XY disorders of sex development have a diverse etiology and often present with atypical genitalia in the newborn period. Sex assignment in those cases in whom this is marked genital ambiguity is a rare, challenging situation that requires multidisciplinary input.

An international registry has shown temporal changes over the last 3 decades in the practice of sex assignment with a greater proportion of severely affected infants being raised as boys, raising the need for long-term monitoring of these children. (Read the full article)

In developed countries, child health disparities across wealth gradients are commonly widening; at the same time, child mortality in low- and middle-income countries is declining. Whether these declines are associated with widening or narrowing disparities is unknown.

A systematic analysis of the evidence on child mortality gradients by wealth in less-developed countries shows that mortality is declining fastest among the poorest in most countries, leading to declining disparities in this important indicator of child health. (Read the full article)

Obesity among youth can have immediate health effects as well as longer-term consequences during adulthood. Overweight/obese children and adolescents are much more likely than normal-weight children to become overweight/obese adults.

This large, multisite longitudinal study examines patterns of exit from and entry into obesity between childhood and adolescence. Socioeconomic factors, body image, television habits, and parental obesity were important predictors of whether children remained obese or became obese. (Read the full article)

Head Start, a federally funded preschool program for low-income US children, has been reported to have beneficial effects on developmental outcomes. The association of Head Start participation with changes in children’s BMI has not been examined.

Preschool-aged children with an unhealthy weight status who participated in Head Start had a significantly healthier BMI by kindergarten entry age than comparison children in a primary care health system (both those receiving and those not receiving Medicaid). (Read the full article)

Adequate sleep is critical for adolescent health. Available data suggest a historical downward trend in sleep behavior, but there has been no rigorous evaluation of recent US trends.

The proportion of adolescents who regularly obtain ≥7 hours of sleep is decreasing. Decreases in sleep exhibit period effects that are constant across adolescents according to gender, race, socioeconomic factors, and urbanicity. The gender gap in adequate sleep is widening. (Read the full article)

Polymyxins are increasingly used as the critical last-resort therapeutic options for multidrug-resistant gram-negative bacteria. Unfortunately, polymyxin resistance has increased gradually for the last few years. Although studies on mechanisms of polymyxin are expanding, system-wide analyses of the underlying mechanism for polymyxin resistance and stress response are still lacking. To understand how Klebsiella pneumoniae adapt to colistin (polymyxin E) pressure, we carried out proteomic analysis of Klebsiella pneumoniae strain cultured with different concentrations of colistin. Our results showed that the proteomic responses to colistin treatment in Klebsiella pneumoniae involving several pathways, including (i) gluconeogenesis and TCA cycle; (ii) arginine biosynthesis; (iii) porphyrin and chlorophyll metabolism; and (iv) enterobactin biosynthesis. Interestingly, decreased abundance of class A β-lactamases including TEM, SHV-11, SHV-4 were observed in cells treated with colistin. Moreover, we also present comprehensive proteome atlases of paired polymyxin-susceptible and -resistant Klebsiella pneumoniae strains. The polymyxin-resistant strain Ci, a mutant of Klebsiella pneumoniae ATCC BAA 2146, showed missense mutation in crrB. The crrB mutant Ci, which displayed lipid A modification with 4-amino-4-deoxy-L-arabinose (L-Ara4N) and palmitoylation, showed striking increases of CrrAB, PmrAB, PhoPQ, ArnBCADT and PagP. We hypothesize that crrB mutations induce elevated expression of the arnBCADTEF operon and pagP via PmrAB and PhoPQ. Moreover, multidrug efflux pump KexD, which was induced by crrB mutation, also contributed to colistin resistance. Overall, our results demonstrated proteomic responses to colistin treatment and the mechanism of CrrB-mediate colistin resistance, which may further offer valuable information to manage polymyxin resistance.

Penn State Law in University Park will have a mandatory credit/no-credit grading system for the spring 2020 semester in order to be supportive of students during the novel coronavirus public health crisis.

As schools apply more scrutiny to the methods and materials they use to teach early reading, educators and parents in some states have started to form new advocacy efforts—trying to pressure states and districts to adopt new approaches to teacher training and evaluating materials.

As schools apply more scrutiny to the methods and materials they use to teach early reading, educators and parents in some states have started to form new advocacy efforts—trying to pressure states and districts to adopt new approaches to teacher training and evaluating materials.

One Bangladeshi woman doesn’t believe her future can change until she participates in an OM tailoring class, gaining skills and a relationship with Jesus.

Dover --

The Delaware Department of Transportation (DelDOT) continues to review operational needs while keeping the health and safety of our employees and customers in mind. To that end, all public facing buildings that deliver various services will be going cashless across the State, including toll plazas and all Division of Motor Vehicle locations, effective Tuesday, March 17, 2020.

At DelDOT's four DMV locations, only credit or debit cards will be accepted, and the Department continues to urge all customers to utilize mydmv.delaware.gov which offers more than 20 services online, including renewal of Delaware Driver License/ID, renewing vehicle registration, and changing your home address. [More]

Dover --

The Delaware Department of Transportation (DelDOT) continues to review operational needs while keeping the health and safety of our employees and customers in mind.

Effective Tuesday, March 17, 2020 at 6:00pm, the Biden Welcome Center on I-95 in Newark will temporarily close to the public as efforts continue to limit crowds from gathering in response to the Coronavirus. Fuel will still be available at the gas station located on the north side of the property and bathroom facilities in the convenience store will also be available to motorists. [More]

Dover --

The Delaware Department of Transportation (DelDOT) continues to review operational needs while keeping the health and safety of our employees and customers in mind.

Effective Monday, March 23, 2020, all four Delaware Division of Motor Vehicles (DMV) locations will go to kiosk, drive-through and emergency appointment only. Dealer paperwork can be dropped off for processing and picked up when notified. [More]

Wilmington --

After statewide Public Hearing Workshops, DART listened to its riders and the public, and as a result, changes were made to the original proposal. The "Bold type" indicates a change from or an addition to the original proposal based on public comments. New schedules will be available online and on buses in early May. [More]

The NSW Government has issued an update with the following information:The Home Affairs Department recently announced that the Subclass 491 Skilled Work Regional visa will replace the present 489 visa in Nov 2019.The visa in the new subclass will have…

The Delaware Department of Transportation (DelDOT) continues to review operational needs while keeping the health and safety of our employees and customers in mind. To that end, all public facing buildings that deliver various services will be going cashless across the State, including toll plazas and all Division of Motor Vehicle locations, effective Tuesday, March […]

DNREC continues to focus on taking a proactive and preventative approach to keep communities and employees safe in the midst of the coronavirus.

The Delaware Department of Transportation (DelDOT) continues to review operational needs while keeping the health and safety of our employees and customers in mind. Effective Tuesday, March 17, 2020 at 6:00pm, the Biden Welcome Center on I-95 in Newark will temporarily close to the public as efforts continue to limit crowds from gathering in response […]

The Delaware Department of Transportation (DelDOT) continues to review operational needs while keeping the health and safety of our employees and customers in mind. Effective Monday, March 23, 2020, all four DMV locations will go to kiosk, drive-through and emergency appointment only. Dealer paperwork can be dropped off for processing and picked up when notified. […]

SMYRNA (March 25, 2020) – With several modifications to protect the health of the staff and customers, the Delaware Division of Public Health (DPH) continues to provide services to Delaware residents during the coronavirus disease 2019 (COVID-19) outbreak. The Office of Vital Statistics is restricting in-person service to appointments only. Customers are encouraged to mail […]

Wilmington. Governor Carney changed upcoming School Board and Municipal Elections in his 6th update to the State of Emergency. The Governor ordered School Board elections scheduled for May 12th delayed until June 16th. He  also ordered municipal elections scheduled before May 15th cancelled and  rescheduled no earlier than May 15, 2020. The Governor further ordered […]

Data Dashboard to be Updated During Noon Hour Starting Monday Smyrna, DE (April 19, 2020) – Starting Monday, April 20, 2020, the Delaware Division of Public Health (DPH) will begin providing its daily updates on COVID-19 statistics on the de.gov/coronavirus website during the noon hour. Data will reflect the most current information available as of […]

The BS6 Mahindra Scorpio drops the entry-level variant as well as is now available only with one diesel engine and 6-speed manual transmission combination.

Two existing employees move into positions of leadership; two new employees join the agency.

The post Staff changes appeared first on Division of Historical and Cultural Affairs - State of Delaware.

WILMINGTON, Del. –  Governor John Carney announced on Friday that Secretary Robert Coupe – a longtime leader in Delaware law enforcement – will step down from his current role as the head of the Delaware Department of Safety and Homeland Security next month to join the Office of the Attorney General. “There are few people […]

The threat for global warming is increasing in this world with each passing day. It is not a distant future when the effects of the global warming will hit hard the lives of the human. However, seeing the future threat Denmark has braced itself with…

The Congress has mandated that the H1-B visa has an annual limit cap of 65,000 visas during each fiscal year. Moreover, the first 20,000 petitions filed by beneficiaries having a US master's degree get an exemption from the cap.A few major changes Presently,…

U.S. Citizenship and Immigration Services has a proposal regarding changing the selection of a number of H-1B visa petitions each year.AimsThis requires employers to register online for getting selected randomly before submitting the visa petitions.…

The study of National Association of Foreign Student Advisers has the opinion that global students made a contribution of $39 billion to the US economy in the academic year of 2017-2018.The studyMoreover, it found that the economic activity of overseas…

The US government proposes to introduce new visa norms. Additionally, it has a plan to strip the work permits benefitting the spouses of H-1B visa holders’ under H-4 visas in the country.The DetailsThis announcement came in a webpage from the agenda…

Many American firms are the major beneficiaries of the H-1B visas. Any restrictions on these visas may impact heavily on the US technology companies because many work permits are issued to Indians with a high skill set. Indian nationals receive two-thirds…

After the implementation of new regulations the odds of MBA candidates increased by more than 10% to get the US work visa.They are burdened with student debt heavily and will be in a position to settle it. They can expect an attractive return on investment…

The agency said the rating on India Infoline Finance's corporate family rating, foreign and local currency debt and its senior secured MTN programme ratings, and also senior unsecured debt rating are placed under review for downgrade. 

Wendy Smith Chief Executive of the South Canterbury Chamber states that the new visa system must provide confidence and certainty to employers that suffer from a skills shortage in regions. Employers in the area can find it easy to bring many temporary…

Work visa rules have modified in a move designed by the government to lessen exploitation and promote migrant worker conditions.The latest rules came into force on 7 October 2019, involve workers having a minimum base salary of $79,560 to be eligible…

Finance minister Nirmala Sitharaman inaugurated the rupee-dollar derivatives trading on the two exchanges on Friday.

Government Of India Announces Major Changes In Foreign Direct Investment (FDI) Policy

Michigan coach Jim Harbaugh has made an open-letter proposal suggesting more flexibility for players considering the jump from college to the NFL, including returning to college if they go undrafted.

As a leading venture capitalist in the electronics technology, as well as CEO of Cadence, Lip-Bu Tan has unique insights into ongoing changes that will impact EDA providers and users. Tan shared some of those insights in a “fireside chat” with Ed Sperling, editor in chief of Semiconductor Engineering, at the Design Automation Conference (DAC 2015) on June 9.

Topics of this discussion included industry consolidation, the need for more talent and more startups, Internet of Things (IoT) opportunities and challenges, the shift from ICs to full product development, and the challenges of advanced nodes. Following are some excerpts from this conversation, held at the DAC Pavilion theater on the exhibit floor.

Ed Sperling (left) and Lip-Bu Tan (right) discuss trends in semiconductors and EDA

Q: As you look out over the semiconductor and EDA industries these days, what worries you most?

Tan: At the top of my list is all the consolidation that is going on. Secondly, chip design complexity is increasing substantially. Time-to-market pressure is growing and advanced nodes have challenges.

The other thing I worry about is that we need to have more startups. There’s a lot of innovation that needs to happen. And this industry needs more top talent. At Cadence, we have a program to recruit over 10% of new hires every year from college graduates. We need new blood and new ideas.

Q: EDA vendors were acquiring companies for many years, but now the startups are pretty much gone. Where does the next wave of innovation come from?

Tan: I’ve been an EDA CEO for the last seven years and I really enjoy it because so much innovation is needed. System providers have very big challenges and very different needs. You have to find the opportunities and go out and provide the solutions.

The opportunities are not just in basic tools. Massive parallelism is critical, and the power challenge is huge. Time to market is critical, and for the IoT companies, cost is going to be critical. If you want to take on some good engineering challenges, this is the most exciting time.

Q: You live two lives—you’re a CEO but you’re also an investor. Where are the investments going these days and where are we likely to see new startups?

Tan: Clearly everybody is chasing the IoT. There is a lot of opportunity in the cloud, in the data center. Also, I’m a big believer in video, so I back companies that are video related. A big area is automotive. ADAS [Advanced Driver Assistance Systems] is a tremendous opportunity.

These companies can help us understand how the industry is transforming, and then we can provide solutions, either in terms of IP, tools, or the PCB. Then we need to connect from the system level down to semiconductors. I think it’s a different way to design.

Q: What happens as we start moving from companies looking to design a semiconductor to system companies who are doing things from the perspective that we have this purpose for our software?

Tan: We are extending from EDA to what we call system design enablement, and we are becoming more application driven. The application at the system level will drive the silicon design. We need to help companies look at the whole system including the power envelope and signal integrity. You don’t want to be in a position where you design a chip all the way to fabrication and then find the power is too high.

We help the customers with hardware/software co-design and co-verification. We have a design suite and a verification suite that can provide customers with high-level abstractions, as well as verify IP blocks at the system level. Then we can break things down to the component level with system constraints in mind, and drive power-aware, system-aware design.

We are starting to move into vertical markets. For example, medical is a tremendous opportunity.

Q: How does this approach change what you provide to customers?

Tan: Every year I spend time meeting with customers. I think it is very important to understand what they are trying to design, and it is also important to know the customer’s customer requirements. We might say, “Wait a minute, for this design you may want to think about power or the library you’re using.” We help them understand what foundry they should use and what process they should use. They don’t view me as a vendor—they view me as a partner.

We also work very closely with our IP and foundry partners. We work as one team—the ultimate goal is customer success.

Q: Is everybody going to say, FinFETs are beautiful, we’re going to go down to 10nm or 7nm—or is it a smaller number of companies who will continue down that path?

Tan: Some of the analog/mixed-signal companies don’t need to go that far. We love those customers—we have close to 50% of that business. But we also have customers in the graphics or processor area who are really pushing the envelope, and need to be in 16nm, 14nm, or 10nm. We work very closely with those guys to make sure they can go into FinFETs.

We always want to work with the customer to make sure they have a first-time silicon success. If you have to do a re-spin, you miss the opportunity and it’s very costly.

Q: There’s a new market that is starting to explode—IoT. How real is that world to you? Everyone talks about large numbers, but is it showing up in terms of tools?

Tan: Everybody is talking about huge profits, but a lot of the time I think it is just connecting old devices that you have. Billions of units, absolutely yes, but if you look close enough the silicon percentage of that revenue is very tiny. A lot of the profit is on the service side. So you really need to look at the service killer app you are trying to provide.

What’s most important to us in the IoT market is the IP business. That’s why we bought Tensilica—it’s programmable, so you can find the killer app more quickly. The other challenges are time to market, low power, and low cost.

Q: Where is system design enablement going? Does it expand outside the traditional market for EDA?

Tan: It’s not just about tools. IP is now 11% of our revenue. At the PCB level, we acquired a company called Sigrity, and through that we are able to drive system analysis for power, signal integrity, and thermal. And then we look at some of the verticals and provide modeling all the way from the system level to the component level. We make sure that we provide a solution to the end customer, rather than something piecemeal.

Q: What do you think DAC will look like in five years?

Tan: It’s getting smaller. We need to see more startups and innovative IP solutions. I saw a few here this year, and that’s good. We need to encourage small startups.

Q: Where do we get the people to pull this off? I don’t see too many people coming into EDA.

Tan: I talk to a lot of university students, and I tell them that this small industry is a gold mine. A lot of innovation is needed. We need them to come in [to EDA] rather than join Google or Facebook. Those are great companies, but there is a lot of fundamental physical innovation we need.

Richard Goering

Related Blog Posts

- Gary Smith at DAC 2015: How EDA Can Expand Into New Directions

- DAC 2015: Google Smart Contact Lens Project Stretches Limits of IC Design

- Q&A with Nimish Modi: Going Beyond Traditional EDA

U.S. Secretary of the Interior David Bernhardt has unveiled changes to the implementing regulations of the Endangered Species Act (ESA) that Interior says is “designed to increase transparency and effectiveness and bring the administration of the Act into the 21st century.”

Minnesota’s largest utility wants to change how the state calculates its trailblazing “value of solar” rate as it faces a potential spike in payments to community solar operators.

U.S. Secretary of the Interior David Bernhardt has unveiled changes to the implementing regulations of the Endangered Species Act (ESA) that Interior says is “designed to increase transparency and effectiveness and bring the administration of the Act into the 21st century.”

Excitement over storing electricity, and expectations for new market rules in the U.S. promise great changes in energy. Instead of hype and speculation, this blog offers a preview of those market changes. For those who are waiting for FERC Order 841 to sort things out, ISO-New England has published something you might want to see.

Changes to the United Kingdom's Feed-In Tariff program could have a negative impact on a number of generation sectors -- including small hydroelectric power -- according to a number of industry groups.