Special Judge Vishal Gogne fixed the matter for the next week after noting that no further clarification was required from the ED on the matter

Hoboken, New Jersey : John Wiley & Sons, Inc., [2024]

Cognizant said it offers ₹4-12 lakh salary to fresh engineering graduates, and the salary being quoted on social media is for non-engineering undergraduate degree holders

Two-time Formula One World Champion Fernando Alonso attended the event and emphasised the pivotal role of Cognizant’s technology in driving improvements on and off the track

“With many advanced technological features present in Formula One cars, Cognizant, the US-based IT company with a large presence in India, plays a critical role in improving the performance of the car”

The high point for Dhanush Srikanth came in 2023 when he bagged a gold in the individual and the silver team medal in the 10 metre Air Rifle event in Germany in the normal category

Many groups have been working for water access to all as a human right, especially for the poor

Lewis Library - ML420.C265 A74 2018

HELENA (April 23, 2020) – Today, U.S. Environmental Protection Agency (EPA) Region 8 Deputy Regional Administrator Deb Thomas recognized students and staff from Capital High School in Helena for winning the ‘See a Bloom, Give It Room’ High School Video Challenge.

PHOENIX – Today, the U.S.

BOSTON – The US Environmental Protection Agency (EPA) is awarding seven local New England organizations with recognition for their work keeping wasted food out of landfills and incinerators and putting it to better use.

DALLAS – (April 23, 2020)  The U.S. Environmental Protection Agency (EPA) announced the 2019 winners of the national WasteWise awards.

WASHINGTON – Today, the U.S. Environmental Protection Agency (EPA) announced the 2019 winners of the national WasteWise awards. EPA is recognizing the outstanding accomplishments of 11 WasteWise partner organizations.

(WASHINGTON) - Today, the U.S. Environmental Protection Agency (EPA) nationally recognizes the exceptional accomplishments of 15 businesses and organizations participating in EPA’s Food Recovery Challenge.

The C-type lectin receptors (CLRs) form a family of pattern recognition receptors that recognize numerous pathogens, such as bacteria and fungi, and trigger innate immune responses. The extracellular carbohydrate-recognition domain (CRD) of CLRs forms a globular structure that can coordinate a Ca2+ ion, allowing receptor interactions with sugar-containing ligands. Although well-conserved, the CRD fold can also display differences that directly affect the specificity of the receptors for their ligands. Here, we report crystal structures at 1.8–2.3 Å resolutions of the CRD of murine dendritic cell-immunoactivating receptor (DCAR, or Clec4b1), the CLR that binds phosphoglycolipids such as acylated phosphatidyl-myo-inositol mannosides (AcPIMs) of mycobacteria. Using mutagenesis analysis, we identified critical residues, Ala136 and Gln198, on the surface surrounding the ligand-binding site of DCAR, as well as an atypical Ca2+-binding motif (Glu-Pro-Ser/EPS168–170). By chemically synthesizing a water-soluble ligand analog, inositol-monophosphate dimannose (IPM2), we confirmed the direct interaction of DCAR with the polar moiety of AcPIMs by biolayer interferometry and co-crystallization approaches. We also observed a hydrophobic groove extending from the ligand-binding site that is in a suitable position to interact with the lipid portion of whole AcPIMs. These results suggest that the hydroxyl group-binding ability and hydrophobic groove of DCAR mediate its specific binding to pathogen-derived phosphoglycolipids such as mycobacterial AcPIMs.

Fucosylation of the innermost GlcNAc of N-glycans by fucosyltransferase 8 (FUT8) is an important step in the maturation of complex and hybrid N-glycans. This simple modification can dramatically affect the activities and half-lives of glycoproteins, effects that are relevant to understanding the invasiveness of some cancers, development of mAb therapeutics, and the etiology of a congenital glycosylation disorder. The acceptor substrate preferences of FUT8 are well-characterized and provide a framework for understanding N-glycan maturation in the Golgi; however, the structural basis of these substrate preferences and the mechanism through which catalysis is achieved remain unknown. Here we describe several structures of mouse and human FUT8 in the apo state and in complex with GDP, a mimic of the donor substrate, and with a glycopeptide acceptor substrate at 1.80–2.50 Å resolution. These structures provide insights into a unique conformational change associated with donor substrate binding, common strategies employed by fucosyltransferases to coordinate GDP, features that define acceptor substrate preferences, and a likely mechanism for enzyme catalysis. Together with molecular dynamics simulations, the structures also revealed how FUT8 dimerization plays an important role in defining the acceptor substrate-binding site. Collectively, this information significantly builds on our understanding of the core fucosylation process.

This report focuses on the development of children of Black immigrants in the United States, comparing against the outcomes for their peers in native-born and other immigrant families. It also compares these U.S. children to those in the United Kingdom, where there is a large Black immigrant population but a notably different policy context of reception.

Este manual ofrece a los formuladores de políticas y especialistas una guía accesible y práctica sobre las iniciativas gubernamentales referentes a la diáspora. Este manual contiene un menú, seleccionado cuidadosamente, de opciones normativas y programáticas viables basadas en experiencias reales en distintas partes del mundo.

A study at Columbia University Mailman School of Public Health found that black subjects who were exposed to highly segregated neighborhoods in young adulthood exhibited worse performance in cognitive skills in mid-life.

A long-term worker overseeing refugee relief work on Lesbos describes the people he’s met on the island, the chances he’s had to share his faith and how God has shown up during the crisis.

Andrea Regalbuto was awarded second place in the oral presentation category for Arts and Humanities at the Penn State Undergraduate Exhibition, held virtually April 15-17.

IT Services Giant Offers Update During Quarterly Financial Results Call
Cognizant estimates that the April ransomware attack that affected its internal network will cost the IT services firm between $50 and $70 million in losses, according to the company's latest financial results. Cognizant has said that the Maze ransomware gang is behind the attack.

Walk into any panel discussion at a geothermal power event and you will often hear about barriers hindering geothermal development. In spite of the obstacles, the geothermal industry has grown and adapted to adversity, and it is unfortunate when more attention is not given to geothermal power’s technological accomplishments and the long-term potential. Today, 73 countries across the globe are actively engaged with the geothermal energy sector, showing that more governments, utilities, and industry stakeholders are recognizing the long-term value geothermal power can bring to their power systems.

IT Services Giant Offers Update During Quarterly Financial Results Call
Cognizant estimates that the April ransomware attack that affected its internal network will cost the IT services firm between $50 and $70 million in losses, according to the company's latest financial results. Cognizant has said that the Maze ransomware gang is behind the attack.

IT Services Giant Offers Update During Quarterly Financial Results Call
Cognizant estimates that the April ransomware attack that affected its internal network will cost the IT services firm between $50 and $70 million in losses, according to the company's latest financial results. Cognizant has said that the Maze ransomware gang is behind the attack.

IT Services Giant Offers Update During Quarterly Financial Results Call
Cognizant estimates that the April ransomware attack that affected its internal network will cost the IT services firm between $50 and $70 million in losses, according to the company's latest financial results. Cognizant has said that the Maze ransomware gang is behind the attack.

IT Services Giant Offers Update During Quarterly Financial Results Call
Cognizant estimates that the April ransomware attack that affected its internal network will cost the IT services firm between $50 and $70 million in losses, according to the company's latest financial results. Cognizant has said that the Maze ransomware gang is behind the attack.

IT Services Giant Offers Update During Quarterly Financial Results Call
Cognizant estimates that the April ransomware attack that affected its internal network will cost the IT services firm between $50 and $70 million in losses, according to the company's latest financial results. Cognizant has said that the Maze ransomware gang is behind the attack.

IT Services Giant Offers Update During Quarterly Financial Results Call
Cognizant estimates that the April ransomware attack that affected its internal network will cost the IT services firm between $50 and $70 million in losses, according to the company's latest financial results. Cognizant has said that the Maze ransomware gang is behind the attack.

IT Services Giant Offers Update During Quarterly Financial Results Call
Cognizant estimates that the April ransomware attack that affected its internal network will cost the IT services firm between $50 and $70 million in losses, according to the company's latest financial results. Cognizant has said that the Maze ransomware gang is behind the attack.

IT Services Giant Offers Update During Quarterly Financial Results Call
Cognizant estimates that the April ransomware attack that affected its internal network will cost the IT services firm between $50 and $70 million in losses, according to the company's latest financial results. Cognizant has said that the Maze ransomware gang is behind the attack.

IT Services Giant Offers Update During Quarterly Financial Results Call
Cognizant estimates that the April ransomware attack that affected its internal network will cost the IT services firm between $50 and $70 million in losses, according to the company's latest financial results. Cognizant has said that the Maze ransomware gang is behind the attack.

IT Services Giant Offers Update During Quarterly Financial Results Call
Cognizant estimates that the April ransomware attack that affected its internal network will cost the IT services firm between $50 and $70 million in losses, according to the company's latest financial results. Cognizant has said that the Maze ransomware gang is behind the attack.

IT Services Giant Offers Update During Quarterly Financial Results Call
Cognizant estimates that the April ransomware attack that affected its internal network will cost the IT services firm between $50 and $70 million in losses, according to the company's latest financial results. Cognizant has said that the Maze ransomware gang is behind the attack.