Bedtime Stories

Bedtime Stories part Two

Staff worldwide expected to sign up

Looking for a house? Well, there’s a free one in New Jersey if you want it. You just need to come and get it. Literally.

Jahvier Perez, 26, faces attempted murder, assault and child endangerment charges in the grisly Saturday morning attack, which may have left the two-year-old brain-damaged, police sources said.

Sometime after 911 was called, the 63-year-old victim — whose name has not been released — went into his bedroom to put out the fire. He soon passed out amid the smoke and flames, officials said. Responding firefighters and EMTs pulled him out of the apartment. "He was badly burned," said a neighbor.

The teen victim was chased to the corner of Utica Ave. and Sterling Place around 4:10 p.m. Thursday before being knocked to the ground. Video then shows a horde of teens descending upon her.

When Pat Spillane competed in the 1979 edition of International Superstars the school teacher from Templenoe was an amateur among pros, but he had the chance to pocket up to €3000 per event if he could win.

The long-sought molecule could one day power high-energy electronics.

That earns this fish, Electrophorus voltai, the title of the strongest known living source of electricity.

Psychiatrist Kenneth Rosenberg's film brings together many strands of American dysfunction: mental healthcare, incarceration, homelessness, policing, race. It provides few answers but helps us ask the right questions.

USC's Onyeka Okongwu was not named the conference's freshman of the year. Instead the honor went to Arizona's Zeke Nnaji.

The hospital-at-home model could help coronavirus patients who need sustained medical supervision but don't need to be admitted into a hospital.

The early end to UCLA baseball's season brought a disappointing end to the careers of some of the team's most talented juniors.

Four fire engines were at the scene

USC officials said they learned Tuesday that some online Zoom classes had been "disrupted by people who used racist and vile language."

Highland Park resident Olivia Arthur calls it "art for social distancing — a drive-by gallery for neighbors." The goal: Bring some joy to quarantine.

Justices hear a dispute over Trump administration rules to limit contraception requirements. Hospitalized Ruth Bader Ginsburg calls in.

The author of "Sweetbitter" juggles child care and promoting her new L.A. area memoir, "Stray," reads poetry and takes solace in "The Office."

Natalie Portman arrived at the 92nd Academy Awards wearing a cape with the names of female directors who weren't nominated Sunday.

Manchester City fans are fuming with manager Pep Guardiola over his team selection for the FA Cup tie against Sheffield Wednesday, as both Phil Foden and Eric Garcia are left out of his starting line up for the clash at Hillsborough.

Sr. Embedded engineer - Automotive Dearborn, MI Longterm Contract Knowledge of analysis, design and implementation of software systems in areas of communication, cellular systems, Automotive IVIs. Personal participation in Requirements and Design of Satellite Radio, Internet Radio Tuners, Autom

O TEMPORA! O mores! One of the most senior figures in the Civil Service, Sir Philip Rutnam, calls a press conference to denounce his Minister, in this case the Home Secretary herself. How times have changed from when civil servants were anonymous and Ministers took the flak when things went wrong.

Legislation that Indiana lawmakers tacked onto other bills received only the most perfunctory, if any, public vetting in the General Assembly.

Do you prefer to be fair or bronzed? This week's Take Away English reports on the dangers of sunbeds.

A Palm Desert man crashed his car, stabbed a good Samaritan who tried to free his daughter from the wreck and flung the girl off a cliff, killing her, according to the Riverside County Sheriff's Department.

With more and more F1 drivers making the move to esports during the lockdown and doing well, could an expert sim racer easily make the leap the other way?

DC's "Joker" may have the edge on Marvel.

Police are investigating a house robbery in which a couple in Amanzimtoti, on the south coast of KwaZulu-Natal, believed to be in their 50s was stabbed.

Police in Haiti are investigating allegations that the president of the national football federation raped teenage girls.

The following article, Video Scrubbed of Obama-Biden Ambassador To China Praising Their Response to Coronavirus: “I take my hat off to China”, was first published on 100PercentFedUp.com.

During a recent interview on CNN, Obama-Biden ambassador to China (2014-2017) Max Baucus compared standing up to China on the coronavirus to “Hitler in the ’30s.” Baucus has proven himself to be sympathetic to China in recent interviews, where he puts down America and praises the Chinese. The MSNBC video via The Washington Free Beacon […]

Continue reading: Video Scrubbed of Obama-Biden Ambassador To China Praising Their Response to Coronavirus: “I take my hat off to China” ...

The following article, Fed Judge Releases 21-Yr-Old Man To “Clean and Sober House” After Appearing In Court For Sexually Assaulting 12-Yr-Old Girl For One Month While Hiding In Her Bedroom, was first published on 100PercentFedUp.com.

The normalizing of pedophilia is not a far-right conspiracy theory...

Continue reading: Fed Judge Releases 21-Yr-Old Man To “Clean and Sober House” After Appearing In Court For Sexually Assaulting 12-Yr-Old Girl For One Month While Hiding In Her Bedroom ...

I. A. Sheipak and T. A. Garmanova
Trans. Moscow Math. Soc. 80 (2020), 189-210.
Abstract, references and article information

Yu. K. Dem'yanovich
St. Petersburg Math. J. 31 (2020), 435-453.
Abstract, references and article information

C. Tintarev
St. Petersburg Math. J. 31 (2020), 421-434.
Abstract, references and article information

The Government has mechanisms to investigate complaints against civil servants impartially, Secretary for the Civil Service Patrick Nip said today.

Mr Nip made the remarks in response to media queries on recent allegations levelled against senior police officers.

He said: “There are established mechanisms to investigate every complaint in accordance with the procedures and rules. Depending on the circumstances and the case details, some are being handled by departments and bureaus. Some may be handled by the Civil Service Bureau.

“There are established mechanisms in dealing with that. Of course we would handle each and every complaint in a very serious and impartial manner.”

(To watch the full press briefing with sign language interpretation, click here.)

Chief Executive Carrie Lam today said law enforcement agencies are investigating cases where police officers are suspected of breaching property rules and will give a full account to society.

Speaking to reporters before the Executive Council meeting this morning, Mrs Lam said nobody is above the law.

“The law will be applied in the same manner regardless of the status, the background, the political affiliation of that particular person.

“As far as I am concerned, as the Chief Executive of Hong Kong and also as an individual, no law-breaking behaviour is acceptable. But it is not for me to stand here to judge each and every case because every case or every complaint has to be investigated and analysed by the law enforcement agencies.

“I am sure that they will do it as diligently as possible and will give a full account to society, especially given the recent concerns.”

The PET radiotracer ⁶⁸Ga-PSMA-HBED-CC (⁶⁸Ga-PSMA-11) shows potential as an imaging biomarker for recurrent and metastatic prostate cancer. The purpose of this study was to determine repeatability of ⁶⁸Ga-PSMA-HBED-CC in a test-retest trial in subjects with metastatic prostate adenocarcinoma. Methods: Subjects with metastatic prostate cancer underwent two PET/CT scans with ⁶⁸Ga-PSMA-HBED-CC within 14 days (mean 6 ± 4 d). Lesions in bone, nodes, prostate/bed, and visceral organs as well as representative normal tissues (salivary glands and spleen) were segmented separately by two readers. Absolute and percent differences in SUV_max and SUVmean were calculated for all test-retest regions. Repeatability was assessed using percentage difference, within-subject coefficient of variation (wCV), repeatability coefficient (RC), and Bland-Altman analysis. Results: 18 subjects were evaluated, 16 of which demonstrated local or metastatic disease on ⁶⁸Ga-PSMA-HBED-CC PET/CT. A total of 136 lesions were segmented in bone (n = 99), nodes (n = 27), prostate/bed (n = 7), and viscera (n = 3). The wCV for SUV_max was 11.7% for bone lesions and 13.7% for nodes. The RC was ±32.5% SUV_max for bone lesions and ±37.9% SUV_max for nodal lesions, meaning 95% of the normal variability between two measurements will be within these numbers, so larger differences are likely attributable to true biological changes in tumor rather than normal physiologic or measurement variability. wCV in the salivary glands and spleen was 8.9% and 10.7% SUVmean, respectively. Conclusion: Repeatability measurements for PET/CT test-retest with ⁶⁸Ga-PSMA-HBED-CC show a wCV 12-14% SUV_max and RC ±33-38% SUV_max in bone and nodal lesions. These estimates are an important aspect of ⁶⁸Ga-PSMA-HBED-CC as a quantitative imaging biomarker. These estimates are similar to those reported for ¹⁸F-FDG, suggesting that ⁶⁸Ga-PSMA-HBED-CC PET/CT may be useful in monitoring response to therapy.

Respiratory gating is the standard to overcome respiration effects degrading image quality in positron emission tomography (PET). Data-driven gating (DDG) using signals derived from PET raw data are promising alternatives to gating approaches requiring additional hardware. However, continuous bed motion (CBM) scans require dedicated DDG approaches for axially-extended PET, compared to DDG for conventional step-and-shoot scans. In this study, a CBM-capable DDG algorithm was investigated in a clinical cohort, comparing it to hardware-based gating using gated and fully motion-corrected reconstructions. Methods: 56 patients with suspected malignancies in thorax or abdomen underwent whole-body ¹⁸F-FDG CBM-PET/CT imaging using DDG and hardware-based respiratory gating (pressure-sensitive belt gating, BG). Correlation analyses were performed on both gating signals. Besides static reconstructions, BG and DDG were used for optimally-gated PET (BG-OG, DDG-OG) and fully motion-corrected PET (elastic motion correction; BG-EMOCO, DDG-EMOCO). Metabolic volumes, SUV_max and SUVmean of lesions were compared amongst the reconstructions. Additionally, the quality of lesion delineation in different PET reconstructions was independently evaluated by three experts. Results: Global correlation coefficients between BG and DDG signals amounted to 0.48±0.11, peaking at 0.89±0.07 when scanning the kidney and liver region. In total, 196 lesions were analyzed. SUV measurements were significantly higher in BG-OG, DDG-OG, BG-EMOCO and DDG-EMOCO compared to static images (P<0.001; median SUV_max: static, 14.3±13.4; BG-EMOCO, 19.8±15.7; DDG-EMOCO, 20.5±15.6; BG-OG, 19.6±17.1; DDG-OG, 18.9±16.6). No significant differences between BG-OG and DDG-OG, and BG-EMOCO and DDG-EMOCO, respectively, were found. Visual lesion delineation was significantly better in BG-EMOCO and DDG-EMOCO than in static reconstructions (P<0.001); no significant difference was found comparing BG and DDG (EMOCO, OG, respectively). Conclusion: DDG-based motion-compensation of CBM-PET acquisitions outperforms static reconstructions, delivering qualities comparable to hardware-based approaches. The new algorithm may be a valuable alternative for CBM-PET systems.

Timothy D Rohrbach
Apr 27, 2020; 0:jlr.D120000809v1-jlr.D120000809
Methods

Mass spectrometry (MS) assisted lipidomic tissue analysis is a valuable tool to assess sphingolipid metabolism dysfunction in disease. These analyses can reveal potential pharmacological targets or direct mechanistic studies to better understand the molecular underpinnings and influence of sphingolipid metabolism alterations on disease etiology. But procuring sufficient human tissues for adequately powered studies can be challenging. Therefore, biorepositories, which hold large collections of cryopreserved human tissues, are an ideal retrospective source of specimens. However, this resource has been vastly underutilized by lipid biologists, as the components of optimal cutting temperature compound (OCT) used in cryopreservation are incompatible with MS analyses. Here, we report results indicating that OCT also interferes with protein quantification assays, and that the presence of OCT impacts the quantification of extracted sphingolipids by LC–ESI–MS/MS. We developed and validated a simple and inexpensive method that removes OCT from OCT-embedded tissues. Our results indicate that removal of OCT from cryopreserved tissues does not significantly affect the accuracy of sphingolipid measurements with LC–ESI–MS/MS. We used the validated method to analyze sphingolipid alterations in tumors compared with normal adjacent uninvolved lung tissues from individuals with lung cancer, and to determine the long-term stability of sphingolipids in OCT-cryopreserved normal lung tissues. We show that lung cancer tumors have significantly altered sphingolipid profiles and that sphingolipids are stable for up to 16 years in OCT-cryopreserved normal lung tissues. This validated sphingolipidomic OCT-removal protocol should be a valuable addition to the lipid biologist’s toolbox.

Marlou L. Dirks
Oct 1, 2016; 65:2862-2875
Metabolism

BOGOTA, Colombia (AP) — A Colombian advertising company is pitching a novel, if morbid, solution to shortages of hospital beds and coffins during the coronavirus pandemic: combine them. ABC Displays has created a cardboard bed with metal...

Former national footballer Arthur Lattimore passed away after a long battle with throat cancer. Lattimore, who represented Jamaica’s football team through­out the 1970s, died at his home in Florida, leaving behind five children, grandchildren, and...

Katherine Henderson is the clinical lead of the emergency department at St Thomas's hospital in London. She worries that lack of ward space is having a domino effect throughout A and E and is the cause of increased waiting time for both patients and ambulances. If you would like to contribute to this collection, please email a brief audio...