Геймеров отправят на Землю, которую снова захватили динозавры.

“The most difficult part was persuading our children that they had the freedom to make anything they wanted,” writes mom Anam Ahmed at Let Grow. (Click here!) …Like most kids, my children live prescheduled lives (at least they did in “the time before”). At school, someone tells them when to play outside and when to […]

Elon Musk thinks a universal basic income is inevitable. Musk doesn't see plausible alternatives. I hope not. So here's the optimistic scenario: On the one hand, manual and low skilled work will mostly get automated out of existence. So one could imagine why demand for people at lower skill levels and lower levels of cognitive ability could just evaporate. On the other hand, automation will cut costs and boost the wealth of those still employed. Even if the pay of manual laborers is low the goods a manual laborer will need to survive should become very cheap. So any upper class people who can find a use for them might pay them enough to survive. But I see a stronger...

Contes de fées aux enfants - Octo-Puce la pieuvre et Craby-la-Pince le crabe.

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Chronic pancreatitis (CP) is considered an irreversible fibroinflammatory pancreatic disease. Despite numerous animal model studies, questions remain about local immune characteristics in human CP. We profiled pancreatic immune cell characteristics in control organ donors and CP patients including those with hereditary and idiopathic CP undergoing total pancreatectomy with islet autotransplantation. Flow cytometric analysis revealed a significant increase in the frequency of CD68+ macrophages in idiopathic CP. In contrast, hereditary CP samples showed a significant increase in CD3+ T cell frequency, which prompted us to investigate the T cell receptor β (TCRβ) repertoire in the CP and control groups. TCRβ sequencing revealed a significant increase in TCRβ repertoire diversity and reduced clonality in both CP groups versus controls. Interestingly, we observed differences in Vβ-Jβ gene family usage between hereditary and idiopathic CP and a positive correlation of TCRβ rearrangements with disease severity scores. Immunophenotyping analyses in hereditary and idiopathic CP pancreases indicate differences in innate and adaptive immune responses, which highlights differences in immunopathogenic mechanisms of disease among subtypes of CP. TCR repertoire analysis further suggests a role for specific T cell responses in hereditary versus idiopathic CP pathogenesis, providing insights into immune responses associated with human CP.

BACKGROUND Mirabegron is a β3-adrenergic receptor (β3-AR) agonist approved only for the treatment of overactive bladder. Encouraging preclinical results suggest that β3-AR agonists could also improve obesity-related metabolic disease by increasing brown adipose tissue (BAT) thermogenesis, white adipose tissue (WAT) lipolysis, and insulin sensitivity.METHODS We treated 14 healthy women of diverse ethnicities (27.5 ± 1.1 years of age, BMI of 25.4 ± 1.2 kg/m2) with 100 mg mirabegron (Myrbetriq extended-release tablet, Astellas Pharma) for 4 weeks in an open-label study. The primary endpoint was the change in BAT metabolic activity as measured by [18F]-2-fluoro-d-2-deoxy-d-glucose (18F-FDG) PET/CT. Secondary endpoints included resting energy expenditure (REE), plasma metabolites, and glucose and insulin metabolism as assessed by a frequently sampled intravenous glucose tolerance test.RESULTS Chronic mirabegron therapy increased BAT metabolic activity. Whole-body REE was higher, without changes in body weight or composition. Additionally, there were elevations in plasma levels of the beneficial lipoprotein biomarkers HDL and ApoA1, as well as total bile acids. Adiponectin, a WAT-derived hormone that has antidiabetic and antiinflammatory capabilities, increased with acute treatment and was 35% higher upon completion of the study. Finally, an intravenous glucose tolerance test revealed higher insulin sensitivity, glucose effectiveness, and insulin secretion.CONCLUSION These findings indicate that human BAT metabolic activity can be increased after chronic pharmacological stimulation with mirabegron and support the investigation of β3-AR agonists as a treatment for metabolic disease.TRIAL REGISTRATION Clinicaltrials.gov NCT03049462.FUNDING This work was supported by grants from the Intramural Research Program of the NIDDK, NIH (DK075112, DK075116, DK071013, and DK071014).

Recently, I’ve found myself thinking more often than not about the past – mistakes I’ve made, where I could have done better, things like that. I think that’s a symptom of unhappiness, really, so yeah… I’m putting a stop to that. It’s a hard and imperfect stop, but I’m not willing to continue to think about things that I can’t change. Instead, I am going to look forward — to my next step and how to make it count! That’s how I’ve been trending, anyway, I hope you can tell! I guess that makes it funny that I roped people into going fossil-hunting with me! Get it? THE PAST. But, I LOVE ANCIENT HISTORY! It’s my first time finding a fossil, and my first time hunting, so I count it as a giant leap forward in this travelogue I call life. :3 Anyways, I found a book in the library about gem hunting in Washington and there was a listing for a site where you could find fossils (!!!!) nearby (!!!!!!!!!!). It’s called Lincoln Creek (there does appear to be a creek somewhere nearby, but it’s not right at the site), and let’s just say that I’ve learned a lot from it, both about fossil hunters (STINGY WITH LOCATIONS) and about fossil hunting itself (by blundering right into it without knowing anything). Thank god there were GPS coordinates in the book, because although I found a lot of reviews on fossil hunting at Lincoln Creek online, as well as a few blurry photos, I couldn’t find any information on how to actually get there or what exactly it looked like. All I had was the GPS coordinates from the book. I know that people want to protect their “stash,” and it comes across as pretty selfish to me, but it really makes it hard to start out as a beginner with only passion to rely on, and I don’t think that being “protective” or “exclusive” is a good way to behave in general. That said, let me help you if you decide to go yourself: – GPS coordinates in Google Maps. – A screencap of the map and the turns I walked to get there. I don’t recommend it, unless you want a really great walk in nature that is also technically trespassing and won’t be disappointed if you find nothing, but if you want to go, go for it and enjoy it all you can! It was only supposed to be a half hour drive or so from my sister’s house to the little logging road that led to the site. But I learned something new that had seriously never once crossed my mind: logging roads can be closed off! There was a gate blocking the main road, so we tried driving for miles in every direction to get in another way, but ALL of those were blocked off, too. There were “no tresspassing, this land belongs to Weyerhaeuser” signs, but we eventually just decided to walk it. I am not sorry at all to say that I have zero respect for companies that clearcut or attempt to think that land can “belong” to them for that purpose. Oh, and they have tried to sue the government to be able to log on lands that contain endangered species. Now, I love paper, but f you, Weyerhaeuser. I’m not at all sorry, and I’d walk these lands again a hundred times if I wanted to. So, we ignored the signs, and walked past the gate all the way to our destination. ALLLLLLLL the two hours. It might not seem like a lot, but we honestly thought that we’d be able to drive right up to the site as it said in the book. Welp, it was an unexpected walk, but super awesome to get back among the trees. Being in the forest and a slow walker anyways, I spent a lot of the time by myself contemplating life and sacred rituals. You know, the usual. Come look at some photos with me, and I’ll tell you a little bit about the journey. ???? When we realized that the road was blocked off, we drove around searching for another way into the deep forest and saw this. You know you’re… oh, wait. It looked like their neighbors a little further down were more my kind of people, though! Here’s my niece, all ready for adventure! I’m pretty sure that these were bear droppings, as they were full of berries. They were also somewhat fresh. There are a lot of bears up here in Western Washington, since there aren’t many settled areas. I never thought for a moment that I’d need to bring bear spray, but I definitely am going to have to buy some for my adventures. :/ It was quite lovely. One of the very few blue, sunny days that we’ve had so far this summer. I won’t be sorry to leave the cold behind, as I’m a desert sprite and being in the cold depletes my magic! But this… it was lovely. There were two clearcut clearings. They made for gorgeous views of the valley, but it was also quite sad. I could feel the souls of all of those trees calling out to me… ???? We delved onto a very overgrown road after over an hour of walking. And there was a huge, recent-looking landslide blocking the path! We weren’t about to turn back, so we picked our way across it. And just a little ways farther, down another overgrown road, this one much more primitive, the fossil site was evident. It was also really, really disappointing. It was exactly where the GPS coordinates said it would be (funny enough, I got better cell signal in the middle of the forest than I do in town), and there was basically a slope of discarded rocks that led up to a little overhang. Oops, I mean a lot overhang. People had dug deep into the cliff, and it looked like the forest above was one hit shy of collapsing in on you. I like adventuring, but I don’t like playing with death. And yet, I still picked for about half an hour, looking for concretions (fossilized crabs in the center of rock balls trapped within the rock, if that makes sense). Supposedly this site was full of them, and there were people online saying that they found 80 within an hour. But we found nothing at all, except for some shells that were indeed trapped in the rock, but looked like any old shell. Fossils, yes, but not really cool. This was supposed to be my “I’m tired and disappointed” face. I guess I shouldn’t have smiled, haha! Guess what, though???? We felt so empty-handed that we decided to see if there was anything in the rock slide, and that’s where I found the concretion!! In the middle of this giant rock that I slowly whittled away at. We must have spent about two hours picking through the debris, and we found a ton more shells, but just that one crab. Still, it’s cool, right? I considered it a win for the day after all, and we decided to get out of there as the sun started to go down. Here’s the slightly-overgrown trail we were on (the panorama makes it look like a circle, but it was a straight path XD). Passed the clearcut areas with the sun much lower in the sky. The fairies started to come out as we entered the wooded paths again in the late afternoon sunlight. We made it home while it was still light out, exhausted and quite sore. Here is my concretion, though! Isn’t it cool? You can barely tell that there was a crab inside when it was formed. I didn’t really know what I was doing, so I think that I didn’t preserve it as well as I could when I cracked it open, but I’m still really proud to have found it. ????   My first fossil. Of many. ????  

Woot is ending the week with a refurbished sale on the 15-inch MacBook Pro, available in multiple storage sizes and colors. The sale starts with the 256GB SSD model (16GB RAM, Intel Core i7) for $1,579.99.

Note: MacRumors is an affiliate partner with Woot. When you click a link and make a purchase, we may receive a small payment, which helps us keep the site running.

For more storage, the 512GB SSD model (16GB RAM, Intel Core i9) is on sale for $1,849.99. Woot's refurbished sales are offering more than $800 in savings when compared to the original prices of these notebooks, which began at $2,399.00 when they launched in May 2019.

Similar to previous Woot sales, each MacBook Pro comes with a One Year Limited Woot Warranty. Each device has been refurbished and is ensured to be in full working condition. When shipped, they are packaged in a generic white box.

You can find even more discounts on new MacBooks by visiting our Best Deals guide for MacBook Pro and MacBook Air. In this guide we track the steepest discounts for the newest MacBook models every week, so be sure to bookmark it and check back often if you're shopping for a new Apple notebook.

This article, "Deals: Refurbished 15-Inch MacBook Pro Notebooks on Sale at Woot From $1,580 ($800+ Off)" first appeared on MacRumors.com

Discuss this article in our forums

Apple recently updated the 13-inch MacBook Pro, and the $1,299 base model remains a popular alternative to the $999 MacBook Air. To help with your buying decision, read our comparison of the notebooks below.


The differences between the base 13-inch MacBook Pro and the MacBook Air are quite nuanced, with each notebook possessing some unique features.

What's the Same

• 13-inch Retina display with 227 pixels per inch and True Tone support


• Magic Keyboard with reliable scissor switch design


• Force Touch trackpad


• 2 × Thunderbolt 3 ports


• 3.5mm headphone jack


• 256GB of SSD storage standard, configurable up to 2TB


• Touch ID


• T2 security chip


• 720p webcam


• 802.11ac Wi-Fi, also known as Wi-Fi 5


• Bluetooth 5.0


• Three-microphone array with directional beamforming


• Dolby Atmos surround sound

Advantages of Base 13-Inch MacBook Pro

• The display supports the P3 wide color gamut for more vibrant and lifelike colors


• The display is brighter at up to 500 nits vs. 400 nits on MacBook Air


• Touch Bar


• Slightly better sounding speakers

Advantages of MacBook Air

• Up to 11 hours of battery life vs. 10 hours on base 13-inch MacBook Pro


• Weighs slightly less at 2.8 pounds vs. 3.1 pounds for base 13-inch MacBook Pro


• Faster RAM: 3733MHz LPDDR4X vs. 2133MHz LPDDR3 for base 13-inch MacBook Pro


• 6K display support vs. 5K on base 13-inch MacBook Pro

Unlike the MacBook Pro, the MacBook Air also has a gold color option.

Performance

Generally speaking, the MacBook Air remains best suited for lightweight day-to-day tasks like web browsing and creating spreadsheets, while the MacBook Pro is better equipped to handle more intensive tasks like rendering large video files. This is not only because the MacBook Pro has faster processors than the Air, but also because it has a more advanced thermal design for dissipating heat inside the computer.

While the MacBook Air has been updated with Intel's latest 10th-generation processors, the base 13-inch MacBook Pro continues to use older 8th-generation processors. However, the Air uses lower-wattage Y-series chips with lower clock speeds, so the Pro still has faster overall performance, as confirmed by benchmarks.

Geekbench 5 scores for the latest 13-inch MacBook Pro and MacBook Air configurations:

• MacBook Air / 1.1GHz dual-core Core i3: 1,002 single-core and 1,998 multi-core


• MacBook Air / 1.1GHz quad-core Core i5: 1,055 single-core and 2,645 multi-core


• MacBook Air / 1.2GHz quad-core Core i7: 1,102 single-core and 2,843 multi-core


• MacBook Pro / 1.4GHz quad-core Core i5: 927 single-core and 3,822 multi-core


• MacBook Pro / 1.7GHz quad-core Core i7: 1,036 single-core and 3,909 multi-core

Takeaways:

• The base model 13-inch MacBook Pro for $1,299 has up to 91 percent faster multi-core performance than the base model MacBook Air for $999


• If considering the MacBook Air, upgrading to the quad-core Core i5 option is well worth the extra $100, as it is up to 32 percent faster than the base model and more closely rivals the base 13-inch MacBook Pro

Geekbench 5 scores are calibrated against a baseline score of 1,000, which is the score of an Intel Core i3-8100. Higher scores are better, with double the score indicating double the performance. Compare with other Mac benchmarks here.

Bottom Line

If you value portability and up to an extra hour of battery life, and are willing to sacrifice some performance, the MacBook Air is a relatively good value. Just remember to consider spending an extra $100 on the quad-core Core i5 processor option, as the $999 base model is equipped with a particularly sluggish dual-core processor.

For more intensive tasks, the 13-inch MacBook Pro's faster processors and more advanced thermal design will allow you to push the limits more without the fans running obnoxiously. You'll also get the Touch Bar, a brighter and more vibrant display, and slightly better sounding speakers with high dynamic range.
This article, "Base 13-Inch MacBook Pro vs. MacBook Air" first appeared on MacRumors.com

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Does a stooge prepare your income tax returns? Watch the Three Stooges prepare a tax return and learn from them. Don't be a stooge: hire a CPA to prepare your next tax return! Continue reading →

NEWS 8 IS YOUR LOCAL ELECTION HEADQUARTERS…. AND TONIGHT…VOODOO ECONOMICS! CHIEF POLITICAL CORRESPONDENT MARK DAVIS TELLING US HOW REPEALING THE STATE INCOME TAX IS THE LATEST HEATED TOPIC BETWEEN THE CANIDATES FOR GOVERNOR.   DEMOCRAT NED LAMONT IS OPENING A … Continue reading →

I really should explain this one, but I thought it might be more interesting if I didn't.

captured camera lens focal length aperture shutter speed shooting mode exposure bias metering mode ISO flash image quality RAW converter image editor plugins (etc) cropped?

1.00pm on 16/3/15 Fujifilm X-T1 XF 16-55mm f/2.8 R LM WR 32mm f/16 1/180 manual n/a average 200 Profoto B1 RAW Camera Raw Photoshop CC (2015) none 1x1

Real heroes deserve their own comics/Los héroes reales merecen sus propios comics

The post Heroes always come home in David Rubín’s free COVID-19 SUPERMAN story (version en español incluída) appeared first on The Beat.

IBM and West Virginia University’s Center for Disability Inclusion (CDI) today announced they are developing a first generation mobile workplace accommodation case management app to help U.S. businesses create inclusive workplaces for employees with disabilities.

MAP Health Management and IBM Watson Health today announced a partnership that aims to address the pervasive problem of relapse among Americans suffering from Substance Use Disorder, a chronic disease. MAP will integrate Watson cognitive technologies into the MAP Recovery Network Platform to enhance the platform’s existing capabilities around patient risk models. In doing so, it is anticipated that behavioral health and substance abuse treatment providers that use the MAP platform will be better able to predict and prevent incidence of relapse nationwide.

[Image: Der Wanderer über dem Nebelmeer by Caspar David Friedrich (c. 1818).] It would be interesting to look at locations of the American popular imagination, as seen in movies and TV, mapped against regional tax breaks for the film industry. There was a brief span of time, for example, when rural Pennsylvania stood in for … Continue reading "Tax Incentives and the Human Imagination"

Digital video consumption is viral and, according to a new study released today by IBM and International Broadcasting Convention (IBC), more than half of the 21,000 consumers surveyed are using mobiles every day to watch streaming videos, and that number is expected to grow 45 percent in the next three years.

IBM Security today announced the results of a global study exploring the factors and challenges of being a Cyber Resilient organization. The study was conducted by Ponemon Institute and sponsored by IBM Resilient and found that 77 percent of respondents admit they do not have a formal cyber security incident response plan (CSIRP) applied consistently across their organization. Nearly half of the 2800 respondents reported that their incident response plan is either informal/ad hoc or completely non-existent.

IBM (NYSE: IBM) announced today it will upgrade the University of Canterbury’s BlueFern High Performance Computing (HPC) facility, enhancing its ability to deliver quality science and technology outcomes and significantly increasing New Zealand’s research capacity.

Cisco e IBM Security anunciaron hoy una magna colaboración para abordar la creciente amenaza global de la delincuencia cibernética. Mediante un nuevo acuerdo, las compañías trabajarán juntas de forma más abierta en productos, servicios e inteligencia de amenazas.

IBM Security anunció los resultados de un estudio global que explora los factores y desafíos de ser una organización ciberresiliente. El estudio encontró que el 77% de los encuestados admiten no tener un plan formal de respuesta a incidentes de seguridad cibernética (CSIRP) aplicado sistemáticamente en toda su organización. Casi la mitad de los encuestados informaron que su plan de respuesta a incidentes es informal o completamente inexistente.

La empresa se afianza como líder de Proveedores Autorizados de Certificación (PAC) y logra procesar grandes volúmenes de transacciones de manera sencilla

L’entité sécurité d’IBM a annoncé aujourd'hui les résultats d'une étude mondiale sondant le niveau de préparation des organisations en matière de résistance à une cyberattaque et de récupération ensuite. L'étude, menée par le Ponemon Institute et sponsorisée par IBM Resilient, a révélé qu'une grande majorité des organisations interrogées ne sont toujours pas prêtes à répondre de façon adéquate aux incidents de cybersécurité, 77% des personne interrogées indiquant qu'ils n'ont pas de plan de réponse aux incidents de cybersécurité appliqué de manière cohérente dans l’ensemble de l'organisation.

One-shot between Harry and Ginny a day before his Auror-training began. Canon, R&R

Six-year-old Teddy Lupin was feeling unnaturally nervous. One-shot Teddy's speech for his primary school about his parents, or people like his parents. R&R!

One-shot,*not what you might think* Now that Harry and Ginny are dating, Ron needs to get his brotherly duties out of way, but who is he going to talk to if not Harry? Read to find out... R&R!

Two StarWars.com writers debate Luke’s choice in Star Wars: The Empire Strikes Back.

View on Instagram https://ift.tt/2mPe4Ss

musicisart magazine SAN HOLO – THE FUTURE (FEAT. JAMES VINCENT MCMORROW)

Producer San Holo, AKA Sander van Dijck, creates ballad like electronic music that brings a listener on a journey full of emotion. San Holo is most known for his hit single ‘Light‘, which reached over 151 thousand likes on Soundcloud. SAN HOLO – THE LIGHT || San Holo’s latest single ‘The Future‘ features the smooth Irish vocals of […]

The post SAN HOLO – THE FUTURE (FEAT. JAMES VINCENT MCMORROW) appeared first on musicisart magazine.

He’s standing in the dead middle of the meat section at Price Chopper screaming “HOW CAN THERE NOT BE ANY FUCKING STEAK?”  Someone comes out bearing chicken from behind the steel clad gates of the backroom where they cut meat and stage the cases. “Hey, you got any steak back there?” “Steak? No sir. None.” […]

When it comes to ways you can increase traffic to your website there are dozens if not hundreds of ways to get more traffic. Depending on your website, the content or products you’re trying to get viewed, and the amount of time you can invest each day on your site, not all of those hundreds or ways are going to be as effective. You also want to avoid anything that could be considered “Black Hat SEO” as these types of tricks to increase your traffic may work in the short term, but get your website kicked out of search engine rankings.

Alexa site rank like Google’s page rank is a measure to determine how popular a particular website or blog is. And while Alexa isn’t an accurate representation since it’s only limited to those who use their toolbar it can still be an important factor when it comes to generating traffic, getting others to link to you, and advertising on your site. If you’re not familiar with how Alexa page ranking works it essentially works like this..................

Include Me 2 Club aims to change the face of social care in East Renfrewshire, by taking a person-centred, community asset-based approach.

Michael McEwan interviews Paul McIlvaney, the Chair of the project.

Transcript of episode

Music Credit: Make your dream a reality by Scott Holmes.

ARE THE GIRLS INCLUDED? if so, let's have a blast!

VIENNA, Austria (AP) - A gust of wind slammed a hot-air balloon into the ground as it was preparing to land near Austria's border with Germany on Saturday. Police said five people were injured, one seriously.
The accident happened around 11 a.m. (1000 GMT) about five kilometers (3 miles) outside the Bavarian town of Koessen as the balloon was about to touch down.
Authorities said the wind drove the basket into the ground and caused it to overturn.
One occupant suffered serious injuries, and four others were less severely hurt, Austrian public broadcaster ORF reported.
Koessen hosts a popular annual series of balloon races.

PotterCast meets to discuss and theorize old and new information in one of three new volumes from J.K. Rowling and Pottermore.

 

The new ‘national living wage’ has seen the sector’s pay bill rise by 6.9%, and further promised increases will add a total £2.3bn to wage costs

When: Thu Dec 3, 2015 to Fri Dec 4, 2015 

Where: Edinburgh, Edinburgh, UK
Event Status: confirmed
Event Description: Aimed at delegates from across Europe, this conference offers an opportunity to share the successes and challenges of recent developments across Europe, and to explore the creation of inclusive services for all children and young people as part of our shared vision of how they can fulfil their potential. For further information, please visit the event website

In light of a recent series of fires in high-rise buildings with combustible facades, including the Grenfell tower fire, the National Fire Protection Association (NFPA) has initiated a project to develop a fire risk assessment tool for these types of buildings to assist local authorities globally with fire safety in their communities.

Fire chiefs from France, the United Kingdom, and the United States gathered in Quincy, Massachusetts at the National Fire Protection Association (NFPA) Urban Fire Forum (UFF) to listen to first-hand accounts of some of the biggest emergency response incidents over the past 15 months, including hurricane response in Texas and Florida, the Grenfell Tower fire in London, and the Pulse Nightclub shooting in Orlando.

Chapel Hill-based firm Arielle Condoret Schechter is known for its commitment to building sustainable homes that don't sacrifice elegance or comfort. The company's latest work includes the spacious Haw River House, which was built with several efficient features to create a net-zero energy home that is seamlessly linked with its natural surroundings.[...]

Nestled on a gently sloping segment of land on the quiet, western end of St. Helena, California, Spottswoode Estate contains a remarkable piece of environmental history. The property became one of the first vineyards in the Napa Valley to farm 100% organically in 1985, eventually evolving into a leader in sustainable farming for the famous wine-growing region.[...]

Cybersecurity firm Cynet today announced the launch of a first of its kind challenge to enable Incident Response professionals to test their skills with 25 forensic challenges that were built by top researchers and analysts. The challenge is available on https://incident-response-challenge.com/ and is open to anyone willing to test his or her investigation skills, between April 21st and May

If you own a Xiaomi smartphone or have installed the Mi browser app on any of your other brand Android device, you should enable a newly introduced privacy setting immediately to prevent the company from spying on your online activities. The smartphone maker has begun rolling out an update to its Mi Browser/Mi Browser Pro (v12.1.4) and Mint Browser (v3.4.3) after concerns were raised over its

DigitalOcean, one of the biggest modern web hosting platforms, recently hit with a concerning data leak incident that exposed some of its customers' data to unknown and unauthorized third parties. Though the hosting company has not yet publicly released a statement, it did has started warning affected customers of the scope of the breach via an email. According to the breach notification

Dramatic action is needed now to blunt the immediate pain of vulnerable workers.