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Transition Releases New Youth MTB Lineup



A new 20” hardtail, a redesigned 24” full suspension, and a 27.5” young adult full suspension bike.
( Photos: 8, Comments: 40 )




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Spirit Airlines ‘prepares to file for bankruptcy after Frontier merger talks break down’

The airline reported a revenue decrease of $61m compared to the same time last year




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Ginsters owner fined £1.28m over worker death

Paul Clarke, 40, died in hospital after he was fatally crushed by the reversing lorry.




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The masked headliners freshening up Download festival

Mysterious metal group Sleep Token are one of three headliners announced for Download festival.




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Gary Lineker steps down as Sports Personality host

The news comes a day after confirmation that he will leave the BBC's Match of the Day.




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Vineyard and Zipline Trends Collide at the Pinot Express

Filed under: , ,

Chris Leschinsky
Vineyards and ziplines have long been used to attract tourist dollars for destinations that, well, could use a little help:
  • Regardless of the area's suitability for growing grapes, plop down a vineyard or winery and travelers will come for a taste and buy a sympathy bottle (pro tip: go for the ice wine as it's harder to mess up)
  • Ski resorts looking to attract off-season dollars or stale attractions looking to draw media coverage and visitors hook up a zipline
So really, the 1,800-foot Pinot Express zipline at Margarita Adventures, which debuted recently at the Santa Margarita Ranch in the Paso Robles wine country on California's Central Coast, is the travel industry's destiny.

Continue reading Vineyard and Zipline Trends Collide at the Pinot Express

Vineyard and Zipline Trends Collide at the Pinot Express originally appeared on Gadling on Wed, 11 Dec 2013 16:54:00 EST. Please see our terms for use of feeds.

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Another Boeing 787 Dreamliner Has a Battery Problem

Filed under: , , ,

Getty Images
Japan Airlines grounded a Boeing 787 Dreamliner aircraft today "after detecting smoke or gases that may have come from faults with the main battery," according to the BBC.

Last year, all 787s were grounded for three months, CBS reports, after a "fire in a lithium ion battery aboard a Japan Airlines 787 parked at Boston's Logan International Airport. That was followed nine days later by another battery incident that forced an emergency landing in Japan by an All Nippon Airways 787.

Continue reading Another Boeing 787 Dreamliner Has a Battery Problem

Another Boeing 787 Dreamliner Has a Battery Problem originally appeared on Gadling on Tue, 14 Jan 2014 14:57:00 EST. Please see our terms for use of feeds.

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Implications of the new US presidency: what awaits Ukraine?

Implications of the new US presidency: what awaits Ukraine? 19 November 2024 — 2:00PM TO 3:30PM Anonymous (not verified) Online

After 1000 days of Kyiv’s resistance, experts discuss how to secure Ukraine’s and Europe’s future.   

The 19 November marks 1,000 days since Russia’s full-scale invasion of Ukraine. The country faces an ever-more ferocious fight for its future existence.

The 19th November marks 1,000 days since Russia’s full-scale invasion of Ukraine. The country faces an ever-more ferocious fight for its future existence.

Having been given time to adapt, largely due to the slow release of Western military aid, the Russian army is pressing home its advantage. Along the entire eastern frontline, the Russians are simultaneously bombarding Ukraine’s energy infrastructure and cities. With the election of Donald Trump in the US, it seems to many that the tide has turned definitively in Putin’s favour at the political, as well as the military, level.

Trump’s declared ambition to resolve the war in 24 hours implies a Russian-American deal, cutting Kyiv out of negotiations. Such an ‘agreement’ would endanger the country’s future and expose the rest of Europe.

This webinar will cover:

  • Ukraine’s strategy of resistance in the context of Trump’s White House.
  • The immediate risks during the transition period.
  • How Kyiv sees Europe’s role in the new geopolitical environment. Will Kyiv completely give up on the US?
  • The extent to which Germany, Ukraine’s second largest donor, can step in.  




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Arenado won't set hard deadline on negotiations

Rockies third baseman Nolan Arenado said Thursday he won't make Opening Day a hard deadline for negotiations on a possible multiyear contract.




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Seven days in medicine: 8-14 June 2016




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Blue Jays latest to embrace spin-rate machine

The Blue Jays have followed the lead of several other teams around Major League Baseball by using a Rapsodo machine to analyze spin-rate data. A Rapsodo camer is used to understand how much movement, velocity and spin pitchers are getting on every toss.




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Correspondence on 'Dispute arises over World Professional Association for Transgender Health’s involvement in WHO’s trans health guideline' by Jennifer Block




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Re: Patient involvement in developing clinical guidelines




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Orbitofrontal Cortex Mediates Sustained Basolateral Amygdala Encoding of Cued Reward-Seeking States

Basolateral amygdala (BLA) neurons are engaged by emotionally salient stimuli. An area of increasing interest is how BLA dynamics relate to evolving reward-seeking behavior, especially under situations of uncertainty or ambiguity. Here, we recorded the activity of individual BLA neurons in male rats across the acquisition and extinction of conditioned reward seeking. We assessed ongoing neural dynamics in a task where long reward cue presentations preceded an unpredictable, variably time reward delivery. We found that, with training, BLA neurons discriminated the CS+ and CS– cues with sustained cue-evoked activity that correlated with behavior and terminated only after reward receipt. BLA neurons were bidirectionally modulated, with a majority showing prolonged inhibition during cued reward seeking. Strikingly, population-level analyses revealed that neurons showing cue-evoked inhibitions and those showing excitations similarly represented the CS+ and behavioral state. This sustained population code rapidly extinguished in parallel with conditioned behavior. We next assessed the contribution of the orbitofrontal cortex (OFC), a major reciprocal partner to the BLA. Inactivation of the OFC while simultaneously recording in the BLA revealed a blunting of sustained cue-evoked activity in the BLA that accompanied reduced reward seeking. Optogenetic disruption of BLA activity and OFC terminals in the BLA also reduced reward seeking. Our data indicate that the BLA represents reward-seeking states via sustained, bidirectional cue-driven neural encoding. This code is regulated by cortical input and is important for the maintenance of vigilant reward-seeking behavior.




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Trained to be a Channel of Hope

OM Russia hosted and participated in AIDSLink International’s (ALI) Channels of Hope Facilitator Training©.




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OM Philippines participates in Run for the World

OM SportsLink hosts a local R4TW race to engage those involved with OM Philippines-Cebu Ministries and encourage people to pray for the nations.




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Typhoon Haiyan slams the Philippines

One of the strongest typhoons ever to hit land slammed the Philippines on Friday, 15 November, forcing millions to take shelter. OM Philippines responds.




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OM Philippines celebrates 25 years of ministry

OM Philippines celebrates 25 years of transforming lives and communities.




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First ever TeenStreet to be held in the Philippines

One hundred Filipino teens, aged 12-18 are expected to come to the five-day event of fun, learning and life-changing encounters in Cebu.




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Touching Lives: First TeenStreet Philippines

After over 10 years of praying, the Philippines had its first-ever TeenStreet!




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Reaching across the continent by reaching across the street

A Zambian worker reaches out with love to the people of Somalia living in his country.




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Jesus likes the cinema too

“Seeing how these boys lived…put my own life into perspective,” said Anne Davidson, after spending time with youth living on the streets of Lusaka.




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A divine appointment

A story how an Asian sister found her way to a local church service in Greece.




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OM Greece on the frontline at sea and on land

OM Greece and partner organisations help Syrians and other refugees as they reach the island of Lesbos from Turkey and disembark from dinghies.




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Norway Marine Office approves internship opportunities with Logos Hope

In January 2013, OM Norway and Norwegian Naval Training Agency agreed on internship programme for deckhands and motormen on board MV Logos Hope.




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Growth on the trampoline

“I am more excited about God now,” says one young Swiss lady after three months working alongside OM Finland to reach youth in Tampere.




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Licht in einer traurigen Realität

Gerechtigkeit zu den Unterdrückten zu bringen ist ein Auftrag für jeden Christen, sagt Natasha Shoultz, die unter Frauen in Prostitution in Prag arbeitet.




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God’s light shines in the darkness of the sex trade – in Czech Republic

As OM Czech Republic team members reach out to sex workers by visiting a brothel regularly, they are able to establish friendships and talk about God and His care for the women there, and offer them Christmas gifts, which touch hearts.




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Tracking who Trump has named to serve in his Cabinet, administration

President-elect Donald Trump is rolling out names for top jobs in his administration.





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US stocks rise after in-line inflation data firm up December rate-cut bets - Investing.com India

  1. US stocks rise after in-line inflation data firm up December rate-cut bets  Investing.com India
  2. Stocks Eye Fresh Peak as CPI Boosts Rate-Cut Bets: Markets Wrap  Mint
  3. Dow rises 100 points as as traders assess state of postelection rally, new inflation data: Live updates  CNBC
  4. Yields Sink as CPI Puts December Fed Cut in Play: Markets Wrap  Bloomberg




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Cruise liner passengers fall by 7% in third quarter of 2024, but cruise liner calls increase

Figures published by the National Statistics Office show that Malta has welcomed 672,276 cruise passengers in 2024




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Police seize 146kg of cocaine in Freeport

The police said that unlike other drug busts of this scale, the shipment was intended for the local market, and had a street value of €20 million. Four Maltese men have been arrested in connection with the bust




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MIA posts €39.5 million net profit in nine-month review

Malta International Airport generated €107.8 million in revenue for the first nine months of 2024, posting a net profit of €39.5 million




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Tarlac woman nabbed for posing as niece in online love scam

MANILA, Philippines — Central Luzon cops arrested a woman with the alias “Tita” for posing as her niece to lure a victim into giving her gifts, the Philippine National Police Anti-Cybercrime Group (PNP ACG) said. According to the PNP ACG’s report released on Wednesday, “Tita” created a Facebook account using her then 17-year-old niece’s name and began messaging a 70-year-old meat vendor in San Manuel town in Tarlac province. The suspect lured the victim into a secret relationship, which lasted for more than a year, getting him to send money and gifts said to be worth a total of nearly […]...

Keep on reading: Tarlac woman nabbed for posing as niece in online love scam




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Chinese man shot in Parañaque; suspects with P1.2-M in drugs nabbed

MANILA, Philippines — Parañaque City police arrested three foreign nationals for shooting a Chinese man and for possessing drugs worth P1.2 million during their arrest on Wednesday, Nov. 13. The victim was identified as “Li”, a 35-year-old Chinese national who works as a money changer employee in Parañaque City. He was shot at a residential complex in Barangay Don Galo on Wednesday morning and was taken to Juan De Dios Hospital in Pasay City for treatment. According to the Southern Police District’s (SPD) report, alias “Syncell”, a 32-year-old Filipino online agent who also lives in the complex, witnessed the incident. […]...

Keep on reading: Chinese man shot in Parañaque; suspects with P1.2-M in drugs nabbed




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Airlines ground Bali flights after volcano erupts

Airlines cancelled flights to and from the Indonesian resort island of Bali on Wednesday, leaving travellers stranded after a nearby volcano catapulted an ash tower miles into the sky.

At least 16 international routes were affected after Mount Lewotobi Laki-Laki on Flores island spewed a nine-kilometre tower a day earlier, the general manager of Bali’s international airport said in a statement.

Flights from Singapore, Hong Kong, Qatar, India, Australia, Malaysia, China’s Pudong and South Korea’s Incheon were all either delayed or grounded, Ahmad Syaugi Shahab said Wednesday.

Animal clinic worker Samsudin, 52, from Indonesia’s main island was transiting in Bali to Malaysia and forced to spend the night at the airport.

“I’m sleeping here rather than going back to Java. It is far,” he told AFP.

“I’m waiting here, until tomorrow,” he added, saying he bought a new flight after his AirAsia ticket was refunded.

Australia’s Jetstar, Qantas and Virgin Australia all grounded flights, while Malaysia Airlines, AirAsia, India’s IndiGo and Singapore’s Scoot also listed flights as cancelled on Wednesday, an AFP journalist at Bali’s airport said.

“Volcanic ash poses a significant threat to safe operations of the aircraft in the vicinity of volcanic clouds,” said AirAsia as it announced several cancellations.

Hong Kong’s Cathay Pacific also listed its flights as cancelled, rescheduling routes to and from Bali until Thursday.

Passengers look at an electronic board displaying cancelled flights after the nearby Mount Lewotobi Laki-Laki volcano catapulted an ash tower miles into the sky, at the Ngurah Rai International Airport in Tuban near Denpasar, on Indonesia’s resort island of Bali on November 13. — AFP

Multiple eruptions from the 1,703-metre twin-peaked volcano in recent weeks have killed nine people, with 31 injured and more than 11,000 evacuated, Indonesia’s disaster mitigation agency said on Tuesday.

Eruptions can pose serious risks to flights, disgorging fine ash that can damage jet engines and scour a plane’s windscreen to the point of invisibility.

The island’s tourism head called for calm after the cancellations, saying the island was “very safe” because the volcano is far away.

“Bali’s tourism activity is still running normally,” Tjok Bagus Pemayun said in a statement on Wednesday.

But airlines said the situation was too dangerous to keep their planes in the sky.

Jetstar said all flights to and from Bali would be halted until noon on Thursday as it was “currently not safe to operate flights”.

Malaysia Airlines said it had cancelled six flights on Wednesday in a statement on its website, while Scoot said it scrapped two flights and rescheduled four more.

The airlines said they would monitor the volcano’s status and provide updates.

Singapore Airlines was still listing its flights as running on Wednesday.

‘Refunds, rescheduling, re-routing’

Bali airport’s Shahab said 26 domestic and 64 international flights had been affected by recent eruptions as of Wednesday afternoon.

“Due to this natural event impacting flight operations, airlines are offering affected passengers the options of refunds, rescheduling, or re-routing,” he added in a statement.

But some said they were set to be stranded for days, with little help forthcoming.

“There’s nobody helping us, nobody is providing us accommodation or food, we are kind of stranded,” said IT consultant Arsh Khurana, 39, from Delhi whose Air India flight was rescheduled to Saturday.

“There is nothing from Air India, there is absolutely no support,” he told AFP, adding that he and his wife were set to lose money as the airline’s travel insurance did not cover disruptions caused by volcanic eruptions.

Local media reported thousands of passengers were affected but Balinese officials gave no estimate.

Bali’s international airport operator PT Angkasa Pura Indonesia said on Wednesday it had conducted tests in its airspace and no volcanic ash was detected, saying the airport was “operating as normal”.

But the airport in the tourist hotspot of Labuan Bajo on Flores island was shuttered on Wednesday until 8pm local time (1200 GMT) because of the volcanic ash from Lewotobi, according to the airport’s Instagram.

Lewotobi erupted again from midnight Wednesday until early morning, and a large ash column could be seen pouring from its crater, an AFP journalist nearby said.

Laki-Laki, which means “man” in Indonesian, is twinned with a calmer volcano named after the Indonesian word for “woman”.

The island’s economy is heavily reliant on tourism but Indonesia is one of the most disaster-prone nations on Earth, straddling the Pacific Ring of Fire where tectonic plates collide.





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Predicting paediatric asthma exacerbations with machine learning: a systematic review with meta-analysis

Background

Asthma exacerbations in children pose a significant burden on healthcare systems and families. While traditional risk assessment tools exist, artificial intelligence (AI) offers the potential for enhanced prediction models.

Objective

This study aims to systematically evaluate and quantify the performance of machine learning (ML) algorithms in predicting the risk of hospitalisation and emergency department (ED) admission for acute asthma exacerbations in children.

Methods

We performed a systematic review with meta-analysis, following the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guidelines. The risk of bias and applicability for eligible studies was assessed according to the prediction model study risk of bias assessment tool (PROBAST). The protocol of our systematic review was registered in the International Prospective Register of Systematic Reviews.

Results

Our meta-analysis included seven articles encompassing a total of 17 ML-based prediction models. We found a pooled area under the curve (AUC) of 0.67 (95% CI 0.61–0.73; I2=99%; p<0.0001 for heterogeneity) for models predicting ED admission, indicating moderate accuracy. Notably, models predicting child hospitalisation demonstrated a higher pooled AUC of 0.79 (95% CI 0.76–0.82; I2=95%; p<0.0001 for heterogeneity), suggesting good discriminatory power.

Conclusion

This study provides the most comprehensive assessment of AI-based algorithms in predicting paediatric asthma exacerbations to date. While these models show promise and ML-based hospitalisation prediction models, in particular, demonstrate good accuracy, further external validation is needed before these models can be reliably implemented in real-life clinical practice.




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Why agents are the next step in transforming your business with gen AI

The rise of generative AI (gen AI) and ChatGPT has brought large language models (LLMs) to the forefront of technological innovation. Unlike traditional AI, these LLMs can process and generate language in a way that mimics human reasoning. Businesses are leveraging this technology in various ways, including content generation, customer service interactions, and document summarization. Gen AI offers businesses a chance to streamline operations and improve efficiency. However, LLMs are not universally…




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Unleash the potential of AI: How businesses can avoid roadblocks and implement use cases to accelerate growth

Artificial intelligence is rapidly transforming industries and is now accessible to small and medium-sized businesses (SMBs). According to Forbes, 91% of SMBs that have implemented AI report improved business success. The benefits of AI extend beyond enhanced customer experiences to include significant cost savings, revenue growth and a competitive edge. However, the journey to effective AI implementation can be challenging for many businesses. Avoiding AI roadblocks For SMBs with limited resources,…




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Prominent Bham exec named CEO of Arizona firm

The entrepreneur has been a mentor to Birmingham's tech community for many years.




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John Krasinski named People magazine's 'sexiest man alive'

Actor and director John Krasinski was named People magazine's 'sexiest man alive', for 2024 on Wednesday (Nov 13), taking over the mantle from Grey's Anatomy actor Patrick Dempsey. "Just immediate blackout, actually. Zero thoughts," Krasinski told People in reaction to the news. The actor is perhaps best known for his sardonic nice guy role in the television comedy The Office. "Other than maybe I'm being punked. That's not how I wake up, thinking, 'Is this the day that I'll be asked to be Sexiest Man Alive?' And yet it was the day you guys did it. You guys have really raised the bar for me," he added. Krasinski, 45, said that out of all of the opportunities he's had as an actor, being a real-life family man is most rewarding. He prefers being a husband and father who happily lives in Brooklyn with his wife of 14 years, actress Emily Blunt, 41, and their daughters Hazel, 10, and Violet, 8. The actor was especially excited to tell Blunt the news, saying "there was a lot of joy involved in me telling her." However, he noted that the new title will change things very little around the house.




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Ex-Philippine President Duterte says ICC should 'hurry up' on drug war investigation

MANILA — Former Philippine President Rodrigo Duterte said the International Criminal Court (ICC) should 'hurry up' with its probe of his war on drugs, remaining firm in his defence of the brutal campaign as he said the investigation should start immediately."I'm asking the ICC to hurry up, and if possible, they can come here and start the investigation tomorrow," Duterte said in a congressional inquiry on his war on drugs. "If I am found guilty, I will go to prison." According to police data, more than 6,200 people died in anti-drug operations under Duterte's presidency, during which police typically said they had killed suspects in self-defence. Human rights groups believe the real toll to be far greater, with thousands more users and small-time peddlers killed in mysterious circumstances by unknown assailants. "I assume full responsibility for whatever happened in the actions taken by law enforcement agencies of this country to... stop the serious problem of drugs affecting our people," Duterte said. The ICC last year cleared the way for an investigation to into the thousands of deaths and other suspected rights abuses.




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Airlines cancel Bali flights due to volcanic ash

DENPASAR, Indonesia — Several international airlines cancelled flights to and from Indonesia's resort island of Bali on Wednesday (Nov 13), after further eruptions of a volcano that has spewed ash clouds as high as 10km and forced thousands to evacuate. Jetstar and Qantas said they had stopped flights to Bali on Wednesday for safety reasons because of volcanic ash, while plane tracking website Flightradar24 showed flights to the island by AirAsia and Virgin were also cancelled. Bali is Indonesia's top tourist hotspot and is a popular destination for Australian visitors. The first eruption of the Mount Lewotobi Laki-laki on Nov 3 in the East Nusa Tenggara province, about 800 km from Bali, killed at least nine people. It has since erupted repeatedly, including multiple times on Tuesday. From Nov 4 to Nov 12, 80 flights in Bali were cancelled, including from Singapore, Hong Kong, and several Australian cities, said Ahmad Syaugi Shahab, general manager of Bali's Ngurah Rai airport. Indonesia has close to 130 active volcanoes and sits on the Pacific "Ring of Fire", an area of high seismic activity atop various tectonic plates.




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Headlines for November 13, 2024

“Gravest International Crimes”: U.N. Aid Chief Blasts Israel’s Deadly Siege on Gaza , Biden Won’t Enforce U.S. Law Requiring Halt of Arms to Israel Despite Clear Human Rights Abuses, Israeli Strikes Kill Dozens in Beirut Suburbs and Mount Lebanon Governorate, National Press Club’s Press Freedom Award Goes to Wael al-Dahdouh for Gaza Coverage, Mike Huckabee, Who Declared “There’s No Such Thing as a Palestinian,” Named U.S. Ambassador to Israel, Trump Nominates Fox News TV Personality Pete Hegseth as Defense Secretary, John Ratcliffe, Who Defended Trump During Impeachment Hearings, Nominated as CIA Director, Trump Picks Elon Musk and Vivek Ramaswamy to Lead Drastic Overhaul of Federal Bureaucracy, Senate GOP Meets to Pick New Leader; House Freedom Caucus May Challenge Speaker Mike Johnson, House Fails to Pass Bill Granting President Sweeping Powers to Target Nonprofits, Jury Orders Military Contractor CACI to Pay $42 Million to Abu Ghraib Torture Survivors, Climate Campaigners Ask Scottish Court to Halt Development of Rosebank Oil Field




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Additional place of business to change as main place

How to change additional place of business as main place of business in gst portal




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12 Prominent Presidents of United States

As Donald Trump and Hillary Clinton slug it out for the most coveted and powerful seat, the entire world waits with abated breath to see who becomes the next US president on November 9th 2016 and gets their name inked among the pantheon.




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Indian-American Amul Thapar On Donald Trump's List For Supreme Court Judge Nominees

Indian-American Amul Thapar is among the shortlisted potential nominees for Supreme Court judge picked by President-elect Donald Trump.




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Bobby Jindal Among Probables In U.S. President-Elect Donald Trump's Cabinet

Two-term Louisiana Governor Bobby Jindal, the first ever Indian-American to be elected as a state Governor, is among the shortlisted candidates for Trump's Cabinet, according to a media report.