x [ASAP] Correction to Toggling Preassembly with Single-Site Mutation Switches the Cytotoxic Mechanism of Cationic Amphipathic Peptides By feedproxy.google.com Published On :: Fri, 24 Apr 2020 04:00:00 GMT Journal of Medicinal ChemistryDOI: 10.1021/acs.jmedchem.0c00608 Full Article
x [ASAP] Discovery of (2<italic toggle="yes">R</italic>)-<italic toggle="yes">N</italic>-[3-[2-[(3-Methoxy-1-methyl-pyrazol-4-yl)amino]pyrimidin-4-yl]-1<italic toggle="yes">H</italic>-indol-7 By feedproxy.google.com Published On :: Tue, 28 Apr 2020 04:00:00 GMT Journal of Medicinal ChemistryDOI: 10.1021/acs.jmedchem.9b01392 Full Article
x [ASAP] Correction to Photoactivatable Prolyl Hydroxylase 2 Inhibitors for Stabilizing the Hypoxia-Inducible Factor with Light By feedproxy.google.com Published On :: Tue, 28 Apr 2020 04:00:00 GMT Journal of Medicinal ChemistryDOI: 10.1021/acs.jmedchem.0c00599 Full Article
x [ASAP] Structure-Based Design of Highly Potent HIV-1 Protease Inhibitors Containing New Tricyclic Ring P2-Ligands: Design, Synthesis, Biological, and X-ray Structural Studies By feedproxy.google.com Published On :: Wed, 29 Apr 2020 04:00:00 GMT Journal of Medicinal ChemistryDOI: 10.1021/acs.jmedchem.0c00202 Full Article
x [ASAP] Degradation versus Inhibition: Development of Proteolysis-Targeting Chimeras for Overcoming Statin-Induced Compensatory Upregulation of 3-Hydroxy-3-methylglutaryl Coenzyme A Reductase By feedproxy.google.com Published On :: Mon, 04 May 2020 04:00:00 GMT Journal of Medicinal ChemistryDOI: 10.1021/acs.jmedchem.0c00339 Full Article
x [ASAP] p62/SQSTM1, a Central but Unexploited Target: Advances in Its Physiological/Pathogenic Functions and Small Molecular Modulators By feedproxy.google.com Published On :: Tue, 05 May 2020 04:00:00 GMT Journal of Medicinal ChemistryDOI: 10.1021/acs.jmedchem.9b02038 Full Article
x [ASAP] Discovery of Potent Inhibitors against P-Glycoprotein-Mediated Multidrug Resistance Aided by Late-Stage Functionalization of a 2-(4-(Pyridin-2-yl)phenoxy)pyridine Analogue By feedproxy.google.com Published On :: Thu, 07 May 2020 04:00:00 GMT Journal of Medicinal ChemistryDOI: 10.1021/acs.jmedchem.0c00337 Full Article
x [ASAP] Discovery of <italic toggle="yes">N</italic>-Ethyl-4-[2-(4-fluoro-2,6-dimethyl-phenoxy)-5-(1-hydroxy-1-methyl-ethyl)phenyl]-6-methyl-7-oxo-1<italic toggle="yes">H</italic>-pyrrolo[2,3-<italic toggle=&q By feedproxy.google.com Published On :: Thu, 07 May 2020 04:00:00 GMT Journal of Medicinal ChemistryDOI: 10.1021/acs.jmedchem.0c00628 Full Article
x [ASAP] Ruthenium(II) Complex Containing a Redox-Active Semiquinonate Ligand as a Potential Chemotherapeutic Agent: From Synthesis to <italic toggle="yes">In Vivo</italic> Studies By feedproxy.google.com Published On :: Thu, 07 May 2020 04:00:00 GMT Journal of Medicinal ChemistryDOI: 10.1021/acs.jmedchem.0c00431 Full Article
x [ASAP] Exploration of the Structural Space in 4(3<italic toggle="yes">H</italic>)-Quinazolinone Antibacterials By feedproxy.google.com Published On :: Fri, 08 May 2020 04:00:00 GMT Journal of Medicinal ChemistryDOI: 10.1021/acs.jmedchem.0c00153 Full Article
x [ASAP] Inhibitors of Hypoxia-Inducible Factors as Treatment for Cancer By feedproxy.google.com Published On :: Wed, 01 Apr 2020 04:00:00 GMT ACS Medicinal Chemistry LettersDOI: 10.1021/acsmedchemlett.0c00116 Full Article
x [ASAP] Peptoid NPhe<sup>4</sup> in AGRP-Based c[Pro<sup>1</sup>-Arg<sup>2</sup>-Phe<sup>3</sup>-Phe<sup>4</sup>-Xxx<sup>5</sup>-Ala<sup>6</sup>-Phe<sup>7</sup> By feedproxy.google.com Published On :: Wed, 01 Apr 2020 04:00:00 GMT ACS Medicinal Chemistry LettersDOI: 10.1021/acsmedchemlett.9b00641 Full Article
x [ASAP] Substituted Naphthalenediimide Compounds Bind Selectively to Two Human Quadruplex Structures with Parallel Topology By feedproxy.google.com Published On :: Thu, 02 Apr 2020 04:00:00 GMT ACS Medicinal Chemistry LettersDOI: 10.1021/acsmedchemlett.0c00041 Full Article
x [ASAP] Exploring the Implication of DDX3X in DENV Infection: Discovery of the First-in-Class DDX3X Fluorescent Inhibitor By feedproxy.google.com Published On :: Thu, 09 Apr 2020 04:00:00 GMT ACS Medicinal Chemistry LettersDOI: 10.1021/acsmedchemlett.9b00681 Full Article
x [ASAP] Sigma Receptor Ligands Carrying a Nitric Oxide Donor Nitrate Moiety: Synthesis, In Silico, and Biological Evaluation By feedproxy.google.com Published On :: Wed, 15 Apr 2020 04:00:00 GMT ACS Medicinal Chemistry LettersDOI: 10.1021/acsmedchemlett.9b00661 Full Article
x [ASAP] Discovery of Adamantane Carboxamides as Ebola Virus Cell Entry and Glycoprotein Inhibitors By feedproxy.google.com Published On :: Fri, 01 May 2020 04:00:00 GMT ACS Medicinal Chemistry LettersDOI: 10.1021/acsmedchemlett.0c00025 Full Article
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x A BEM syntax with UX in mind By simurai.com Published On :: Thu, 24 Oct 2013 00:00:00 +0000 At some point, while working on the MontageJS framework, the question came up what CSS naming convention we should start using. After a long discussion we settled on using the BEM methodology, but changed the syntax a bit. To keep this post short, I won’t go into detail why using BEM is a good idea, but rather explain why we chose a different syntax. Here some examples: .digit-Progress /* org-Component */ .digit-Progress-bar /* org-Component-childElement */ .digit-Progress--small /* org-Component--variation */ Note: The org- (digit-) prefix is used as a name-space so it wouldn’t conflict with other packages/libraries/frameworks. Now let’s take a look at the reasons for choosing such a syntax. Hyphens (-) The main reason why we’re using a hyphen (-) instead of underscores (_), has to do with the fact that their behavior is different when double-clicking to select text. Try for yourself: component__element /* underscores */ component-element /* hyphen */ See how when you’re using underscores it selects the part before and after, in this case the whole component__element. But with hyphens it let’s you select only the part you double-clicked. component OR element. This let’s you quickly edit only the parts you want: camelCase Now, what if the component or child element consists of multiple words? We could use underscores like component_name-element_name. It would still be double-clickable, but readability suffers since it’s harder to see what belongs together. Better to use camelCase which groups each part visually: componentName-elementName. MainComponent OK, I think we’re getting closer. As a last rule, for the “main” component we use PascalCase. The reason for it is to add emphasis and make it easier to distinguish the main component from a child element. Also when using a namespace, the component moves to the second position, which makes it even more important to have it stick out: org-Component-childElement –variation We kept the more commonly used double hyphens (–) for variations. digit-Progress--small. It makes sense, because it pulls the variation (–small) visually more apart and makes it look like it’s something “different” than the default component. So that’s about it. For more details about this naming convention, take a look at the SUIT framework, which also started to use the same syntax and documented it really well. In the end, whatever Shade of BEM you choose to cook with probably depends on your personal taste, but thinking about a great UX by improving usability and readability won’t hurt either. Full Article
x Contextual styling with custom properties By simurai.com Published On :: Sun, 01 Apr 2018 00:00:00 +0000 Something I’ve been wanting for a long time, define different regions like a footer section, or side bar and not have to deal with all the contextual styling hassle. A.k.a. “Now that this button is used on a dark background, the button needs to change its colors too. Where should the styles live?”. Here an old post about struggling with contextual styling. So then the other day I was doing some experiments with using custom properties for Atom’s UI. Turns out, using custom properties might make contextual styling a bit easier. For the rest of the post, let’s switch to a more simple example. A page where the main area is light, but then has a dark hero and footer section. Like this: In the past, I probably would’ve created variations like Button--dark or overwrote it with header .Button {…}. Depends a bit on the project. Here another approach: Create themes with a set of variables, then apply the theme to the different areas. 1. Default theme First let’s define our default theme with a bunch of variables. [data-theme="default"] { --fg: hsl(0,0%,25%); --border: hsl(0,0%,75%); --bg: hsl(0,0%,95%); --button-bg: hsl(0,0%,99%); --input-bg: hsl(0,0%,90%); } Then we create some components where we use the variables defined above. [data-theme] { color: var(--fg); background-color: var(--bg); } .Button { color: var(--fg); border: 1px solid var(--border); background-color: var(--button-bg); } .Input { color: var(--fg); border: 1px solid var(--border); background-color: var(--input-bg); } And lastly we add the [data-theme="default"] attribute on the body so that our components will pick up the variables. <body data-theme="default"> If you wonder why use data-theme attributes over classes? Well, no specific reason. Maybe with attributes, it’s a hint that only one theme should be used per element and is more separated from your other classes. At this point we get this: See the Pen Contextual styling with custom properties (1/3) by simurai (@simurai) on CodePen. 2. Dark theme But our designer wants the hero and footer to be dark. Alright, let’s define another theme region. [data-theme="dark"] { --fg: hsl(0,10%,70%); --border: hsl(0,10%,10%); --bg: hsl(0,0%,20%); --button-bg: hsl(0,0%,25%); --input-bg: hsl(0,0%,15%); } And add the theme attribute to the header and footer. <header data-theme="dark"> <footer data-theme="dark"> Which gives us this: See the Pen Contextual styling with custom properties (2/3) by simurai (@simurai) on CodePen. The reason why this works is that custom properties cascade and can be overridden on nested elements, just like normal properties. 3. Hero theme A few months pass and our designer comes back with a redesigned hero section. “To make it look fresh” with a splash of color. No problem! Just like with the dark theme, we define a new “hero” theme. [data-theme="hero"] { --fg: hsl(240,50%,90%); --border: hsl(240,50%,10%); --bg: hsl(240,33%,30%); --button-bg: hsl(240,33%,40%); --input-bg: hsl(240,33%,20%); } <header data-theme="hero"> And here is that fresh hero: See the Pen Contextual styling with custom properties (3/3) by simurai (@simurai) on CodePen. It’s also not limited to colors only, could be used for sizes, fonts or anything that makes sense to define as variables. Benefits Using these theme “regions” lets your components stay context un-aware and you can use them in multiple themes. Even on the same page. Developers can add components, move components around, without having to know about in what context (theme) they live. The markup for the components stays the same. Design systems authors can create new components without worrying about where they get used, the variables used in components stay the same. Designers can define new theme regions, or change existing ones, without having to make changes to a component’s HTML or CSS, it stays the same. Less time to talk about who, how and where, more time to talk about the weather. ☔️???? Concerns Yeah, right. The big question: But does it scale? Can this be used for all use cases. Ok, I’m pretty sure it doesn’t fit all situations. There are just too many to find a single solution for them all. And I’m actually not sure how well it scales. I guess it works great in these simple demos, but I have yet to find a larger project to test it on. So if you have used (or plan to use) this approach, I’m curious to know how it went. A concern I can imagine is that the list of variables might grow quickly if themes have totally different characteristics. Like not just a bit darker or lighter backgrounds. Then you might need to have foreground and border colors for each component (or group of components) and can’t just use the general --fg and --border variables. Naming these variables is probably the hardest part. Update I @giuseppegurgone made an interesting comment: in suitcss projects I used to define component level custom props, theme variables and then create themes by mapping the former to the latter suitcss-toolkit So if I understood it correctly, by mapping theme variables to component variables, you could avoid your theme variables from growing too much and you can decide for each component how to use these theme variables. Update II If it’s too early to use custom properties in your project, @szalonna posted an example how to do something similar in SCSS. Full Article
x એલજી નવા બે સ્માર્ટફોન X230Z અને M320H એફસીસી ઘ્વારા સર્ટિફાઈડ By feedproxy.google.com Published On :: Mon, 06 Mar 2017 04:00:00 +0530 એફસીસી ઘ્વારા એલજી ઘ્વારા લાવવામાં આવી રહેલા બે સ્માર્ટફોન મોડલ X230Z અને M320H સર્ટિફાઈડ કરી દેવામાં આવ્યા છે. આ બંને બજેટ સ્માર્ટફોન તરીકે આવી શકે છે.અમને ચોક્કસ ખાતરી છે કે એલજીના આ બંને મોડલમાંથી એક X230Z વિશે પહેલા પણ ઘણી અફવાહો Full Article
x Huguette Caland / edited by Anne Barlow, Sara Matson and Giles Jackson ; texts by Anne Barlow, Brigitte Caland and Negar Azimi By library.mit.edu Published On :: Sun, 16 Feb 2020 06:00:01 EST Rotch Library - N6537.C329 A4 2019 Full Article
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x Altered states: Substanzen in der zeitgenössischen Kunst = substances in contemporary art / herausgegeben von = edited by Milena Mercer ; Texte = texts, Max Daly ... [and thirteen others] By library.mit.edu Published On :: Sun, 23 Feb 2020 06:00:02 EST Rotch Library - N8251.S555 A48 2018 Full Article
x Panos Charalambous, Eva Stefani, Zafos Xagoraris / curated by Katerina Tselou By library.mit.edu Published On :: Sun, 23 Feb 2020 06:00:02 EST Rotch Library - N6488.I8 V433 2019 G8 Full Article
x Design by accident: for a new history of design / Alexandra Midal By library.mit.edu Published On :: Sun, 23 Feb 2020 06:00:02 EST Rotch Library - NK1175.M53 2019 Full Article
x Touch me / Johannes Frandsen ; text, Mattias Lundblad By library.mit.edu Published On :: Sun, 23 Feb 2020 06:00:02 EST Rotch Library - TR650.F73 2018 Full Article
x Albanian pavilion 2019: maybe the cosmos is not so extraordinary: Driant Zaneli By library.mit.edu Published On :: Sun, 23 Feb 2020 06:00:02 EST Rotch Library - N6488.I8 V433 2019 A38 Full Article
x April in Paris: theatricality, modernism, and politics at the 1925 Art Deco Expo / Irena R. Makaryk By library.mit.edu Published On :: Sun, 23 Feb 2020 06:00:02 EST Hayden Library - N6493 1925.M35 2018 Full Article
x Exercises in freedom: polnische Konzeptkunst, 1968-1981 = Polish conceptualism, 1968-1981 / Herausgeber = editor, Staatliche Kunstsammlungen Dresden, Kupferstich-Kabinett, Björn Egging By library.mit.edu Published On :: Sun, 23 Feb 2020 06:00:02 EST Rotch Library - N7255.P6 E88 2018 Full Article
x Animal: exploring the zoological world / project editor, Lucy Kingett By library.mit.edu Published On :: Sun, 23 Feb 2020 06:00:02 EST Hayden Library - N7660.A653 2018 Full Article
x Sergei Romanov / edited by Oksana Salamatina ; essay by Lyle Rexer By library.mit.edu Published On :: Sun, 23 Feb 2020 06:00:02 EST Rotch Library - TR655.R66 2018 Full Article
x Conversation pieces: the world of Bruegel / Abdelkader Benali, Alexandra van Dongen, Katrien Lichtert, Sabine Pénot, Lucinda Timmermans ; translation, Patrick Lennon, Michael Lomax By library.mit.edu Published On :: Sun, 23 Feb 2020 06:00:02 EST Rotch Library - ND673.B73 B46 2018 Full Article
x Ghana freedom: Ghana pavilion at the 58th International Art Exhibition La Biennale di Venezia By library.mit.edu Published On :: Sun, 23 Feb 2020 06:00:02 EST Rotch Library - N6488.I8 V433 2019 G4 Full Article
x Mary Corse: a survey in light / Kim Conaty ; with contributions from Robin Clark, Michael Govan, Alexis Lowry, and David Reed By library.mit.edu Published On :: Sun, 23 Feb 2020 06:00:02 EST Rotch Library - N6537.C663 A4 2018 Full Article
x My art guide: Venice 2019, 58th Biennale Arte: national participations, collateral events, exhibitions, events, museums, foundations, restaurants, hotels, city maps By library.mit.edu Published On :: Sun, 23 Feb 2020 06:00:02 EST Rotch Library - N6488.I8 V433 2019 A11 Full Article
x Voyaging out: British women artists from suffrage to the sixties / Carolyn Trant By library.mit.edu Published On :: Sun, 1 Mar 2020 06:00:02 EST Rotch Library - N8354.T72 2019 Full Article
x The art of return: the sixties & contemporary culture / James Meyer By library.mit.edu Published On :: Sun, 8 Mar 2020 06:00:02 EDT Rotch Library - N6512.M479 2019 Full Article
x Art beyond borders: artistic exchange in communist Europe (1945-1989) / edited by Jérôme Bazin, Pascal Dubourg Glatigny, and Piotr Piotrowski By library.mit.edu Published On :: Sun, 8 Mar 2020 06:00:02 EDT Online Resource Full Article
x Poetry of the revolution: Marx, manifestos, and the avant-gardes / Martin Puchner By library.mit.edu Published On :: Sun, 8 Mar 2020 06:00:02 EDT Online Resource Full Article
x Expanded internet art: twenty-first century artistic practice and the informational milieu / Ceci Moss By library.mit.edu Published On :: Sun, 8 Mar 2020 06:00:02 EDT Rotch Library - N7433.8.M67 2019 Full Article
x Bestowing beauty: masterpieces from Persian lands-selections from the Hossein Afshar collection / edited by Aimée Froom ; with essays by Walter B. Denny, Aimée Froom, Melanie Gibson, and David J. Roxburgh; and contributions by Robert Hillenbrand By library.mit.edu Published On :: Sun, 15 Mar 2020 06:00:01 EDT Rotch Library - N7280.B47 2019 Full Article
x The Oxford dictionary of American art and artists / Ann Lee Morgan By library.mit.edu Published On :: Sun, 12 Apr 2020 06:00:01 EDT Online Resource Full Article
x Folk masters: a portrait of America / photographs by Tom Pich ; text by Barry Bergey By library.mit.edu Published On :: Sun, 26 Apr 2020 06:00:01 EDT Rotch Library - TR681.A7 P53 2018 Full Article
x Experimental Beijing: gender and globalization in Chinese contemporary art / Sasha Su-Ling Welland By library.mit.edu Published On :: Sun, 26 Apr 2020 06:00:01 EDT Rotch Library - N7345.6.W46 2018 Full Article