1. ▶ President van gastland Azerbeidzjan noemt olie en gas ‘godsgeschenk’ tijdens klimaattop  De Morgen
2. LIVE Klimaatconferentie - Spaanse premier dringt aan op meer klimaatactie om rampen als in Valencia te vermijden  VRT.be
3. "Olie en gas zijn godsgeschenk”: ambities klimaattop krijgen nieuwe klap na uitspraken president van gastland Azerbeidzjan  Het Laatste Nieuws
4. Veel Europese leiders slaan de klimaattop dit jaar over: zijn de hoogdagen van Europa’s groene politiek voorbij?  De Morgen
5. COP29: Wil de spaarder investeren in het klimaatbeleid?  De Standaard

1. Man die slapende dakloze in Rotterdam ernstig verwondde met steen mogelijk aangehouden in Franse stad Toulon  VRT.be
2. Man die zware tegel op hoofd van slapende dakloze gooide mogelijk gearresteerd in Frankrijk  Het Laatste Nieuws
3. Verdachte (32) van aanval met betonblok op slapende dakloze in Rotterdam opgepakt in Franse stad Toulon  Het Nieuwsblad
4. Poging moord op slapende, dakloze man  Opsporing Verzocht
5. Arrestatie in Frankrijk na dood dakloze, link met Rotterdamse zaak onderzocht  NOS

Kinderopvang wordt duurder in Bilzen-Hoeselt: “Daarvoor zijn we geen fusie aangegaan”  Het Belang van LimburgHele verhaal bekijken via Google Nieuws

1. Grote verkeershinder verwacht in Brussel door betoging boeren  De Standaard
2. Vandaag en morgen grote verkeershinder verwacht in Brussel door betoging boeren en taxichauffeurs  Het Nieuwsblad
3. Betogingen én verkeersellende in Brussel verwacht morgen en donderdag, ook gevolgen voor wie naar Rode Duivels gaat  Het Laatste Nieuws
4. 2 dagen hinder in Brussel door boerenprotest en taxiprotest  VRT.be
5. Politie verwacht grote verkeershinder door betoging boeren en taxi's  BRUZZ

1. Overleden vrouw aangetroffen op oprit van woning in Zwijndrecht, parket opent onderzoek  VRT.be
2. Vrouw vermoord op oprit van woning in Zwijndrecht bij Antwerpen: schedel van slachtoffer werd ingeslagen  Het Laatste Nieuws
3. Vrouw dood aangetroffen op oprit van een woning in Zwijndrecht, parket start onderzoek naar gewelddadig overlijden  Het Nieuwsblad
4. Vermoorde vrouw aangetroffen voor woning in Zwijndrecht: parket start onderzoek  Gazet van Antwerpen
5. Levenloos lichaam van vrouw gevonden op oprit van woning in Zwijndrecht: schedel van slachtoffer werd ingeslagen  Het Laatste Nieuws

1. Petra De Sutter is geen kandidaat-voorzitter Groen: "Partij heeft nu iemand nodig die tanden laat zien"  VRT.be
2. Petra De Sutter geen kandidaat-voorzitter voor Groen - Musk gaat onder Trump ministerie voor ‘overheidsefficiëntie’ leiden  De Standaard
3. “Andere partijen zijn geoliede machines, wij vergaderen ons dood”: Groen snakt naar nieuwe voorzitter en heeft topfavoriet, maar wil Petra De Sutter ook?  Het Nieuwsblad
4. Neen, Petra De Sutter wordt geen voorzitter van Groen. In dit interview legt ze uit waarom  De Morgen

1. Nu Bart De Wever (N-VA) aan zet blijft als formateur: krijgt hij in 2 weken rond wat al 5 maanden niet lukt?  VRT.be
2. “De Wever wil Open Vld én Vooruit in federale regering”  Het Laatste Nieuws
3. De Wever wil Arizona nog eens reanimeren met ‘trucje’, maar of Vooruit deze keer hapt?  Het Laatste Nieuws
4. De Wever grijpt naar beproefd recept om Vooruit snel weer aan tafel te krijgen: het ‘saucissoneren’  De Morgen
5. Formatie: ‘Bart De Wever voert een toneeltje op’  Knack.be

Izegem zet verder koers richting coalitie met Vlaams Belang: “We hebben hier een omgekeerd cordon sanitaire”  Gazet van AntwerpenHele verhaal bekijken via Google Nieuws

1. Spanje bereidt zich voor op nieuw noodweer: code rood in Malaga en Tarragona, weerdienst waarschuwt voor ‘extreem gevaar’  De Morgen
2. Spanje zet zich schrap voor nieuwe ‘DANA’: code rood in Malaga en Tarragona, al 3.000 mensen geëvacueerd  Het Laatste Nieuws
3. Opnieuw code rood voor regen in delen van Spanje: “extreem gevaar” in Malaga en Tarragona  Het Nieuwsblad
4. Evacuaties in Valencia door instortingsgevaar 50 appartementen  De Morgen
5. Spaanse weerdienst waarschuwt opnieuw voor noodweer: “Zeer sterke en aanhoudende regen”  De Standaard

1. Hoe een ‘hedendaagse pogrom’ wantrouwen zaait  De Standaard
2. De rellen in Amsterdam: voor de één een “Arabische pogrom”, voor de ander “zionistische propaganda”  De Standaard
3. Over antisemitisme en de haat jegens de andere mens  Trouw
4. Opinie: Het gaat te weinig over het antisemitisme van de PVV en haar leider zelf  de Volkskrant
5. Als ik als neutrale Nederlander de straat op zou gaan, zou ik zwaaien met een Palestijnse vlag, keppeltje op mijn kop  AD

1. Anneleen Van Bossuyt: “Een N-VA-kiezer is niet minder Gents dan wie links stemt”  De Standaard
2. Breed glimlachend op de foto, maar schaduw van N-VA hangt over Gents schepencollege: “Er is nog wantrouwen in onze afdeling”  Het Nieuwsblad
3. ‘In Gent moet Filip Watteeuw de kelk tot op de bodem ledigen’  Knack.be
4. ▶ Dit is het verschil tussen het akkoord met N-VA en het akkoord met Groen in Gent  De Morgen
5. Hafsa El-Bazioui (Groen) na tumultueuze weken in Gent: "Ik kan me niet excuseren voor mensen die spontaan op straat komen"  VRT.be

1. Trump breidt ‘dreamteam’ uit en benoemt Elon Musk tot hoofd “ministerie voor overheidsefficiëntie": “Dit zal schokgolven sturen door het systeem”  Het Laatste Nieuws
2. Trump wijst oude bekende Ratcliffe aan als hoofd CIA | Presidentsverkiezingen VS  Het Laatste Nieuws
3. Trump plaatst Elon Musk mee aan hoofd van nieuw ministerie: “Dit gaat schokgolven door het systeem jagen”  Het Nieuwsblad
4. Miljardairs Elon Musk en Vivek Ramaswamy aan hoofd van Trumps nieuwe ministerie van ‘overheidsefficiëntie’  De Standaard
5. Trump benoemt Musk tot 'minister van overheidsefficiëntie'  De Tijd

The GAA's annual Congress in county Laois votes to make adjustments to the controversial winter training ban for intercounty teams.

During Tuesday night’s Save Your Vote Special Broadcast Event, attorney Gerald Griggs, who serves as the President of the NAACP of Georgia, called for action to counter the increasing threats to voters of color from white supremacist groups. It’s a threat that the Palast Investigations team knows is... READ MORE

From Billboard Charts:

The Cure hits the top 10 of this week's #AdultAlternativeAirplay with "A Fragile Thing" (up 12-10). It earns the band its first top 10 hit at the format.

It also earns the band its first top 10 on any Billboard airplay chart since "Maybe Someday" peaked at No. 10 on #AlternativeAirplay in 2000.

"A Fragile Thing" is the lead single from Songs of a Lost World, which concurrently debuts at No. 1 on Top Rock & Alternative Albums.

The inaugural Princeton GAASA Conference will be an enriching and dynamic event that brings scholars, activists, historians, and community leaders together to discuss African American history in the state of New Jersey. This year's conference theme is "Institutional Memory and African American History in New Jersey" which brings crucial narratives of African American contributions to the state to the forefront of public consciousness. This event aims to deepen the understanding of African American life, promote meaningful dialogue, and inspire actionable change. The conference will take place on the campus of Princeton University on Saturday, November 23, 2024.

The inaugural Princeton GAASA Conference will be an enriching and dynamic event that brings scholars, activists, historians, and community leaders together to discuss African American history in the state of New Jersey. This year's conference theme is "Institutional Memory and African American History in New Jersey" which brings crucial narratives of African American contributions to the state to the forefront of public consciousness. This event aims to deepen the understanding of African American life, promote meaningful dialogue, and inspire actionable change. The conference will take place on the campus of Princeton University on Saturday, November 23, 2024.

The inaugural Princeton GAASA Conference will be an enriching and dynamic event that brings scholars, activists, historians, and community leaders together to discuss African American history in the state of New Jersey. This year's conference theme is "Institutional Memory and African American History in New Jersey" which brings crucial narratives of African American contributions to the state to the forefront of public consciousness. This event aims to deepen the understanding of African American life, promote meaningful dialogue, and inspire actionable change. The conference will take place on the campus of Princeton University on Saturday, November 23, 2024.

The inaugural Princeton GAASA Conference will be an enriching and dynamic event that brings scholars, activists, historians, and community leaders together to discuss African American history in the state of New Jersey. This year's conference theme is "Institutional Memory and African American History in New Jersey" which brings crucial narratives of African American contributions to the state to the forefront of public consciousness. This event aims to deepen the understanding of African American life, promote meaningful dialogue, and inspire actionable change. The conference will take place on the campus of Princeton University on Saturday, November 23, 2024.

The inaugural Princeton GAASA Conference will be an enriching and dynamic event that brings scholars, activists, historians, and community leaders together to discuss African American history in the state of New Jersey. This year's conference theme is "Institutional Memory and African American History in New Jersey" which brings crucial narratives of African American contributions to the state to the forefront of public consciousness. This event aims to deepen the understanding of African American life, promote meaningful dialogue, and inspire actionable change. The conference will take place on the campus of Princeton University on Saturday, November 23, 2024.

The inaugural Princeton GAASA Conference will be an enriching and dynamic event that brings scholars, activists, historians, and community leaders together to discuss African American history in the state of New Jersey. This year's conference theme is "Institutional Memory and African American History in New Jersey" which brings crucial narratives of African American contributions to the state to the forefront of public consciousness. This event aims to deepen the understanding of African American life, promote meaningful dialogue, and inspire actionable change. The conference will take place on the campus of Princeton University on Saturday, November 23, 2024.

The inaugural Princeton GAASA Conference will be an enriching and dynamic event that brings scholars, activists, historians, and community leaders together to discuss African American history in the state of New Jersey. This year's conference theme is "Institutional Memory and African American History in New Jersey" which brings crucial narratives of African American contributions to the state to the forefront of public consciousness. This event aims to deepen the understanding of African American life, promote meaningful dialogue, and inspire actionable change. The conference will take place on the campus of Princeton University on Saturday, November 23, 2024.

The Oscar-nominated trio behind 'A Single Life' is back with a new dark comedy about climate change and individual responsibility.

Oliver Bearman replaces Kevin Magnussen for the entire Sao Paulo Grand Prix weekend after the Dane had to pull out through illness.

Arsenal captain Martin Odegaard says he must "listen to my body" after withdrawing from Norway's squad.

If you’re an entrepreneur nurturing your own company to a full-blown success, you are always looking for insights and ideas to take your business to the next level, right? But you’re probably super busy as well, and don’t always have the time to figure out where you should be looking for those insights.

The 2Checkout team kicked off Feb 2019 by joining over 12,000 participants in San Jose for SaaStr Annual 2019, the largest conference in the world for B2B software. The general consensus of 2Checkout team members at the end of the conference was simple and to the point: “It. Was. Amazing.”

Forbes.com published an article by Dan Woods where he describes a battle between the traditional enterprise software providers (Microsoft, SAP, and Oracle) and Saas providers like Salesforce.com and NetSuite.

According to Woods, SaaS applications are easier to use because they offer streamlined interfaces that are modeled after successful web consumer sites like Amazon.com, Yahoo!, eBay, Google, etc. These SaaS interfaces were designed to be easily configurable.

Traditional enterprise software is not as easy to use because user interfaces are often created before it is known exactly how the software would be used. Customization to the user interface is often done at installation by systems integrators who do not have any actual user behavior on which to base their customizations.

The Big Three are well aware of the usability gap between their products and SaaS software, but it is unclear how to solve the problem. Oracle emphasizes Fusion as an integration platform. SAP recently announced an experiment called Blue Ruby that is attempting to adapt Ruby on Rails as a user interface and programming technology for its applications. But is it possible to affordably automate a business starting with a configurable application platform that must be adapted to the specific user interfaces and business processes in a company? The SaaS model starts with a usable interface and a working automation of common processes, and then has the configuration proceed from there. The hosted nature of SaaS removes the deployment barriers.

Kenta Suzuki of the Massachusetts Institute of Technology (MIT) is awarded the 2025 American Mathematical Society (AMS)-Mathematical Association of America (MAA)-Society for Industrial and Applied Mathematics (SIAM) Frank and Brennie Morgan Prize for his extraordinary research in the representation theory of $p$-adic groups. His papers, including two solo works, represent significant progress in different areas of the field.

From the citation

Suzuki worked on deep problems in representation theory, and he has authored and coauthored six research papers. In particular, he has made important contributions to the representation theory of $p$-adic groups. His results include asymptotics for the dimension of spaces fixed by a congruence subgroup in an admissible representation of $GL(n).$ His joint works include working out the local Langlands correspondence for several rank two $p$-adic groups, and the determination of canonical bases in the subregular quotient of the affine Hecke algebra and its antispherical module, along with their “coherent” categorifications.

Response of Kenta Suzuki

It is an honor for me to receive the Frank and Brennie Morgan Prize. I thank the Morgan family and the AMS, MAA, and SIAM for their generosity. I thank my mentors throughout the years, Toshihiko Nakazawa, Li Li, Michael Zieve, and Colin Hinde, for kindling my interest in mathematics. Toshihiko Nakazawa patiently explored mathematics with me from a young age and continues to inspire me with his insights. I thank Roman Bezrukavnikov, Wei Zhang, Zhiwei Yun, Ivan Losev, Vasily Krylov, and Calder Morton-Ferguson for further stimulating my interest in mathematics at MIT and introducing me to the many wonders of representation theory. Wei Zhang’s unwavering support has motivated me to explore many areas of mathematics. I leave every conversation with Roman Bezrukavnikov with new ideas, and he has helped me grow as a researcher by encouraging me to pursue even my most ambitious ideas. The mathematical community at MIT and Harvard have been supportive and taught me so much, both mathematical and nonmathematical. Finally, I thank my parents, particularly my mother, for supporting me throughout my journey in every possible way. She has been my role model and is one of the most intelligent and charismatic people I know.

Biographical sketch of Kenta Suzuki

Kenta Suzuki is a fourth-year undergraduate at MIT from Tokyo, Japan, and Plymouth, Michigan. Suzuki’s work focuses on the representation theory of $p$-adic groups and geometric representation theory. Suzuki is particularly interested in applying geometric methods to solve problems of representation theory. In his free time, he runs, reads, and is (slowly) learning how to cook.

About the prize

The AMS-MAA-SIAM Frank and Brennie Morgan Prize for Outstanding Research in Mathematics by an Undergraduate Student is awarded annually to an undergraduate (or students for joint work) for outstanding research in mathematics. The prize recipient's research can include more than one paper, however, the paper or papers to be considered for the prize must be completed while the student is an undergraduate. Publication of research is not required.

Established in 1995, the prize is entirely endowed by a gift from Mrs. Frank (Brennie) Morgan. The current prize amount is $1,200.

The prize will be presented at the 2025 Joint Mathematics Meetings in Seattle.

Learn more about the prize and previous recipients.

Contact: AMS Communications

*****

The American Mathematical Society is dedicated to advancing research and connecting the diverse global mathematical community through our publications, meetings and conferences, MathSciNet, professional services, advocacy, and awareness programs.

The actin cytoskeleton is of profound importance to cell shape, division, and intracellular force generation. Profilins bind to globular (G-)actin and regulate actin filament formation. Although profilins are well-established actin regulators, the distinct roles of the dominant profilin, profilin 1 (PFN1), versus the less abundant profilin 2 (PFN2) remain enigmatic. In this study, we use interaction proteomics to discover that PFN2 is an interaction partner of the actin N-terminal acetyltransferase NAA80, and further confirm this by analytical ultracentrifugation. Enzyme assays with NAA80 and different profilins demonstrate that PFN2 binding specifically increases the intrinsic catalytic activity of NAA80. NAA80 binds PFN2 through a proline-rich loop, deletion of which abrogates PFN2 binding. Small-angle X-ray scattering shows that NAA80, actin, and PFN2 form a ternary complex and that NAA80 has partly disordered regions in the N-terminus and the proline-rich loop, the latter of which is partly ordered upon PFN2 binding. Furthermore, binding of PFN2 to NAA80 via the proline-rich loop promotes binding between the globular domains of actin and NAA80, and thus acetylation of actin. However, the majority of cellular NAA80 is stably bound to PFN2 and not to actin, and we propose that this complex acetylates G-actin before it is incorporated into filaments. In conclusion, we reveal a functionally specific role of PFN2 as a stable interactor and regulator of the actin N-terminal acetyltransferase NAA80, and establish the modus operandi for NAA80-mediated actin N-terminal acetylation, a modification with a major impact on cytoskeletal dynamics.

Visual Abstract

Yadong Yu
Dec 1, 2020; 19:1997-2014
Research

AAA+ ATPases constitute a large family of proteins that are involved in a plethora of cellular processes including DNA disassembly, protein degradation and protein complex disassembly. They typically form a hexametric ring-shaped structure with six subunits in a (pseudo) 6-fold symmetry. In a subset of AAA+ ATPases that facilitate protein unfolding and degradation, six subunits cooperate to translocate protein substrates through a central pore in the ring. The number and type of nucleotides in an AAA+ ATPase hexamer is inherently linked to the mechanism that underlies cooperation among subunits and couples ATP hydrolysis with substrate translocation. We conducted a native MS study of a monodispersed form of PAN, an archaeal proteasome AAA+ ATPase, to determine the number of nucleotides bound to each hexamer of the WT protein. We utilized ADP and its analogs (TNP-ADP and mant-ADP), and a nonhydrolyzable ATP analog (AMP-PNP) to study nucleotide site occupancy within the PAN hexamer in ADP- and ATP-binding states, respectively. Throughout all experiments we used a Walker A mutant (PAN^K217A) that is impaired in nucleotide binding as an internal standard to mitigate the effects of residual solvation on mass measurement accuracy and to serve as a reference protein to control for nonspecific nucleotide binding. This approach led to the unambiguous finding that a WT PAN hexamer carried – from expression host – six tightly bound ADP molecules that could be exchanged for ADP and ATP analogs. Although the Walker A mutant did not bind ADP analogs, it did bind AMP-PNP, albeit at multiple stoichiometries. We observed variable levels of hexamer dissociation and an appearance of multimeric species with the over-charged molecular ion distributions across repeated experiments. We posit that these phenomena originated during ESI process at the final stages of ESI droplet evolution.

This study evaluates the diagnostic utility of PET/MRI for primary, locoregional, and nodal head and neck squamous cell carcinoma (HNSCC) through systematic review and metaanalysis. Methods: A systematic search was conducted using PubMed and Scopus to identify studies on the diagnostic accuracy of PET/MRI for HNSCC. The search included specific terms and excluded nonhybrid PET/MRI studies, and those with a sample size of fewer than 10 patients were excluded. Results: In total, 15 studies encompassing 638 patients were found addressing the diagnostic test accuracy for PET/MRI within the chosen subject domain. Squamous cell carcinoma of the nasopharynx was the most observed HNSCC subtype (n = 198). The metaanalysis included 12 studies, with pooled sensitivity and specificity values of 93% and 95% per patient for primary disease evaluation, 93% and 96% for locoregional evaluation, and 89% and 98% per lesion for nodal disease detection, respectively. An examination of a subset of studies comparing PET/MRI against PET/CT or MRI alone for evaluating nodal and locoregional HNSCC found that PET/MRI may offer slightly higher accuracy than other modalities. However, this difference was not statistically significant. Conclusion: PET/MRI has excellent potential for identifying primary, locoregional, and nodal HNSCC.

The Federal Aviation Administration has banned flights to-and-from Haiti for at least 30 days after JetBlue and Spirit Airlines planes were hit by gunfire Monday during attempts to land in Port-au-Prince.

A hole in the atmosphere's ozone layer is the seventh-smallest since recovery began in 1992, the National Oceanic and Atmospheric Administration announced Wednesday.

Curtis Jones, a U.S. Army veteran who has led Georgia's Bibb County school system since 2015, has been named the 2019 AASA National Superintendent of the Year.

The Winnipeg Jets claimed Kaapo Kahkonen off waivers from the Avalanche on Tuesday afternoon

David Schuler, the superintendent of Township High School District 214 in Arlington Heights, Ill., has been named 2018 National Superintendent of the Year.

Tennessee soccer earned an NCAA Tournament berth for the fourth straight season and will face No. 7 seed Virginia Tech in the first round Friday

Elena Neumann
Oct 9, 2024; 44:e0591242024-e0591242024
Systems/Circuits

GABAergic neurons and GABA_A receptors (GABA_ARs) are critical elements of almost all neuronal circuits. Most GABA_ARs of the CNS are heteropentameric ion channels composed of two α, two β, and one subunits. These receptors serve as important drug targets for benzodiazepine (BDZ) site agonists, which potentiate the action of GABA at GABA_ARs. Most GABA_AR classifications rely on the heterogeneity of the α subunit (α1–α6) included in the receptor complex. Heterogeneity of the subunits (1–3), which mediate synaptic clustering of GABA_ARs and contribute, together with α subunits, to the benzodiazepine (BDZ) binding site, has gained less attention, mainly because 2 subunits greatly outnumber the other subunits in most brain regions. Here, we have investigated a potential role of non-2 GABA_ARs in neural circuits of the spinal dorsal horn, a key site of nociceptive processing. Female and male mice were studied. We demonstrate that besides 2 subunits, 1 subunits are significantly expressed in the spinal dorsal horn, especially in its superficial layers. Unlike global 2 subunit deletion, which is lethal, spinal cord-specific loss of 2 subunits was well tolerated. GABA_AR clustering in the superficial dorsal horn remained largely unaffected and antihyperalgesic actions of HZ-166, a nonsedative BDZ site agonist, were partially retained. Our results thus suggest that the superficial dorsal horn harbors functionally relevant amounts of 1 subunits that support the synaptic clustering of GABA_ARs in this site. They further suggest that 1 containing GABA_ARs contribute to the spinal control of nociceptive information flow.