial structural constraints into spectral constraints on graph matrices and develop an optimization framework based on block majorization-minimization to solve structured graph learning problem. The proposed algorithms are provably convergent and practically amenable for a number of graph based applications such as data clustering. Extensive numerical experiments with both synthetic and real data sets illustrate the effectiveness of the proposed algorithms. An open source R package containing the code for all the experiments is available at https://CRAN.R-project.org/package=spectralGraphTopology.




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GADMM: Fast and Communication Efficient Framework for Distributed Machine Learning

When the data is distributed across multiple servers, lowering the communication cost between the servers (or workers) while solving the distributed learning problem is an important problem and is the focus of this paper. In particular, we propose a fast, and communication-efficient decentralized framework to solve the distributed machine learning (DML) problem. The proposed algorithm, Group Alternating Direction Method of Multipliers (GADMM) is based on the Alternating Direction Method of Multipliers (ADMM) framework. The key novelty in GADMM is that it solves the problem in a decentralized topology where at most half of the workers are competing for the limited communication resources at any given time. Moreover, each worker exchanges the locally trained model only with two neighboring workers, thereby training a global model with a lower amount of communication overhead in each exchange. We prove that GADMM converges to the optimal solution for convex loss functions, and numerically show that it converges faster and more communication-efficient than the state-of-the-art communication-efficient algorithms such as the Lazily Aggregated Gradient (LAG) and dual averaging, in linear and logistic regression tasks on synthetic and real datasets. Furthermore, we propose Dynamic GADMM (D-GADMM), a variant of GADMM, and prove its convergence under the time-varying network topology of the workers.




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Alternating Maximization: Unifying Framework for 8 Sparse PCA Formulations and Efficient Parallel Codes. (arXiv:1212.4137v2 [stat.ML] UPDATED)

Given a multivariate data set, sparse principal component analysis (SPCA) aims to extract several linear combinations of the variables that together explain the variance in the data as much as possible, while controlling the number of nonzero loadings in these combinations. In this paper we consider 8 different optimization formulations for computing a single sparse loading vector; these are obtained by combining the following factors: we employ two norms for measuring variance (L2, L1) and two sparsity-inducing norms (L0, L1), which are used in two different ways (constraint, penalty). Three of our formulations, notably the one with L0 constraint and L1 variance, have not been considered in the literature. We give a unifying reformulation which we propose to solve via a natural alternating maximization (AM) method. We show the the AM method is nontrivially equivalent to GPower (Journ'{e}e et al; JMLR 11:517--553, 2010) for all our formulations. Besides this, we provide 24 efficient parallel SPCA implementations: 3 codes (multi-core, GPU and cluster) for each of the 8 problems. Parallelism in the methods is aimed at i) speeding up computations (our GPU code can be 100 times faster than an efficient serial code written in C++), ii) obtaining solutions explaining more variance and iii) dealing with big data problems (our cluster code is able to solve a 357 GB problem in about a minute).




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Deep Learning Framework for Detecting Ground Deformation in the Built Environment using Satellite InSAR data. (arXiv:2005.03221v1 [cs.CV])

The large volumes of Sentinel-1 data produced over Europe are being used to develop pan-national ground motion services. However, simple analysis techniques like thresholding cannot detect and classify complex deformation signals reliably making providing usable information to a broad range of non-expert stakeholders a challenge. Here we explore the applicability of deep learning approaches by adapting a pre-trained convolutional neural network (CNN) to detect deformation in a national-scale velocity field. For our proof-of-concept, we focus on the UK where previously identified deformation is associated with coal-mining, ground water withdrawal, landslides and tunnelling. The sparsity of measurement points and the presence of spike noise make this a challenging application for deep learning networks, which involve calculations of the spatial convolution between images. Moreover, insufficient ground truth data exists to construct a balanced training data set, and the deformation signals are slower and more localised than in previous applications. We propose three enhancement methods to tackle these problems: i) spatial interpolation with modified matrix completion, ii) a synthetic training dataset based on the characteristics of real UK velocity map, and iii) enhanced over-wrapping techniques. Using velocity maps spanning 2015-2019, our framework detects several areas of coal mining subsidence, uplift due to dewatering, slate quarries, landslides and tunnel engineering works. The results demonstrate the potential applicability of the proposed framework to the development of automated ground motion analysis systems.




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A unified principled framework for resampling based on pseudo-populations: Asymptotic theory

Pier Luigi Conti, Daniela Marella, Fulvia Mecatti, Federico Andreis.

Source: Bernoulli, Volume 26, Number 2, 1044--1069.

Abstract:
In this paper, a class of resampling techniques for finite populations under $pi $ps sampling design is introduced. The basic idea on which they rest is a two-step procedure consisting in: (i) constructing a “pseudo-population” on the basis of sample data; (ii) drawing a sample from the predicted population according to an appropriate resampling design. From a logical point of view, this approach is essentially based on the plug-in principle by Efron, at the “sampling design level”. Theoretical justifications based on large sample theory are provided. New approaches to construct pseudo populations based on various forms of calibrations are proposed. Finally, a simulation study is performed.




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A framework for mesencephalic dopamine systems based on predictive Hebbian learning

PR Montague
Mar 1, 1996; 16:1936-1947
Articles




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Crisis management framework: what remains to be done?

Welcoming remarks by Mr Fernando Restoy, Chairman, Financial Stability Institute, Bank for International Settlements, at the FSI-IADI conference on crisis management, resolution and deposit insurance: what's next and how to prepare, Basel, 4 September 2019.




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Basel Committee publishes consultation paper on revisions to the credit valuation adjustment risk framework

Press release about the Basel Committee publishing consultation paper on revisions to the credit valuation adjustment risk framework, 28 November 2019.




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Launch of the consolidated Basel Framework

Press release about the Basel Committee launching the consolidated Basel Framework, 16 December 2019.




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Basel Committee assesses members' implementation of the Net Stable Funding Ratio and large exposures framework

Press release about Basel Committee assesses members' implementation of the Net Stable Funding Ratio and large exposures framework, 19 March 2020




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Picture special: Shahbaz Majeed puts Scotland in the frame

RIGHT now, Shahbaz Majeed should be heading to Glencoe. Or flying over central Scotland. Or making his way to Harris which he has been trying to get back to since his first visit in 2018. Or maybe visiting some other part of Scotland so he can capture it in a photograph. Instead, he is at home in Dundee (where he is web development manager at the University of Dundee), “climbing the walls,” and looking forward to life after lockdown.




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Herald Diary: Roddy Frame, errant golf balls and the world’s worst thesaurus

Dried up talent




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Identifying Very Preterm Children at Educational Risk Using a School Readiness Framework

Children born very preterm (VPT) are at high risk of educational delay. School readiness has been identified as a potentially useful clinical framework for early detection of those at greatest risk. However, evidence to support its predictive validity is limited.

VPT preschoolers are at risk of impairment across the 5 American Academy of Pediatrics school readiness domains. The number of domains affected predicted likelihood of later learning problems, supporting the utility of schoolreadiness frameworks for identifying children needing surveillance and/or support. (Read the full article)




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Burundi: Breaking the Deadlock, The Urgent Need for a New Negotiating Framework




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A Framework for Responsible Aid to Burundi




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Chad: A New Conflict Resolution Framework




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Save Up to $1,250 on Samsung's 2019 'The Frame' 4K TV

Use the coupon code below to snag the 55-inch model for just $1,249 (down from $1,999.99) or the 65-inch model for $1,549 (down from $2,799.99).




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Review of Securities Lending and Borrowing (SLB) Framework

 Review of Securities Lending and Borrowing (SLB) Framework

Full Article



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How to implement Gesture Sequences in Unity 3D game engine via TouchScript framework

  When configuring touch targets to control other elements of a scene, it’s important to minimize the screen space that the controlling elements occupy. In this way, you can devote more of the Ult...




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How to analyze the performance of C/C++ and debugging OpenGL ES frames on ARM and x86 Android devices

  When developing an Android* application, you usually need to test, optimize, and debug on many different platforms. While basically every hardware and chip manufacturer provides a set of custom tools...




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Efsa publishes framework for scientific assessments

Intended for staff and external experts




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Nordic Council: keep ambition high on post-2020 chemicals framework

'Necessary' for sustainable recovery after Covid-19 pandemic




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Framework for Domestic Systemically Important Banks

RBI releases Framework for dealing with Domestic Systemically Important Banks (D-SIBs)




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Golden Frames 2016 International Short Film Festival

Golden Frames 2016 - International Short Film Festival, Mumbai, India




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Create the title & frame for view schematic

Hi all,

I want to write a script SKILL to create the title & frame for view schematic. My question is whether SKILL supports any function for me to do this.

Best regards,

Huy Hoang




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WebSploit Framework 4.0.1

WebSploit is an advanced man-in-the-middle framework.




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Mobile Security Framework MobSF 0.9.2 Beta

Mobile Security Framework (MobSF) is an all-in-one open source mobile application (Android/iOS) automated pen-testing framework capable of performing static and dynamic analysis. It can be used for effective and fast security analysis of Android and iOS Applications and supports both binaries (APK & IPA) and zipped source code. MobSF can also do Web API Security testing with it's API Fuzzer that performs Information Gathering, analyze Security Headers, identify Mobile API specific vulnerabilities like XXE, SSRF, Path Traversal, IDOR, and other logical issues related to Session Management and API Rate Limiting.




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Mobile Security Framework MobSF 0.9.3 Beta

Mobile Security Framework (MobSF) is an all-in-one open source mobile application (Android/iOS) automated pen-testing framework capable of performing static and dynamic analysis. It can be used for effective and fast security analysis of Android and iOS Applications and supports both binaries (APK & IPA) and zipped source code. MobSF can also do Web API Security testing with it's API Fuzzer that performs Information Gathering, analyze Security Headers, identify Mobile API specific vulnerabilities like XXE, SSRF, Path Traversal, IDOR, and other logical issues related to Session Management and API Rate Limiting.




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Building A Simple Proxy Fuzzer For THe MQTT Protocol Using The Polymorph Framework

Whitepaper that shows how easy you can build a fuzzer for the MQTT protocol by using the Polymorph framework.




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.NET Framework 4.6 DLL Hijacking

A DLL side loading vulnerability was found in the .NET Framework version 4.6 when running on Windows Vista or Windows 7. This issue can be exploited by luring a victim into opening an Office document from the attacker's share. An attacker can use this issue to execute arbitrary code with the privileges of the target user. This can potentially result in the attacker taking complete control of the affected system. If the WebDAV Mini-Redirector is enabled, it is possible to exploit this issue over the internet. This issue can be exploited even if the Office document is opened in Protected View.




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GNUnet P2P Framework 0.11.5

GNUnet is a peer-to-peer framework with focus on providing security. All peer-to-peer messages in the network are confidential and authenticated. The framework provides a transport abstraction layer and can currently encapsulate the network traffic in UDP (IPv4 and IPv6), TCP (IPv4 and IPv6), HTTP, or SMTP messages. GNUnet supports accounting to provide contributing nodes with better service. The primary service build on top of the framework is anonymous file sharing.




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Macs Framework 1.14f Cross Site Scripting / SQL Injection

Macs Framework version 1.14f suffers from cross site scripting and remote SQL injection vulnerabilities.




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RBI: Information Security Framework Released

The Institute for Development and Research in Banking Technology has prepared an information security framework to help banks in benchmarking their systems and enhancing information security.




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NVIDIA and King’s College London Announce MONAI Open Source AI Framework for Healthcare Research

It’s never been more important to put powerful AI tools in the hands of the world’s leading medical researchers. That’s why we’re introducing MONAI, our latest initiative with King’s College London. This open-source AI framework for healthcare builds on the best practices from existing tools, including NVIDIA Clara, NiftyNet, DLTK and DeepNeuro. MONAI is user-friendly, Read article >

The post NVIDIA and King’s College London Announce MONAI Open Source AI Framework for Healthcare Research appeared first on The Official NVIDIA Blog.




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Streets Ahead on Devolution? – Consultation Launched on Greater Manchester’s Spatial Framework

Manchester is the City Region that has most enthusiastically embraced the devolution agenda – unsurprisingly, perhaps, given its long standing commitment to the cause of devolved powers and city region autonomy. In addition to embracing the Me...




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Court of Appeal finds that injunctions against “persons unknown” can (i) be framed by reference to a defendant’s intention and (ii) prohibit lawful conduct

Cuadrilla Bowland Ltd & Ors v Persons Unknown & Ors [2020] EWCA Civ 9 Background In Boyd v Ineos Upstream Ltd...