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Red Cell Transfusion and Thrombotic Risk in Children




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Eosinophilic Pneumonia and Lymphadenopathy Associated With Vaping and Tetrahydrocannabinol Use

Idiopathic acute eosinophilic pneumonia is a rare and potentially life-threatening condition that is defined by bilateral pulmonary infiltrates and fever in the presence of pulmonary eosinophilia. It often presents acutely in previously healthy individuals and can be difficult to distinguish from infectious pneumonia. Although the exact etiology of idiopathic acute eosinophilic pneumonia remains unknown, an acute hypersensitivity reaction to an inhaled antigen is suggested, which is further supported by recent public health risks of vaping (electronic cigarette) use and the development of lung disease. In this case, a patient with a year-long history of vaping in conjunction with tetrahydrocannabinol cartridge use who was diagnosed with idiopathic acute eosinophilic pneumonia with associated bilateral hilar lymphadenopathy is described.




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Perspectives on Informed Consent Practices for Minimal-Risk Research Involving Foster Youth




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Improving Antibiotic Prescribing for Pediatric Urinary Tract Infections in Outpatient Settings

OBJECTIVES:

To determine if a multicomponent intervention was associated with increased use of first-line antibiotics (cephalexin or sulfamethoxazole and trimethoprim) among children with uncomplicated urinary tract infections (UTIs) in outpatient settings.

METHODS:

The study was conducted at Kaiser Permanente Colorado, a large health care organization with ~127 000 members <18 years of age. After conducting a gap analysis, an intervention was developed to target key drivers of antibiotic prescribing for pediatric UTIs. Intervention activities included development of new local clinical guidelines, a live case-based educational session, pre- and postsession e-mailed knowledge assessments, and a new UTI-specific order set within the electronic health record. Most activities were implemented on April 26, 2017. The study design was an interrupted time series comparing antibiotic prescribing for UTIs before versus after the implementation date. Infants <60 days old and children with complex urologic or neurologic conditions were excluded.

RESULTS:

During January 2014 to September 2018, 2142 incident outpatient UTIs were identified (1636 preintervention and 506 postintervention). Pyelonephritis was diagnosed for 7.6% of cases. Adjusted for clustering of UTIs within clinicians, the proportion of UTIs treated with first-line antibiotics increased from 43.4% preintervention to 62.4% postintervention (P < .0001). The use of cephalexin (first-line, narrow spectrum) increased from 28.9% preintervention to 53.0% postintervention (P < .0001). The use of cefixime (second-line, broad spectrum) decreased from 17.3% preintervention to 2.6% postintervention (P < .0001). Changes in prescribing practices persisted through the end of the study period.

CONCLUSIONS:

A multicomponent intervention with educational and process-improvement elements was associated with a sustained change in antibiotic prescribing for uncomplicated pediatric UTIs.




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Reflections From a Pediatrician Who Went Back to Summer Camp




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Chronic Thrombocytopenia as the Initial Manifestation of STIM1-Related Disorders

Pediatric thrombocytopenia has a wide differential diagnosis, and recently, genetic testing to identify its etiology has become more common. We present a case of a 16-year-old boy with a history of chronic moderate thrombocytopenia, who later developed constitutional symptoms and bilateral hand edema with cold exposure. Laboratory evaluation revealed evidence both of inflammation and elevated muscle enzymes. These abnormalities persisted over months. His thrombocytopenia was determined to be immune mediated. Imaging revealed lymphadenopathy and asplenia, and a muscle biopsy was consistent with tubular aggregate myopathy. Ophthalmology evaluation noted photosensitivity, pupillary miosis, and iris hypoplasia. Genetic testing demonstrated a pathogenic variant in STIM1 consistent with autosomal dominant Stormorken syndrome. Our case is novel because of the overlap of phenotypes ascribed to both gain-of-function and loss-of-function pathogenic variants in STIM1, thereby blurring the distinctions between these previously described syndromes. Pediatricians should consider checking muscle enzymes when patients present with thrombocytopenia and arthralgia, myalgia, and/or muscle weakness. Our case highlights the importance of both multidisciplinary care and genetic testing in cases of chronic unexplained thrombocytopenia. By understanding the underlying genetic mechanism to a patient’s thrombocytopenia, providers are better equipped to make more precise medical management recommendations.




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Office-Based Screening for Sexually Transmitted Infections in Adolescents

Almost 1 in 4 adolescents have a sexually transmitted infection (STI). These infections are preventable through safe sexual practices and routine screening. Pediatricians are the first line of clinical care for adolescents and are well positioned to offer sexual and reproductive health care counseling and services to their patients; yet, there is a paucity of sexual health screening provided at routine health supervision visits. This article addresses the epidemiology of STIs in adolescents, reviews the evidence of current clinical practice, presents recommended STI screening from government and medical agencies, and offers strategies to address barriers to providing care for adolescents and for sexual health screening in primary care.




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The Big Red Bus in Ballina

OM Ireland's Big Red Bus visited a housing estate in the town of Ballina in County Mayo.




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OM sows seeds at National Ploughing Championships

OM Ireland's community outreach team participates in one of Ireland's biggest events: the 2011 National Ploughing Championships in Athy, Co. Kildare from 20 -22 September.




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Immersed in ministry life

OM Ireland's Immersion team reflects on their first month as interns in churches around Ireland.




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Big Red Bus school tour reaches over 400 youth

OM Ireland's Creative Arts Team and a group from the US lead a week-long tour into schools and a kids’ club in a housing estate.




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OM Sweden and OM Ireland team up over Easter

OM Sweden joined OM Ireland for outreach over the Easter holiday in Carlow town.




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Children encouraged to 'Pass the Parcel'

To present the true meaning of Christmas, OM Ireland’s creative arts team performs a multimedia production in schools, churches and community centres around Ireland.




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Transformed by love

One Irish family experienced the transforming love of God...one woman at a time.




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Trained and equipped in Ireland

Through training at OM, Rebecca became more confident sharing Jesus in her home country.




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Encouraged to continue

Brandy and her daughter Alexia (USA) went to Ireland for a two-week outreach and left impacted just as much as they'd impacted others.




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Continuing to plant seeds

The opportunity to continue planting gospel seeds keeps drawing short-term outreach participants back to Ireland.




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Prayerful obedience

Sent from OM Ireland, the Fitzgibbon family followed God's call on their lives to Russia and back.




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Ploughing with the Big Red Bus

After years of the team dreaming, the Big Red Bus finally joins the National Ploughing Championships during a windstorm.




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Minas for the unreached

Africa Trek Coordinator Eduard* reflects on God's gifts: his life, his wife and 13 participants sharing the Gospel with Topnaar and Himba peoples in Namibia.




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2000km walked

Three men arrive home safely after walking 2000 kilometres to raise awareness about the 2000 languages still without the Bible.




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Unexpected impact

God uses theatrical evangelism camps to impact children from vulnerable populations as well as the short-term volunteers who serve.




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Others need to know and get involved

After a trip to repair war damaged churches in the east, construction workers share their experience in order to inspire others to go.




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Loved and not forgotten

Workers of OM Panama remind young boys with a troubled past that God has a purpose for their lives.




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Breaking into freedom

Balboa, Panama :: Crewmembers teach sewing skills to young mothers from a local tribe and donate sewing machines to the community.




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This is how God showed His power

Martin (Argentina) wasn’t sure whether short-term missions was his idea or God’s—until he went on an unforgettable 14-day outreach to Panama.




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Young, achingly hip and social media savvy: welcome to the world of Scotland's fashion influencers

Founded by Wendy H Gilmour in 2011, Thankfifi began as a fashion blog and has since grown to cover lifestyle, travel and interiors.




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Fin24.com | Hedge funds

A properly diversified portfolio needs some exposure to hedge funds, but negative perceptions remain a problem.




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Fin24.com | MONEY CLINIC: My loans are giving me a low credit score; how do I properly deal with them?

A Fin24 user looks to an expert for help in improving his credit score by paying off his debt.




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Fin24.com | MONEY CLINIC: Which debt should I pay off first in order to improve my credit score?

A Fin24 user wants to know whether paying off a car loan or credit card will make her credit score 'look better.'




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Fin24.com | MONEY CLINIC: I've been forced into early retirement and can't afford to repay my debt, what can I do?

A Fin24 user who was forced into early retirement is struggling to pay credit card debt amounting to over R109 000. An expert responds.




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Fin24.com | MONEY CLINIC: My debt has climbed to R82 000, I can't afford to pay

A Fin24 user urgently seeks guidance on how to pay off debt owing to the amount of R82 000. An expert responds with workable solutions.




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Fin24.com | MONEY CLINIC: Can we invest our retirement annuity without a broker, and negotiate fees charged?

A Fin24 reader looking to invest in a living annuity, was shocked to find that she would have to pay fees of up to R110 000 per annum. She wants to know if there are other options. An investment expert responds.




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Gerard Richardson: Californian reds

WELL, I don't know about you but my central heating has already been on twice in September and although I don't need much of an excuse to delve into the big heavy reds, two heating days is my current one.




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'A mesmerising voice that commands your undivided attention': A Thousand Moons by Sebastian Barry

A Thousand Moons




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Scots complaints about cancelled holidays and events soars as watchdog launches probe

COMPLAINTS about holidays have overtaken job concerns as the number one issue for hundreds of Scots contacting two independent national advice services every day during the coronavirus crisis.




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Picture special: Shahbaz Majeed puts Scotland in the frame

RIGHT now, Shahbaz Majeed should be heading to Glencoe. Or flying over central Scotland. Or making his way to Harris which he has been trying to get back to since his first visit in 2018. Or maybe visiting some other part of Scotland so he can capture it in a photograph. Instead, he is at home in Dundee (where he is web development manager at the University of Dundee), “climbing the walls,” and looking forward to life after lockdown.




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Harrington WE, Mato S, Burroughs L, Carpenter PA, Gershon A, Schmid DS, Englund JA. Vaccine Oka Varicella Meningitis in Two Adolescents. Pediatrics. 2019;144(6):e20191522




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Back to the future: how Vixy Rae is breathing new life into tartan and tweed from inside Edinburgh's oldest tailor

IT’S not everyone who’s given the chance to design their own tartan so when the opportunity arose, Vixy Rae didn’t need to give it a second thought.




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Hot List 2020: Anna Acquroff, Francine Toon, SHHE and Helen Sedgwick

ANNA ACQUROFF, MODEL/MUSICIAN




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Fin24.com | Stats SA approached by Treasury to cut budget, but Census 2021 will go ahead

The budget for Census 2021 is ringfenced and won't be compromised as Treasury seeks funds to fight Covid-19, says Statistician-General Risenga Maluleke.




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Over and above what was asked

God provides for OM EAST’s Bosnia Schoolbags Project this year in special and surprising ways.




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New booklet for red light ministries

OM EAST produces a new booklet that brings a message of hope to women working in prostitution.




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An unexpected letter

OM EAST rejoices at God’s provision sent by post.




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Media for minority languages

Graphic designers, translators and distributors from 130 organisations meet to develop media for minority languages in Eurasia.




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Shared joy in Serbia

After years of work and anticipation, Gypsy Smith has been published in Serbian, a cause for rejoicing in a Roma church in Serbia.




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Students equipped for His work

On 26 June, students from Austria Training Centre’s first year completed training in church planting, evangelism and discipleship.




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Andy Murray admits he may need another operation

ANDY MURRAY may need to have another operation as he continues his bid to return to top-level tennis.




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Tim Henman: Andy Murray's comeback attempt is unprecedented

ANDY MURRAY has had a bumpy ride over the past couple of years, undergoing hip surgery, staging a comeback which saw him win his first title in two years before another injury setback has seen him sidelined since the tail-end of last year.




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Swindon's Swedish adventure

We follow Swindon Town Football in the Community Under-17 girls on their journey from England to the Gothia Cup in Sweden.