A loggerhead turtle named ‘Chad’ — who was found entangled in cargo netting last October — was released into the waters off our coast last week after a lengthy rehabilitation at Bermuda Aquarium Museum and Zoo [BAMZ]. “Divers from Blue Water Divers found Chad floating in Ely’s Harbour in October of last year. Chad was […] (Click to read the full article)

ill-Logical Linguistics is a Bermudian hip-hop duo that consists of the rapper Josh “Fatz” Simons and producer Craig Simons. The Simons cousins have enjoyed considerable success in the past, with their song ‘Go Slow’ winning the 2012 Hollywood Music in Media Award for Best Rap/Hip Hop. Their other hits include ‘A Place with A Vibe’ and […] (Click to read the full article)

The Bermuda Zoological Society [BZS] hosted a virtual spring break camp for students, with a virtual walk through a nature trail, online lectures, crafts, a Zoom Bluebird box building session and more. A spokesperson said, “Children usually rejoice in a break from school. However, this year with schools already closed parents were looking for ways to […] (Click to read the full article)

TRB has been closely monitoring the evolving situation related to the coronavirus disease (COVID-19) outbreak. The health and safety of our volunteers, sponsors, meeting guests, staff, and the greater community are of utmost importance to us. In light of the current situation, we have decided that the event cannot be held as scheduled. Convened by Transportation Research Board, the Sustainability and Emerging Transportation Technology (SETT) Conference was to be held on August 31 – September 2, 2020, at ...

Most U.S. state departments of transportation (DOTs) are collecting weigh-in-motion data with a wide variety of sensor types and using them in a variety of applications. Many agencies use WIM data to aid in pavement design, although most are not currently using a Pavement ME (mechanistic-empirical) Design application. WIM for bridge and asset management purposes is used much less often. The TRB National Cooperative Highway Research Program's NCHRP Synthesis 546: Use of Weigh-in-Motion Data for Pavement, ...

Removed From Network (Open for application) Astrology: Gemini (Astrology and New Age); Witchcraft (Religion: Paganism)

How to remove ConsoleLog from Mac?

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What is ConsoleLog?

ConsoleLog adware is designed to promote the Safe Finder website (by opening it through akamaihd.net), serve various advertisements and collect sensitive information. It is not common for users to download and install adware knowingly, intentionally. Therefore, ConsoleLog and other apps of this type are categorized as potentially unwanted applications (PUAs).

Most nuclear data measurements are performed at accelerators large enough to occupy a geologic formation a kilometer wide. But a portable device that can reveal the composition of materials quickly on-site would greatly benefit cases such as in archaeology and nuclear arms treaty verification. Research published this week in AIP Advances used computational simulations to show that with the right geometric adjustments, it is possible to perform accurate neutron resonance transmission analysis in a device just 5 meters long.

BACKGROUND The anti–programmed cell death 1 (anti–PD-1) antibody pembrolizumab is clinically active against non–small cell lung cancer (NSCLC). In addition to T cells, human natural killer (NK) cells, reported to have the potential to prolong the survival of patients with advanced NSCLC, also express PD-1. This study aimed to investigate the safety and efficacy of pembrolizumab plus allogeneic NK cells in patients with previously treated advanced NSCLC.METHODS In total, 109 enrolled patients with a programmed death ligand 1 (PD-L1) tumor proportion score (TPS) of 1% or higher were randomly allocated to group A (n = 55 patients given pembrolizumab plus NK cells) or group B (n = 54 patients given pembrolizumab alone). The patients received i.v. pembrolizumab (10 mg/kg) once every 3 weeks and continued treatment until the occurrence of tumor progression or unacceptable toxicity. The patients in group A continuously received 2 cycles of NK cell therapy as 1 course of treatment.RESULTS In our study, patients in group A had longer survival than did patients in group B (median overall survival [OS]: 15.5 months vs. 13.3 months; median progression-free survival [PFS]: 6.5 months vs. 4.3 months; P < 0.05). In group A patients with a TPS of 50% or higher, the median OS and PFS was significantly longer. Moreover, the patients in group A treated with multiple courses of NK cell infusion had better OS (18.5 months) than did those who received a single course of NK cell infusion (13.5 months).CONCLUSIONS Pembrolizumab plus NK cell therapy yielded improved survival benefits in patients with previously treated PD-L1+ advanced NSCLC.TRIAL REGISTRATION ClinicalTrials.gov NCT02843204.FUNDING This work was supported by grants from the National Natural Science Foundation of China (NSFC) – Guangdong Joint Foundation of China (no. U1601225); the NSFC (no. 81671965); the Guangdong Provincial Key Laboratory Construction Project of China (no. 2017B030314034); and the Key Scientific and Technological Program of Guangzhou City (no. 201607020016).

BACKGROUND Since December 2019, an outbreak of coronavirus disease 2019 (COVID-19) caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) emerged in Wuhan, and is now becoming a global threat. We aimed to delineate and compare the immunological features of severe and moderate COVID-19.METHODS In this retrospective study, the clinical and immunological characteristics of 21 patients (17 male and 4 female) with COVID-19 were analyzed. These patients were classified as severe (11 cases) and moderate (10 cases) according to the guidelines released by the National Health Commission of China.RESULTS The median age of severe and moderate cases was 61.0 and 52.0 years, respectively. Common clinical manifestations included fever, cough, and fatigue. Compared with moderate cases, severe cases more frequently had dyspnea, lymphopenia, and hypoalbuminemia, with higher levels of alanine aminotransferase, lactate dehydrogenase, C-reactive protein, ferritin, and D-dimer as well as markedly higher levels of IL-2R, IL-6, IL-10, and TNF-α. Absolute numbers of T lymphocytes, CD4+ T cells, and CD8+ T cells decreased in nearly all the patients, and were markedly lower in severe cases (294.0, 177.5, and 89.0 × 106/L, respectively) than moderate cases (640.5, 381.5, and 254.0 × 106/L, respectively). The expression of IFN-γ by CD4+ T cells tended to be lower in severe cases (14.1%) than in moderate cases (22.8%).CONCLUSION The SARS-CoV-2 infection may affect primarily T lymphocytes, particularly CD4+ and CD8+ T cells, resulting in a decrease in numbers as well as IFN-γ production by CD4+ T cells. These potential immunological markers may be of importance because of their correlation with disease severity in COVID-19.TRIAL REGISTRATION This is a retrospective observational study without a trial registration number.FUNDING This work is funded by grants from Tongji Hospital for the Pilot Scheme Project, and partly supported by the Chinese National Thirteenth Five Years Project in Science and Technology for Infectious Disease (2017ZX10202201).

Facioscapulohumeral muscular dystrophy (FSHD) is caused by loss of repression of the DUX4 gene; however, the DUX4 protein is rare and difficult to detect in human muscle biopsies, and pathological mechanisms are obscure. FSHD is also a chronic disease that progresses slowly over decades. We used the sporadic, low-level, muscle-specific expression of DUX4 enabled by the iDUX4pA-HSA mouse to develop a chronic long-term muscle disease model. After 6 months of extremely low sporadic DUX4 expression, dystrophic muscle presented hallmarks of FSHD histopathology, including muscle degeneration, capillary loss, fibrosis, and atrophy. We investigated the transcriptional profile of whole muscle as well as endothelial cells and fibroadiopogenic progenitors (FAPs). Strikingly, differential gene expression profiles of both whole muscle and, to a lesser extent, FAPs, showed significant overlap with transcriptional profiles of MRI-guided human FSHD muscle biopsies. These results demonstrate a pathophysiological similarity between disease in muscles of iDUX4pA-HSA mice and humans with FSHD, solidifying the value of chronic rare DUX4 expression in mice for modeling pathological mechanisms in FSHD and highlighting the importance FAPs in this disease.

Hypoxia-inducible factor (HIF) is strikingly upregulated in many types of cancer, and there is great interest in applying inhibitors of HIF as anticancer therapeutics. The most advanced of these are small molecules that target the HIF-2 isoform through binding the PAS-B domain of HIF-2α. These molecules are undergoing clinical trials with promising results in renal and other cancers where HIF-2 is considered to be driving growth. Nevertheless, a central question remains as to whether such inhibitors affect physiological responses to hypoxia at relevant doses. Here, we show that pharmacological HIF-2α inhibition with PT2385, at doses similar to those reported to inhibit tumor growth, rapidly impaired ventilatory responses to hypoxia, abrogating both ventilatory acclimatization and carotid body cell proliferative responses to sustained hypoxia. Mice carrying a HIF-2α PAS-B S305M mutation that disrupts PT2385 binding, but not dimerization with HIF-1β, did not respond to PT2385, indicating that these effects are on-target. Furthermore, the finding of a hypomorphic ventilatory phenotype in untreated HIF-2α S305M mutant mice suggests a function for the HIF-2α PAS-B domain beyond heterodimerization with HIF-1β. Although PT2385 was well tolerated, the findings indicate the need for caution in patients who are dependent on hypoxic ventilatory drive.

Have you ever noticed that the Internal Revenue Service's regulations often are illogical? Does anyone at the IRS think through its regulations? Continue reading →

Are accountants destined to be the anthropologists of the cyber era? Gillian Tett appears to suspect such. Continue reading →

IBM and Stone Ridge Technology today announced a performance milestone in reservoir simulation designed to help improve efficiency and lower the cost of production. Working with NVIDIA, the companies shattered previous published results using one-tenth the power and 1/100th of the space. The news demonstrates the ability of NVIDIA GPUs to simulate one billion cell models in a fraction of the published time, while delivering 10x the performance and efficiency than legacy CPU codes.

IBM announced today a new experimental laboratory for nanotechnology research in Brazil. The NanoLab is part of a $4M investment within the recently upgraded IBM Research-Brazil lab in Rio de Janeiro and will focus on projects related to research in Oil & Gas, Agriculture and Health across Latin America.

IBM and AOS, - a Colombian company specializing in providing business solutions- today announced they are collaborating to create a solution to enhance efficiency in the logistics and transport industry throughout the country, built on IBM Blockchain and Watson IoT on the IBM Cloud.

IBM MTN, a leading African telecommunications provider, Wageningen University (WU) in the Netherlands and Prodapt, today announced they are harnessing IBM Internet of Things (IoT) technology as part of the MTN Connected Wildlife Solution. The solution will help predict threats and combat the poaching of endangered rhinos at Welgevonden Game Reserve in South Africa, with the intent to expand the solution to other reserves in future.

IBM suma esfuerzos con Movimiento STEM, una asociación civil sin fines de lucro que busca involucrar a diferentes actores sociales para impulsar la educación en México en Ciencia, Tecnología, Ingeniería y Matemáticas, con enfoque de género.

IBM (NYSE: IBM) reinventa hoy el correo electrónico empresarial con una nueva oferta de colaboración social freemium que utiliza la tecnología de analítica integrada para dar a los empleados una nueva forma de conversar, encontrar a las personas y la información correcta rápidamente, y hacer su trabajo de manera eficiente. IBM Verse es el resultado de una inversión de US$100 millones en diseño e innovación, y reúne las plataformas líderes cloud, analytics, social y de seguridad de la compañía para transformar el futuro del trabajo.

Seguridad, aplicaciones estratégicas y analítica móvil son clave para que las organizaciones inteligentes mejoren sus resultados

Empresas y organizaciones como bancos, agencias de viajes, restaurantes, proveedores de salud y gobiernos municipales en toda América Latina están adoptando nuevas tecnologías de nube, movilidad y analítica que llevan a una mayor eficiencia, menores costos y un mejor servicio a sus clientes y ciudadanos.

IBM dio a conocer que el Tecnológico de Monterrey está transformando la gestión del entorno laboral de todas sus unidades de negocios con su solución de gestión de talento, Kenexa. La solución permite a los profesionales de Talento y Cultura (Recursos Humanos) del Tecnológico de Monterrey, tomar decisiones estratégicas a fin de impulsar los resultados de negocio basadas en hechos, es decir, sobre la base del análisis de talento (reporteadores) de su tradicional encuesta de clima organizacional.

MineHub Technologies e IBM anunciaron hoy una colaboración para utilizar la tecnología blockchain con el objetivo de mejorar la eficiencia operativa, logística, financiamiento y reducir los costos en la cadena de suministro de concentrados minerales de alto valor, desde la mina hasta el comprador final.

La compañía energética BP anunció el lanzamiento de su aplicación móvil BPme, desarrollada con capacidades de inteligencia artificial (IA) de IBM Watson, buscando mejorar constantemente la experiencia de los usuarios de las estaciones de servicio de BP en México.

IBM has replaced Auckland University of Technology (AUT)’s core IT network as part of a new five year services contract. The new network, which went live in March, gives AUT great flexibility for deploying equipment to meet the changing needs of the university and enables it to capitalise on future enhancements in technology, such as video and data centres.

El 67% de los usuarios en todo el mundo se siente actualmente cómodo utilizando tecnologías biométricas (lectura de huella dactilar, escaneado de retina y reconocimiento facial o de voz) para acceder a sus aplicaciones, según el estudio IBM Security Future of Identity elaborado por IBM.

IBM today announced that energy system supplier Alstom, and Ikerlan-IK4, an energy technology research and development organization, are using IBM software to develop wind turbine control systems that significantly improve the performance of sustainable power systems based on wind-generated energy.

IBM (NYSE: IBM) a annoncé aujourd'hui le Cloud Pak for Security, qui présente des innovations révolutionnaires qui lui permettent de se connecter à n’importe quel outil de sécurité, Cloud ou système en local sans avoir à déplacer des données de leur source d'origine. Disponible dès aujourd'hui, la plateforme inclut une technologie open source pour rechercher les menaces, des capacités d'automatisation pour aider à accélérer les réponses aux cyberattaques et la possibilité de fonctionner dans n'importe quel environnement.

Cette semaine, des chercheurs d’IBM Research et de l’Université de Yamagata au Japon ont annoncé leur collaboration pour utiliser l’IA d’IBM, couplée à des algorithmes de machine learning et des données géospatiales, afin d’en découvrir davantage à propos de ces mystérieux anciens géoglyphes. Grâce à IBM Power Systems, ce partenariat a déjà abouti à la découverte d’un nouveau géoglyphe à figure humaine avec trois éléments décoratifs sur la tête, le premier grâce à l’IA.

@IBM et Hardis Group signent un accord mondial pour transformer la chaîne logistique à l'heure du #client connecté #smartercommerce

IBM (NYSE: IBM) today announced that AGC, a leading provider of fabrication, construction and integrated services for the oil, gas and mining industries throughout Australia and South East Asia, selected IBM XIV storage technology to replace its storage system and to support plans for its future business growth.

IBM (NYSE: IBM) today announced it has partnered with academia, government and industry to launch the Smart Transport Research Centre (STRC) based at Queensland University of Technology (QUT), which is being opened today by the Minister for Transport, the honourable Annastacia Palasczuk. IBM will contribute its global consulting expertise and technology in developing smarter traffic solutions to help make Australia’s transportation infrastructure smarter, improve commuter experiences and reduce environmental impact.

The IBM Research findings achieve the highest recorded accuracy of 86 percent by using deep learning and pathology insights to identify the severity of diabetic retinopathy.

IBM today announced the signing of a new five-year infrastructure services agreement with The Westpac Group, which marks a key step in Westpac’s technology transformation program.

IBM (NYSE: IBM) today announced that the University of Melbourne, a world class research university, has selected IBM to design and install a high efficiency, high density cooling solution to support new IT initiatives such as Cloud and Research computing, in its new data centre, Data Hall 2.

Icon Group first in Australia to adopt world-leading technology as part of its comprehensive cancer care offering

Watson matched tumor board treatment recommendations in up to 96% of cases;reduced clinical trial screening time by 78%, studies find. Prostate cancer is latest add to Watson for Oncology; the tech will be available to support 80 percent of the incidence of cancer by year-end. Nine new adopters of Watson oncology offerings around the globe expands Watson's reach to 55 organizations worldwide.

Leading Australian insurer Suncorp today announced it has successfully integrated IBM (NYSE: IBM) Watson artificial intelligence technology into its online claims process.

Zoo and Aquarium Association Uses IBM Technology to Support Endangered Species Programme

IBM (NYSE: IBM) today announced that Digital Alchemy, a leading Australian database marketing service provider, has extended its commitment to IBM’s Enterprise Marketing Management (EMM) software to more quickly and easily enable cross-channel interactive campaigns for its clients.

HCF and IBM (NYSE: IBM) today jointly announced a multi-million dollar deal that will see them working together in Australia to continue to transform HCF’s IT systems, streamline processes and deliver a tailored experience for its members.

IBM (NYSE: IBM) today announced the successful implementation of a first of its kind smart grid data management platform, designed and built with Ausgrid to give the utility more data from part of its electricity distribution grid.

IBM (NYSE: IBM) today announced Melbourne start-up Localz as the winner of IBM SmartCamp Australia 2015, a global competition that brings together entrepreneurs, investors and experienced mentors. Localz provides software that connects the digital and physical worlds for enterprise, using the latest micro-location technology to enhance customer’s in-store experience, improve asset and inventory tracking and provide frictionless mobile payments, at scale. One of the key differentiators of the solution is that it works across different technologies (iBeacons, Bluetoth Low Energy, GPS or even QR Codes).

Woodside Energy and IBM will work together to re-imagine the way work is done using next-generation technologies, such as artificial intelligence (AI) and quantum computing to help Woodside realise its vision of an “intelligent plant”.

2019.9.19うすどうもはいるいてぃですルイティーなのかなるいティなのかなどっちでも、いいけどcircus大阪公演終えておうちただいまおおきに洗濯して寝るぞこれは富山からのバス移動での色々休憩とか続きをみる

『著作権保護のため、記事の一部のみ表示されております。』

In case you hadn't noticed recently, Fashionable Reader, I've been lax about posting to this blog.

 Maintaining two blogs has gotten a bit overwhelming for me. Something has got to give. Much as I love fashion, it isn't actually my primary working world. Writing is, so that has to take most of my focus.

What's Going On?

I have been migrating and posting my historical fashion stuff, which ties to my books, over on my main blog, at my gailcarriger.com website.

There is a Victorian fashion tag there if you want to see all my posts on the subject.

And I have been posting pictures of myself in my outfits there as part of the footers there.

In other words, I'm fading this one away.

However! I promise there are ways to stay in touch with me and my fashion.

Instagram

Of course I am also on Instagram. I would truly LOVE it if you follow me there. Apparently there are secret things you can unlock and have access to if you get over 10k followers and I am ... almost ... there.

Pinterest

Alternatively I have a whole Pinterest board dedicated to my Retro Style & Looks and their inspiration, you can always follow that board. Or I have one that is all my Steampunk outfits.

Facebook

I always post pictures of my event outfits to Retro Rack's Facebook group.

I know that's not ALL the platforms, but again, writing and lack of time mean I have to be selective about where I spend my online chips.

Anyway! Thank you for sticking with me for almost 10 years, and I hope you will not lose touch.

I will keep this blog's old posts, particularly the useful ones like eShakti shopping tips and how to prepare for breast reduction surgery, and links alive as long as Blogger will let me.

I might move some of my popular ones of these plus steampunk DIYs over to my author blog eventually. I won't be deleting this blog, I will just stop posting to it. 

Stay in touch, please.

Yours,
Miss Gail