As of August 2016, PMC is home to four million articles! To make this wealth of full-text content easier to navigate, PMC has rolled out a few updates:

1) Search Result Filters
On all search results pages, you will now see filters (similar to PubMed’s filters) on the left-hand side that allow you to filter your results by article attributes, publication date, research funder, and search fields. These filters replace the Limits page and allow you to more readily:

• find open access articles (PMC has more than 1.35 million open access articles that can be reused according to their license statements),
• explore PMC’s rich historical content from NLM's back issue digitization project,
• browse research supported by PMC-participating funding organizations (click "Customize" to view additional funder options),
• and much more.

You can now also quickly add articles that are under a 12-month or less embargo in PMC to your search results by selecting the “Include embargoed articles” filter option under Text Availability. See the PMC User Guide for more information on these filters.

2) Reference List Display
Using related article data available in PMC, articles that cite papers that have been either retracted or named in a Findings of Research Misconduct issued by the HHS Office of Research Integrity and not yet retracted will now include a red hyperlink to the relevant notice directly from the article’s reference list. This update will help users more easily identify post-publication updates to existing research.

In collaboration with Europe PMC, PMC has rolled out several updates to our article display in order to enhance the transparency and readability of the content.

Navigating from the PMC record to the PubMed record has been made easier by the addition of hyperlinked PubMed IDs (PMIDs) in the upper right-hand corner of article records. Clicking the PMID link will take you to the corresponding citation record in PubMed.

The PMC Disclaimer link has also been moved out of the Copyright and License information section for easier discovery and access. This page describes what content is included in PMC as well as other important NCBI and NLM disclaimer information.

Additionally, two changes have been implemented to improve the functionality of author names. Users can now click on an author name to view the author’s affiliation(s). Users also have the option of running a quick author name search in PMC by clicking the linked author name in “Find articles by [author name]”. In the example pictured above, the search would be for “Sawyer SL”[Author].

And finally, figures and tables have been moved inline in the article display. By moving away from the thumbnail display, PMC hopes to make it easier for users to view figure and table data as they read articles. Users may still click on the figure/table title or “Open in separate window” (as available) link for a closer look.

We hope these updates improve the overall user experience in PMC and look forward to hearing your feedback.

References

Screenshots from:

Qiao, Y., Yang, J., Liu, L., Zeng, Y., Ma, J., Jia, J., … Wang, Y. (2018). Successful treatment with pazopanib plus PD-1 inhibitor and RAK cells for advanced primary hepatic angiosarcoma: a case report. BMC Cancer, 18, 212. http://doi.org/10.1186/s12885-018-3996-3

Stabell, A. C., Meyerson, N. R., Gullberg, R. C., Gilchrist, A. R., Webb, K. J., Old, W. M., … Sawyer, S. L. (2018). Dengue viruses cleave STING in humans but not in nonhuman primates, their presumed natural reservoir. eLife, 7, e31919. http://doi.org/10.7554/eLife.31919

Both articles made available under a CC-BY license.

Site-specific arrest of RNA polymerases (RNAPs) is fundamental to several technologies that assess RNA structure and function. Current in vitro transcription “roadblocking” approaches inhibit transcription elongation by blocking RNAP with a protein bound to the DNA template. One limitation of protein-mediated transcription roadblocking is that it requires inclusion of a protein factor extrinsic to the minimal in vitro transcription reaction. In this work, we developed a chemical approach for halting transcription by Escherichia coli RNAP. We first established a sequence-independent method for site-specific incorporation of chemical lesions into dsDNA templates by sequential PCR and translesion synthesis. We then show that interrupting the transcribed DNA strand with an internal desthiobiotin-triethylene glycol modification or 1,N6-etheno-2'-deoxyadenosine base efficiently and stably halts Escherichia coli RNAP transcription. By encoding an intrinsic stall site within the template DNA, our chemical transcription roadblocking approach enables display of nascent RNA molecules from RNAP in a minimal in vitro transcription reaction.

In 2016, the proportion of Neisseria gonorrhoeae isolates with reduced susceptibility to azithromycin rose to 3.6%. A phylogenetic analysis of 334 N. gonorrhoeae isolates collected in 2016 revealed a single, geographically diverse lineage of isolates with MICs of 2 to 16 μg/ml that carried a mosaic-like mtr locus, whereas the majority of isolates with MICs of ≥16 μg/ml appeared sporadically and carried 23S rRNA mutations. Continued molecular surveillance of N. gonorrhoeae isolates will identify new resistance mechanisms.

Flexible displays for wearable devices can now be made using fish scales instead of plastic – and the new displays biodegrade within a month of being discarded

Scheme by tech entrepreneur Elon Musk's SpaceX firm casts unique chain of lights in Britain's night skies

The Royal Horticultural Society (RHS) said this summer would mark its first ever "virtual" version of the event at Royal Hospital Chelsea, London.

A care home nurse used the knowledge she gained during the swine flu outbreak to help save the lives of 13 dementia patients who were displaying symptoms of the coronavirus.

Stargazers can expect to see up to 40 meteors per hour blaze through the night sky before sunrise on Wednesday

Some hospital trusts have seen a dramatic drop in cancer referrals from GPs in recent weeks

Manchester United paid tribute to NHS workers battling the coronavirus pandemic at Old Trafford on Wednesday night.

Scottish Premiership club Hibernian will don the message "Thank you NHS" on their home kit next season.

Japanese electronics manufacturer Hitachi Displays Ltd., agreed to plead guilty and pay a $31 million fine for its role in a conspiracy to fix prices in the sale of Thin Film Transistor-Liquid Crystal Display panels (TFT-LCD) sold to Dell Inc.

A federal grand jury in San Francisco has returned an indictment against a former executive of a large Taiwanese color display tube (CDT) manufacturing company for participating in a global conspiracy to fix prices of CDTs, a type of cathode ray tube used in computer monitors and other specialized applications.

A federal grand jury in San Francisco today returned an indictment against a former executive of a large Taiwan-based color display tube (CDT) manufacturing company for his participation in a global conspiracy to fix prices of CDTs, a type of cathode ray tube used in computer monitors and other specialized applications, the Department of Justice announced.

A federal grand jury in San Francisco today returned an indictment against three former executives from two color display tube (CDT) manufacturing companies for their participation in a global conspiracy to fix prices of CDTs.

Samsung SDI Company Ltd. has agreed to plead guilty and to pay a $32 million criminal fine for its role in a global conspiracy to fix prices, reduce output and allocate market shares of color display tubes.

Major, major kudos to Ann Kagawa Lee of Honolulu, Hawaii, winner of Cheap Chic Wedding's annual toilet-paper wedding dress contest, who made this mind-boggling matrimonial ensemble out of bathroom tissue—a textile fit

Everywhere you look for the next week in London there is an arty billboard.

Massimiliano Locatelli is writing a new language of design that reflects the new technology.

Why do we always think other animals are so simple?

"If a touchscreen must be used, it should be embedded alongside a set of fixed, physical buttons that support muscle memory and single actions."

Our photo of the day comes from above the Pacific Ocean.

Our photo of the day comes from Hampton, New Hampshire.

The new-to-science Amazonian glassfrog has skin so transparent that its tiny heart can be seen beating in its chest.

Huawei Matepad T8 has been launched in Romania along with the Huawei Y5P and the Huawei Y6P phones. The tablet is available in a single Deepsea Blue color and traditional themed design. The tablet has a thick bezel around

Posted by Victoria Strauss for Writer Beware®

BookExpo (formerly known as BookExpo America, but still referred to as BEA) is the US's leading publishing industry event. Attended by publishers, agents, booksellers, retailers, librarians, and people and companies from all aspects of the book trade, it's an opportunity for industry professionals to network, do business, and learn about new trends, titles, and opportunities in the book world.

Although BEA doesn't happen until May 27 this year, it's not too soon for industry professionals to begin planning for attendance. It's also not too soon for authors to start receiving solicitations--by phone and by email--to buy expensive services and packages that supposedly will give their books visibility at the fair.

Here's what author and editor Jane Friedman has to say about paying to display at BEA. (Jane's website is an amazingly comprehensive and useful resource on all aspects of writing and publishing; you should definitely bookmark it.)

Aside from the Author Market [a designated area of the exhibit floor where self-published authors can buy display space], there are a handful of opportunities for authors to get visibility for their work at BEA. As far as I’m concerned—as someone who attended this show for 10 years, mainly as an editor with a traditional publishing house—it is not worth the investment. Here’s why.

The emphasis of the show is on traditional publishing, rights sales and pre-publication marketing, and does not favor indie title promotion. It is a New York industry event where traditional publishing insiders talk to other traditional publishing insiders. Yes, there are librarians and booksellers, but they’re rarely paying attention to the places where an indie book may be showcased or promoted.

Nobody is going to notice your book there. Your book is likely to be promoted with many other books, with no way of attracting attention even if someone did pause for a second within 50 feet of your book. Imagine setting a copy of your book down in the world’s largest book fair, and expecting someone to not only notice it, but be entranced by it so much they can ignore 10,000 other things happening at the same time.

If you—the author—are not present to advocate for it, your book doesn’t stand a chance. Services that offer to promote your book at BEA are rarely, if ever, hand-selling or promoting your book in a meaningful way. But they will be happy to cash your check and say that your book had a “presence” at BEA. If you want to satisfy your ego, go ahead. But it’s not going to lead to meaningful sales. (I challenge anyone in the comments to provide evidence that a self-published book gained traction at BEA because the author paid a fee to secure placement—and the author was not present.)

I'll add a fourth consideration: You will likely be hugely overcharged, especially by companies that sell book fair packages, or re-sell the exhibit services of others.

SOLICITATIONS YOU MAY ENCOUNTER


1. You may already have received an email from the Combined Book Exhibit's New Title Showcase. The CBE, an area of standing bookshelves outside the entrance to the BEA display floor, offers display packages for a few hundred dollars. For a few hundred more, you can buy an ad in its catalog; for many hundreds more, you can buy an autographing session.

Your book will be placed on a shelf with hundreds of others, in no particular order: there are no separate areas for genres, for instance. I've attended BEA many times, and the CBE is often completely deserted, with not a customer or a staff person in sight. I've never seen more than a handful of people browsing it at any one time. There is definitely no handselling involved.

A number of predatory marketing companies re-sell CBE services for enormous markups. The CBE is aware of this, and has posted a warning on its website (it's no coincidence that all the companies named in the warning appear on the scam list in the sidebar of this blog).

2. If you've chosen an assisted self-publishing company, you may be encouraged to buy presence in their BEA booth.

The Author Solutions imprints sell BEA as part of a package that includes several fairs and costs nearly $3,000. (What do you get for that? Basically, a spot on a shelf, higglety-pigglety in among an unknown number of other books by writers no one has heard of). Xulon Press sells BEA on its own, but with multiple options for spending big bucks, from shelf space only ($599) to a "Boutique High Top Table with 30 Books" ($1,999--do you get to take the table home?).

Outskirts Press re-sells CBE services--for over $150 more than you'd pay if you dealt with CBE directly.

3. Vanity publishers (yes, vanity publishers do attend and display at BEA and other fairs) may offer their authors the "opportunity" for BEA presence--at extra (possibly significantly extra) cost.

Here's my post about SterlingHouse, a vanity publisher that is now defunct but in its heyday charged its authors as much as $9,500 for BEA display of their books, signings, and other perks. (As Jane indicates above, being present to advocate for your book may make a difference--but $9,500 worth? Even if the author sold all 150 books included in the package, they wouldn't come close to making that money back.)

Here's one of the many BEA-related solicitations with which the late, unlamented PublishAmerica bombarded its authors:


4. Some unscrupulous literary agents sell slots in catalogs or portfolios that they claim to bring to BEA, supposedly to market to publishers.

Examples of this scheme that I've seen involve fees of anywhere from $150 to four figures (here's one that charges $300). If your agent is the kind of agent who exploits clients in this way, they are not the kind of agent who has contacts with publishers.

This sort of thing is far less common than it used to be, thank goodness (there are fewer literary agent scams in general, thanks to self-publishing and the many small presses that deal directly with authors), but it's still a ripoff. Don't do it.

5. The most aggressive solicitations--especially by phone--come from unscrupulous or scammy marketing companies.

Services run from the basic--a spot on a shelf in a not-always-very-professional-looking display area (you have to supply the book)--to basic with perks--mostly junk marketing, like press releases, a listing in the company's proprietary magazine, and a "post fair fulfillment report"--to elaborate packages that include an autographing session.

Prices I've seen range from $750 for shelf space only, to mid-four figures for signing packages. For instance, here's Stonewall Press's deluxe offering, which doesn't even include author presence. Note the effort to create faux urgency by pretending that space is limited.


Looking for a bargain? AuthorCentrix is a tad more economical--here are its 2019 BEA packages. The "standard" doesn't include a badge, which would add around $400 to the total.


BOOK FAIR RIPOFFS AREN'T LIMITED TO BEA

Multiple predatory marketing companies and PR services hawk book fair presence to authors. It's one of the most common marketing solicitations you'll receive. Why? Because it's insanely lucrative--for the predator.

The photo below is last year's BEA booth for publishing and marketing scammer URLink Print and Media.


More than 100 books can be counted in this photo. All the authors have paid to be there. URLink also sells ad space in a 50-page catalog, with most of the pages listing eight book per page. Writers have bought the banners shown in the photo, and others have paid to host signings. Still others have bought ads and features in URLink's fake magazine, Harbinger Post, which sits in piles on a table on the off chance someone picks one up.

The minimum cost for any of these "services" is several hundred dollars, with more elaborate packages running into the mid-four figures (see the examples above). From one book fair, a company like URLink can gross well over $100,000--a considerable profit, even taking into account the cost of booth rental, travel, and badges. Now multiply that by multiple book fairs attended per year.

The Miami Book Fair, which along with BEA is one of the fairs most frequently targeted by marketing scammers, appears to be aware of the exploitation, and provides a warning.

THE TAKEAWAY

My feeling about book fairs is the same as Jane Friedman's: book fairs are not the best place for authors to self-promote. If you do decide to attend, do it with the aim of learning and having fun--not getting "discovered"--and don't pay someone else to take you or your books there. At best, you'll get little return on your money. At worst, you'll be ripped off.

A missing platform stands between Mumbaikars and the restored tram the Brihanmumbai Municipal Corporation (BMC) had promised to set up for display at Bhatia Baug, by the first week of April. While the tram coach is nearly ready, the tender for construction of the platform, which will serve as its base, didn't receive an adequate response, and a second tender cannot be floated until after the Lok Sabha elections in the city.

The BMC floated a tender last month to appoint a contractor who will construct a 3 feet tall platform. The tram, as well as part of tracks, will be installed on top of it. The overall of cost of restoration of the tram and construction of the platform is estimated to be R28 lakh. "We received a response from a single bidder so we have to float another tender. However, since the model code of conduct is in place, we will have to wait for the elections to get over," said Kiran Dighavkar, assistant municipal commissioner of A ward. He added that they will float the tender next week and it will remain open for a period of eight days.

Also read: Elections 2019: 422 polling stations in Mumbai declared 'critical'

Based on the plan, the BMC is considering letting people enter the tram under certain conditions. Before the final setup, however, the BMC will need the approval of the heritage committee. Unlike most projects that are approved based on documents, for this project, the committee members will have to inspect the tram. On April 24, A ward officials wrote to the heritage committee asking them to inspect the tram and give their approval for the project. Dighavkar added that the tram will be brought to a godown in Cuffe Parade from Rabale sometime this week.

Over the past couple of months, the tram was restored in a workshop in Rabale using the parts of another tram that was functional in Kolkata between 1874 and 1907. Once the tram has been assembled at Bhatia Baug, the BMC is planning to set up lighting in the area to attract visitors. Civic officials are also planning to install LED screens inside the tram which will display information about the history of trams in Mumbai from the horse drawn ones till the electrical ones which were taken off the road around 50 years ago.

Also read: Elections 2019: Netas appeal to citizens to vote

Catch up on all the latest Crime, National, International and Hatke news here. Also download the new mid-day Android and iOS apps to get latest updates

The actress, 33, attended the star-studded bash held at Quaglino's restaurant wearing an off-the-shoulder mini dress with statement puff sleeves.

The TOWIE star, 25, appeared to have a full glam squad at hand to assist her with her awards ceremony look as she got ready for the night ahead.

She recently hit headlines when it emerged her ex-boyfriend Jack had secretly become a father.  Yet Dani looked in good spirits as she headed out on a stroll around Essex on Wednesday.

The reality star, 29, slipped into a sheer black shirt with ruched detailing and ripped denim jeans as she stepped out in London on Thursday.

She recently added her voice to ongoing rumours of a fallout in the ITV family, after speaking out against veteran presenter Phillip Schofield.

Quotation - dated 20.10.2011 - Disposal of Office Staff Car bearing No. WE3 02E 5189 - Display of Sale Notice, Terms and Conditions on Ministrys website - reg.

The stunning surfer, 29, donned a sexy nude two-piece with a white lace detailing and tiny triangle cups to make the most of her eye-popping cleavage

Alexandra Cane was exuding confidence in a figure-hugging outfit when she left the Groucho Club in Soho, London on Monday evening.

The Love Island star, 28, looked incredible as she exuded confidence and displayed her slimmed down physique in a backless silver sparkly halterneck gown.

The model, 33, put her ample cleavage front and centre in her dazzling ensemble as she arrived at The Lowry Hotel in Manchester, on Friday night.

The 27-year-old pop star showed off a new 'freedom' hand tattoo on Sunday as well as new ink showing a note from Yoko Ono.

The Baywatch star, 37, couldn't contain her emotions as she was seen both cheering, laughing and with her hands in the air.

Alessandra Ambrosio was spotted with her mini-me daughter, Anja Mazur, 11, at Serena Williams' fashion show on Tuesday as part of New York Fashion Week.

Williams previously shared a photo of herself having a mother/daughter playdate with Alexis Jr, two, in costume as Anna from Frozen: 'Princess attire required for conversations with @olympiaohanian.'

The 24-year-old Olympic medallist looked as though he had let his training regime slide somewhat as he partied up a storm in Ibiza with his pals.

The silver medal-winning gymnast displayed the fruits of his labour as he went shirtless during an intense Tabata workout at Fusion Gym in central London.

Novak Djokovic proved he is every inch the doting father as he larked around with his two kids during an outing the local park on Wednesday afternoon.

She's known for her daring sense of style.

The activist, 47, set pulses racing in a daring black dress which left nearly nothing to the imagination. Laverne flaunted her figure in the sheer black number which showed off nearly all of her full chest.