'Last Dance' brings back memories of tough 90's NBA for Pacers coach Nate McMillan

This week, PrepVolleyball.com released its Class of 2020 recruiting rankings. The Hoosiers came in at No. 15 — a program best.

Simon executives are furious at Indianapolis officials.

US space agency satellites follow the melting trends in Antarctica and Greenland over 16 years.

Mediterranean sediments are shown to have up to 1.9 million tiny plastic pieces per square metre.

1. Coronavirus LIVE Updates: Maharashtra's Tally of Infections Crosses 20,000 with 1,165 New Cases, 48 Deaths in Last 24 Hours  News18
2. Coronavirus India News LIVE | Tamil Nadu COVID-19 tally zooms to 6,535 with 526 new cases; 44 die  Moneycontrol
3. Retirement age hiked for all Tamil Nadu government staff  Deccan Chronicle
4. Andra Prasdesh to Reduce Retail Liquor Outlets to 2,934 by May End  News18
5. In Pictures | Day-45 of coronavirus lockdown leaves people in limbo  The Hindu
6. View Full coverage on Google News

Clashes erupt after people complain about a perceived failure to help the poor during the pandemic.

It's a very American phenomenon - here's what's behind the growing aversion to face coverings.

Founder of the Khan Academy, Salman Khan, wants to make a world class education available to everyone.

Three years ago it was barely walking. Now, Atlas, the humanoid robot from Boston Dynamics is performing gymnastic routines that mimic professional athletes.

This year’s Classic, a 1¼-mile race for 3-year-olds and up, will be held at Churchill Downs and features several strong entrants.

Fans of the Disney animated movie celebrated its addition to the National Film Registry.

“The transition happens so quickly; it’s like you don’t even get to move your furniture out until the new president takes the oath of office,” Obama told Gayle King in an interview at Essence Festival.

The "Charmed" actress defended her decision to help raise money for the controversial Democratic candidate, saying Williamson is addressing the "soulful ache of the nation."

Stars criticized the president after two mass shootings that occurred less than 24 hours apart in El Paso and Dayton, Ohio.

Tom Bergeron tweeted that he thought the producers had agreed the show should be “free of inevitably divisive bookings from ANY party affiliations.”

Anthony Fauci praised Brad Pitt's performance, saying "Everything he said on SNL is what’s going on.”

Discover what it is like to fly Air Tahiti Nui Boeing Dreamliner in Poerava Business Class. I discuss and review the aircraft, layout, seats, food, drink, service and facilities on board. Find out of this airline and business class is a thumbs up or thumbs down from me.

Note: I received a discount off the full fare price of my Air Tahiti Business class flight from Paris to Papeete Tahiti. The airline had no input of the content or opinions expressed in my video.

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Gary Bembridge's Tips For Travellers aims to help you make more of your precious travel time and money on land and when cruising the oceans or rivers of the world. To help you, in every video I draw on my first-hand tips and advice from travelling every month for over 20 years and 60+ cruises.

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And now, we’re woefully unprepared.

Trump's own industry — leisure and hospitality — saw all its job gains since 1988 wiped out.

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MTN on Friday announced a drop in the price of monthly data bundles and customers will now pay R99 for 1GB, 33% lower than previously.

A mimosa, the classic combination of orange juice and sparkling wine, makes the perfect pick-me-up drink. It’s light, refreshing, and easy to make. Don’t have orange juice? Mix and match with any citrus fruit you have around.

Continue reading "Classic Mimosa" »

velocityconf: LAST DAY for #velocityconf EU call for speakers http://t.co/qShofQCDPl Share your best #WPO, #Ops, and #DevOps stories.

velocityconf: Who's up for a 5 minute lightning talk. Last day to get your #Ignite proposal in for #velocityconf CA. http://t.co/pzL0WJtQH5

Las Vegas, Nevada

Mountain Gorillas in Uganda and Rwanda

The Amateur Traveler talks to Deanna about cruising to Alaska aboard a small boat from Cruise West In a nights ashore / days at sea program.

The Amateur Traveler talks to Sarah from Whitehorse in the Yukon about that corner of Canada with long winters but dramatic scenery. She tells of of Winter festivals like the Yukon Sourdough Rendezvous as well as Summer festivals like Dawson City Music fest, Atlin Arts and Music Fest and the Kluane Mountain Bluegrass Festival. We talk about sporting events like the 24 Hours of Light and Kluane to Chilkat (Haines to Haines) bike races because Sarah says you have to like the outdoors to come to the Yukon. Sarah also gives us some itineraries for road warriors like the Top of the World Highway to Dawson (and the Dempster Highway for the bold among you) and the Golden Circle route into Alaska. We walk the Chilkoot Trail but without the requirement to bring 1,000 pounds of supplies like in the Yukon gold rush. It is the beauty of Kluane National Park that you will remember but strangely enough it was something else that Sarah was looking at when she decided to move to the Yukon.

The Amateur Traveler talks to Joe Bickley of Alaska Backcountry Consulting about traveling to Alaska, particularly the interior and back country. Alaska is a bug state and Joe lives in the center of it near Fairbanks but at the northern end of the Alaskan road system. Joe gives us some directions on places to go to see Alaska’s vistas and encounter its wildlife. He takes us above the tree line at Denali National Park (aka Mt McKinley) which is not quite half the size of the state of Rhode Island. At that Denali is not even the largest National Park in Alaska. That honor goes to Wrangell-St. Elias. Alaska also has the largest National Forest which is Tongass National Forest. Joe takes us to one of his favorite spots off the Denali “highway”. He also directs us down to the Kenai Peninsula known for great fishing and also to the town of Homer with its artist culture. Learn what some Alaskans call those bells that a tenderfoot might wear to scare off bears.

Chihuahua is also known for the beautiful Cooper Canyon which is best seen from the train that transverses it. Copper Canyon is a popular tourist destination with Mexicans. Copper Canyon is larger and portions are deeper than the Grande Canyon.

The Amateur Traveler talks to Hunter Hillegas author of the Vegas Mate iPhone app about Las Vegas. The Amateur Traveler has covered Las Vegas before but the city is constantly changing.

Hear about travel to Lassen National Park in northern California as the Amateur Traveler talks to Dick Jordan about this spectacular if less visited destination. Lassen is in northeastern California. It is just as easy to get to from San Francisco as Yosemite National Park but with fewer tourists and one more volcano. The park centers around the dormant volcano Mt. Lassen and features other geothermal active areas.

Hear about travel to remote parts of Alaska as the Amateur Traveler talks again to Sherry Ott from ottsworld.com about travel to Wrangell-St. Elias National Park in the east, above the Arctic Circle to Coldfoot Camp and far to the west to Nome Alaska.

Hear about travel to Dallas, Texas  as the Amateur Traveler talks to Penny Sadler from adventuresofacarryon.com about her hometown of Dallas, Texas. Penny tells us why we might be surprised at all Dallas has to offer and why we should leave our cowboy hats at home.

Hear about Cruising Southeastern Alaska on Un-Cruise Adventures as the Amateur Traveler goes on a cruise where dressing for dinner and bingo are replaced with kayaking and bushwhacking.

Hear about travel to Alaska's Kenai Peninsula as the Amateur Traveler talks to tour guide Mareth Griffith about her adopted home. 

Hear about travel to Alaska's National Parks as the Amateur Traveler talks once again to Gary Arndt about his visits to each of the 8 National Parks in Alaska.

Nicholas Love's Penguin Classics cover generator lets you upload an image and set type in humorous imitation of the label. It can also do the similar but inverted Oxford World Classics look. But sadly not the classic classics look.

Many excellent designs in this twitter thread; embedded here is my contribution. Read the rest

A massive boom heard Wednesday night over Puget Sound on the northwestern coast of Washington was most likely an exploding meteor. Or that's what They want us to believe anyway. The American Meteor Society registered a dozen reports. Video above. Keep your eyes on the upper left of the frame.

"The more I read the more inclined I am to believe this was a fireball (which is a meteor that is larger and brighter than normal)," the American Meteor Society's Bob Lunsford said. "I'm certain now that this was a meteoric event."

From KOMONews:

Most meteors' explosions are heard about a minute or two after they explode due to the time it takes the sound to reach the Earth's surface, Lunsford said. Sound travels at 767 mph in standard atmosphere conditions, indicating this fireball exploded some 35 miles away.

"If this was larger than normal then the sound could have originated from a higher altitude. So a delay of 3 minutes is entirely possible," Lunsford said. "Meteors become visible at a height of around 50 miles so your estimate is well within that range."

Lunsford said because there was a boom, it’s very likely there are small, rock-sized pieces of the meteor somewhere on the ground. When a meteor causes a boom, it’s “pretty far down” in the atmosphere.

Read the rest

One positive upside of the past two months is how sheltering at home has all but emptied area animal shelters. It’s tough to get solid numbers nationally, but shelters in cities and regions all across America are reporting massive surges in animal adoptions. 

Even the steep increase in Google searches for “adopt a pet,” up a whopping 335 percent in April, proves what we probably all knew anyway — that in times of stress, having a furry friend is a huge comfort for millions.

Unfortunately, one of the downsides of the past two months is there are no trainers available to help whip some of these new family pets, particularly puppies, into shape. From barking and jumping to house training and scratching, The Complete Guide to Puppy and Dog Training Bundle is a full plan for getting the newest member of your family integrated into the house safely and sanely all by yourself.

The collection includes eight courses all geared toward getting a new dog or puppy behaving the right way. And if you’ve ever had any thoughts about starting a dog training business of your own, this coursework is a perfect starting spot.

Puppies: A-Z Guide to Puppy & Dog Training kicks off the learning, explaining the best way to train, teach and socialize your puppy so they grow into a joyful, well balanced, and well-behaved dog. 

Of course, most puppies each have their particular issues, so a handful of courses look more closely at some of the tactics for helping your puppy overcome certain challenging behaviors. Read the rest

I have a love/hate relationship with musical reaction videos. There are kids reacting to heavy metal (or The Beatles), vocal teachers and opera singers reacting to rock vocalists, millennials reacting to classic rock, and on and on. Some of these are quite moving, for instance, a 20-something hearing Zep's "Since I've Been Loving You" for the first time or a vocal teacher reacting to a Black Metal vocalist's cookie monster growl.

In these two videos, Heline, a classical flutist and music teacher, listens to Jethro Tull's Ian Anderson performing "Bouree" at a 1969 concert and then she listens and reacts to a performance from 1976.

I didn't realize that Anderson had only been playing the flute for a year and had no formal training at the time of the 69 video (their first tour). Heline can appreciate his chutzpah in the first performance and the fact that he's only been playing for a year(!), but is perhaps predictably critical of his playing. She is more impressed with what she sees and hears in the 76 performance.

Personally, I always thought his playing was inspired and his playing, vocalizing, singing and playing, and his other stage antics (the goofy one-legged stance) were a perfect example of "the street finding its own uses for things," using technology in ways in which it was never intended. As with all things artistic, your mileage may vary.

Image: YouTube Read the rest

Philadelphia Phillies star Bryce Harper believes Major League Baseball should relax its "dumb" rule preventing top players from competing in the Olympics.

The following article, Attorney for Jailed Dallas Salon Owner Shelley Luther Slams Obama Loyalist Judge as a “Tiny Tyrant”, was first published on 100PercentFedUp.com.

Warren Norred, attorney for Shelley Luther, joined Tucker Carlson to discuss the decision by an Obama loyalist Texas judge to jail his client for reopening her salon during the COVID-19 pandemic. Norred said the judge has exposed himself for the “tiny tyrant” that he is. The judge jailed Luther and even fined her $7,000. Texas […]

Continue reading: Attorney for Jailed Dallas Salon Owner Shelley Luther Slams Obama Loyalist Judge as a “Tiny Tyrant” ...

The following article, Video: Dallas Salon Owner Shelley Luther Gets Surprise Visit from Sen Ted Cruz for a Celebratory Haircut, was first published on 100PercentFedUp.com.

When Dallas, Texas salon owner Shelley Luther opened her salon in defiance of the lockdown order in Texas, she was visited numerous times by the local police and then sentenced to 7 days in jail with a fine of $7,000. After public outrage at her punishment, the Texas Supreme Court stepped in to demand her […]

Continue reading: Video: Dallas Salon Owner Shelley Luther Gets Surprise Visit from Sen Ted Cruz for a Celebratory Haircut ...

Treatment of patients with triple-negative breast cancer (TNBC) is limited by a lack of effective molecular therapies targeting this disease. Recent studies have identified metabolic alterations in cancer cells that can be targeted to improve responses to standard-of-care chemotherapy regimens. Using MDA-MB-468 and SUM-159PT TNBC cells, along with LC-MS/MS and HPLC metabolomics profiling, we found here that exposure of TNBC cells to the cytotoxic chemotherapy drugs cisplatin and doxorubicin alter arginine and polyamine metabolites. This alteration was because of a reduction in the levels and activity of a rate-limiting polyamine biosynthetic enzyme, ornithine decarboxylase (ODC). Using gene silencing and inhibitor treatments, we determined that the reduction in ODC was mediated by its negative regulator antizyme, targeting ODC to the proteasome for degradation. Treatment with the ODC inhibitor difluoromethylornithine (DFMO) sensitized TNBC cells to chemotherapy, but this was not observed in receptor-positive breast cancer cells. Moreover, TNBC cell lines had greater sensitivity to single-agent DFMO, and ODC levels were elevated in TNBC patient samples. The alterations in polyamine metabolism in response to chemotherapy, as well as DFMO-induced preferential sensitization of TNBC cells to chemotherapy, reported here suggest that ODC may be a targetable metabolic vulnerability in TNBC.

N. Leigh Anderson
Apr 1, 2004; 3:311-326
Research

Myriam Ferro
May 1, 2003; 2:325-345
Research