Research Event

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MS Brown
Jul 1, 1980; 21:505-517
Reviews

29 November 2019

Many clinical studies and epidemiological investigations have clearly demonstrated that women are twice as likely to develop cholesterol gallstones as men, and oral contraceptives and other estrogen therapies dramatically increase that risk. Further, animal studies have revealed that estrogen promotes cholesterol gallstone formation through the estrogen receptor (ER) α, but not ERβ, pathway. More importantly, some genetic and pathophysiological studies have found that G protein-coupled estrogen receptor (GPER) 1 is a new gallstone gene, Lith18, on chromosome 5 in mice and produces additional lithogenic actions, working independently of ERα, to markedly increase cholelithogenesis in female mice. Based on computational modeling of GPER, a novel series of GPER-selective antagonists were designed, synthesized, and subsequently assessed for their therapeutic effects via calcium mobilization, cAMP, and ERα and ERβ fluorescence polarization binding assays. From this series of compounds, one new compound, 2-cyclohexyl-4-isopropyl-N-(4-methoxybenzyl)aniline (CIMBA), exhibits superior antagonism and selectivity exclusively for GPER. Furthermore, CIMBA reduces the formation of 17β-estradiol-induced gallstones in a dose-dependent manner in ovariectomized mice fed a lithogenic diet for 8 weeks. At 32 μg/day/kg CIMBA, no gallstones are found, even in ovariectomized ERα (^–/–) mice treated with 6 μg/day 17β-estradiol and fed the lithogenic diet for 8 weeks. In conclusion, CIMBA treatment protects against the formation of estrogen-induced cholesterol gallstones by inhibiting the GPER signaling pathway in female mice. CIMBA may thus be a new agent for effectively treating cholesterol gallstone disease in women.­

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"The coronavirus pandemic has made abundantly clear that if life is to thrive on this Earth, human and nonhuman, we need cooperation at all scales-global, regional, binational, within a nation, interstate, and in our local communities. And we need to learn how to coexist with and have compassion for our nonhuman relatives-and acknowledge in the midst of this pandemic that bats are not our enemies."

Startups moving to the scale-up phase will naturally experience growing pains, here's how to manage your team through that period with as little disruption as possible

Hilaf Hasson and Jeffrey Yelton
Trans. Amer. Math. Soc. 373 (2020), 3009-3030.
Abstract, references and article information

N. V. Krylov
St. Petersburg Math. J. 31 (2020), 509-520.
Abstract, references and article information

Mahmoud Benkhalifa
Proc. Amer. Math. Soc. 148 (2020), 2695-2706.
Abstract, references and article information

Moacir Aloisio, Silas L. Carvalho and César R. de Oliveira
Proc. Amer. Math. Soc. 148 (2020), 2509-2523.
Abstract, references and article information

The Immigration Department today reminded the public to stay vigilant against phone scammers claiming to be from the department.

The department said victims in recent cases received pre-recorded voice calls from scammers posing as immigration officers informing them that they would have immigration restrictions imposed on them.

Such calls were then transferred to another scammer posing as a non-local law enforcement officer who asked the call recipient to provide sensitive information such as personal particulars, bank account numbers and passwords.

The department stressed that it does not make any pre-recorded voice calls to the public, nor will it transfer calls to other non-local authorities or ask the call recipient to provide information such as bank account numbers and passwords.

It reminded people to verify the identity of a caller and not to disclose their personal information.

If people have any doubts about a call, they should immediately report it to Police.

The Leisure & Cultural Services Department will present Nobody but a princess..., a multimedia production featuring Nordic singers, dancers from the Hong Kong Ballet and overseas acrobats from November 8 to 10.

A story of a modern princess who discovers her identity and true love through her fantastic journey of wonders, the performance will be staged in a custom-made giant dome, complete with a state-of-the-art kinetic light display and pyrotechnics.

It will be held at 6pm, 7pm and 8.30pm from November 8 to 10 at the Cultural Centre Piazza.

The show will be conducted in English and include a strobe light effect. Admission is free.

Click here for details.

The 52nd edition of the Index of Streets, House Numbers & Lots in Hong Kong, Kowloon & New Kowloon, and the 21st edition of the New Territories Lot/Address Cross Reference Table on compact disc are now on sale.

Licences for using the street index and the cross reference table on computer networks are also available for sale.

An online version of the new street index and cross reference table is available on the Land Registry's website or the Integrated Registration Information System Online Services website.

They are designed to facilitate land record searches by correlating property addresses, building names or lot numbers.

The latest edition of the index features 444 amendments, 11 new streets, and the addition of 30 new lots, sections or subsections.

The latest edition of the table features 1,522 amendments, 10 new streets, and 1,146 new lots, sections or subsections.

Click here for order forms.

The Land Registry recorded 4,866 sale and purchase agreements for all building units for registration in April, up 6.8% from March but 50.9% lower year-on-year.

The total consideration for such agreements rose 7.1% from March to $38.4 billion, representing a 55.9% year-on-year decline.

Of the agreements, 4,102 were for residential units in April, up 6% from March but 47.6% lower than the same month a year ago.

The total consideration for residential units was $33.7 billion, up 6.2% compared with March and 51.9% lower year-on-year.

There were 375,802 land register searches last month.

Gretchen Benson
Feb 1, 2011; 24:36-40
Nutrition FYI

Jacob Oleck
Aug 1, 2016; 29:180-184
Pharmacy and Therapeutics

The value of total retail sales in March, provisionally estimated at $23 billion, fell 42% compared with the same month in 2019, the Census & Statistics Department announced today.

After netting out the effect of price changes over the same period, the volume of total retail sales decreased 43.8% year-on-year.

The value of sales of food, alcoholic drinks and tobacco decreased 21.2%.

This was followed by commodities in department stores (-42.7% in value); other consumer goods, not elsewhere classified (-29.1%); electrical goods and other consumer durable goods, not elsewhere classified (-39.6%); jewellery, watches and clocks, and valuable gifts (-75.2%); medicines and cosmetics (-63.8%); wearing apparel (-67.2%); motor vehicles and parts (-19.8%); fuels (-8%); furniture and fixtures (-14.4%); books, newspapers, stationery and gifts (-48.4%); Chinese drugs and herbs (-51.7%); footwear, allied products and other clothing accessories (-60.6%); and optical shops (-46.6%).

The value of sales of commodities in supermarkets increased 16.1% for the period.

The Government said retail sales continued to plummet in March as the COVID‑19 pandemic and resulting anti-epidemic measures brought inbound tourism to a standstill and seriously disrupted consumption-related activities.

For the first quarter as a whole, the volume of retail sales fell 36.9% year-on-year, the largest decline for a single quarter on record.

Noting that the business environment for retail trade will remain very difficult in the near term amid the deep economic recession and sharp deterioration in the labour market, the Government said it will closely monitor the developments.

The coach and rail journey app has launched a new AI voice app for automated disruption alerts

The virtual-based office hours is to connect female founders with early-stage VC investors who will provide business advice and investments

SAS Visual Analytics can be configured to send a notification to specific users when report objects contain data that meets certain criteria. This SAS note contains frequently asked questions about setting up alerts.

(Center for Genomic Regulation) An analysis of 13,000 tumours highlights two previously overlooked genes as potential new therapeutic targets for cancer treatment. Researchers also identify potential new therapeutic targets for male infertility. Both findings are the result of the most comprehensive evolutionary analysis of RNA modification proteins to date, published today in the journal Genome Biology.

(King's College London) A study of female astronauts has assessed the risk of blood clots associated with spaceflight.The study, published in Aerospace Medicine and Human Performance, in collaboration with King's College London, the Centre for Space Medicine Baylor College of Medicine, NASA Johnson Space Centre and the International Space University, examines the potential risk factors for developing a blood clot (venous thromboembolism) in space.

Palestinian officials said Friday that Israel is forcing banks in the occupied West Bank to close accounts held by the families of prisoners in Israeli jails to prevent the Palestinian Authority from providing stipends to them. Israel has long objected to the Palestinian Authority's payments to the families of prisoners and those killed in the conflict, including militants, saying it rewards terrorism. The Palestinians view the payments as a social safety net for those living under decades of military occupation.

Lawrence Fisher
Oct 1, 2004; 17:215-219
Articles

Sonia Podvin
Apr 15, 2020; 0:RA120.002079v1-mcp.RA120.002079
Research

Qingbo Shu
Apr 1, 2020; 19:672-689
Research

Research Event

Event participants

Galectins are carbohydrate-binding proteins overexpressed in bladder cancer (BCa) cells. Dendritic galactose moieties have a high affinity for galectin-expressing tumor cells. We radiolabeled a dendritic galactose carbohydrate with fluorine-18 – ¹⁸F-labeled galactodendritic unit 4 – and examined its potential in imaging urothelial malignancies. Methods: The ¹⁸F-labeled 1st generation galactodendritic unit 4 was obtained from its tosylate precursor. We conducted in vivo studies in galectin-expressing UMUC3 orthotopic BCa model to determine the ability of ¹⁸F-labeled galactodendritic unit 4 to image BCa. Results: Intravesical administration of ¹⁸F-labeled galactodendritic unit 4 allowed specific accumulation of the carbohydrate radiotracer in galectin-1 overexpressing UMUC3 orthotopic tumors when imaged with PET. The ¹⁸F-labeled galactodendritic unit 4 was not found to accumulate in non-tumor murine bladders. Conclusion: The ¹⁸F-labeled galactodendritic unit 4 and similar analogs may be clinically relevant and exploitable for PET imaging of galectin-1 overexpressing bladder tumors.