Disclosed are methods for making read sensors using developable bottom anti-reflective coating and amorphous carbon (a-C) layers as junction milling masks. The methods described herein provide an excellent chemical mechanical polishing or planarization (CMP) stop, and improve control in reader critical physical parameters, shield to shield spacing (SSS) and free layer track width (FLTW).

Systems and methods for liquid deposition photolithography are described. In particular, some embodiments relate to systems and methods for using photolithography to control the 2D structure of a thin layer of material (e.g., photopolymer) using various masks, projection optics and materials. In one or more embodiments, this thin layer can be manipulated by micro-fluidic techniques such that it can be formed, patterned and post-processed in a liquid environment, vastly simplifying the creation of multi-layer structures. Multiple layers are rapidly built up to create thick structures of possibly multiple materials that are currently challenging to fabricate by existing methods.

A method includes scanning a lithography mask with a repair process, and measuring back-scattered electron signals of back-scattered electrons generated from the scanning. An endpoint is determined from the back-scattered electron signals. A stop point is calculated from the endpoint. The step of scanning is stopped when the calculated stop point is reached.

Disclosed is a positive photosensitive resin composition that includes (A) an alkali soluble resin prepared by a phosphorous-containing diamine represented by the following Chemical Formula 1, (B) a photosensitive diazoquinone compound, and (C) a solvent. A photosensitive resin film prepared using the same and a semiconductor device including the photosensitive resin film are also disclosed. In Chemical Formula 1, each substituent is the same as defined in the detailed description.

Provided are an electrophotographic photosensitive member in which leakage doesn't easily occur, a process cartridge and an electrophotographic apparatus each including the electrophotographic photosensitive member, and a method of manufacturing the electrophotographic photosensitive member. The electrophotographic photosensitive member includes a conductive layer including titanium oxide particle coated with tin oxide doped with a hetero element. When an absolute value of a maximum current amount flowing through the conductive layer in a case of performing a test of applying −1.0 kV including DC voltage to the conductive layer is defined as Ia, and an absolute value of a current amount flowing through the conductive layer in a case where a decrease ratio of a current amount per minute reaches 1% or less for the first time is defined as Ib, the relations of Ia≦6000 and 10≦Ib are satisfied. A volume resistivity of the conductive layer before the test is 1.0×108 Ω·cm to 5.0×1012 Ω·cm.

To provide an amine compound, represented by General Formula (I) below: [In General Formula (I), R1 and R2 represent a substituted or unsubstituted alkyl group, a substituted or unsubstituted aralkyl group, or a substituted or unsubstituted aromatic hydrocarbon group, which may be identical or different; m and n are an integer of 1 or 0; Ar1 represents a substituted or unsubstituted aromatic hydrocarbon group; Ar2 and Ar3 represent a substituted or unsubstituted alkyl group, a substituted or unsubstituted aralkyl group, or a substituted or unsubstituted aromatic hydrocarbon group; and Ar1 and Ar2 or Ar2 and Ar3 may bind to each other to form a substituted or unsubstituted heterocyclic group including a nitrogen atom.]

Provided is a toner satisfying low-temperature fixing performance and long-term storage stability of fixed images. Further, provided is a toner capable of obtaining toner images excellent in long-term storage stability irrespective of use environments even in the case where images are formed by a high-speed fixing system having low internal pressure of a fixing nip of a fixing device and a high printing speed. The toner includes toner particles containing a binder resin having a resin A and B, and a coloring agent, in which the resin A includes a resin including a moiety capable of forming a crystalline structure; the resin B includes a resin free of a moiety capable of forming a crystalline structure; and ΔHhigh and ΔHlow satisfy the expressions: 2≦ΔHhigh≦45 3[%]≦{(ΔHlow−ΔHhigh)/ΔHlow}×100≦70[%] where ΔHhigh and ΔHlow represent a heat of melting derived from the binder resin measured at a temperature increase speed of 100° C./min and 10° C./min, respectively.

A solution of a gallium phthalocyanine contains a compound of formula (1) and a gallium phthalocyanine of formula (2), H2N—CH2—R1—CH2—NH2 (1) wherein R1 represents a single bond, or a substituted or unsubstituted alkylene group having 1 to 10 main-chain carbon atoms, a substituent of the substituted alkylene group is an alkyl group having 1 to 3 carbon atoms, an alkyl group having 1 to 3 carbon atoms and being substituted with an amino group, or a hydroxy group, one of the carbon atoms in the main chain of the alkylene group may be replaced with an oxygen atom, a sulfur atom, or a bivalent group represented by the formula —NR2—, and R2 represents a hydrogen atom, an alkyl group having 1 to 3 carbon atoms, or an alkyl group having 1 to 3 carbon atoms and being substituted with an amino group, and wherein X1 represents a chlorine atom or hydroxy group.

A resist composition including a base component which exhibits changed solubility in an alkali developing solution under action of acid and an acid-generator component which generates acid upon exposure, the acid-generator including an acid generator consisting of a compound represented by general formula (b1-1) shown below: In which RX represents a hydrocarbon group which may have a substituent exclusive of a nitrogen atom; each of Q2 and Q3 independently represents a single bond or a divalent linkage group; Y1 represents an alkylene group or fluorinated alkyl group of 1 to 4 carbon atoms; and Z+ represents an organic cation exclusive of an ion represented by general formula (w-1).

The present invention relates to a developable bottom antireflective coating (BARC) composition and a pattern forming method using the BARC composition. The BARC composition includes a first polymer having a first carboxylic acid moiety, a hydroxy-containing alicyclic moiety, and a first chromophore moiety; a second polymer having a second carboxylic acid moiety, a hydroxy-containing acyclic moiety, and a second chromophore moiety; a crosslinking agent; and a radiation sensitive acid generator. The first and second chromophore moieties each absorb light at a wavelength from 100 nm to 400 nm. In the patterning forming method, a photoresist layer is formed over a BARC layer of the BARC composition. After exposure, unexposed regions of the photoresist layer and the BARC layer are selectively removed by a developer to form a patterned structure in the photoresist layer. The BARC composition and the pattern forming method are especially useful for implanting levels.

A method for forming patterns of a semiconductor device includes providing a photomask that includes an array of contact holes in an active region, a plurality of first dummy contact holes for restricting pattern distortion of the contact holes in an area outside of the array of the contact holes, a plurality of first assist features for restricting pattern distortion of the first dummy contact holes disposed inside a corresponding one of the first dummy contact holes, and an array of second assist features for additionally restricting pattern distortion of the first dummy contact holes. The array of second assist features is disposed outside of the first dummy contact holes. The method also includes forming an array of contact holes and first dummy contact holes on a wafer by using the photomask as an exposure mask.

A pattern forming method contains: (i) a step of forming a bottom anti-reflective coating on a substrate by using a first resin composition (I), (ii) a step of forming a resist film on the bottom anti-reflective coating by using a second resin composition (II), (iii) a step of exposing a multi-layered film having the bottom anti-reflective coating and the resist film, and (iv) a step of developing the bottom anti-reflective coating and the resist film in the exposed multi-layered film by using an organic solvent-containing developer to form a negative pattern.

Provided is a method of producing an electrophotographic photosensitive member having improved sensitivity and capable of outputting an image having less image defects due to a ghost phenomenon not only under a normal-temperature, normal-humidity environment but also under a low-temperature, low-humidity environment as a particularly severe condition. The method of producing a gallium phthalocyanine crystal includes subjecting a gallium phthalocyanine and a specific amine compound, which are added to a solvent, to a milling treatment to perform crystal transformation of the gallium phthalocyanine. In addition, the gallium phthalocyanine crystal is used in the photosensitive layer of the electrophotographic photosensitive member.

Techniques for reducing the number of shots required by a radiation beam writing tool to write a pattern, such as fractured layout design, onto a substrate. One or more apertures are employed by a radiation beam writing tool to write a desired pattern onto a substrate using L-shaped images, T-shaped images, or some combination of both. By reducing the number of shots required to write a pattern onto a substrate, various implementations of the invention may reduce the write time and/or write complexity of the write process.

A mask blank for use in the manufacture of a binary mask adapted to be applied with ArF excimer laser exposure light has, on a transparent substrate, a light-shielding film for forming a transfer pattern. The light-shielding film has a laminated structure of a lower layer and an upper layer and has an optical density of 2.8 or more for exposure light and a thickness of 45 nm or less. The lower layer is made of a material in which the total content of a transition metal and silicon is 90 at % or more, and has a thickness of 30 nm or more. The upper layer has a thickness of 3 nm or more and 6 nm or less. The phase difference between exposure light transmitted through the light-shielding film and exposure light transmitted in air for a distance equal to the thickness of the light-shielding film is 30 degrees or less.

An automatic performance apparatus includes a memory device, an input device, a write device, a switching device, and a write control device. The memory device stores performance information. The input device inputs the performance information. The write device sequentially writes the performance information at predetermined addresses of the memory device on the basis of an operation of the input device. The switching device commands rewriting. In response to a command from the switching device, the write control device returns a write address of the memory device to an immediately preceding start point of a predetermined music composition unit having two or more notes, thereby enabling an easy and accurate edit of the once stored performance information.

A reverb generator comprises a delay circuit for delaying an input audio signal, a feed back path connecting an output port of the delay circuit to its input port, and a phase shifter connected in series to the delay circuit. The phase shifter produces a dispersion in the spectrum of the input audio signal in accordance with frequency dependent delay characteristic in such a manner that the delay time is large in a low frequency range and small in a higher frequency range. By including the phase shifter in the feed back path, one can obtain an output audio signal having a spectrum which is repeatedly subjected to dispersion, thus simulating the effect of dispersion due to the multiple reflections taking place in an actual concert hall.

The musical scale indicator according to a first preferred embodiment of the present invention is composed of two cooperating parts. A base is provided having thereon printed information pertaining to a particular musical instrument and which, in addition, has printed thereon fingering patterns for playing tones on that instrument arranged in a predetermined sequence indicative of any number of desired musical scales. A slidable, clear overlay is slidably connected with the base. The overlay has printed thereon the letter designations for the musical tones arranged in a predetermined sequence so as to cooperate with the fingering patterns indicated on the base in order to selectively indicate to the user the finger positions on the subject musical instrument that will produce the tones of a selected musical scale and simultaneously the finger positions on that instrument that will produce those tones.

External sound signal coupled through a MIC IN terminal is fed through an operating switch panel section to an A/D converter for conversion to a digital signal. The digital signal is stored in a record memory through a waveform R/W controller under the control of a CPU. The digital signal stored in the record memory is read out from the CPU according to control data stored in a work memory to be fed to an external sound system for sounding.

Apparatus and method for rotating an object using a music box mechanism having a spring motor. Apparatus includes a mechanical motor having a spring coupled between a body and a shaft of the music box where the shaft and the body are mounted for rotation relative to each other. The spring is windable by a user to store mechanical potential energy and when released, unwindable to release the stored energy and cause relative rotation between the body and the shaft. A base adapted for stationary placement against a surface such as a table or desktop or a wall or other stationary surface is fixedly coupled to or integrally formed with the shaft of the music box motor. An object such as a spherical planetary object or globe or any other object is connected to the body and includes an aperture or hole through which the base extends to the shaft. This aperture permits the object to rotate about the shaft without interference so that the body and the object rotate about the shaft as the spring unwinds. Connection of the winding mechanism shaft to the fixed base causes the body of the music box and attached object such as the globe to rotate.

A modular automated assistive guitar is described comprising a base assembly, a pick assembly, a strumming mechanism and a fretting mechanism which, in combination with a standard guitar or similar stringed musical instrument (e.g., banjo, steel guitar, ukulele), forms a musical device that can be played by an individual with a range of independence, cognitive and physical abilities. The base assembly accepts, positions, and secures a standard guitar. The pick assembly includes quick attach and spring-loaded features for attaching and detaching picks, in addition to flexibility for smooth interaction with the guitar strings. The strumming mechanism provides cyclic motion and speed control to create pleasant and variable rhythm from the mounted guitar. The fretting mechanism allows a user to change chords and tone. An unmodified, traditional guitar is preferably used in the musical device. The guitar is easily interchangeable with another guitar or other stringed instrument, at the convenience of the user. The modular automated assistive musical device, with or without the guitar, is compact, light, portable, and easily adjustable to different individual's needs, motor skills, and dexterity.

Described is a bass drum foot pedal having a variable drive lever linkage with variable arc ratios connecting the foot pedal to a beater bracket. The beater bracket is formed with a mounting surface that tips a beater shaft forward to create a forward beater angle that maximizes the beater impact against a bass drum.

A dual rotor axial-flow rotor valve structure includes a rotor valve seat for rotatably receiving rotatable first and second rotor valves. The rotor valve seat has a first and a second extension sections connected to end sections of a second and a first tuning slide assembly s. The first rotor valve communicates with end sections of first and second flow passages with a mouthpiece and the other end of the second tuning slide assembly and communicate the other end of the second flow passage with the first or second extension section. The second rotor valve communicates ends of the first and second flow passages with the other end of the first tuning slide assembly and a main tuning slide assembly and communicate the other end of the second flow passage with the first or second extension section.

A method of managing content format conversion for transmission of converted content to a mobile device includes retrieving initial content, which includes video content, having a first format over a data communications network. The retrieved initial content is analyzed based on an identification of data delivery parameters relating to potential delivery of converted content and a determination is made as to whether or not the data delivery parameters meet predetermined criteria. The format of the initial content is converted to a second format only in response to a determination that the data delivery parameters meet the predetermined criteria. The converted content forms a message body of a message. A conversion management system configured to manage content format conversion for transmission of converted content to a mobile device, and a computer program for performing the method, are also provided.

An example method transmits a path message to an egress node, via intermediate nodes, that configures OAM monitoring of an entire connection between an ingress node and the egress node and also configures OAM monitoring of at least one segment of the connection shorter than the entire connection by at least one intermediate node. The path message comprises a LSP attributes object and an ERO. The LSP object comprises technology-specific attributes defining descriptors for configuring the egress node in accordance with a communication protocol utilized for the connection; and technology-independent OAM parameters that, irrespective of the communication protocol, define an OAM type to be used by the egress node, and define desired monitoring actions for the egress node to perform. The ERO comprises a respective HOP Attributes sub-object for configuring each of the at least one intermediate nodes. Each HOP Attributes sub-object also comprises technology-specific attributes and technology-independent OAM parameters.

A technique dynamically configures and verifies routing information of broadcast networks using link state protocols in a computer network. According to the novel technique, a router within the broadcast network receives a link state protocol routing information advertisement from an advertising router, e.g., a designated router or other adjacent neighbor. The router learns of a next-hop router (“next-hop”) to reach a particular destination from the advertisement, and determines whether the next-hop is located within the same broadcast network (e.g., subnet) as the designated router. If so, the router further determines whether the next-hop is directly addressable (i.e., reachable), such as, e.g., by checking for link adjacencies to the next-hop or by sending request/reply messages (e.g., echo messages or “ping” messages) to the next-hop. In the event the next-hop for the destination is not directly addressable by the router (e.g., no adjacency or reply), the router installs a route to the destination via the designated router. Otherwise, the router installs a route to the destination via the next-hop.

A virtual computer system includes virtualization software, and one or more physical network interfaces for connecting to one or more computer networks. The virtualization software supports one or more virtual machines (VMs), and exports one or more virtual network interfaces to the VM(s) to enable the VM(s) to access the computer network(s) through the physical network interface(s). The virtualization software modifies and filters network data frames from the VM(s) and from the physical network interface(s) to restrict one or more VMs to one or more virtual local area networks (VLANs) that are implemented within a VLAN topology. Restricting a VM to a VLAN limits the broadcast domain to which the VM belongs, which may reduce security risks facing the VM. Implementing the VLAN functionality within the virtualization software provides the functionality to every VM in the computer system, without requiring every VM to provide the functionality.

A system and method can support a flooding mechanism using a multicast group in a middleware machine environment. The middleware machine environment can comprise a gateway instance that includes an external port for receiving one or more data packets from an external network. The middleware machine environment also comprises one or more host servers, each of which is associated with one or more virtual machines that can process the data packets. Furthermore, said host servers can provide virtual interfaces that belong to a virtual hub associated with the gateway instance. At least one said packet is a flooded packet that is specified with an unknown destination address when it is received at the external port. The gateway instance operates to send the flooded packet to the multicast group that operates to forward the flooded packet to one or more said host servers in the multicast group.

One embodiment may include an automotive timing chain system component (10, 12) such as a tensioner arm (10) or a chain guide (12) that, during use, bears directly or indirectly against a chain (22) of an automotive timing chain system (14). The component (10, 12) may have an elongated body (16, 116) made into a generally hollow shape by a hydroforming process. The body may have a first open free end (26, 126) and a second open free end (28, 128).

A method for joining structural elements onto a shaft may include generating at least one projection at a respective joining position on the shaft, sliding at least one of the structural elements over at least one projection and maintaining the structural elements in at least on projection.

A distributed drive includes a frame, a main sprocket, and a plurality of drive assemblies mounted therearound for rotation of the main sprocket. The main sprocket has a circumferential drive rim around which the drive assemblies are mounted in driving engagement with the drive rim so as to selectively rotate the main sprocket relative to the frame. Each drive assembly includes at least two auxiliary sprockets lying substantially in the plane of the main sprocket. An endless belt is mounted around the auxiliary sprockets so that a span of the endless belt spans between a pair of the auxiliary sprockets in an arc-of-contact with the drive rim. At least one of the two auxiliary sprockets is a selectively driven drive sprocket for selective rotation of the main sprocket.

An arrangement for supplying oil to a chain drive which drives a transmission oil pump that is axially offset relative to a torque converter and embedded in an intermediate plate in a vehicle having a torque converter. The driven sprocket of the chain drive is supported by a converter neck mounted in a centering plate. A seal is provided between the converter neck and the sprocket and is arranged adjacent the sliding fit between the converter neck and the sprocket. To compensate for the suppression of lubrication of the seal, the neck bearing and the chain drive, a valve is integrated in the intermediate plate, and a duct is provided in the plane, in which the centering plate is screwed to the intermediate plate, such that excess oil flowing from the valve is selectively directed to the seal, the neck bearing and the chain drive.

A vehicle has a motor-gear unit, a trailing wheel of the vehicle being connected the output shaft of the gear and an input shaft of the gear being connected to a motor. The gear has an outer wheel, an inner wheel and a traction means extending between the outer wheel and the inner wheel. A revolving transmitter is also provided which lifts the traction means off the outer periphery of the inner wheel and pushes it against the inner periphery of the outer wheel.

A chain ring protector having a substantially planar mounting bracket operably secured to the bottom bracket sleeve of a vehicle with a durable semi-circumferential guard extending therefrom is disclosed. The durable guard has a substantially arcuate outer edge sized to approximate the outer diameter of a chain ring, and it is operably secured to the planar mounting bracket such that the outer edge extends slightly beyond the outer diameter of the portion of the chain ring extending below the bottom bracket sleeve.

The cotton variety FM 2011GT is disclosed. The invention relates to seeds, plants, plant cells, plant tissue, harvested products and cotton lint as well as to hybrid cotton plants and seeds obtained by repeatedly crossing plants of variety FM 2011GT with other plants. The invention also relates to plants and varieties produced by the method of essential derivation from plants of FM 2011GT and to plants of FM 2011GT reproduced by vegetative methods, including but not limited to tissue culture of regenerable cells or tissue from FM 2011GT.

Provided herein are mitochondrial-nuclear exchanged cells and animals comprising mitochondrial DNA (mtDNA) from one subject and nuclear DNA (nDNA) from a different subject. Methods for producing a mitochondrial-nuclear exchanged animal and animals made by the methods are provided. Also provided are methods of screening for agents useful for treating a disease or disorder using mitochondrial-nuclear exchanged animals or cells, tissues or organs thereof.

The invention provides specific transgenic soybean plants, plant material and seeds, characterized in that these products harbor a stack of specific transformation events at specific locations in the soybean genome (elite event EE-GM3 and elite event EE-GM2, or elite event EE-GM3 and elite event EE-GM1). The invention also provides for methods of producing soybean plants and seeds having elite event EE-GM3 and elite event EE-GM2, or elite event EE-GM3 and elite event EE-GM1.

A method and apparatus for conveying a cellulosic feedstock are disclosed. The apparatus, such as a holding tank, has a passage. At the outlet to the passage, a conveyance member is provided to convey the cellulosic feedstock laterally across the outlet. The conveyance member, e.g., at least one screw conveyor, may have a variable pitch along its length. The method comprises passing the cellulosic feedstock through an impregnation chamber to an outlet of the impregnation chamber; passing the cellulosic feedstock from the outlet of the impregnation chamber to an inlet of a holding tank; passing the cellulosic feedstock downwardly through the holding tank; maintaining a generally constant residence time in the holding tank; and subsequently subjecting the cellulosic feedstock to a hydrolysis process.

An apparatus for conveying a cellulosic feedstock is disclosed. The apparatus comprises an enclosed volume having a lower surface comprising a plurality of longitudinally extending portions. Each longitudinally extending portion has an inner surface that is arcuate in transverse section. A plurality of conveyance members are provided within the enclosed volume. Each conveyance member is associated with one of the inner surfaces and configured to sweep the one of the inner surfaces. Additionally, a method for treating a cellulosic feedstock is disclosed. The method comprises providing a cellulosic feedstock being less than 100% saturated moisture. The cellulosic feedstock is introduced into a longitudinally extending enclosed volume, and conveyed longitudinally through the enclosed volume while being mixed.

The present invention relates to an apparatus for mixing and controlling the temperature of laboratory vessel contents with an accommodating device in detachable connection with an exchangeable block for accommodating and controlling the temperature of laboratory vessels and with a drive by which the accommodating device can be set in a mixing motion, and with a temperature control device with a heat source or sink in heat-conducting connection with the exchangeable block at least through in each case at least one adjoining contact face firstly on the accommodating device and secondly on the exchangeable block, which is characterized in that the detachable connection is maintained by a spring element which, by virtue of its spring force, horizontally clamps together a first undercut between the accommodating device and the exchangeable block in at least one first direction.

A dissolution generator includes: an upright housing; a screen assembly extending across an interior of the housing, and configured to support a column of powder thereabove; a spray nozzle disposed below the screen assembly and directed towards the screen assembly; and a pressure mechanism disposed above the screen assembly, and configured to apply a substantially constant downward pressure.

A mixing rotor includes: a rotor shaft portion that includes a cooling passageway formed therein, and a mixing blade portion that is formed in an outer circumferential portion of the rotor shaft portion, wherein each of the long blades of the mixing blade portion includes a land portion as an end surface of the long blade facing a radially outside of the mixing rotor, a length of each of the long blades in the axis direction is set to be 0.6 times or more as large as a length of the mixing blade portion in the axis direction, a biting angle of each of the long blades is set to an angle equal to or smaller than 31°, and a center angle with respect to a land width as a width of the land portion in the cross-section of each of the long blades orthogonal to the axis direction is set to an angle equal to or larger than 7°.

An agitator, particularly for abrasive media includes a support disk to which agitator blades are connected substantially perpendicular to the support disk. The blades are arranged substantially in a radial direction. The support disk also includes a hub that receives an agitator shaft which is preferably motor-driven. The trailing faces of the blades of the agitator and/or the area of the blade connections to the support disk are designed to largely prevent vortex shedding. This is accomplished by implementing a specific geometry for the agitator blades, the support disk, and the connection of the blades to the support disk.

This invention relates to novel compounds which are inhibitors of the Rearranged during Transfection (RET) kinase, to pharmaceutical compositions containing them, to processes for their preparation, and to their use in therapy, alone or in combination, for the normalization of gastrointestinal sensitivity, motility and/or secretion and/or abdominal disorders or diseases and/or treatment related to diseases related to RET dysfunction or where modulation of RET activity may have therapeutic benefit including but not limited to all classifications of irritable bowel syndrome (IBS) including diarrhea-predominant, constipation-predominant or alternating stool pattern, functional bloating, functional constipation, functional diarrhea, unspecified functional bowel disorder, functional abdominal pain syndrome, chronic idiopathic constipation, functional esophageal disorders, functional gastroduodenal disorders, functional anorectal pain, inflammatory bowel disease, proliferative diseases such as non-small cell lung cancer, hepatocellular carcinoma, colorectal cancer, medullary thyroid cancer, follicular thyroid cancer, anaplastic thyroid cancer, papillary thyroid cancer, brain tumors, peritoneal cavity cancer, solid tumors, other lung cancer, head and neck cancer, gliomas, neuroblastomas, Von Hippel-Lindau Syndrome and kidney tumors, breast cancer, fallopian tube cancer, ovarian cancer, transitional cell cancer, prostate cancer, cancer of the esophagus and gastroesophageal junction, biliary cancer, adenocarcinoma, and any malignancy with increased RET kinase activity.

The invention relates to compounds represented by Structural Formula I, which can bind to CCR9 receptors and block the binding of a ligand (e.g., TECK) to the receptors. The invention also relates to a method of inhibiting a function of CCR9, and to the use compounds represented by Structural Formula I in research, therapeutic, prophylactic and diagnostic methods.

The present invention relates to novel synthetic substituted heterocyclic compounds and pharmaceutical compositions containing the same that are capable of inhibiting or antagonizing a family of receptor tyrosine kinases, Tropomysosin Related Kinases (Trk), in particular the nerve growth factor (NGF) receptor, TrkA. The invention further concerns the use of such compounds in the treatment and/or prevention of pain, cancer, restenosis, atherosclerosis, psoriasis, thrombosis, or a disease, disorder or injury relating to dysmyelination or demyelination or the disease or disorder associated with abnormal activities of NGF receptor TrkA.

Compounds are described herein useful for treating diseases and conditions by modulation of one or more alpha adrenergic receptor. The compounds can include a naphthalene, a quinoline, a benzoimidazole or an isoquinoline as a core structure. Methods of making, using and formulating these compounds are described.

The present disclosure relates to Oxime-Substituted Quinoxaline-Type Piperidine Compounds, such as those of Formula (I): and the pharmaceutically acceptable salts and solvates thereof, wherein R1, R2, R3, R4, R20, R21, Q, Y1, Z, A, B, and a are as defined herein; compositions comprising an effective amount of an Oxime-Substituted Quinoxaline-Type Piperidine Compound, and methods to treat or prevent a condition, such as pain, comprising administering to an animal in need thereof an effective amount of an Oxime-Substituted Quinoxaline-Type Piperidine Compound.

The present invention is directed to a compound of Formula (I) and to pharmaceutical compositions comprising compounds of Formula (I). Methods of making and using the compounds of Formula (I) are also within the scope of the invention.

The present invention generally relates to use of compounds and compositions as a chemosensitizers and/or radiosensitizers and/or inhibitors of PNKP phosphatase activity. The present invention provides pharmaceutical combinations and/or a pharmaceutically acceptable salt thereof, kits containing such compounds and/composition and methods of using such compounds and/or compositions.