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Bayes Factor Testing of Multiple Intraclass Correlations

Joris Mulder, Jean-Paul Fox.

Source: Bayesian Analysis, Volume 14, Number 2, 521--552.

Abstract:
The intraclass correlation plays a central role in modeling hierarchically structured data, such as educational data, panel data, or group-randomized trial data. It represents relevant information concerning the between-group and within-group variation. Methods for Bayesian hypothesis tests concerning the intraclass correlation are proposed to improve decision making in hierarchical data analysis and to assess the grouping effect across different group categories. Estimation and testing methods for the intraclass correlation coefficient are proposed under a marginal modeling framework where the random effects are integrated out. A class of stretched beta priors is proposed on the intraclass correlations, which is equivalent to shifted $F$ priors for the between groups variances. Through a parameter expansion it is shown that this prior is conditionally conjugate under the marginal model yielding efficient posterior computation. A special improper case results in accurate coverage rates of the credible intervals even for minimal sample size and when the true intraclass correlation equals zero. Bayes factor tests are proposed for testing multiple precise and order hypotheses on intraclass correlations. These tests can be used when prior information about the intraclass correlations is available or absent. For the noninformative case, a generalized fractional Bayes approach is developed. The method enables testing the presence and strength of grouped data structures without introducing random effects. The methodology is applied to a large-scale survey study on international mathematics achievement at fourth grade to test the heterogeneity in the clustering of students in schools across countries and assessment cycles.




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Bayesian Effect Fusion for Categorical Predictors

Daniela Pauger, Helga Wagner.

Source: Bayesian Analysis, Volume 14, Number 2, 341--369.

Abstract:
We propose a Bayesian approach to obtain a sparse representation of the effect of a categorical predictor in regression type models. As this effect is captured by a group of level effects, sparsity cannot only be achieved by excluding single irrelevant level effects or the whole group of effects associated to this predictor but also by fusing levels which have essentially the same effect on the response. To achieve this goal, we propose a prior which allows for almost perfect as well as almost zero dependence between level effects a priori. This prior can alternatively be obtained by specifying spike and slab prior distributions on all effect differences associated to this categorical predictor. We show how restricted fusion can be implemented and develop an efficient MCMC (Markov chain Monte Carlo) method for posterior computation. The performance of the proposed method is investigated on simulated data and we illustrate its application on real data from EU-SILC (European Union Statistics on Income and Living Conditions).




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The 2019 Victoria’s Secret Fashion Show Is Canceled After Facing Backlash for Lack of Body Diversity

The reaction on social media has been fierce.




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Brain-Derived Neurotrophic Factor Protection of Cortical Neurons from Serum Withdrawal-Induced Apoptosis Is Inhibited by cAMP

Steven Poser
Jun 1, 2003; 23:4420-4427
Cellular




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Afterschool Program Instructors




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Aquatics Instructor




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Oportunidades y riesgos de la entrada de las big tech en el sector financiero

Spanish version of BIS Press Release - Big tech in finance: opportunities and risks, 23 June 2019




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7 success factors to empowering rural women through ICTs

The digital revolution has changed the way we work, access information and connect with each other. It offers opportunities to those who can use the new technologies, but also presents new challenges for those who are left behind. Often referred to collectively as Information and Communications Technologies or ICTs, these technologies are any method of electronically sharing or storing data: telephones, [...]




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Poo-Sniffing Peeps, Miss Ameripeep and More Emerge Victorious in #PeepYourScience 2020 Competition

Blending marshmallows with scientific rigor, the contest offers levity during a difficult time




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Archaeologists Unearth Remnants of Lost Scottish Wine-Bottle Glass Factory

The 18th-century Edinburgh factory once produced a million bottles a week




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October Baby




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$612K award to Giant Mine contractor overturned

In a written decision released Thursday, a panel of three appeal court judges said the judge who granted the award to McCaw North Drilling and Blasting Ltd. misinterpreted a clause in the contract for the cleanup.



  • News/Canada/North

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Comment on Tamil flick Endhiran slated to hit theatres on 1st October by Media Wettbewerbe

<span class="topsy_trackback_comment"><span class="topsy_twitter_username"><span class="topsy_trackback_content">Tamil flick Endhiran slated to hit theatres on 1st October | RSS ...: Mumbai (Bollypatrika News): Tamil flick “End... http://bit.ly/dxOe6H</span></span>




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Alberta doctors push back against government's 'divide-and-conquer' strategy

"It is unfortunate that it has come to pass that we have to collectively and overtly publicly declare that we are unified," says Alberta Medical Association president Christine Molnar.



  • News/Canada/Edmonton

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Should you go to your camp? Island doctor says seasonal visitors 'a perfect storm' during COVID-19

A doctor on Manitoulin Island is encouraging seasonal residents to stay home and not to come visit during the COVID-19 pandemic.



  • News/Canada/Sudbury

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Two-Step Bacterial Artificial Chromosome (BAC) Engineering: Electroporation of Competent BAC Host Cells with the Recombinant Shuttle Vector

Bacterial artificial chromosome (BAC) clones are rendered electrocompetent and transformed with the recombinant shuttle vector, pLD53SCAB/AB-box. Cointegrates are selected by growth on chloramphenicol and ampicillin to ensure recombination of the shuttle vector into the BAC.




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Two-Step Bacterial Artificial Chromosome (BAC) Engineering: Preparation and Verification of the Recombinant Shuttle Vector

Plasmid DNA is prepared from the recombinant shuttle vector pLD53.SCAB/A-B created by cloning of the A and B homology arms for two-step bacterial artificial chromosome (BAC) engineering. To confirm that the A-box and B-box arms have been successfully incorporated into pLD53.SCAB, the pattern of enzyme digestion of the modified plasmid is compared with that of the unmodified pLD53.SCAB. Once the shuttle vector is shown to carry the proper sequences, it is ready for transfer into the BAC host.




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Two-Step Bacterial Artificial Chromosome (BAC) Engineering: Cloning of the A and B Homology Arms into the Shuttle Vector

This protocol describes the preparation of the shuttle vector before its introduction into bacterial artificial chromosome (BAC) host cells for BAC two-step engineering. The homology arm sequences, prepared previously, are introduced by ligation into the digested shuttle vector DNA to provide sites for recombination within the BAC clone. Crude lysates of individual bacterial transformants serve as templates in polymerase chain reaction (PCR) analysis to confirm the presence of the homology arms in the recombinant shuttle vector.




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Two-Step Bacterial Artificial Chromosome (BAC) Engineering: Preparation of Shuttle Vector DNA

In two-step bacterial artificial chromosome (BAC) engineering, a single plasmid is introduced into the BAC-carrying cell lines. The shuttle vector pLD53.SCAB (or pLD53.SCAEB) carries the recA gene and the R6K origin, which requires the protein to replicate. PIR2 cells, expressing , are typically used for the amplification of the vector and maintain about 15 copies/cell of the donor vector, which is relatively stable in this host.




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Covid-19 and corporate sector liquidity

The Covid-19 shock is placing enormous strains on corporates cash buffers. Corporate financial statements from 2019 suggest that 50% of firms do not have sufficient cash to cover total debt servicing costs over the coming year. Credit lines could provide firms with additional liquidity. On average undrawn credit stood around 120% of debt servicing costs at end 2019. However, access is uneven and banks may be reluctant to renew or extend them in the current environment. Sticky operating expenses result in many firms running operating losses, placing an additional burden on cash buffers. Estimates indicate that following a 10% drop in revenues, operating expenses only fall by 6% on average. Simulations suggest that if revenues fall by 25% in 2020, then closing the entire funding gap with debt would raise firm leverage by around 10 percentage points.




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Equities: Will Early Trends in Select Sectors Last?

Information technology, health care, and consumer discretionary stocks that outperformed in the last decade have done well in the first four months of 2020.




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Dimitar Radev: The Bulgarian banking sector under Covid-19

Publication by Mr Dimitar Radev, Governor of the Bulgarian National Bank, in the Quarterly Bulletin of the Association of Banks in Bulgaria, issue 61, March 2020.




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Thomas Jordan: Introductory remarks, Swiss National Bank news conference

Introductory remarks by Mr Thomas Jordan, Chairman of the Governing Board of the Swiss National Bank, at the Media News Conference of the Swiss National Bank, Berne, 25 March 2020.




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Cyber Actors Take Advantage of COVID-19 Pandemic to Exploit Increased Use of Virtual Environments




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B.C. government extends deadline on Victoria tent city closures

The province has extended the deadline for people to leave tent cities in Victoria until May 20. The original deadline was May 9 for campers to be out of Vancouver's Oppenheimer Park as well as Topaz and Pandora parks in Victoria.



  • News/Canada/British Columbia

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Boa constrictor, weapons seized from Oppenheimer park by Vancouver police

Vancouver police officers have seized an eight-foot boa constrictor and multiple weapons from a tent at the Oppenheimer park encampment in Vancouver.



  • News/Canada/British Columbia

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Victory over death in a cemetery - Zimbabwe

An OM team has a rare opportunity to share the Gospel with the Doma people at the funeral of a senior member of the community.




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Community spread blamed for over half of Ontario's new COVID-19 cases, 'perplexing' top doctor

After several days in which fewer than 400 cases of COVID-19 were added to the provincial tally, Friday's report was up again, with 477 new cases reported.



  • News/Canada/Toronto

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Putin presides over slimmed down Victory Day as coronavirus cases rise

Russia marked 75 years since the Soviet victory over Nazi Germany in the Second World War on Saturday, but the coronavirus outbreak forced it to scale back celebrations seen as boosting support for President Vladimir Putin.




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Canucks and B.C.'s top doctor show interest in hosting NHL games in Vancouver

Provincial health officer Dr. Bonnie Henry says there are ways to safely host NHL games in Vancouver if the league goes ahead with resuming the season in a small number of hub cities.



  • News/Canada/British Columbia

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13 cases of COVID-19 linked to curling bonspiel attended by doctors from across western Canada

The bonspiel took place in Edmonton March 11-14, starting the same day COVID-19 was declared a global pandemic.



  • News/Canada/Saskatchewan

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Christine Lagarde: ECB press conference - introductory statement

Introductory statement by Ms Christine Lagarde, President of the European Central Bank, and Mr Luis de Guindos, Vice-President of the European Central Bank, Frankfurt am Main, 30 April 2020.




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Credit to the non-financial sector

Advanced preliminary release for Q4 2019 quarterly data on total credit to the non-financial sectors; comprising private non-financial sector and general government for 44 economies and regional aggregates have been updated. Data are available for the following borrowing subsectors: general government, private non-financial sector (series on credit from domestic banks as lending sector are also available), non-financial corporations and households. Data are presented in three versions: in billions of local currency and US dollars, and as a percentage of GDP.




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Debt service ratios for the private non-financial sector

Advanced preliminary release for Q4 2019 quarterly data on debt service ratios (DSRs) for the private non-financial sector (PNFS) for 32 countries have been updated. DSRs for PNFS breakdown sectors, ie for households and for non-financial corporations are also available for 17 countries.




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Effects of Covid-19 on the banking sector: the market's assessment

Banks' performance on equity and debt markets since the Covid-19 outbreak has been on a par with that experienced after the collapse of Lehman Brothers in 2008. During the initial phase, the market sell-off swept over all banks, which underperformed significantly relative to other sectors. Still, markets showed some differentiation by bank nationality, and credit default swap (CDS) spreads rose the most for those banks that had entered the crisis with the highest level of credit risk. The subsequent stabilisation, brought about by forceful policy measures since mid-March, has favoured banks with higher profitability and healthier balance sheets. Less profitable banks saw their long-term rating outlooks revised to negative. And the CDS spreads of the riskiest banks continued increasing even through the stabilisation phase.




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Equities: Will Early Trends in Select Sectors Last?

Information technology, health care, and consumer discretionary stocks that outperformed in the last decade have done well in the first four months of 2020.




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The making of a cyber crash: a conceptual model for systemic risk in the financial sector

European Systemic Risk Board Occasional Papers by Greg Ros




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Measuring Systemic Risk: A Quantile Factor Analysis

Central Bank of Chile Working Papers by Andrés Sagner




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‘I Do Fear for My Staff,’ a Doctor Said. He Lost His Job.

Health care professionals are being punished for protecting themselves, and us.




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A Young Doctor, Fighting for His Life

“I just went down on my knees,” his mother recalled later. “I just implored God for mercy.”




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Thank God the Doctor Is In

Peeking out our windows, we see America shriveling.




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O’Bannon’s Hollow Victory Over the N.C.A.A.

The association is happy with a ruling that found it violated the law.




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What the witch doctor saw

A Malagasy witch doctor comes to faith in Christ during an OM outreach and is baptised just one week before his death.




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Octodon degus (Molina 1782): A Model in Comparative Biology and Biomedicine

One major goal of integrative and comparative biology is to understand and explain the interaction between the performance and behavior of animals in their natural environment. The Caviomorph, Octodon degu, is a native rodent species from Chile, and represents a unique model to study physiological and behavioral traits, including cognitive and sensory abilities. Degus live in colonies and have a well-structured social organization, with a mostly diurnal–crepuscular circadian activity pattern. More notable is the fact that in captivity, they reproduce and live between 5 and 7 yr and show hallmarks of neurodegenerative diseases (including Alzheimer's disease), diabetes, and cancer.




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Doctors and therapists point to Jesus

On a recent outreach to several towns in the Amazon jungle, OM Peru worked with the Presbyterian Church of Moyabamba and its annexes.




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From web manager to national director

Stephen Brandon takes on the role of national director for OM New Zealand after serving as OM’s International Web Manager for six years.




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Factors Associated With Seizure Onset in Children With Autism Spectrum Disorder

BACKGROUND AND OBJECTIVES:

Children with autism spectrum disorder (ASD) have a higher prevalence of epilepsy compared with general populations. In this pilot study, we prospectively identified baseline risk factors for the development of seizures in individuals with ASD and also identified characteristics sensitive to seizure onset up to 6 years after enrollment in the Autism Speaks Autism Treatment Network.

METHODS:

Children with ASD and no history of seizures at baseline who either experienced onset of seizures after enrollment in the Autism Treatment Network or remained seizure free were included in the analysis.

RESULTS:

Among 472 qualifying children, 22 (4.7%) experienced onset of seizures after enrollment. Individuals who developed seizures after enrollment exhibited lower scores at baseline on all domains of the Vineland Adaptive Behavior Scales, greater hyperactivity on the Aberrant Behavior Checklist (25.4 ± 11.8 vs 19.2 ± 11.1; P = .018), and lower physical quality of life scores on the Pediatric Quality of Life Inventory (60.1 ± 24.2 vs 76.0 ± 18.2; P < .001). Comparing change in scores from entry to call-back, adjusting for age, sex, length of follow-up, and baseline Vineland II composite score, individuals who developed seizures experienced declines in daily living skills (–8.38; 95% confidence interval –14.50 to –2.50; P = .005). Adjusting for baseline age, sex, and length of follow-up, baseline Vineland II composite score was predictive of seizure development (risk ratio = 0.95 per unit Vineland II composite score, 95% confidence interval 0.92 to 0.99; P = .007).

CONCLUSIONS:

Individuals with ASD at risk for seizures exhibited changes in adaptive functioning and behavior.




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What it feels like ... to work as creative director for Johnstons of Elgin

Alan Scott, creative director at Johnstons of Elgin




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Food: Mum's the word for actor John Partridge

Actor and Celebrity MasterChef winner John Partridge shares his culinary journey of recovery and grief with Jenny Stallard.




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Video director Rohan Edwards talks business

At a time when there are no entertainment events being held, players in the industry are looking at options to remain relevant.Music video director Rohan Kashwayne Edwards believes there is an even greater demand for music videos during this COVID-19 crisis.