A method and system for treating tissue with a combined therapy profile is disclosed. In one exemplary embodiment, ultrasound energy is used to treat numerous depths of tissue within a region of interest and the spatial and temporal properties of the ultrasound energy are varied for more effective treatment. The method and system of the present invention are configured to treat all of the tissue from the surface on down and not spare intervening tissue.

A system for arm therapy comprises a first drive (M2) that can be fixedly connected to an element (10) determining the position of a user (19) and rotationally driving, about a first axis (A2), a part (21, 22, 23, 24, 25, M1, 26) of the arm therapy system which can be connected to an upper arm module (26, M3, M4). The driven part of the arm therapy system comprises a second drive (M1) adapted to rotationally drive said upper arm module (26, M3, M4) about a second axis (A1), wherein said second axis (A1) is oriented orthogonal to the first axis (A2). The system can provide a statically determined exoskeleton with correct anatomical axes and misaligned technical axes.

A method and system uniquely capable of generating thermal bubbles for improved ultrasound imaging and therapy. Several embodiments of the method and system contemplates the use of unfocused, focused, or defocused acoustic energy at variable spatial and/or temporal energy settings, in the range of about 1 kHz-100 MHz, and at variable tissue depths. The unique ability to customize acoustic energy output and target a particular region of interest makes possible highly accurate and precise thermal bubble formation. In an embodiment, the energy is acoustic energy. In other embodiments, the energy is photon based energy (e.g., IPL, LED, laser, white light, etc.), or other energy forms, such radio frequency electric currents (including monopolar and bipolar radio-frequency current). In an embodiment, the energy is various combinations of acoustic energy, electromagnetic energy and other energy forms or energy absorbers such as cooling.

The present invention extends to a disinfection cap for disinfecting a male luer end of an infusion therapy device. The disinfection cap can include an internal reservoir containing an antimicrobial or saline solution which is sealed with a flexible septum to prevent the solution from evaporating. The septum can include one or more slits or pierceable seams that allow a male luer end of an infusion therapy device to be inserted through the septum and into the solution. While the male luer is inserted through the septum, the solution contacts both the inner and outer surfaces of the male luer. Because the septum reduces evaporation of the solution and prevents the solution from leaking out of the cap, the solution remains in contact with the male luer for a longer duration then when typical disinfection caps are used thereby increasing the effectiveness of the disinfectant.

The present invention relates generally to a home therapy system for aiding spinal cord decompression and for treating related health issues. More specifically, the present invention teaches a garment system combining an upper portion and lower portion. According to a preferred embodiment, the upper portion includes a head band and yoke for cervical vertebra disc decompression and for aiding in treating Obstructive Sleep Apnea by repositioning and opening up breathing airways. Further in accordance with a preferred embodiment, the lower portion includes vertical decompression straps attached to leg bands and extending over the shoulders for thoracic and lumbar disc decompression by arching the spinal column back and opening the vertebra.

Disclosed is a novel photosensitizer based on polymer derivatives-photosensitizer conjugates for photodynamic therapy capable of being selectively accumulated in cancerous tissues and producing singlet oxygen or free radical by laser irradiation. The polymer derivatives-photosensitizer conjugates for photodynamic therapy are prepared as nano-sized particles, and have excellent selection and accumulation ratio for cancerous tissues. The photosensitizer conjugates can produce singlet oxygen or free radical by a specific laser wavelength. Owing to the excellent selection and accumulation ratio for cancerous tissues, the conjugates minimizes photo-cytotoxicity of the conventional photosensitizer having a low molecular amount. Accordingly, the conjugates are very useful as a photosensitizes for photodynamic therapy with reduced side effects and excellent therapeutic effectiveness.

The present invention relates to antibody molecules against anticoagulants, in particular dabigatran, and their use as antidotes of such anticoagulants.

The present invention relates to fusion proteins comprising an antibody, functional fragment or functional derivative thereof having specific binding affinity to either the extracellular domain of oncofetal fibronectin (ED-B) or at least one of the extracellular domains of oncofetal tenascin fused to a cytokine selected from the group consisting of IL-10, IL15, IL-24 and GM-CSF, functional fragments and functional derivatives thereof. The invention is also directed to the use of at least one of said fusion proteins for the manufacture of a medicament. In particular, the invention concerns the use of said medicament for the treatment of tumors or chronic inflammatory diseases such as atherosclerosis, arthritis and psoriasis.

An instrument is configured to receive a staple cartridge to staple tissue and expel a fluid from within a container in the staple cartridge. The staple cartridge has an upper deck including staple apertures and orifices formed therein. The orifices are in fluid communication with the containers. The staple cartridge includes staple drivers having a driver body to translate a staple and a container protrusion to expel the fluid out the orifices. The fluid may be expelled while driving the staples out through the staple apertures. The container may be vertically compressible container or, in one alternative, may be a container having a channel and a sealant that is configured to be pierced as the fluid is expelled. Some configurations for the fluid include a hemostatic agent, thrombin, a gel, or a medicament. The containers may also be formed as reservoirs defined within the upper deck and/or cartridge body.

The present invention relates to a composition useful for the diagnosis of diseases associated with aberrant expression of the genes encoding the secreted proteins Futrin 1, 2, 3 and/or 4(=R-Spondin 2, 3, 1 and 4, respectively), e.g. in connection with tumors or diseases of the muscle, kidneys or bones. The present invention also relates to a pharmaceutical composition containing a compound which is capable of modifying (a) the expression of the gene encoding Futrin 1, 2, 3 and/or 4 or (b) the activity of the Futrin 1, 2, 3 and/or 4 protein.

A method of treating an object with radiation that includes generating volumetric image data of an area of interest of an object and emitting a therapeutic radiation beam towards the area of interest of the object in accordance with a reference plan. The method further includes evaluating the volumetric image data and at least one parameter of the therapeutic radiation beam to provide a real-time, on-line or off-line evaluation and on-line or off-line modification of the reference plan.

The present invention provides method and apparatus to perform combined cognitive and motor rehabilitation on a computerized non-portable system or on single portable device. A patient can play a variety of games that require the patient to perform a variety of memory exercises which involve physical exertion. The activities of the patient are monitored with pattern analysis software which provides feedback to the patient. The feedback can include voice synthesis, video guidance, progression messages etc. Patient data obtained while the patient is performing each of the memory exercises is stored locally on a database module and then uploaded to a cloud server. A remote psychologist/psychiatrist monitors the patient by logging into the same cloud, and updating cognition exercises. The same therapist can have live chats with the patient for further interaction and coaching.

Apparatus for performing electron radiation therapy on a breast cancer patient preferably includes an intraoperative electron radiation therapy machine, an intraoperative electron radiation therapy collimator tube connected to the intraoperative electron radiation therapy machine, and a plurality of filters made of a material having substantially the same density as human breast tissue for placement between the machine and the patient to change the energy of a monoenergetic beam after the beam has left the machine, allowing a filter to be chosen to reduce the energy traveling through the tube to a desired amount of energy to treat the patient. A method of controlling the amount of energy to reach a breast cancer patient undergoing electron radiation therapy includes selecting a filter made of a material having substantially the same density as human tissue and placing the filter between an intraoperative electron radiation therapy machine and a breast cancer patient to change the energy of a monoenergetic beam after it has left the machine, the filter being chosen to reduce the energy traveling from the machine to a desired amount of energy to treat the patient.

Provided herein are methods of treating a proliferative disease in a subject, comprising administering to the subject a therapeutically effective amount of AC220 and a nucleoside analog, a topoisomerase inhibitor or an anthracycline, or a combination thereof.

The present invention relates to Chimeric Antigen Receptors (CAR) that are recombinant chimeric proteins able to redirect immune cell specificity and reactivity toward selected membrane antigens, and more particularly in which extracellular ligand binding is a scFV derived from a CD123 monoclonal antibody, conferring specific immunity against CD123 positive cells. The engineered immune cells endowed with such CARs are particularly suited for treating lymphomas and leukemia.

The present invention relates to Chimeric Antigen Receptors (CAR) that are recombinant chimeric proteins able to redirect immune cell specificity and reactivity toward selected membrane antigens, and more particularly in which extracellular ligand binding is a scFV derived from a BCMA monoclonal antibody, conferring specific immunity against BCMA positive cells. The engineered immune cells endowed with such CARs are particularly suited for treating lymphomas, multiple myeloma and leukemia.

A device and methods for bilateral or unilateral physical therapy of lower limbs are disclosed. The device comprises a curved rail mounted on a base and a pair of support members configured to accommodate a portion of a leg of a person, and to slide along the curved rail. The curved rail allows lateral movements of the lower limbs with the support members, the movements being driven by a force of the lower limbs. The methods of the invention allow physical unilateral or bilateral therapy of lower limbs of a person. The initial reinforcement of the lower limbs of a person is improved by the use of this device, which reduces the friction or the resistance caused by the device during the prescribed movements. The invention provides to patients with severe lower limb disability, a physical therapy device that is easy to use with minimum supervision by a physical therapist.

A universally adjustable pillow for use in healthcare and/or therapy includes a base board (1), and pillows for, respectively, right lateral recumbency (4), supine recumbency (2), left lateral recumbency (5) and for the neck (3) that are arranged on said base board (1). The pillows for left and right lateral recumbency (5,4) each include an external cushion, a mechanism enabling adjustment to fit vertebral curvature (52, 42), a mechanism enabling adjustment to inhibit too great an angle of lateral tilt (53, 43) and height adjustment members (51, 41). The longitudinal axes of the pillows for left and right lateral recumbency (5, 4) are set an angles α and β to the longitudinal axis of the pillow for supine recumbency (2).

Method and devices for treating equine laminitis by cryotherapy, comprising a boot to be fitted over the horse's hoof, having a wedge shaped sole that is angled by 20° toward the front; The purpose is accomplished by the boot in conjunction with three opportunely shaped removable soles, and a cryotherapy reservoir of flexible material, that is inserted into the boot and connected to an external device for refrigeration by circulation of a fluid.

In certain example embodiments, a system and/or method of guiding transitions between therapy modes in connection with the treatment and/or diagnosis of a patient for a respiratory disorder is/are provided. Respiratory disorder treatment according to a first therapy mode is provided. Input indicating a second therapy mode to be transitioned to following provision of the first therapy mode is received, with the second therapy mode being different from the first therapy mode. At least one default treatment parameter suitable for the second therapy mode is assigned or calculated. Each default treatment parameter of the second therapy mode is presented, with each default treatment parameter being adjustable by an operator during the presenting. Transitioning from the first therapy mode to the second therapy mode is performed by providing respiratory disorder treatment in accordance with the second therapy mode and each default treatment parameter and any adjustments made thereto prior to the transitioning. Advantageously, the chances of a patient being disturbed by transitioning from mode-to-mode are reduced.

Methods, systems, and apparatuses are described that indicate an amount at which various gas flow rates should be manually adjusted in order to achieve targeted total flow rates and concentration levels.

One embodiment is directed to a method for controllably managing pain in the afferent nervous system of a patient having a targeted tissue structure that has been genetically modified to have light sensitive protein, comprising: providing a light delivery element configured to direct radiation to at least a portion of a targeted tissue structure, a light source configured to provide light to the light delivery element, and a controller operatively coupled to light source, wherein the targeted tissue structure comprises a sensory neuron of the patient; and automatically operating the controller to illuminate the targeted tissue structure with radiation such that a membrane potential of cells comprising the targeted tissue structure is modulated at least in part due to exposure of the light sensitive protein to the radiation.

A renal failure blood therapy system includes a renal failure blood therapy machine, concentration levels for each of a plurality of solutes removed from a patient's blood at each of the multiple times, a display device configured to display for selection at least one removed blood solute from the plurality of removed blood solutes, and a device programmed to (i) estimate at least one renal failure blood therapy patient parameter using the determined concentration levels for the at least one selected removed blood solute, (ii) determine a plurality of acceptable renal failure blood therapy treatments that meet a predetermined removed blood solute clearance for the at least one selected removed blood solute using the at least one renal failure blood therapy patient parameter, and (iii) enable selection of at least one of the plurality of acceptable renal failure blood therapy treatments for operation at the renal failure blood therapy machine.

The present invention relates to in vitro methods of assessing the susceptibility or responsiveness of a subject to the treatment with an epidermal growth factor receptor (EGFR) inhibitor/antagonist, wherein the subject has been diagnosed or suspected of suffering from inflammation-associated. These methods comprise determining the level of expression of EGFR in myeloid cells in a sample from the subject, wherein an expression of EGFR in the myeloid cells is indicative of the subject being susceptible to the treatment with an EGFR inhibitor/antagonist. The invention also relates to EGFR inhibitors/antagonists for use in the treatment or amelioration of inflammation-associated cancer. The invention furthermore provides in vitro methods of prognosing the survival time, progression-free survival time or disease course of a subject that has been diagnosed or suspected of suffering from from inflammation-associated cancer. In addition thereto, the invention relates to in vitro diagnostic methods of assessing the proneness of a subject to develop inflammation-associated cancer in which the expression of EGFR is determined in myeloid cells from the subject.

In sporadic Alzheimer's disease, neurofibrillary lesion formation is preceded by extensive post-translational modification of the microtubule associated protein tau. Immunoassays have been developed recently that detect tau in biological specimens, thus providing a means for pre-mortem diagnosis of Alzheimer's disease, which has remained elusive. These assays have been improved by the analysis of relevant post-translational modifications, such as phosphorylation, however opportunity for improvement remains. The present invention addresses this issue by disclosing synthetic methylated peptides derived from the tau protein of paired helical filaments and non-diseased control brain. Alzheimer's disease specificity is provided by the presence or absence of methyl moieties on lysine residues and differences between mono-, di-, and tri-methylation. The methylated peptide is useful as an antigen and a binding partner for identifying compounds that interact with the peptide and the methylated tau protein, including antibodies that can distinguish non-diseased brain from that affected by Alzheimer's disease. The resulting antibodies are useful diagnostically and therapeutically. The compounds that specifically bind to methylated tau proteins are useful for eliminating abnormally methylated tau.

As affordable mental health care becomes harder to access, more people are downloading self-help and therapy apps to address problems as wide ranging as phobias, depression, procrastination, and anxiety. But do these apps actually work? In the brave new world of digitally delivered mental health care, will your next therapist be an algorithm? Guests: Elissa Chakoff, Clinical Implementation Manager, Recovery Record Christy Choy, Marriage and Family Therapist and Talkspace Provider C. Barr Taylor, MD, Professor of Psychiatry and Behavioral Sciences, Emeritus, Stanford University and Research Professor and Director of the Center for M2 Health at Palo Alto Universiy. Resources: Psyberguide VA App Store

Float Therapy is the moniker of 19-year-old musician Padraig Wilson. In fact, he also happens to write and record all the instruments himself. Float Therapy is a relatively new artist with a whole lot to say and he only recently released his first single "Gaffer Tape"- an intense, solid anthem that takes inspiration from the […]

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CHARLESTON, W.Va. (AP) — Dig. Plant. Breathe. As spring’s arrival in the Northern Hemisphere coincides with government stay-at-home orders, the itch to get outside has turned backyard gardens into a getaway for the mind in chaotic times. Gardeners who already know that working with soil is a way to connect with nature say it helps […]

The coronavirus hits New York City hard, doctors revisit a century-old blood therapy in the hopes of treating COVID-19, a hockey commentator is doing play-by-play for fans' pet videos, what the coronavirus outbreak means for the zero waste movement, toilet paper shortages spark an interest in bidets, Mariko Tamaki is taking over writing DC's Wonder Woman comic, and more.

Thunder Bay psychologist and the healing power of forest therapy walks, Torbay Nfld boy gets bravery award for saving a classmate's life, London Ontario cabbie of twenty years talks about what he enjoys and what irks him and remembering 97 year old Sara Sexton of Newfoundland who died last month.

A Rotary Club in WA has been trialling a form of cheap and simple therapy for people living with dementia. Having seen some remarkable results, the plan is now to push the program further.

A team of volunteer dog owners are faithfully visiting aged-care homes with their canine companions, bringing much joy and contentment to many of the residents.

Music teacher and actress Kimmie Jonceski performed a lead role in a musical while undergoing chemotherapy for breast cancer this year and wants her courageous story to inspire other young women facing a cancer diagnosis.

Cancer patients in the remote Pilbara will soon be trialling chemotherapy via video link, saving them a 1,500-kilometre trip for life-saving treatment.

Cryotherapy is used by pro athletes and "weekend warriors" alike. But are the benefits of subjecting your body to extreme cold really worth it? I jumped into the chamber to find out.

An openly gay and Christian psychologist says gay conversion therapy nearly killed him and some of his clients and the sooner it is outlawed the better.

On the outskirts of Bendigo in central Victoria, a farm run by a social worker is helping children and adults with behavioural and mental health issues.

You might expect to see wheelchairs and walking frames in the corridors of an aged care facility, but you might not expect to see a 850-kilogram horse.

After 25 years as a sniper in war zones, Robert later went on to photograph road fatalities. After being plagued by anxiety, depression and flashbacks, he has finally found peace with the power of painting.

Lego is being used in both informal and clinical sessions to improve the communication and cooperation skills of children with autism.

People who experience homelessness are more likely to be exposed to trauma, but experts say creative therapies could help them heal.