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In a step that brings silicon-based quantum computers closer to reality, researchers at Princeton University have built a device in which a single electron can pass its quantum information to a particle of light. The particle of light, or photon, can then act as a messenger to carry the information to other electrons, creating connections that form the circuits of a quantum computer.

Princeton University has a substantial impact on the New Jersey economy, generating an annual total of $1.58 billion in economic output as an employer, research and innovation leader, sponsor of construction projects, purchaser of goods and services, and financial and civic contributor to local communities. That total supports an estimated 13,450 jobs with $970.7 million in earnings.

Theories developed at Princeton University led to the creation of time crystals reported in the journal Nature March 9 by two groups of researchers based at Harvard University and the University of Maryland. Time crystals feature atoms and molecules arranged across space and time and are opening up entirely new ways to think about the nature of matter. They also eventually may help protect information in futuristic devices known as quantum computers.

HELENA (April 23, 2020) – Today, U.S. Environmental Protection Agency (EPA) Region 8 Deputy Regional Administrator Deb Thomas recognized students and staff from Capital High School in Helena for winning the ‘See a Bloom, Give It Room’ High School Video Challenge.

PHILADELPHIA (April 29, 2020) — The U.S. Environmental Protection Agency announced today that Lea Wang, a sophomore at Council Rock High School in Holland, Pennsylvania, is the 2019 winner of a President’s Environmental Youth Award (PEYA) for EPA’s Mid-Atlantic Region.

PHILADELPHIA (April 29, 2020) – The U.S. Environmental Protection Agency announced today that science teacher Ann Strozyk from the Howard County Public School District in Maryland is a 2019 winner of a Presidential Innovation Award for Environmental Educators (PIAEE).

PAGO PAGO, American Samoa - Today, the U.S. Environmental Protection Agency (EPA) announced that American Samoa was selected to receive a $300,000 grant to assess and clean up contaminated properties under the agency’s Brownfields Program.

Environmental NewsFOR IMMEDIATE RELEASE

Metz, France (May 7, 2019) - Yesterday, U.S. Environmental Protection Agency (EPA) Administrator Andrew Wheeler concluded his visit to Metz, France where he attended the annual G7 Environmental Ministers Meeting.

KARUIZAWA, JAPAN – Yesterday, U.S. Environmental Protection Agency (EPA) Administrator Andrew Wheeler concluded his visit to Karuizawa, Japan where he attended the inaugural G20 Energy and Environmental Ministers Meeting.

(MEXICO CITY) – Today, U.S. Environmental Protection Agency Administrator Andrew Wheeler wrapped up trilateral meetings with Canada and Mexico as part of the 25th Anniversary of the Commission for Environmental Cooperation (CEC) Council meetings in Mexico City.

SAN DIEGO – Hoy, la Agencia de Protección Ambiental de Estados Unidos (EPA, por sus siglas en inglés), en coordinación con el Banco de Desarrollo de América del Norte (BDAN), emitió una Solicitud de Propuestas (RFP, por sus siglas en inglés) a través del Programa Frontera 2020.

SAN DIEGO – Today, the U.S. Environmental Protection Agency (EPA), in coordination with the North American Development Bank (NADB), released a Request for Proposals (RFP) through the Border 2020 Program.

Tahnée Seagrave provides some insight into her thought process during the 2018 Val di Sole World Cup.
( Comments: 4 )

Unilever is recalling Wall’s Mini Calippo (Orange and Lemon-Lime) multi-packs because they may contain small pieces of metal. The presence of metal makes this product unsafe to eat.

Indianapolis police arrested a man on Saturday near the location of the fatal police shooting of Dreasjon "Sean" Reed days earlier.

Emacs "predates Linux, and was once far more popular," writes LWN.net, while adding that the text editor "has fallen into relative obscurity over the years." Then it reports on a "mega-thread" on the emacs-devel mailing list about how to make Emacs more appealing and attractive to users: The discussion started with a post from "ndame" asking why Emacs is "so square"; the appearance of things like buttons could be improved with rounded corners, they said. Richard Stallman, one of the original authors of Emacs, seemed somewhat dismissive in his reply: "Perhaps we should implement a mode that puts cosmetics on Emacs so it will appeal to those who judge by the surface of things." But Stefan Kangas thought there was more to it than that: I think it's unfortunate if we assume that this is all bells and whistles. Graphical design elements can also improve usability. I also don't know that it's helpful to assume that the rest of the world will take the enlightened stance.... He wondered if there was "any reason not to improve the default look". Stallman said that there are some technical barriers in finding someone interested in and capable of doing the work needed, but there is an overarching problem that needs to be addressed first: The code to interface Emacs to X-based GUIs needs rewriting by an expert, and has needed it for decades. Until it gets that rewrite, changes in it are likely to break something. Stallman did agree that the graphical design could improve usability, "but I have a feeling that the changes that would help are deeper issues than the shape of corners". It was a long and interesting discussion, touching on the popularity of both Vim and Visual Studio Code, while another post questioned whether Emacs should even be prioritizing its menu bar and tool bar. One post suggested "starter kits" to make the text editor more friendly to newcomers, another suggested making Cntrl-C cut-and-paste the default key binding, and one asked whether it was Emacs' terminology and keyboard shortcuts that might be confusing to users coming from Microsoft Word. "You are basically making a commitment to being or becoming a power user..." argued another post. "If you just want to do 'casual' text editing emacs is a very weird choice in 2020."

Read more of this story at Slashdot.

Deaths and hospitalizations related to COVID-19 could increase dramatically in Montreal if social distancing measures are lifted, according to a new study.

Prince Charles praises their "dedication, resilience and hard work" in a letter left outside his home.

Lebogang Manyama is the most important player for Kaizer Chiefs in their quest to win the Absa Premiership title, according to Stellenbosch midfielder Mpho Matsi.

School, friends and normal day to day interactions have taken a virtual shift. However, for those with limited access to the internet, devices and other technology, isolation can be challenging.

Antibodies are widely used as cancer therapeutics, but their current use is limited by the low number of antigens restricted to cancer cells. A receptor tyrosine kinase, receptor tyrosine kinase-like orphan receptor 2 (ROR2), is normally expressed only during embryogenesis and is tightly down-regulated in postnatal healthy tissues. However, it is up-regulated in a diverse set of hematologic and solid malignancies, thus ROR2 represents a candidate antigen for antibody-based cancer therapy. Here we describe the affinity maturation and humanization of a rabbit mAb that binds human and mouse ROR2 but not human ROR1 or other human cell-surface antigens. Co-crystallization of the parental rabbit mAb in complex with the human ROR2 kringle domain (hROR2-Kr) guided affinity maturation by heavy-chain complementarity-determining region 3 (HCDR3)-focused mutagenesis and selection. The affinity-matured rabbit mAb was then humanized by complementarity-determining region (CDR) grafting and framework fine tuning and again co-crystallized with hROR2-Kr. We show that the affinity-matured and humanized mAb retains strong affinity and specificity to ROR2 and, following conversion to a T cell–engaging bispecific antibody, has potent cytotoxicity toward ROR2-expressing cells. We anticipate that this humanized affinity-matured mAb will find application for antibody-based cancer therapy of ROR2-expressing neoplasms.

β-Glucocerebrosidase (GBA) hydrolyzes glucosylceramide (GlcCer) to generate ceramide. Previously, we demonstrated that lysosomal GBA1 and nonlysosomal GBA2 possess not only GlcCer hydrolase activity, but also transglucosylation activity to transfer the glucose residue from GlcCer to cholesterol to form β-cholesterylglucoside (β-GlcChol) in vitro. β-GlcChol is a member of sterylglycosides present in diverse species. How GBA1 and GBA2 mediate β-GlcChol metabolism in the brain is unknown. Here, we purified and characterized sterylglycosides from rodent and fish brains. Although glucose is thought to be the sole carbohydrate component of sterylglycosides in vertebrates, structural analysis of rat brain sterylglycosides revealed the presence of galactosylated cholesterol (β-GalChol), in addition to β-GlcChol. Analyses of brain tissues from GBA2-deficient mice and GBA1- and/or GBA2-deficient Japanese rice fish (Oryzias latipes) revealed that GBA1 and GBA2 are responsible for β-GlcChol degradation and formation, respectively, and that both GBA1 and GBA2 are responsible for β-GalChol formation. Liquid chromatography–tandem MS revealed that β-GlcChol and β-GalChol are present throughout development from embryo to adult in the mouse brain. We found that β-GalChol expression depends on galactosylceramide (GalCer), and developmental onset of β-GalChol biosynthesis appeared to be during myelination. We also found that β-GlcChol and β-GalChol are secreted from neurons and glial cells in association with exosomes. In vitro enzyme assays confirmed that GBA1 and GBA2 have transgalactosylation activity to transfer the galactose residue from GalCer to cholesterol to form β-GalChol. This is the first report of the existence of β-GalChol in vertebrates and how β-GlcChol and β-GalChol are formed in the brain.

Lens proteins become increasingly cross-linked through nondisulfide linkages during aging and cataract formation. One mechanism that has been implicated in this cross-linking is glycation through formation of advanced glycation end products (AGEs). Here, we found an age-associated increase in stiffness in human lenses that was directly correlated with levels of protein–cross-linking AGEs. α-Crystallin in the lens binds to other proteins and prevents their denaturation and aggregation through its chaperone-like activity. Using a FRET-based assay, we examined the stability of the αA-crystallin–γD-crystallin complex for up to 12 days and observed that this complex is stable in PBS and upon incubation with human lens–epithelial cell lysate or lens homogenate. Addition of 2 mm ATP to the lysate or homogenate did not decrease the stability of the complex. We also generated complexes of human αA-crystallin or αB-crystallin with alcohol dehydrogenase or citrate synthase by applying thermal stress. Upon glycation under physiological conditions, the chaperone–client complexes underwent greater extents of cross-linking than did uncomplexed protein mixtures. LC-MS/MS analyses revealed that the levels of cross-linking AGEs were significantly higher in the glycated chaperone–client complexes than in glycated but uncomplexed protein mixtures. Mouse lenses subjected to thermal stress followed by glycation lost resilience more extensively than lenses subjected to thermal stress or glycation alone, and this loss was accompanied by higher protein cross-linking and higher cross-linking AGE levels. These results uncover a protein cross-linking mechanism in the lens and suggest that AGE-mediated cross-linking of α-crystallin–client complexes could contribute to lens aging and presbyopia.

Fucosylation of the innermost GlcNAc of N-glycans by fucosyltransferase 8 (FUT8) is an important step in the maturation of complex and hybrid N-glycans. This simple modification can dramatically affect the activities and half-lives of glycoproteins, effects that are relevant to understanding the invasiveness of some cancers, development of mAb therapeutics, and the etiology of a congenital glycosylation disorder. The acceptor substrate preferences of FUT8 are well-characterized and provide a framework for understanding N-glycan maturation in the Golgi; however, the structural basis of these substrate preferences and the mechanism through which catalysis is achieved remain unknown. Here we describe several structures of mouse and human FUT8 in the apo state and in complex with GDP, a mimic of the donor substrate, and with a glycopeptide acceptor substrate at 1.80–2.50 Å resolution. These structures provide insights into a unique conformational change associated with donor substrate binding, common strategies employed by fucosyltransferases to coordinate GDP, features that define acceptor substrate preferences, and a likely mechanism for enzyme catalysis. Together with molecular dynamics simulations, the structures also revealed how FUT8 dimerization plays an important role in defining the acceptor substrate-binding site. Collectively, this information significantly builds on our understanding of the core fucosylation process.

The operator Jamaica’s two largest airports wants to scrap or delay non-essential capital projects. It forms part of a wider halt of capital projects by the Grupo Aeroportuario del Pacífico – which translate to Pacific Airport Group, or GAP –...

Car-rental companies in Jamaica are facing a serious crush, with at least one medium player looking to shut down operations, and others, big and small, saying that they are barely holding on. The collapse in the vacation market and travel...

(AP): South Korea’s capital, Seoul, has closed down more than 2,000 bars and other nightspots because of a new cluster of COVID-19 infections; Germany scrambled to contain fresh outbreaks at slaughterhouses; and...

This book reflects the effort of the Transatlantic Council on Migration to map how profound demographic change is likely to affect the size and character of global migration flows; and how governments can shape immigration policy in a world increasingly attuned to the hunt for talent.

This edited volume develops a pragmatic approach to the engagement of highly skilled members of the diaspora for the benefit of their countries of origin. The book, edited by a World Bank senior economist, is based on empirical work in middle-income and high-income economies.

New research shows that the rhythm of breathing directly impacts neural activity in a network of brain areas involved in smell, memory and emotions

The rhythm of breathing co-ordinates electrical activity across a network of brain regions associated with smell, memory, and emotions, and can enhance their functioning, according to a new study by researchers at Northwestern University. The findings, published in the Journal of Neuroscience, suggest that breathing does not merely supply oxygen to the brain and body, but may also organise the activity of populations of cells within multiple brain regions to help orchestrate complex behaviours.

Related: Your nose knows death is imminent | Mo Costandi

Related: A cooler way to evaluate brain surgery patients

Billy Crystal, Tiffany Haddish, Kenan Thompson and Byron Allen are set to co-host Sunday's Feeding America Comedy Festival.

Part of a series exploring issues likely to be addressed by the new National Integration Plan, this webinar, with perspectives from MPI, the National Partnership for New Americans, and the National Skills Coalition, looks at the role of adult education and English language and skills training in the immigrant integration process.

This webinar, with perspectives from MPI, the National Partnership for New Americans, and the National Skills Coalition, looks at the role of adult education and English language and skills training in the immigrant integration process.

The total number of cases in the province remains 284, with 30 now considered active.

George Mason University professor Elise Miller-Hooks and her team have been studying and modeling the flow of patients through American hospitals in times of crisis since 2014.

Gurus of classical music, dance go digital  Times of India

Fire officials are asking people in B.C. to test smoke alarms and take care in the kitchen as 15 people have died in the province so far this year due to fires — three times the number of deaths for the same time period in 2019.

Rose (Scotland) as been developing a growing ministry among residents at a local retirement community. What started with a single conversation has grown into a ministry that impacts many lives through friendship and community outreach.

(Source: Italian Evangelical Alliance) North African refugees flooding into Lampedusa are now being moved to various centres throughout Italy. The Italian Evangelical Alliance and their partner organisations are working to reach out to these displaced peoples.

The coordinator of OM Italy’s anti-trafficking ministry describes the birth of the ministry through meeting a Nigerian woman forced into prostitution in Rome.

Danish students gain perspective and experience with OM Italy.