3

Identification of type 2 diabetes loci in 433,540 East Asian individuals




3

Therapeutic targeting of p300/CBP HAT domain for the treatment of NUT midline carcinoma




3

The β-catenin/TCF-4-LINC01278-miR-1258-Smad2/3 axis promotes hepatocellular carcinoma metastasis




3

Rad53 limits CMG helicase uncoupling from DNA synthesis at replication forks




3

The functions of IL-23 and IL-2 on driving autoimmune effector T-helper 17 cells into the memory pool in dry eye disease




3

IL-33/ST2/IL-9/IL-9R signaling disrupts ocular surface barrier in allergic inflammation




3

Why It's So Hard to Junk Bad Decisions—Edging Closer to Understanding “Sunk Cost”

Humans, rats and mice all exhibit the decision-making phenomenon, but new research suggests not all choices are equally vulnerable to it




3

Recruitment for director and research principal investigators of Shanghai Key Laboratory of Tissue Engineering Research, at Shanghai Ninth People's Hospital, Shanghai Jiao Tong University

Position
Laboratory director and independent principal investigators

Employer
Shanghai Ninth People’s Hospital affiliated to Shanghai Jiao Tong University School of Medicine

Location
639 Zhi Zao Ju Rd, Huang Pu District, 200011, Shanghai, China

Discipline
Tissue engineering and regenerative medicine related disciplines including: Stem Cell, Developmental Biology, Biomaterials, Biomedical Engineering

Aim:
Shanghai Tissue Engineering Key Laboratory is among the l…




3

Single-cell RNA counting at allele and isoform resolution using Smart-seq3




3

Androgen receptor phosphorylation at serine 81 and serine 213 in castrate-resistant prostate cancer




3

Lifespan-increasing drug nordihydroguaiaretic acid inhibits p300 and activates autophagy




3

Differential effectiveness of tyrosine kinase inhibitors in 2D/3D culture according to cell differentiation, p53 status and mitochondrial respiration in liver cancer cells




3

WTAP and BIRC3 are involved in the posttranscriptional mechanisms that impact on the expression and activity of the human lactonase PON2




3

LncRNA <i>SNORD3A</i> specifically sensitizes breast cancer cells to 5-FU by sponging miR-185-5p to enhance UMPS expression




3

Chromosome 11 open reading frame 30 (C11orf30), calpain small subunit 1 (CAPNS1; CAPN4), signal transducer and activator of transcription 6 (STAT6) and ankyrin repeat domain 27 (ANKRD27) as diagnostic markers for eosinophilic esophagitis (EoE)

Genomewide association studies identified four genes that could serve as diagnostic markers and/or therapeutic targets for EoE.




3

Angiopoietin 2 (ANG2; ANGPT2); placental growth factor (PGF; PlGF); tissue inhibitor of metalloproteinases 3 (TIMP3)

Mouse studies suggest inhibiting PGF could help treat hypertension.




3

c-jun N-terminal kinase (JNK); MAP kinase 1 (MAPK1; ERK-2); MAPK3 (ERK-1)

In vitro and rodent studies suggest ophiopogonin D could help prevent doxorubicin-induced cardiotoxicity.




3

Globohexaosylceramide (globo-H); stage-specific embryonic antigen-3 (SSEA-3); SSEA-4

Mouse studies suggest chemically modified carbohydrate conjugates could be useful as antigens for the development of cancer vaccines.




3

Epidermal growth factor receptor 1 (EGFR1; ErbB1; HER1); HER2 (EGFR2; ErbB2; neu); HER3 (EGFR3; ErbB3); VEGF

Tumor cell and mouse studies suggest tetravalent antibodies that target four different antigens could help treat cancers resistant to HER-targeted therapies.




3

Tripartite motif containing 37 (TRIM37)

In vitro and mouse studies suggest inhibiting TRIM37 could help treat breast cancer.




3

Estrogen receptor; LYN kinase (LYN); phosphoinositide 3-kinase (PI3K)

Studies in mice and human samples suggest inhibiting LYN could help treat estrogen receptor–positive breast cancers resistant to anti-estrogen therapy.




3

Genocea's mark on malaria

Genocea has identified an immunological imprint in patients with malaria and is using a $1.2 million grant from the Gates Foundation to turn the findings into a vaccine.




3

Myeloid PTEN promotes chemotherapy-induced NLRP3-inflammasome activation and antitumour immunity




3

Bridging naïve and primed pluripotency




3

UNC5B mediates G2/M phase arrest of bladder cancer cells by binding to CDC14A and P53




3

Nongjian Tao (1963–2020)




3

Peter Ward: 'Membership organisations can thrive and prosper'




3

You're invited to an online congress




3

NLRP3 inflammasome activity as biomarker for primary progressive multiple sclerosis




3

COVID-19's Painful Lesson About Strategy and Power

Joseph Nye writes that while trade wars have set back economic globalization,  the environmental globalization represented by pandemics and climate change is unstoppable. Borders are becoming more porous to everything from drugs to infectious diseases to cyber terrorism, and the United States must use its soft power of attraction to develop networks and institutions that address these new threats.




3

There's No Such Thing as Good Liberal Hegemony

Stephen Walt argues that as democracies falter, it's worth considering whether the United States made the right call in attempting to create a liberal world order.




3

Poll: What the American Public Likes and Hates about Trump's Nuclear Policies

The authors conducted a study which highlights how the U.S. public as a whole and various demographic groups view President Donald Trump's positions on nuclear weapons.




3

Oil's Collapse Is a Geopolitical Reset In Disguise

The world is on the cusp of a geopolitical reset. The global pandemic could well undermine international institutions, reinforce nationalism and spur de-globalization. But far-sighted leadership could also rekindle cooperation, glimmers of which appeared in the G-20’s offer of debt relief for some of the world’s poorest countries, a joint plea from more than 200 former national leaders for a more coordinated pandemic response and an unprecedented multinational pact to arrest the crash in oil markets.  




3

Romney's Reckless China Rhetoric Risks New Cold War

Rachel Esplin Odell argues for a wiser and more conservative strategy that resists the temptation to exaggerate the challenge posed by China.




3

Maxwell Taylor's Cold War: From Berlin to Vietnam

Nathaniel Moir reviews Maxwell Taylor's Cold War: From Berlin to Vietnam by Ingo Trauschweizer.




3

The Global Pandemic Has Spawned New Forms of Activism — and They're Flourishing

The authors have identified nearly 100 distinct methods of nonviolent action that include physical, virtual and hybrid actions.




3

There's No Such Thing as Good Liberal Hegemony

Stephen Walt argues that as democracies falter, it's worth considering whether the United States made the right call in attempting to create a liberal world order.




3

Poll: What the American Public Likes and Hates about Trump's Nuclear Policies

The authors conducted a study which highlights how the U.S. public as a whole and various demographic groups view President Donald Trump's positions on nuclear weapons.




3

What I Wish I Had Said on CNN About Trump's 'Lysol and Sunshine' Speech

Joel Clement appeared on CNN's Erin Burnett OutFront on April 23, 2020.  In this blog post for the Union of Concerned Scientists, he elaborates on what he wishes he had said during that interview.




3

U.S. Intervention in Russia-Saudi Impasse Isn't Tenable (Radio)

Meghan L. O’Sullivan, Professor of International Affairs at Harvard’s Kennedy School, former National Security Council advisor, and a Bloomberg Opinion columnist, discusses the oil market plunge, and the Russia-Saudi relationship. Hosted by Lisa Abramowicz and Paul Sweeney.




3

The Global Pandemic Has Spawned New Forms of Activism — and They're Flourishing

The authors have identified nearly 100 distinct methods of nonviolent action that include physical, virtual and hybrid actions.




3

Oil's Collapse Is a Geopolitical Reset In Disguise

The world is on the cusp of a geopolitical reset. The global pandemic could well undermine international institutions, reinforce nationalism and spur de-globalization. But far-sighted leadership could also rekindle cooperation, glimmers of which appeared in the G-20’s offer of debt relief for some of the world’s poorest countries, a joint plea from more than 200 former national leaders for a more coordinated pandemic response and an unprecedented multinational pact to arrest the crash in oil markets.  




3

The Global Pandemic Has Spawned New Forms of Activism — and They're Flourishing

The authors have identified nearly 100 distinct methods of nonviolent action that include physical, virtual and hybrid actions.




3

There's No Such Thing as Good Liberal Hegemony

Stephen Walt argues that as democracies falter, it's worth considering whether the United States made the right call in attempting to create a liberal world order.




3

Poll: What the American Public Likes and Hates about Trump's Nuclear Policies

The authors conducted a study which highlights how the U.S. public as a whole and various demographic groups view President Donald Trump's positions on nuclear weapons.




3

What I Wish I Had Said on CNN About Trump's 'Lysol and Sunshine' Speech

Joel Clement appeared on CNN's Erin Burnett OutFront on April 23, 2020.  In this blog post for the Union of Concerned Scientists, he elaborates on what he wishes he had said during that interview.




3

Centros de documentación de diarios en el siglo XXI. Panorama después del tsunami

Guallar, Javier and Cornet, Anna Centros de documentación de diarios en el siglo XXI. Panorama después del tsunami. BiD, 2020, n. 44. [Journal article (Unpaginated)]




3

e-EMGDE, RIC, NEDA y las normas de codificación: más allá de un perfil de aplicación en archivos

Baños-Moreno, María-José and Valentín-Ruiz, Francisco-José and Blázquez-Martín-de-las-Mulas, Antonio e-EMGDE, RIC, NEDA y las normas de codificación: más allá de un perfil de aplicación en archivos., 2019 . In IV Congreso ISKO España-Portugal, Barcelona, 11-12 de julio de 2019. [Conference paper]




3

El aspecto social de la biblioteca pública y la inclusión social de las minorías

Saurin-Parra, Julia . El aspecto social de la biblioteca pública y la inclusión social de las minorías., 2019 In: El libro y la lectura en recintos penitenciarios. Gráfica Nacional, pp. 73-81. [Book chapter]




3

El libro y la lectura en los recintos penitenciarios de la región de Valparaíso

Sequeiros, Paula and Silveira, Fabrício José Nascimento da and Rivera Donoso, Miguel and Armingol Jaime, Karla and Díaz Rubio, Sara and Sáez Alarcón, Daniela and Muñoz Muño, Alexia and Saurin Parra, Julia and Cosgrove, Kimberly and Parra, Pablo and Barbosa, Andreza Gonçalves and Piñeiros, Gabriela . El libro y la lectura en los recintos penitenciarios de la región de Valparaíso., 2019 Universidad de Playa Ancha. [Book]