Bob Iaccino, Path Trading Partners

Todd Colvin, Ambrosino Brothers

Bob Iaccino, Path Trading Partners

Bob Iaccino, Path Trading Partners

Dan Deming, KKM Financial

An Ontario court has declined to review a decision to deny Peter Nygard bail while the former fashion mogul appeals his sexual assault convictions and sentence.

Two buildings collapsed on Hamilton’s Gore Park early Monday morning after being boarded up for over a decade. The fire department says no one was injured and the city has issued an emergency demolition order.

Toronto's redesigned vacant home tax rollout has begun, with over 59,000 people filing their paperwork in the first week. Some councillors say they were left responding to complaints about the rollout, after the city's online declaration portal experienced technical problems shortly after launch.

Striking Brampton city workers paused their picket lines on Monday to show respect for war veterans and that means public transit buses in the city ran on their usual schedules without disruption.

One person is dead after a motorcycle and an SUV collided in Mount Albert, Ont., on Monday, Ontario Provincial Police say.

Ontario Provincial Police (OPP) have released dashcam footage of a crash that sent two people to hospital in life-threatening condition, linked to an ongoing investigation into rocks being thrown at moving vehicles in the GTA.

The Toronto Police Services Board unanimously approved a new five-year hiring plan for the force on Tuesday.

Brampton has reached a tentative deal with nearly 1,200 city workers who have been on strike since last week, according to Mayor Patrick Brown and the union.

The high cost of pet care can be an unfair burden to place on your family when you’re gone. Experts say you should set aside cash pet care expenses, and make sure you have a trusted beneficiary in your will.

At 101-years-old, Chase is one of a dwindling number of living veterans in the city who served in the second world war as a member of the Royal Canadian Air Force. 

Sgt. Harman Dhaliwal, who is from Calgary, says he's proud to be a part of the growing exhibit that highlights the relationship between the Sikh faith and military service.

A new course offered to nursing students at the University of Calgary is shining a light on the impacts of colonization on the health experiences of Indigenous peoples.

Some Ukrainians living in Calgary say they're even more worried for their friends and family back home in light of Donald Trump's election win.

Calgarians who contributed to peacekeeping missions around the world reflected on the country's contributions to this work, highlighting the country's mission in Cyprus, which started 60 years ago.

The Calgary-based team beat Hamilton Forge FC in a 2-1 nail-biter at home on Saturday, in front of a sold-out crowd of over 7,000 fans at Spruce Meadows.

New rebuilding regulations in Jasper have been approved, but roadblocks — including the sheer number of people that are needed for construction — are popping up.

After Canada Post workers gave a 72-hour notice to strike early Tuesday, some Calgary business owners are worried about what this means for holiday season sales. 

Eyare died of injuries she sustained while moving between back of house spaces, Wilder Institute director of animal care, health and welfare, Colleen Baird said Tuesday.

Charlottetown-born curler Brett Gallant says competing in the Olympics will be a dream come true for him and his fiancée, Jocelyn Peterman, even if COVID-19 protocols will make it difficult for them to see each other.

After COVID-19 challenges forced the cancellation of Canada's mixed doubles trials, several top curlers are anxiously waiting to learn whether they will be chosen to represent the country in the discipline at the Beijing Games.

The cancellation of the mixed doubles curling trials has generated a wide variety of emotions among players — illuminating a handful of issues, particularly about scheduling and the selection process as a whole.

Laura Walker made a game-winning draw Sunday afternoon to win the Alberta women's curling playdowns and secure a berth in the upcoming national championship.

Rachel Homan and John Morris join That Curling Show fresh off the news they have been chosen to represent Canada in mixed doubles curling at the Beijing Olympics.

Curling Canada, with the assistance of Own the Podium and the Canadian Olympic Committee, announced Rachel Homan and John Morris as the mixed doubles team for Canada competing at the Beijing Olympics.

Now that all of Canada's Olympic curling teams are finally set, CBC Sports' daily newsletter takes a look at the three tournaments.

Newly announced mixed doubles duo Rachel Homan and John Morris, skips Jennifer Jones and Brad Gushue, and broadcasters Mike Harris, Joanne Courtney and Bruce Rainnie all break down a busy week in curling news.

Canadian curler Kaitlyn Lawes looks back on her Olympic gold in mixed doubles at PyeongChang 2018, reflects on her disappointment in not qualifying with Team Jones in 2018, and her mentality heading into Beijing 2022, looking to add to her two Olympic gold medals.

Curling Canada says the Scotties Tournament of Hearts in Thunder Bay, Ont., will operate under Ontario's current public health measures and an approved framework from the office of the chief medical officer.

CME Group, the world's leading derivatives marketplace, today announced that open interest in its global benchmark Henry Hub futures contract reached a record 1.73 million contracts on October 30,...

CME Group, the world's leading derivatives marketplace, today declared a fourth-quarter dividend of $1.15 per share. The dividend is payable December 27, 2024, to shareholders of record as of...

Indiana University took first place, with the rest of the top five from outside the United States Record participation from nearly 570 teams across 24 countries CHICAGO, Nov. 7, 2024 /PRNewswire/...

Chief Financial Officer Lynne Fitzpatrick Appointed to President and CFO Chief Operating Officer Julie Holzrichter to Step Down and Assume Advisory Role Suzanne Sprague to Succeed Holzrichter CHICAGO,

Mosquitoes transmit deadly pathogens from person to person as they obtain the blood meal that is essential for their life cycle. Female mosquitoes of many species are unable to reproduce without consuming protein that they obtain from blood. This developmental stage makes them highly efficient disease vectors of deadly pathogens. They can transmit pathogens between members of the same species and different species that can provide a route for evolving zoonotic viruses to jump from animals to humans. One possible way to develop novel strategies to combat pathogen transmission by mosquitoes is to study the sensory systems that drive mosquito reproductive behaviors, in particular the neural architecture and circuits of mosquito sensory afferent neurons, the central circuits that process sensory information, and the downstream circuits that drive reproductive behaviors. The study of mosquito neuroanatomy and circuitry also benefits basic neuroscience, allowing for comparative neuroanatomy in insect species, which has great value in the current model species-heavy landscape of neuroscience. Here, we introduce two important techniques that are used to study neuroanatomy and neural circuitry—namely, immunofluorescent labeling and neural tracing. We describe how to apply these approaches to study mosquito neuroanatomy and describe considerations for researchers using the techniques.

Sleep is likely a whole-brain phenomenon, with most of the brain probably benefiting from this state of decreased arousal. Recent advances in our understanding of some potential sleep functions, such as metabolite clearance and synaptic homeostasis, make it evident why the whole brain is likely impacted by sleep: All neurons have synapses, and all neurons produce waste metabolites. Sleep experiments in the fly Drosophila melanogaster suggest that diverse sleep functions appear to be conserved across all animals. Studies of brain activity during sleep in humans typically involve multidimensional data sets, such as those acquired by electroencephalograms (EEGs) or functional magnetic resonance imaging (fMRI), and these whole-brain read-outs often reveal important qualities of different sleep stages, such as changes in frequency dynamics or connectivity. Recently, various techniques have been developed that allow for the recording of neural activity simultaneously across multiple regions of the fly brain. These whole-brain-recording approaches will be important for better understanding sleep physiology and function, as they provide a more comprehensive view of neural dynamics during sleep and wake in a relevant model system. Here, we present a brief summary of some of the findings derived from sleep activity recording studies in sleeping Drosophila flies and discuss the value of electrophysiological versus calcium imaging techniques. Although these involve very different preparations, they both highlight the value of multidimensional data for studying sleep in this model system, like the use of both EEG and fMRI in humans.

The establishment of neural connectivity is a major part of neural development. The central nervous system (CNS) midline is the most characterized axon guidance choice point, and work in Drosophila has played a pivotal role in understanding the molecular mechanisms responsible. Axons respond to attractive cues such as Netrin via the Frazzled receptor, and repulsive cues such as Slit via Robo receptors. Both signals are expressed at the CNS midline, affect pioneer axons, and have dramatic effects on the axon scaffold as a whole. Here, we focus on previous research analyzing classic mutants in the Slit/Robo pathway, which can readily be detected with a dissecting microscope. We also discuss analyzing these mutants in a teaching lab situation. The combination of sophisticated genetics and reliable axonal markers in Drosophila allows phenotypic analysis to be performed at the single-cell level. The elaborate architecture of neurons is very sensitive to disruption by genetic mutations, allowing the effects of novel mutations to be easily detected and assessed.

Analysis of taste sensory responses has been a powerful approach for understanding principles of taste detection and coding. The shared architecture of external taste sensing units, called sensilla, in insects opened up the study of tastant-evoked responses in any model of choice using a single-sensillum tip recording method that was developed in the mid-1900s. Early studies in blowflies were instrumental for identifying distinct taste neurons based on their responses to specific categories of chemicals. Broader system-wide analyses of whole organs have since been performed in the genetic model insect Drosophila melanogaster, revealing principles of stereotypical organization and function that appear to be evolutionarily conserved. Although limited in scope, investigations of taste sensory responses in mosquitoes showcase conservation in sensillar organization, as well as in groupings of functionally distinct taste neurons in each sensillum. The field is now poised for more thorough dissections of mosquito taste function, which should be of immense value in understanding close-range chemosensory interactions of mosquitoes with their hosts and environment. Here, we provide an introduction to the basic structure of a taste sensillum and functional analysis of the chemosensory neurons within it.

The host associations of mosquitoes vary by species, with some species being relative generalists, whereas others specialize, to varying extents, on a particular subset of the available host community. These host associations are driving factors in transmission dynamics of mosquito-vectored pathogens. For this reason, characterizing the host associations of mosquito species is critical for understanding the epidemiology of mosquito-vectored pathogens. Diverse methods have been used to associate mosquito species with their hosts. These typically include collecting mosquitoes that bite a restrained host (bait) or collecting wild blood-engorged mosquitoes and matching their blood meal to reference samples (blood meal analysis). Blood meal analysis refers to a collection of molecular techniques for determining the taxonomic identity of the source of a mosquito blood meal using cytological, serological, or DNA-based characteristics of the blood meal. Blood meal analyses that are based on DNA markers have advantages over cytological and serological methods and are effective for determining species-level identities of hosts from a broad range of potential host taxa. Here, we discuss effective techniques for analyzing blood meals.

Although church planting has progressed at a slower pace than the team first expected, a few important milestones in Bar, Montenegro, have been reached.

When OM Montenegro began in 2007 with a team of three, holding a full Sunday meeting seemed a long way off—but not anymore.

Four OM guys in Bar, Montenegro, and four guys from a nearby Roma camp take a hiking/camping trip together.

No public playground exists in Bar, Montenegro. This year, OM Montenegro plans to build one with the help of an outreach team.

Four volunteers from Switzerland. One empty park. Ten days to build a playground. Could it be done?

OM Montenegro partners with Serbian singer-songwriter Dejan Milinov to bring worship music to believers in their own language.

A couple in Montenegro, working with children in a tough neighbourhood in Bar, desire to find ways to reach them with Jesus’ love.

Can young people be united in faith, irrespective of their ethnic background? The answer is yes!