The year 222 BCE saw the Roman Emperor Elagabalus assassinated by the Praetorian Guard, to be replaced by Alexander Severus,...

So now the rest of the world is discovering virtual communities. I'm feeling very hipster; we were doing it before...

Hibiscus tea mixed with tequila, lime, jalapeno, and pineapple makes this one delicious cocktail!

craving more? check out TasteSpotting

'B' is for basic controls that up and disappeared

A study of the UK online advertising market, conducted by global accounting firm PwC, has found that publishers get just half of what advertisers spend, with the other half siphoned off by ad-supply chain intermediaries.…

We all need to tighten our belts

For the first time in over three decades, BT has suspended its dividend scheme as the former state-owned teleco grapples with the fallout from the novel coronavirus pandemic, and the financial uncertainty that'll inevitably ensue.…

I realize that sounds kinda nuts — why are we asking PARENTS to show us their KIDS being independent? Who, after all, is better at making videos? Mom or little Ava (who’s 5)? But legally we can’t ask anyone under 13 to do anything. So go document your children doing something new on their own, […]

This flow chart, created by University of Virginia Psychology Professors Jim Coan and Daniel Willingham, is just plain terrific. “Could a child do this alone?” asks the chart. Then let ’em! “Could a child do this with some instruction?” Then let ’em. Etc. etc. Check it out — print it out! — by clicking here. […]

Date: April 29, 2020

On the fifth day of the Hebrew month of Iyar, Israeli communities worldwide celebrate their Independence Day, known locally as Yom Ha’atzmaut. Today’s Doodle pays tribute to this annual holiday in recognition of the day in 1948 when the State of Israel declared its independence. 

Depicted in the Doodle artwork, the flag of Israel features two blue stripes running horizontally over the white background with the Star of David at its center. Officially adopted in 1948, the same year as independence, the flag will be waved proudly wherever Israeli’s call home. 

Happy Yom Ha’atzmaut, Israel!​

Location: Israel

Tags: national day, National Holiday, independence, history, Israel

Королева Великобритании Елизавета II — единственная из действующих глав государств, служившая в вооруженных силах во время Второй мировой войны, — произнесла речь в честь Дня победы в Европе, который отмечается 8 мая. В своем выступлении она воздала дань памяти погибших и подчеркнула, что они гордились бы потомками.

We previously established that global deletion of the enhancer of trithorax and polycomb (ETP) gene, Asxl2, prevents weight gain. Because proinflammatory macrophages recruited to adipose tissue are central to the metabolic complications of obesity, we explored the role of ASXL2 in myeloid lineage cells. Unexpectedly, mice without Asxl2 only in myeloid cells (Asxl2ΔLysM) were completely resistant to diet-induced weight gain and metabolically normal despite increased food intake, comparable activity, and equivalent fecal fat. Asxl2ΔLysM mice resisted HFD-induced adipose tissue macrophage infiltration and inflammatory cytokine gene expression. Energy expenditure and brown adipose tissue metabolism in Asxl2ΔLysM mice were protected from the suppressive effects of HFD, a phenomenon associated with relatively increased catecholamines likely due to their suppressed degradation by macrophages. White adipose tissue of HFD-fed Asxl2ΔLysM mice also exhibited none of the pathological remodeling extant in their control counterparts. Suppression of macrophage Asxl2 expression, via nanoparticle-based siRNA delivery, prevented HFD-induced obesity. Thus, ASXL2 controlled the response of macrophages to dietary factors to regulate metabolic homeostasis, suggesting modulation of the cells’ inflammatory phenotype may impact obesity and its complications.

Elevated pressure in the pancreatic gland is the central cause of pancreatitis following abdominal trauma, surgery, endoscopic retrograde cholangiopancreatography, and gallstones. In the pancreas, excessive intracellular calcium causes mitochondrial dysfunction, premature zymogen activation, and necrosis, ultimately leading to pancreatitis. Although stimulation of the mechanically activated, calcium-permeable ion channel Piezo1 in the pancreatic acinar cell is the initial step in pressure-induced pancreatitis, activation of Piezo1 produces only transient elevation in intracellular calcium that is insufficient to cause pancreatitis. Therefore, how pressure produces a prolonged calcium elevation necessary to induce pancreatitis is unknown. We demonstrate that Piezo1 activation in pancreatic acinar cells caused a prolonged elevation in intracellular calcium levels, mitochondrial depolarization, intracellular trypsin activation, and cell death. Notably, these effects were dependent on the degree and duration of force applied to the cell. Low or transient force was insufficient to activate these pathological changes, whereas higher and prolonged application of force triggered sustained elevation in intracellular calcium, leading to enzyme activation and cell death. All of these pathological events were rescued in acinar cells treated with a Piezo1 antagonist and in acinar cells from mice with genetic deletion of Piezo1. We discovered that Piezo1 stimulation triggered transient receptor potential vanilloid subfamily 4 (TRPV4) channel opening, which was responsible for the sustained elevation in intracellular calcium that caused intracellular organelle dysfunction. Moreover, TRPV4 gene–KO mice were protected from Piezo1 agonist– and pressure-induced pancreatitis. These studies unveil a calcium signaling pathway in which a Piezo1-induced TRPV4 channel opening causes pancreatitis.

Lamin A is a component of the inner nuclear membrane that, together with epigenetic factors, organizes the genome in higher order structures required for transcriptional control. Mutations in the lamin A/C gene cause several diseases belonging to the class of laminopathies, including muscular dystrophies. Nevertheless, molecular mechanisms involved in the pathogenesis of lamin A–dependent dystrophies are still largely unknown. The polycomb group (PcG) of proteins are epigenetic repressors and lamin A interactors, primarily involved in the maintenance of cell identity. Using a murine model of Emery-Dreifuss muscular dystrophy (EDMD), we show here that lamin A loss deregulated PcG positioning in muscle satellite stem cells, leading to derepression of non–muscle-specific genes and p16INK4a, a senescence driver encoded in the Cdkn2a locus. This aberrant transcriptional program caused impairment in self-renewal, loss of cell identity, and premature exhaustion of the quiescent satellite cell pool. Genetic ablation of the Cdkn2a locus restored muscle stem cell properties in lamin A/C–null dystrophic mice. Our findings establish a direct link between lamin A and PcG epigenetic silencing and indicate that lamin A–dependent muscular dystrophy can be ascribed to intrinsic epigenetic dysfunctions of muscle stem cells.

Apple today announced that it will begin reopening its retail stores in Germany on May 11, nearly two months after they were closed due to the global health crisis.


In a statement shared with German website Macerkopf, Apple said the stores will initially be focusing on Genius Bar service and support. Enhanced health and safety measures will be implemented, such as body temperature checks prior to entry, limits on how many customers can be in the store at once, social distancing, and reduced hours of operation.

Apple operates 15 retail stores in Germany and will be posting specific hours of operation for each location on its website.

Apple closed all of its retail stores outside of the Greater China region in mid-March. The company has since started to reopen some locations, including in South Korea, Austria, and Australia. All locations in the United States remain closed.

This article, "Apple Stores in Germany to Begin Reopening May 11 With Enhanced Health and Safety Measures" first appeared on MacRumors.com

Discuss this article in our forums

Apple in mid-April reopened Apple Garosugil, its lone store in South Korea, located in the Seoul's Gangnam District.


Apple's South Korea reopening has served as a test ground for further store reopenings, and Apple created an instructional video on reopening practices that's now being shared with other retail employees around the world as they prepare to reopen stores. We're not able to share the video, but it provides a good overview of the measures Apple is putting in place to safely operate retail locations.

Retail employees are following a strict set of guidelines that very heavily emphasize social distancing of two meters (or six feet in the United States). Apple is taking the following measures:

• Prior to when work starts, all employees undergo a health screening complete with a temperature check, with the results logged in a daily spreadsheet.


• Daily briefings are done in the mornings in the Forum area at Apple Stores, with employees making sure to sit at least two meters apart.


• Prior to being allowed in the store, customers are also given a temperature check.


• All ‌Apple Stores‌ are providing hand sanitizer, which customers are encouraged to use.


• Stores are limiting the number of people inside, forming lines with customers waiting at least two meters apart.


• Products purchased by customers or returned after repair are delivered from the back in a relay system, being handed off from employee to employee to allow each person to stay in a separated zone without back and forth.


• Product specialists and Genius Bar staff are positioning themselves across tables away from customers in order to maintain distance.


• In the forum area, employees sit one cube away from customers they're interacting with.


• Employees are encouraged to communicate with one another through the Talk app to cut down on unnecessary movement within the store.


• Half of the workstations in the back are empty, with employees working at alternating workstations to keep more distance between them.


• Tables have been rearranged to put products on corners to prevent customers from being near one another.


• Products on tables have been reduced.


• Communal tables and couches have been removed from employee break rooms and have been replaced with individual chairs evenly spaced about the room.


• Operating hours are reduced.


• Employees are all wearing face masks.

After opening its South Korea store on April 16, Apple has reopened its sole store in Vienna, Austria, and 21 stores located in Australia. Stores in Germany will begin reopening on May 11, and all of the newly opened locations are following many of the same guidelines listed above to keep both customers and employees safe.

There's no word yet on when Apple retail stores in the United States will start to reopen, but Apple CEO Tim Cook last week said that stores in North America will begin reopening starting in the month of May.

Apple plans to evaluate data and make reopening decisions on a city by city, county by county basis, following local guidelines and recommendations before opening up a store.
This article, "Apple Preparing Retail Employees to Return to Work With Tips From South Korea Reopening" first appeared on MacRumors.com

Discuss this article in our forums

Apple will begin reopening its retail stores in the United States next week, reports CNBC, starting with locations in Idaho, South Carolina, Alabama, and Alaska.


Apple plans to limit the number of customers in the store at a time, and temperature checks will be performed at the door. Apple also has a number of other measures in place to keep customers and employees safe, as we outlined this morning.

"We're excited to begin reopening stores in the US next week, starting with some stores in Idaho, South Carolina, Alabama and Alaska. Our team is constantly monitoring local heath data and government guidance, and as soon as we can safely open our stores, we will."

"Our new social distance protocol allows for a limited number of visitors in the store at one time so there may be a delay for walk-in customers. We recommend, where possible, customers buy online for contactless delivery or in-store pick up."

Reopened Apple Stores will operate on reduced hours and will primarily focus on repairs, with Apple encouraging customers to purchase online where possible.

Most stores are not listing hours at this time with the exception of Apple Boise Towne Square, which reopens Monday at 11:00 a.m.

During last week's earnings call, Apple CEO Tim Cook said that Apple planned to start reopening some stores in the United States in May. Store reopenings are done on a city by city, county by county basis, with Apple taking into account local data and guidelines.

Apple has already reopened stores in South Korea, Austria, and Australia, with plans to also reopen stores in Germany next week.
This article, "Apple to Start Reopening U.S. Stores Next Week" first appeared on MacRumors.com

Discuss this article in our forums

The Ursa Majors are ready for votes and the nominees have been revealed. Voting can be found at their website and is open throughout the month of March. Two categories, however, received no nominees due to being an insufficient number of nominations and will not be put up to vote for a winner. Those two categories being Fursuits and Non-Fiction.

If you enjoy film, fiction, art, or any other of the many items that are up for selection as the best of the best for the year of 2019 be sure to vote this month. If you like non-fiction or fursuits, well, you can always be sure to nominate next year.

The nominees are:

read more

Disney has announced that it will be producing a new Robin Hood movie.

Yes, that Robin Hood.

read more

The tenth annual Open Hardware Summit will be in New York held online on March 13. I’ll be participating in a panel looking back at the past ten years of open source hardware and looking forward to the next decade as well. The schedule is filled with great speakers and I’m looking forward to seeing … Continue reading Open Hardware Summit 2020 →

IBM Research today opened its second research location on the African continent and announced several new project collaborations in the areas of data driven healthcare, digital urban ecosystems and astronomy.

IBM today announced it is now offering ThinkData Works’ open data solution on IBM’s platform-as-a-service, Bluemix, to give application developers access to clean, open data from all levels of government in Canada.

Bank of Montreal (BMO), CaixaBank, Commerzbank and Erste Group have joined an initiative launched by UBS and IBM in 2016 to build a new global trade platform based on blockchain technology. This new platform, called Batavia, is built to be openly accessed by organisations of all sizes anywhere in the world, and can support trade finance for transactions across all modes of trade, whether goods are being transported by air, land or sea.

La inteligencia artificial (IA) promete transformar tanto el futuro del trabajo como la función de Recursos Humanos (RRHH). Alineado con esta premisa, IBM (NYSE: IBM) anunció hoy IBM Talent & Transformation, una nueva unidad destinada a ayudar a las organizaciones y a sus empleados a tener éxito en la era de la inteligencia artificial y la automatización.

IBM y la Asociación de Tenis de los Estados Unidos (USTA por sus siglas en inglés) anunciaron que IBM Watson participará en el campeonato US Open por primera vez por medio de una nueva característica de consejería cognitiva piloteada en las aplicaciones móviles oficiales del torneo, a fin de mejorar la experiencia de los aficionados presentes en el Billie Jean King National Tennis Center.

A new IBM study of more than 1,700 Chief Executive Officers from 64 countries and 18 industries worldwide reveals that CEOs are changing the nature of work by adding a powerful dose of openness, transparency and employee empowerment to the command-and-control ethos that has characterised the modern corporation for more than a century.

Les revendeurs internationaux observent une croissance significative pendant Thanksgiving et le Black Friday. IBM enregistre un engagement record dans son rapport annuel Holiday Readiness Clients

La nouvelle plateforme URights s’appuie sur les solutions analytiques et cloud d’IBM pour mieux valoriser les droits des auteurs, compositeurs et éditeurs de musique

Melbourne, Australia - 18 August 2014: IBM (NYSE: IBM) and the City of Melbourne today launched a new interactive online experience for this year’s Melbourne Spring Fashion Week (MSFW) to enhance the iconic event and help shoppers hunt down the best retail bargains. The launch of the experience signifies the beginning of a three-year partnership between the City of Melbourne and IBM as the Official Innovation and Technology Partner for MSFW.

IBM (NYSE: IBM) and Tennis Australia today announced new and expanded data driven experiences that will enhance Australian Open 2015 for fans on site and around the world. IBM SlamTracker has been redesigned with new point-by-point data visualisations, commentary and statistics that include player and ball movement data for the first time ever at the Australian Open. IBM CrowdTracker, new for 2015, will provide fans with live match, venue and social information via ausopen.com and the official Australian Open apps.

IBM Security today announced a new capability from IBM Trusteer that helps banks identify fraudulent accounts before they are opened. The technology also protects consumers even if they are not a customer of the bank being targeted with the fake account.

A new IBM (NYSE: IBM) study of more than 1,700 Chief Executive Officers from 64 countries and 18 industries worldwide reveals that CEOs are changing the nature of work by adding a powerful dose of openness, transparency and employee empowerment to the command-and-control ethos that has characterised the modern corporation for more than a century.

dollypopinspiration:

nanushka

Open space with natural light in the Lousiana Museum of Modern Art ✨ via

@mariavannguyen

The voice of Ahsoka Tano tells StarWars.com about writing the new Little Golden Book and rewatching Star Wars: The Clone Wars for inspiration.

It's official! Starfighter t-shirts are ready for PRE-ORDER!

Black American Apparel t-shirts with silkscreen print, available in different sizes! We got the first batch in and the print quality is fantastic! Shirts are estimated to ship on 8/20/09! Limited quantity for the time being!

ORDER AVAILABLE ONLINE @ STARFIGHTER SHOP
http://shop.starfightercomic.com/

Thank you guys so much! More merchandise is on the way! -HamletMachine

Kvůli epidemii koronaviru se vláda na čas vzdá EET, projektu, který vnímá jako klíčový pro snížení daňových úniků. Sněmovna kývla na odklad celé EET do konce letošního roku. Potvrdit to ještě musí Senát. Neprošly návrhy opozice odložit EET ještě déle, když přitom Pirát Mikuláš Ferjenčík navrhoval odklad až do stých narozenin premiéra Andreje Babiše v roce 2054.

Donald Trump is getting nervous. Internal polls show him losing in November unless the economy comes...

Sports Minister Kiren Rijiju said the first priority for this would be given to those who have qualified for the Olympics.

Nová zákon „Lex voucher“ stanovil pravidla pro vypořádání cestovních kanceláří s klienty. Na problematické situace, které mohou být s koupeným zájezdem spojeny, jsme se zeptali advokáta Ondřeje Vokála.

A convocation of the Lover Triad of United States Grand Lodge will be held in Cleveland, Ohio, August 14-16 2020. Registration for the convocation is now open. See this site for more information.

In 2017, a team from Northeastern University released Turnstile, a framework for implementing propositionally typed languages in Racket; cf. naasking's story Type Systems as Macros. The system was really nice because it allowed type systems to be expressed in a manner similar to the way theoretical PL researchers would in a paper, and because it hooked into Racket's clean compiler backend.

Now Stephen Chang, one of that team, together with new coauthors Michael Ballantyne, Usamilo Turner and William Bowman, have released a rewrite that they call Turnstile+, together with a POPL article, Dependent Type Systems as Macros. From that article's introduction:

Turnstile+ represents a major research leap over its predecessor. Specifically, we solve the major challenges necessary to implement dependent types and their accompanying DSLs and extensions (which Turnstile could not support), while retaining the original abilities of Turnstile. For example, one considerable obstacle was the separation between the macro expansion phase and a program’s runtime phase. Since dependently typed languages may evaluate expressions while type checking, checking dependent types with macros requires new macrology design patterns and abstractions for interleaving expansion, type checking, and evaluation. The following summarizes our key innovations.

• Turnstile+ demands a radically different API for implementing a language’s types. It must be straightforward yet expressive enough to represent a range of constructs from base types, to binding forms like Π-types, to datatype definition forms for indexed inductive type families.
• Turnstile+ includes an API for defining type-level computation, which we dub normalization by macro expansion. A programmer writes a reduction rule using syntax resembling familiar on-paper notation, and Turnstile+ generates a macro definition that performs the reduction during macro expansion. This allows easily implementing modular type-level evaluation.
• Turnstile+’s new type API adds a generic type operation interface, enabling modular implementation of features such as error messages, pattern matching, and resugaring. This is particularly important for implementing tools like tactic systems that inspect intermediate type-checking steps and construct partial terms.
• Turnstile+’s core type checking infrastructure requires an overhaul, specifically with first-class type environments, in order to accommodate features like dependent binding structures of the shape[x:τ]...,i.e., telescopes [de Bruijn 1991; McBride 2000].
• Relatedly, Turnstile+’s inference-rule syntax is extended so that operations over telescopes, or premises with references to telescopes, operate as folds instead of as maps

The code is available at https://github.com/stchang/macrotypes.

Minister De Croo (Open Vld): 'Hoop dat misbruik van coronasteun door zelfstandigen randfenomeen is'  De MorgenHele verhaal bekijken via Google Nieuws

1. 76 nieuwe overlijdens in de afgelopen 24 uur, evenveel ziekenhuisopnames  Het Belang van Limburg
2. OVERZICHT. Dalende curve zet zich voort. 76 overlijdens, 210 patiënten naar huis en 76 nieuwe opnames  Het Laatste Nieuws
3. Coronavirus: 76 overlijdens, 210 patiënten ontslagen uit het ziekenhuis  newsmonkey
4. Minder patiënten in onze ziekenhuizen  Het Nieuwsblad
5. OVERZICHT. 76 nieuwe ziekenhuisopnames en overlijdens, 585 nieuwe besmettingen | Binnenland | Nieuws  Het Laatste Nieuws
6. Hele verhaal bekijken via Google Nieuws

1. Verbod om water op te pompen komt vroeger dan ooit  De Tijd
2. Extreem droge maand april: verbod om water op te pompen uit tien kwetsbare stromen in provincie Antwerpen  Gazet van Antwerpen
3. Vlaams infocentrum land- en tuinbouw - Captatieverbod in 10 stroomgebieden in Antwerpen  Vilt
4. Water oppompen verboden in tiental kleine waterlopen in Antwerpen door aanhoudende droogte  VRT NWS
5. Captatieverbod in tien ecologisch kwetsbare stroomgebieden i...  Het Nieuwsblad
6. Hele verhaal bekijken via Google Nieuws

1. Uitvoerders van roofmoord op Leopoldine De Decker krijgen 28 jaar, opdrachtgevers hoeven niet terug naar de cel  Gazet van Antwerpen
2. Na negen uur in beraad: vier veroordelingen en één vrijspraak in roofmoord Leopoldine (76)  Het Nieuwsblad
3. Straffen tussen 3 en 29 jaar cel geëist in zaak roofmoord op Leopoldine De Decker  Gazet van Antwerpen
4. ASSISEN. Tot 28 jaar cel voor roofmoord op Leopoldine De Decker, familie opgelucht: “Nu kunnen we eindelijk verder met ons leven”  Het Laatste Nieuws
5. ASSISEN. Roofmoord op Leopoldine De Decker: 28 jaar cel voor uitvoerders, (deels) voorwaardelijke straffen voor opdrachtgevers  Het Laatste Nieuws
6. Hele verhaal bekijken via Google Nieuws

Hi guys,  I don’t know what happened to all of my recent messages, I am guessing that the Clouds were at their nasty work again – stealing!  So I am going to write more and you write me back ok? Well I just got back from one of my favorite little planets, planet Earth.  I […]

1. Should You Get A Nintendo Switch Lite If You Can’t Find Switch Availability? It Depends  Forbes
2. Nintendo Switch Lite is in stock at Amazon and Best Buy: Latest inventory update  CNET
3. Best Switch Games So Far In 2020  Trusted Reviews
4. Nintendo Switch Capture Cards: How to Record Video of Your Gameplay  Screen Rant
5. View Full coverage on Google News

Air travelers cannot receive cash compensation if their flight is delayed by a passenger biting others and assaulting crew members, an adviser at the Court of Justice of the European Union said on Thursday.

Chewy and Miley, both two-year-old Schnauzer dogs, are getting their hair cut at a groomer in Bangkok for the first time since the new coronavirus outbreak began in Thailand in January.