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Drug delivery applications of starch biopolymer derivatives / Jin Chen, Ling Chen, Fengwei Xie and Xiaoxi Li

Online Resource




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Biomedical chemistry: current trends and developments / Nuno Vale ; managing editor, Anna Rulka ; language editor, Reuben Hudson & Michael Jones

Online Resource




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Precision medicine and the reinvention of human disease / Jules J. Berman

Online Resource




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Continuous manufacturing for the modernization of pharmaceutical production: proceedings of a workshop / Joe Alper, rapporteur ; Board on Chemical Sciences and Technology, Division on Earth and Life Studies, the National Academies of Sciences, Engineering

Online Resource




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Nanoparticle (NP)-based delivery vehicles / Navid Rabiee, Mahsa Kiani, Mojtaba Bagherzadeh, Mohammad Rabiee, Sepideh Ahmadi

Online Resource




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Goodman & Gilman's the pharmacological basis of therapeutics / editor-in-chief, Laurence L. Brunton ; editors, Randa Hilal-Dandan, Björn C. Knollmann

Hayden Library - RM300.G644 2018




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Principles of pharmacology: the pathophysiologic basis of drug therapy / David E. Golan, MD, PhD, editor in chief ; Ehrin J. Armstrong, MD, MSc, April W. Armstrong, MD, MPH, associate editors

Hayden Library - RM301.P65 2017




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Characterization and biology of nanomaterials for drug delivery: nanoscience and nanotechnology in drug delivery / edited by Shyam S. Mohapatra, Shivendu Ranjan, Nandita Dasgupta, Raghvendra Kumar Mishra, Sabu Thomas

Online Resource




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Translational Research Methods in Diabetes, Obesity, and Nonalcoholic Fatty Liver Disease: A Focus on Early Phase Clinical Drug Development / editors, Andrew J. Krentz, Christian Weyer and Marcus Hompes

Online Resource




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Radiopharmaceutical chemistry / Jason S. Lewis, Albert D. Windhorst, Brian M. Zeglis, editors

Online Resource




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Polymer capsules / edited by Ye Liu, Xian Jun Loh

Online Resource




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The medicalization of marijuana: legitimacy, stigma, and the patient experience / Michelle Newhart and William Dolphin

Hayden Library - RM666.C266 N49 2019




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The medical marijuana guide: cannabis and your health / by Patricia C. Frye with Dave Smitherman

Hayden Library - RM666.C266 F79 2018




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Cytotoxic payloads for antibody--drug conjugates / edited by David E. Thurston and Paul J.M. Jackson

Online Resource




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Marine and freshwater toxins / editors, P. Gopalakrishnakone, Vidal Haddad Jr., William R. Kem, Aurelia Tubaro, Euikyung Kim

Online Resource




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Solid oral dose process validation Ajay Pazhayattil, Naheed Sayeed-Desta, Emilija Fredro-Kumbaradzi, Marzena Ingram, Jordan Collins

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Pharmacological properties of native plants from Argentina / María Alejandra Alvarez

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Sleep-wake neurobiology and pharmacology Hans-Peter Landolt, Derk-Jan Dijk, editors

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Drug discovery in Japan: investigating the sources of innovation / Sadao Nagaoka, editor

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Targeted intracellular drug delivery by receptor mediated endocytosis / Padma V. Devarajan, Prajakta Dandekar, Anisha A. D'Souza, editors

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Juzen-taiho-to (shi-quan-da-bu-tang): scientific evaluation and clinical applications / edited by Haruki Yamada, Ikuo Saiki

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Herbal medicine in India: Indigenous Knowledge, Practice, Innovation and Its Value / Saikat Sen, Raja Chakraborty, editors

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Practical statistics for pharmaceutical analysis: with Minitab applications / Jaames E. De Muth

Online Resource




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Nijkamp and Parnham's principles of immunopharmacology / Michael J. Parnham, Frans P. Nijkamp, Adriano G. Rossi, editors

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Essentials of pharmaceutical analysis Muhammad Sajid Hamid Akash, Kanwal Rehman

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Nanomedicine for the treatment of disease: from concept to application / editors, Sarwar Beg, Mahfoozur Rahman, Md. Abul Barkat, Farhan J. Ahmad

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Natural medicines: clinical efficacy, safety and quality / edited by Dilip Ghosh and Pulok K. Mukherjee

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Unit Operation in Downstream Processing / Husnul Azan Tajarudin, Mardiana Idayu Ahmad & Mohd Nazri Ismail

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The Practice of Consumer Exposure Assessment edited by Gerhard Heinemeyer, Matti Jantunen, Pertti Hakkinen

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Antiarrhythmic Drugs edited by Antoni Martínez-Rubio, Juan Tamargo, Gheorghe- Andrei Dan

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Valerian: the genus Valeriana / edited by Peter J. Houghton

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Psychoactive medicinal plants and fungal neurotoxins Amritpal Singh Saroya, Jaswinder Singh

Online Resource




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The role of NIH in drug development innovation and its impact on patient access: proceedings of a workshop / Francis K. Amankwah, Alexandra Andrada, Sharyl J. Nass, and Theresa Wizemann, rapporteurs ; Board on Health Care Services ; Board on Health Scienc

Online Resource




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‘Miedo de ser enfermera’: Los trabajadores de la salud están bajo ataque

Estigmatizados como focos de contagio en algunos países, los trabajadores de la salud han sido agredidos, maltratados y marginados.




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As India Loosens Its Strict Lockdown, Coronavirus Deaths Jump Sharply

The streets have suddenly come alive, especially at night, in many areas where social distancing is impossible.




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Gas Injection into Geological Formations and Related Topics, Volume 8


 
This is the eighth volume in the series, Advances in Natural Gas Engineering, focusing on gas injection into geological formations and other related topics, very important areas of natural gas engineering. This volume includes information for both upstream and downstream operations, including chapters detailing the most cutting-edge techniques in acid gas injection, carbon capture, chemical and thermodynamic models, and much more.


Read More...




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Object.assign Side Effects and How To Copy

In How To Copy Objects post I'll explain the difference between various native ways to copy own keys and properties, describing also the fact that Object.assign is full of surprises and side effects.

As example, assigning to an object something like {get next() {return ++this.i}, i:0} instead of {i:0, get next() {return ++this.i}} will result in different values copied over: next === 1 and i === 1 in the first case, next === 1 and i === 0 in the second one.




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Exporting modules in JavaScript

In my latest entry I explain the difference about exporting a module between server side or CLI environments such Nashorn, SpiderMonkey, JSC, or micro controller and embedded engines such Duktape, Espruino, KinomaJS, and Desktop UI space via GJS.
Using this is a universal way to attach and export properties but when it comes to ES2015 modules, incompatible with CommonJS and with an undefined execution context.
Enjoy




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The missing analysis in JavaScript "Real" Mixins

I love hacks and unusual patterns! As logical consequence, I loved this post about "Real" Mixins!!!
The only hitch about that post is that I believe there are few points closer to a "gonna sell you my idea" discussion than a non disillusioned one.
Let's start this counter analysis remembering what are actually classes in latest JavaScript standard, so that we can move on explaining what's missing in there.

JavaScript embraces prototypal inheritance

It doesn't matter if ES6 made the previously reserved class keyword usable; at the end of the day we're dealing with a special syntactical shortcut to enrich a generic prototype object.

// class in ES2015
class A {
constructor() {}
method() {}
get accessor() {}
set accessor(value) {}
}

// where are those methods and properties defined?
console.log(
Object.getOwnPropertyNames(A.prototype)
// ["constructor", "method", "accessor"]
);
Accordingly, declaring a generic class consists in bypassing the following procedure:

function A() {}
Object.defineProperties(
A.prototype,
{
// constructor is implicitly defined
method: {
configurable: true,
writable: true,
value: function method() {}
},
accessor: {
configurable: true,
get: function get() {},
set: function set(value) {}
}
}
);
If you don't trust me, trust what a transpiler would do, summarized in the following code:

var A = (function () {
// the constructor
function A() {
_classCallCheck(this, _temporalAssertDefined(A, "A", _temporalUndefined) && A);
}
// the enriched prototype
_createClass(_temporalAssertDefined(A, "A", _temporalUndefined) && A, [{
key: "method",
value: function method() {}
}, {
key: "accessor",
get: function get() {},
set: function set(value) {}
}]);

return _temporalAssertDefined(A, "A", _temporalUndefined) && A;
})();
If there is some public static property in the definition, its assignment to the constructor would be the second bypassed part.

The super case

The extra bit in terms of syntax that makes ES6 special is the special keyword super. Being multiple inheritance not possible in JavaScript, we could think about super as the static reference to the directly extended prototype. In case of the previous B class, which extends A, we can think about super variable like if it was defined as such:

// used within the constructor
let super = (...args) => A.apply(this, arguments);

// used within any other method
super.method = (...args) => A.prototype.method.apply(this, args);

// used as accessor
Object.defineProperty(super, 'accessor', {
get: () => Object.getOwnPropertyDescriptor(
A.prototype, 'accessor'
).get.call(this),
set: (value) => Object.getOwnPropertyDescriptor(
A.prototype, 'accessor'
).set.call(this, value)
});
Now that we have a decent understanding on how inheritance works in JavaScript and what it means to declare a class, let's talk about few misleading points sold as pros or cons in the mentioned article.

Prototypes are always modified anyway!

We've just seen that defining a class technically means enriching its prototype object. This already invalidates somehow Justin point but there's more to consider.
When Justin exposes his idea on why current solutions are bad, he says that:
When using mixin libraries against prototype objects, the prototypes are directly mutated. This is a problem if the prototype is used anywhere else that the mixed-in properties are not wanted.
The way Justin describes this issue is quite misleading because mutating prototypes at runtime is a well known bad practice.
Indeed, I believe every single library he mentioned in that post, and he also forgot mine, is not designed to mutate classes prototypes at runtime ... like: not at all!
Every single mixin proposal that is capable of implementing mixins via classes is indeed designed to define these classes at definition time, not at runtime!
Moreover, whatever solution Justin proposed will not guard any class from being modified at runtime later on!
The same way he's defining his final classes during their definitions, mixins-for-classes oriented libraries have exactly the same goal: you define your class and its mixins during the class definition time!
The fact mixins add properties to a prototype is a completely hidden matter that at class definition time is everything but bad.
Also, no property is modified in place, because mixins are there to enrich, not to modify ... and having a prototype enriched means also that it's easier to spot name clashing and methods or properties conflicts ... but I'll come back to that later ...

super actually should NOT work!

The main bummer about the article is that it starts in a very reasonable way, describing mixins and classes, and also analyzing their role in a program.
The real, and only, difference between a mixin and normal subclass is that a normal subclass has a fixed superclass, while a mixin definition doesn't yet have a superclass.
Justin started right at the very beginning, and then degenerated with all sort of contradictions such:
Then finally he's back to Sanity Village with the following sentence:
super calls can be a little unintuitive for those new to mixins because the superclass isn't known at mixin definition, and sometimes developers expect super to point to the declared superclass (the parameter to the mixin), not the mixin application.
And on top of that, Justin talks about constructors too:
Constructors are a potential source of confusion with mixins. They essentially behave like methods, except that overriden methods tend to have the same signature, while constructors in a inheritance hierarchy often have different signatures.
In case you're not convinced yet how much messed up could be the situation, I'd like to add extra examples to the plate.
Let's consider the word area and its multiple meanings:
  • any particular extent of space or surface
  • a geographical region
  • any section reserved for a specific function
  • extent, range, or scope
  • field of study, or a branch of a field of study
  • a piece of unoccupied ground; an open space
  • the space or site on which a building stands
Now you really have to tell me in case you implement a basic Shape mixin with an area() method what the hack would you expect when invoking super. Moreoever, you should tell me if for every single method you are going to write within a mixin, you are also going to blindly invoke super with arbitrary amount of arguments in there ...

So here my quick advice about calling blindly a super: NO, followed by DON'T and eventually NEVER!

Oversold super ability

No kidding, and I can't stress this enough ... I've never ever in my life wrote a single mixin that was blindly trusting on a super call. That would be eventually an application based on mixins but that's a completely different story.
My feeling is that Justin tried to combine at all cost different concepts, probably mislead by his Dart background, since mentioned as reference, where composition in Dart was indeed classes based and the lang itself exposes native mixins as classes ... but here again we are in JavaScript!

instanceof what?

Another oversold point in Justin's article is that instanceof works.
This one was easy to spot ... I mean, if you create a class at runtime everytime the mixin is invoked, what exactly are you capable of "instanceoffing" and why would that benefit anyone about anything?
I'm writing down his very same examples here that will obviously all fail:

// a new anonymous class is created each time
// who's gonna benefit about the instanceof?
let MyMixin = (superclass) => class extends superclass {
foo() {
console.log('foo from MyMixin');
}
};

// let's try this class
class MyClass extends MyMixin(MyBaseClass) {
/* ... */
}

// Justin says it's cool that instanceof works ...
(new MyClass) instanceof MyMixin; // false
// false ... really, it can't be an instance of
// an arrow function prototype, isn't it?!
Accordingly, and unless I've misunderstood Justin point in which case I apologies in advance, I'm not sure what's the exact point in having instanceof working. Yes, sure the intermediate class is there, but every time the mixin is used it will create a different class so there's absolutely no advantage in having instanceof working there ... am I right?

Improving **Objects** Composition

In his Improving the Syntax paragraph, Justin exposes a very nice API summarized as such:

let mix = (superclass) => new MixinBuilder(superclass);

class MixinBuilder {
constructor(superclass) {
this.superclass = superclass;
}

with(...mixins) {
return mixins.reduce((c, mixin) => mixin(c), this.superclass);
}
}
Well, this was actually the part I've liked the most about his article, it's a very simple and semantic API, and it also doesn't need classes at all to be implemented for any kind of JS object!
How? Well, simply creating objects from objects instead:

let mix = (object) => ({
with: (...mixins) => mixins.reduce(
(c, mixin) => Object.create(
c, Object.getOwnPropertyDescriptors(mixin)
), object)
});
It could surely be improved in order to deal with classes too but you get the idea:

let a = {a: 'a'};
let b = {b: 'b'};
let c = {c: 'c'};
let d = mix(c).with(a, b);
console.log(d);
Since the main trick in Justin proposal is to place an intermediate class in the inheritance chain, defining at runtime each time the same class and its prototype, I've done something different here that doesn't need to create a new class with its own prototype or object each time, while preserving original functionalities without affecting them.

Less RAM to use, a hopefully coming soon native Object.getOwnPropertyDescriptors that should land in ES7 and make extraction faster, and the ability to use the pattern with pretty much everything out there, modern or old.
The gist is here, feel free to reuse.

As Summary ...

Wrapping up this post, with latter proposal we can actually achieve whatever Justin did with his intermediate classes approach but following different goals:
  1. Mixins are added to the prototype chain.
  2. Mixins are applied without modifying existing objects.
  3. Mixins do no magic, and don't define new semantics on top of the core language.
  4. super.foo property access won't hopefully work within mixins but it will with subclasses methods.
  5. super() calls won't hopefully work in mixins constructors because you've no idea what kind of arguments you are going to receive. Subclasses still work as expected.
  6. Mixins are able to extend other mixins.
  7. instanceof has no reason to be even considered in this scenario since we are composing objects.
  8. Mixin definitions do not require library support - they can be written in a universal style and be compatible with non classes based engines too.
  9. bonus: less memory consumption overall, there's no runtime duplication for the same logic each time
I still want to thanks Justin because he made it quite clear that still not everyone fully understands mixins but there's surely a real-world need, or better demand, in the current JavaScript community.

Let's hope the next version of ECMAScript will let all of us compose in a standard way that doesn't include a footgun like super through intermediate classes definition could do.
Thanks for your patience reading through this!




j

new JS book finally published

Not exactly the technical book I've half written already and mentioned last year, put on a garage until few things change in the current ECMAScript specification, yet I've manged to finally publish my JavaScript glossary on demand.

I've written a whole blog post about it, and I can't wait to know your opinions!




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JS Glossary On Demand: Now Paperback!

Updated and Hand Crafted for A5

Imagine you are trying to learn something about Art and images are split between different pages ... that's what I feel every time I read a technical book with code examples split and very hard to follow.
It's embarrassing how much work it takes to have a proper pagination that never breaks for both paragraphs and code examples but I've finally did it in here!
The Leanpub E-Book, specially the PDF version, is also well formatted but it's for US letter.
I've ordered a proof of copy for both formats but there's no competition: the Lulu.com A5 paperback version is too handy and kinda cute!

Full Article


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JavaScript Interfaces

In this Implementing Interfaces in JavaScript blog entry I'll show a new way to enrich prototypal inheritance layering functionalities a part, without modifying prototypes at all. A different, alternative, and in some case even better, approach to mixins.




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Do you still jQuery ?

In this Strongly coupled with the past post, I'd like to ask you, in case your next big project is still using jQuery, if that's strictly necessary, considering the many new standards that meanwhile landed in every browser.
Also, don't forget why polyfills are a very useful "moe forward" approach ;-)




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A Transpiled JS Limbo

When I've updated my Custom Elements polyfill to reflect latest V1 specifications, I've realized modern JavaScript has a super problem that transpilers are incapable to fix.
Ideally, we should serve native to native capable browsers, and transpiled, to incapable one ... nobody is doing it though, and this is an issue.




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Wildlife tourism, environmental learning and ethical encounters: ecological and conservation aspects / edited by Ismar Borges de Lima, Ronda J. Green

Online Resource




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Springer handbook of global navigation satellite systems / Peter J.G. Teunissen, Oliver Montenbruck (Eds.)

Online Resource




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Geographical information systems theory, applications and management: second International Conference, GISTAM 2016, Rome, Italy, April 26-27, 2016, Revised selected papers / Cédric Grueau, Robert Laurini, Jorge Gustavo Rocha (eds.)

Online Resource




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Spatial big data science: classification techniques for Earth observation imagery / Zhe Jiang, Shashi Shekhar

Online Resource




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Placing empire: travel and the social imagination in imperial Japan / Kate McDonald

Online Resource




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Picturing America: the golden age of pictorial maps / Stephen J. Hornsby

Hayden Library - G1201.A5 H67 2017