A record 62 clubs from 50 countries have entered the 2019/20 edition: see who is aiming for Vienna.

Just like grocery stores offer free food samples, technology companies, such as VoiceThread, offer free accounts for educators who want to try their products.

Digital curricula repositories are helping to fill the growing need for more and better multimedia content.

U.S. Department of Education money will help public television develop projects promoting math and literacy for children ages 2 to 8.

Summer programs that use multimedia may improve student literacy, numeracy, phonics skills, and math vocabulary, according to a study released by WestEd, a nonprofit education research organization. The report examines the Electric Company's Summer Learning Program, which is sponsored by the Sesame

Students are learning how to research and write scripts, hone interviewing techniques, and edit video footage, and some teenagers are even earning certifications in media technology.

Have you noticed that the Internet is changing the world into a

Public libraries are moving deeper into digital learning, often in partnership with schools and other institutions, to help prepare students for the skills they'll need for college and careers.

Education Week takes a close look at the obstacles and opportunities for American Indian children in finding success in school and beyond.

Most districts have the technology to support the basic digital textbooks of today, but not the interactive, multimedia-rich ones of the future.

The California Teachers Association continues its assault on NCLB. To supplement its Web ads, it has turned to YouTube and radio ads. The YouTube video tears at heartstrings and predicts that NCLB will lead to the end of public education as we know it. The radio ad includes standard union criticism

The Newseum in Washington has just launched Decision 2012: Exploring Elections and the Media, an online resource for teaching about the presidential campaign and election.

Participate in a chat about how multimedia tools are transforming teaching and learning in core academic subjects.

Video, audio, photo galleries and infographics on education news and issues from preschool through the 12th grade.

Like other Americans, liberal and conservative teachers perceive news sources' credibility differently. How does that affect their teaching of media literacy?

Unable to host their senior capstone showcase as an on-campus celebration of their work with family and friends in attendance, graduating students in the Graphic Design undergraduate program in the Stuckeman School at Penn State are turning to Instagram to highlight their design work in a creative way to an even larger potential audience during the week of May 4-8.

Burundi’s year-long crisis has not gone away. It started with President Pierre Nkurunziza’s determination to claim a third term, trampling over the constitutional arrangements that ended a decade-long civil war. Press freedom is a major casualty of the new strife; but the turmoil has also transformed the way in which Burundians get information. For better or worse, social media has filled the vacuum left by the shutting down of the most popular radio stations and forcing out of many of the country’s professional journalists.

Polymyxins are increasingly used as the critical last-resort therapeutic options for multidrug-resistant gram-negative bacteria. Unfortunately, polymyxin resistance has increased gradually for the last few years. Although studies on mechanisms of polymyxin are expanding, system-wide analyses of the underlying mechanism for polymyxin resistance and stress response are still lacking. To understand how Klebsiella pneumoniae adapt to colistin (polymyxin E) pressure, we carried out proteomic analysis of Klebsiella pneumoniae strain cultured with different concentrations of colistin. Our results showed that the proteomic responses to colistin treatment in Klebsiella pneumoniae involving several pathways, including (i) gluconeogenesis and TCA cycle; (ii) arginine biosynthesis; (iii) porphyrin and chlorophyll metabolism; and (iv) enterobactin biosynthesis. Interestingly, decreased abundance of class A β-lactamases including TEM, SHV-11, SHV-4 were observed in cells treated with colistin. Moreover, we also present comprehensive proteome atlases of paired polymyxin-susceptible and -resistant Klebsiella pneumoniae strains. The polymyxin-resistant strain Ci, a mutant of Klebsiella pneumoniae ATCC BAA 2146, showed missense mutation in crrB. The crrB mutant Ci, which displayed lipid A modification with 4-amino-4-deoxy-L-arabinose (L-Ara4N) and palmitoylation, showed striking increases of CrrAB, PmrAB, PhoPQ, ArnBCADT and PagP. We hypothesize that crrB mutations induce elevated expression of the arnBCADTEF operon and pagP via PmrAB and PhoPQ. Moreover, multidrug efflux pump KexD, which was induced by crrB mutation, also contributed to colistin resistance. Overall, our results demonstrated proteomic responses to colistin treatment and the mechanism of CrrB-mediate colistin resistance, which may further offer valuable information to manage polymyxin resistance.

Chromosomal and plasmid-borne AmpC cephalosporinases are a major resistance mechanism to β-lactams in Enterobacteriaceae and Pseudomonas aeruginosa. The new β-lactamase inhibitor avibactam effectively inhibits class C enzymes and can fully restore ceftazidime susceptibility. The conserved amino acid residue Asn³⁴⁶ of AmpC cephalosporinases directly interacts with the avibactam sulfonate. Disruption of this interaction caused by the N³⁴⁶Y amino acid substitution in Citrobacter freundii AmpC was previously shown to confer resistance to the ceftazidime-avibactam combination (CAZ-AVI). The aim of this study was to phenotypically and biochemically characterize the consequences of the N³⁴⁶Y substitution in various AmpC backgrounds. Introduction of N³⁴⁶Y into Enterobacter cloacae AmpC (AmpC_cloacae), plasmid-mediated DHA-1, and P. aeruginosa PDC-5, led to 270-, 12,000-, and 79-fold decreases in the inhibitory efficacy (k₂/K_i) of avibactam, respectively. The kinetic parameters of AmpC_cloacaeand DHA-1 for ceftazidime hydrolysis were moderately affected by the substitution. Accordingly, AmpC_cloacaeand DHA-1 harboring N³⁴⁶Y conferred CAZ-AVI resistance (MIC of ceftazidime of 16 µg/ml in the presence of 4 µg/ml of avibactam). In contrast, production of PDC-5 N³⁴⁶Y was associated with a lower MIC (4 µg/ml) since this β-lactamase retained a higher inactivation efficacy by avibactam in comparison to AmpC_cloacaeN³⁴⁶Y. For FOX-3, the I³⁴⁶Y substitution did not reduce the inactivation efficacy of avibactam and the substitution was highly deleterious for β-lactam hydrolysis, including ceftazidime, preventing CAZ-AVI resistance. Since AmpC_cloacaeand DHA-1 display substantial sequence diversity, our results suggest that loss of hydrogen interaction between Asn³⁴⁶ and avibactam could be a common mechanism of acquisition of CAZ-AVI resistance.

Florfenicol belongs to a class of phenicol antimicrobials widely used as feed additives and for the treatment of respiratory infections. In recent years, increasing resistance to florfenicol has been reported in Campylobacter spp., the leading foodborne enteric pathogen causing diarrheal diseases worldwide. Here, we reported the identification of fexA, a novel mobile florfenicol resistance gene in Campylobacter. Of the 100 Campylobacter jejuni strains isolated from poultry in Zhejiang, China, nine of them were shown to be fexA positive, and their whole genome sequences were further determined by integration of Illumina short-read and MinION long-read sequencing. The fexA gene was found in the plasmid of one strain and chromosomes of eight strains, and its location was verified by S1 nuclease pulsed-field gel electrophoresis (S1-PFGE) and Southern blotting. Based on comparative analysis, the fexA gene was located within a region with the tet(L)-fexA-catA-tet(O) gene arrangement, demonstrated to be successfully transferrable among C. jejuni strains. Functional cloning indicated that acquisition of the single fexA gene significantly increased resistance to florfenicol, whereas its inactivation resulted in increased susceptibility to florfenicol in Campylobacter. Taken together, these results indicated that the emerging fexA resistance is horizontally transferable, which might greatly facilitate the adaptation of Campylobacter in food producing environments where florfenicols are frequently used.

BACKGROUND AND OBJECTIVES:

Children with medical complexity (CMC) comprise only 6% of the pediatric population, account for ~40% of pediatric health care spending, and provide an important opportunity for cost saving. Savings in this group can have an important impact on pediatric health care costs. The objective of this study was to assess the impact of a multicenter care management program on spending and use in CMC.

BACKGROUND:

Elevated non–high-density lipoprotein cholesterol (HDL-C) levels are used to identify children at increased cardiovascular risk, but the use of non–HDL-C in childhood to predict atherosclerosis is unclear. We examined whether the National Heart, Lung, and Blood Institute classification of youth non–HDL-C status predicts high common carotid artery intima-media thickness in adulthood.

An Albanian man's heart is forever changed after suffering a heart attack and meeting Jesus in his recuperation.

Michelle R. Darnell, associate clinical professor in management and director of honor and integrity at Smeal, has been appointed as the inaugural director of the Tarriff Center for Business Ethics and Social Responsibility.

Penn State Health has appointed Don McKenna as president of Penn State Health Hampden Medical Center.

Penn State Health Milton S. Hershey Medical Center has begun enrolling participants in an international clinical trial evaluating an investigational antiviral drug, remdesivir, for treatment of coronavirus disease 2019 (COVID-19).

Ricardinho has been named the first-ever official UEFA Futsal EURO Player of the Tournament after captaining Portugal to the title and finishing seven-goal top scorer.

An Albanian man's heart is forever changed after suffering a heart attack and meeting Jesus in his recuperation.

Wine, fish, and excessive use of social media were a few of the topics that earned students top honors in Penn State Hazleton's first-ever virtual Undergraduate Research Fair.

An Albanian man's heart is forever changed after suffering a heart attack and meeting Jesus in his recuperation.

Katherine H. Burns
Oct 1, 2010; 126:638-646
ARTICLES

Like other Americans, liberal and conservative teachers perceive news sources' credibility differently. How does that affect their teaching of media literacy?

Lyon and England right-back Lucy Bronze is the first defender to win the poll of coaches and journalists.

A recent school tour of three Bay Area schools with some blended learning experts helped provide answers to some of the common questions we hear about how to implement blended learning.

Penn State Brandywine is offering a complimentary virtual seminar on Practical Social Media Tactics for the Busy Entrepreneur from 11:30 a.m. to 1:30 p.m. May 18, through Zoom video conferencing.

People find it convenient to use Facebook or other social media accounts to sign up for most new apps and services, but they prefer to use their e-mail address or open a new account if they feel the information in the app is too sensitive, according to a team of researchers.

Entries from two Penn State students were among winners in categories for professional television journalists as part of the Keystone Media Awards.

Penn State Health has opened two regional clinics to care for patients with confirmed or suspected COVID-19 who have health care needs that are serious enough to warrant a face-to-face appointment.

Eight Penn State Health doctors have been named among the Pennsylvania Medical Society's "Top Physicians Under 40."

The staff of Hershey Medical Center is one of only several academic hospitals in the country with specialized infrastructure and and training geared around offering care during a contagion outbreak. But they have another advantage, too. “We are all a family,” says one doctor. “And we look out for one another.”

The spring season at Penn State College of Medicine is packed full of research presentations, awards and ceremonies. Since experts cannot predict when social distancing guidelines will be relaxed, College of Medicine leaders plan on celebrating many of these springtime celebrations virtually — including commencement.

Reports of suspected child abuse have declined in Pennsylvania since the onset of social distancing guidelines. But experts in the Penn State Center for the Protection of Children say this does not correlate with an actual decline in abuse cases.

The arts, geography, economics, and foreign languages will lose their place in the testing line-up as the National Assessment of Educational Progress is being streamlined to cut costs.

For their longstanding support of the Center for the Performing Arts and the Penn State community, Deb and Stan Latta have been named the center’s 2020 Distinguished Service Award recipients.

In 2019 alone, Corner LaunchBox had 10 accelerator program graduates, supported five new startups anchored in Pennsylvania, and helped create 20 new jobs. More than 900 individuals utilized the facility for a variety of free and low-cost activities, including the 10-week Corner Opportunity accelerator program, an Idea TestLab, small business and entrepreneurship workshops, free legal clinics, weekly information sessions, and networking events.