Metallomics, 2020, Advance Article
DOI: 10.1039/C9MT00316A, Paper

Nikita Lotlikar, Samir Damare, Ram Murti Meena, Saranya Jayachandran
Copper is one of the essential trace dietary minerals for all living organisms, but is potentially toxic at higher concentrations, mainly due to the redox reactions in its transition state.
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Metallomics, 2020, Advance Article
DOI: 10.1039/C9MT00312F, Paper

Open Access

  This article is licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported Licence.

Trang Q. Nguyen, Joshua E. Kim, Hayley N. Brawley, Paul A. Lindahl
Labile metal pools in the cytosol of yeast, including those of iron, copper, zinc, and manganese, can be detected and characterized using size-exclusion chromatography with online ICP-MS.
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Metallomics, 2020, Advance Article
DOI: 10.1039/D0MT00015A, Paper

Norika Goto, Hirokazu Hara, Mao Kondo, Naomi Yasuda, Tetsuro Kamiya, Kensuke Okuda, Tetsuo Adachi
Copper (Cu) is an essential trace element and acts as a redox cofactor for many enzymes; however, excess Cu is toxic to cells.
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Metallomics, 2020, Advance Article
DOI: 10.1039/D0MT00008F, Paper

Open Access

  This article is licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported Licence.

Laura K. Stultz, Alexandra Hunsucker, Sydney Middleton, Evan Grovenstein, Jacob O’Leary, Eliot Blatt, Mary Miller, James Mobley, Pamela K. Hanson
Proteomic analysis reveals that the anticancer ruthenium KP1019 induces proteotoxic, genotoxic, and oxidative stress responses in Saccharomyces cerevisiae.
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Metallomics, 2020, Advance Article
DOI: 10.1039/C9MT00286C, Paper

Stephen A. Pearson, Christine Wachnowsky, J. A. Cowan
Atm1p mediated mitochondrial Fe–S cluster export is investigated, providing support for a [2Fe–2S](GS)₄ cluster as a physiological substrate. A detailed mechanism of cluster export, combining kinetic, thermodynamic, and structural data is presented.
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Metallomics, 2020, Advance Article
DOI: 10.1039/D0MT00006J, Paper

Sebastiano Masuri, Enzo Cadoni, Maria Grazia Cabiddu, Francesco Isaia, Maria Giovanna Demuru, Lukáš Moráň, David Buček, Petr Vaňhara, Josef Havel, Tiziana Pivetta
The novel complex Cu(phen)₂(salubrinal)(ClO₄)₂ shows high free radical scavenging activity and good cytotoxic activity and induces cell death through ER-stress.
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Metallomics, 2020, Accepted Manuscript
DOI: 10.1039/D0MT00064G, Paper

Diana Fontinha, Silvia Andreia Sousa, Tânia S. Morais, Miguel Prudêncio, Jorge Leitão, Yann Le Gal, Dominique Lorcy, Rafaela Silva, Mariana Velho, Dulce Belo, Manuel Almeida, Joana Guerreiro, Teresa Pinheiro, Fernanda M. Marques
The anticancer, antimicrobial and antiplasmodial activities of six gold(III) bis(dithiolene) complexes were studied. Complexes (1-6) showed relevant anticancer properties against A2780/A2780cisR ovarian cancer cells (IC50 values of 0.08-2 µM), also...
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Metallomics, 2020, Accepted Manuscript
DOI: 10.1039/D0MT00084A, Paper

Sabiha Parveen, J. A. Cowan, Zhen Yu, Farukh Arjmand
Copper-based binuclear enantiomeric complexes 1S and 1R were synthesized as anticancer chemotherapeutic agents to target G-quadruplex rich region of DNA and thoroughly characterized by various spectroscopic and single X-ray crystal...
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Metallomics, 2020, 12,474-490
DOI: 10.1039/C9MT00271E, Paper

Zhijun He, Shuangxue Han, Chong Wu, Lina Liu, Huazhang Zhu, Ang Liu, Qiying Lu, Jingqiang Huang, Xiubo Du, Nan Li, Qinguo Xie, Lu Wan, Jiazuan Ni, Lingling Chen, Xiaogai Yang, Qiong Liu
BEOV activates PPARγ to affect JAK2/STAT3/SOCS1 signaling and eventually prevents Aβ generation. Meanwhile, BEOV inactivates PTP1B to affect PI3K/Akt/GSK3β signaling and finally reduces tau hyperphosphorylation.
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Metallomics, 2020, 12,504-513
DOI: 10.1039/C9MT00192A, Paper

Qiong Wu, Shuang-Yan Zhang, Si-Yan Liao, Jie-Qiong Cao, Wen-Jie Zheng, Li Li, Wen-Jie Mei
A novel approach has been proposed to develop a potent gene carrier system for enantioselectivity on the self-assembly of G-quadruplex DNA promoted by chiral Ru(II) complexes, and the different assembled nanostructures of cellular uptake to the nucleus and cytoplasm.
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Metallomics, 2020, 12,528-538
DOI: 10.1039/C9MT00289H, Paper

Desmond I. Bannon, Wenjun Bao, Stephen D. Turner, Wilfred C. McCain, William Dennis, Russ Wolfinger, Ed Perkins, Roger Abounader
Implanted nickel becomes toxic when it exceeds homeostasis, initiating a range of global gene effects over time, including oxidative phosphorylation and immune responses, which are impacted in opposite directions.
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Metallomics, 2020, 12,514-527
DOI: 10.1039/C9MT00244H, Paper

Maggie-Anne Harvey, Peter D. Erskine, Hugh H. Harris, Gillian K. Brown, Elizabeth A. H. Pilon-Smits, Lachlan W. Casey, Guillaume Echevarria, Antony van der Ent
Elemental mapping of selenium in the hyperaccumulator Neptunia amplexicaulis determined whole plant and tissue level selenium distribution. The total concentrations and chemical forms of selenium are also reported for this species.
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Metallomics, 2020, 12,592-606
DOI: 10.1039/C9MT00291J, Paper

Miao Yu, Jinghua Yang, Xiang Gao, Wenchang Sun, Shiyu Liu, Yarao Han, Xiaobo Lu, Cuihong Jin, Shengwen Wu, Yuan Cai
Lanthanum chloride damages hippocampal nerve cells of rats through inducing [Ca²⁺]_m overload, mitochondrial fission–fusion disorder, and excessive mitophagy.
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Metallomics, 2020, 12,547-561
DOI: 10.1039/C9MT00272C, Paper

Adriana Pereira Mundim Guedes, Francyelli Mello-Andrade, Wanessa Carvalho Pires, Maria Alice Montes de Sousa, Paula Francinete Faustino da Silva, Mariana S. de Camargo, Hendryk Gemeiner, Menegário A. Amauri, Clever Gomes Cardoso, Paulo Roberto de Melo Reis, Elisângela de Paula Silveira-Lacerda, Alzir A. Batista
Antimetastatic activity, high selectivity and cytotoxicity for human tumor cell lines make ruthenium(II) complexes attractive for the development of new chemotherapeutic agents for cancer treatment.
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Metallomics, 2020, 12,562-571
DOI: 10.1039/C9MT00302A, Paper

Lanqiao Wang, Xu Shi, Shufang Zheng, Shiwen Xu
Se deficiency can induce necroptosis in tracheal tissue. LPS-induced necroptosis can be exacerbated by Se deficiency. The miR-16-5p-PI3K/AKT pathway participates in the occurrence of necroptosis.
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Metallomics, 2020, 12,607-616
DOI: 10.1039/C9MT00295B, Paper

Yuan Zhang, Dahai Yu, Jiuli Zhang, Jun Bao, Chaohua Tang, Ziwei Zhang
Necroptosis is regarded as a new paradigm of cell death that plays a key role in the liver damage observed with selenium (Se) deficiency.
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Metallomics, 2020, 12,631-631
DOI: 10.1039/D0MT90008G, Correction

Open Access

  This article is licensed under a Creative Commons Attribution 3.0 Unported Licence.

Zhijun He, Shuangxue Han, Chong Wu, Lina Liu, Huazhang Zhu, Ang Liu, Qiying Lu, Jingqiang Huang, Xiubo Du, Nan Li, Qingguo Xie, Lu Wan, Jiazuan Ni, Lingling Chen, Xiaogai Yang, Qiong Liu
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Metallomics, 2020, 12,491-503
DOI: 10.1039/D0MT00054J, Paper

Samantha E. Huffman, Gideon K. Yawson, Samuel S. Fisher, Paige J. Bothwell, David C. Platt, Marjorie A. Jones, Christopher G. Hamaker, Michael I. Webb
Alzheimer's Disease (AD) is a devastating neurodegenerative disorder where one of the commonly observed pathological hallmarks is extracellular deposits of the peptide amyloid-β (Aβ).
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Metallomics, 2020, Accepted Manuscript
DOI: 10.1039/D0MT00074D, Paper

Fabiane Bicca Obetine Baptista, Marina Lopes Machado, Aline da Silva Franzen, Larissa Marafiga Cordeiro, Tassia da Silveira, Leticia Arantes, Félix A. A. Soares
Huntington’s disease (HD) is an autosomal dominant, progressive neurodegenerative disease with a distinct phenotype. It occurs due to a mutation in huntingtin (or IT19) gene with abnormal CAG repeat, leading...
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Metallomics, 2020, Accepted Manuscript
DOI: 10.1039/D0MT00069H, Paper

Marie Monestier, AnaÏS M. Pujol, Aline Lamboux, Martine Cuillel, Isabelle Pignot-Paintrand, Doris Cassio, Peggy Charbonnier, Khémary Um, Amélie Harel, Sylvain BOHIC, Christelle GATEAU, Vincent Balter, Virginie Brun, Pascale Delangle, Elisabeth Mintz
Copper chelation is the most commonly used therapeutic strategy nowadays to treat Wilson’s disease, a genetic disorder primarily inducing a pathological accumulation of Cu in the liver. The mechanism of...
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Metallomics, 2020, Advance Article
DOI: 10.1039/D0MT00051E, Paper

Federica Violi, Nikolay Solovyev, Marco Vinceti, Jessica Mandrioli, Marianna Lucio, Bernhard Michalke
Gene-environment interaction is as a possible key factor in the development of ALS. The levels of redox species of Cu, Fe, and Mn were assessed in cerebrospinal fluid, showing a possible positive association between Cu and genetic ALS.
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Metallomics, 2020, Advance Article
DOI: 10.1039/D0MT00048E, Paper

Melissa Scholefield, Stephanie J. Church, Jingshu Xu, Sarah Kassab, Natalie J. Gardiner, Federico Roncaroli, Nigel M. Hooper, Richard D. Unwin, Garth J. S. Cooper
Metal findings in human Alzheimer brains are consistent despite differences in sample post-mortem delay, age, Braak stage and biobank location.
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DOI: 10.1021/acscombsci.0c00012

DOI: 10.1021/acscombsci.9b00170