ca Puttanesca pasta By www.abc.net.au Published On :: Tue, 10 May 2016 16:37:00 +0800 8 garlic cloves, peeled 1 red chilli, deseeded and roughly chopped 1 teaspoon sea salt 8 anchovies 1/3 cup olive oil 2 punnets cherry tomatoes, cut in quarters 4 tablespoons kalamata olives, chopped 2 tablespoons baby capers, rinsed 1 cup flat leaf parsley, chopped 30g butter 500g spaghetti pasta Shaved parmesan to serve Full Article ABC Local wheatbelt Lifestyle and Leisure:Recipes:Entree Lifestyle and Leisure:Recipes:Main Lifestyle and Leisure:Recipes:Mostly Vegetarian Australia:WA:Geraldton 6530
ca Grilled rib on the bone with brocolini and cafe de paris By www.abc.net.au Published On :: Mon, 16 May 2016 12:26:00 +1000 Delicious weekend dish. Full Article ABC Local brisbane Lifestyle and Leisure:Recipes:All Australia:QLD:Brisbane 4000
ca Charred cabbage with olive and truffle tapenade By www.abc.net.au Published On :: Mon, 16 May 2016 12:44:00 +1000 Cabbage at its best. Full Article ABC Local brisbane Lifestyle and Leisure:Recipes:All Australia:QLD:Brisbane 4000
ca Mocha-Cappuccino Caramel Biscuit Cheesecake By www.abc.net.au Published On :: Mon, 23 May 2016 11:39:00 +1000 This indulgent cheesecake is as light as air, with all the ingredients of an afternoon tea rolled into one - coffee, chocolate and caramel biscuits. Full Article ABC Local widebay Lifestyle and Leisure:Recipes:All Lifestyle and Leisure:Recipes:Dessert Australia:QLD:Bundaberg 4670
ca BORLOTTI BEAN AND TUSCAN BLACK KALE (CAVOLO NERO) SOUP By www.abc.net.au Published On :: Thu, 02 Jun 2016 10:09:00 +1000 Fortunately Tuscan black kale (cavolo nero) with its sweet, earthy flavour is readily available now, however as it's gratifyingly hardy and easy to grow, if you have a small patch or pot to put some in I can't encourage you enough to do so; it will pay you back in spades. The crinkly blue/green leaves are quite tough, but with long, slow cooking they become tender and gently sweet, and that's the quality they give to this stick-to-your-ribs soup. I usually make it on the weekend when I have a bit more time to potter around in the kitchen, and love that it makes rather a lot (I've never been one to cook by halves! Although by all means make half the recipe if you'd rather not have leftovers) as having a tub tucked away in the fridge is like gold in the bank in a busy week. There's a fair bit of chopping required to start with, however once that's done the recipe is really straightforward. Full Article ABC Local northcoast Lifestyle and Leisure:Food and Cooking:All Lifestyle and Leisure:Recipes:All Lifestyle and Leisure:Recipes:Main Australia:NSW:Lismore 2480
ca Betel leaf with seared scallops, lime and sticky tamarind sauce By www.abc.net.au Published On :: Fri, 03 Jun 2016 12:26:00 +1000 Seafood in a different way by the Golden Pig. Full Article ABC Local brisbane Lifestyle and Leisure:Recipes:All Australia:QLD:All Australia:QLD:Brisbane 4000
ca Zucchini and Parmesan Savoury Pancakes By www.abc.net.au Published On :: Mon, 06 Jun 2016 10:11:00 +1000 A vegetarian dish with a tasty side salad Full Article ABC Local brisbane Lifestyle and Leisure:Recipes:All Australia:QLD:Brisbane 4000
ca Banana Choc chip cake By www.abc.net.au Published On :: Thu, 09 Jun 2016 10:28:00 +1000 A luscious light chocolate banana cake for any occasion. Do you have overripe bananas in the fruit bowl? Pop them into a freezer bag and freeze. Then when you have time to whip up this easy and delicious cake, just thaw bananas a few hours ahead at room temperature then mash them. Full Article ABC Local shepparton goulburnmurray Lifestyle and Leisure:All:All Lifestyle and Leisure:Food and Cooking:All Lifestyle and Leisure:Recipes:All Australia:VIC:Shepparton 3630 Australia:VIC:Wodonga 3690
ca Greek syrup drenched semolina, yoghurt and almond cake somali By www.abc.net.au Published On :: Fri, 10 Jun 2016 10:36:00 +1000 1 1/2 cups fine semolina 1 1/2 cups sugar 1/2 cups Greek yogurt 2 tsps. baking soda 1/2 tsp ground mastic resin, we are substituting ground fennel 3-4 tbsps. butter, melted slivered almonds For the syrup: 2 1/2 cups sugar 1 1/2 cups water 1 lemon, cut in half 1/2 tsp. rose water Dash of vanilla extract 1 cinnamon stick Full Article ABC Local widebay Lifestyle and Leisure:Recipes:All Australia:QLD:Bundaberg 4670
ca Greek cauliflower with a minted maple and tamarind sauce By www.abc.net.au Published On :: Thu, 23 Jun 2016 13:11:00 +1000 150g panko crumbs 1 clove of crushed garlic 1 tsp. ground ginger 2 tsps. curry powder 1 tsp. ground cumin 2 tsps. ground coriander 1 tsp. black mustard seeds 1 tsp. chilli flakes 2 tsps. caster sugar Pinch of salt 3 free range eggs, beaten 100g plain flour with a pinch of salt 1 cauliflower, broken in to small florets Sunflower oil for deep frying Sauce: Handful of chopped parsley Handful of chopped coriander leaves Handful of chopped mint leaves 1 tbsp. tamarind paste 1 tsp. maple syrup 1 tbsp. olive oil 2 tsps. lime juice Pinch of salt 2 tbsps. water Full Article ABC Local widebay Lifestyle and Leisure:Recipes:All Australia:QLD:Bundaberg 4670
ca Local Pecan & Carrot Cake with cheats Caramelised Fig Vanilla Ice Cream By www.abc.net.au Published On :: Thu, 30 Jun 2016 11:46:00 +1000 I love a carrot cake . Usually walnuts are used however who doesn't want to take advantage of the local new season pecans at our local markets . Happy baking! Full Article ABC Local northcoast Lifestyle and Leisure:Food and Cooking:All Lifestyle and Leisure:Recipes:All Lifestyle and Leisure:Recipes:Main Australia:NSW:Lismore 2480
ca Milk poached veal, beets, brassica, avocado By www.abc.net.au Published On :: Mon, 04 Jul 2016 12:05:00 +1000 A different take on veal to warm up a dinner party. Full Article ABC Local brisbane Lifestyle and Leisure:Recipes:All Australia:QLD:Brisbane 4000
ca Malaysian chicken satay with roasted macadamia dipping sauce By www.abc.net.au Published On :: Fri, 08 Jul 2016 12:48:00 +1000 I seriously love cooking on the Weber more in winter cooler temperature make us feel more cosy and accentuate the taste buds and smell . Replaced the traditional peanuts with our wonderful local macadamias Full Article ABC Local northcoast Lifestyle and Leisure:Food and Cooking:All Lifestyle and Leisure:Recipes:All Lifestyle and Leisure:Recipes:Main Australia:NSW:Lismore 2480
ca Chicken, Chorizo and Chick Pea Casserole By www.abc.net.au Published On :: Fri, 08 Jul 2016 14:31:00 +1000 1.25 kg free-range chicken pieces eg thighs and legs 1/4 cup seasoned plain flour 1 1/2 tablespoons olive oil 1 large onion, chopped 2 cloves garlic, crushed or chopped 150g raw chorizo, thickly sliced 1 cup chopped celery 2 medium carrots, peeled and diced 3/4 cup dry white wine eg Riesling, pinot grigio or vermentino 3/4 cup chicken stock 400g can diced tomatoes with juice 1 tablespoon finely chopped fresh thyme or oregano 2 wide strips lemon zest salt and freshly ground black pepper, to taste 400g can chick peas, drained and rinsed* *When in season, use whole peeled and blanched fresh or frozen chestnuts in place of chick peas. Full Article ABC Local shepparton goulburnmurray Lifestyle and Leisure:All:All Lifestyle and Leisure:Recipes:All Australia:VIC:Shepparton 3630 Australia:VIC:Wodonga 3690
ca Roasted Baby Carrot Moroccan Style By www.abc.net.au Published On :: Tue, 23 Aug 2016 15:43:00 +1000 This recipe features on Foodie Tuesday, a weekly segment on 774 Drive with Raf Epstein, 3.30PM, shared by Jad Choucair of Mankoushe. Full Article ABC Local melbourne Lifestyle and Leisure:Recipes:All Australia:VIC:Melbourne 3000
ca Brussels Sprout Caesar with Croutons, Borlotti Beans and Sunflower Seeds By www.abc.net.au Published On :: Tue, 06 Sep 2016 12:23:00 +1000 This recipe features on Foodie Tuesday, a weekly segment on 774 Drive with Raf Epstein, 3.30PM, shared by Hetty McKinnon, founder of Surry Hills community kitchen Arthur Street Kitchen and author of 'Neighbourhood'. Full Article ABC Local melbourne Lifestyle and Leisure:Recipes:All Australia:VIC:Melbourne 3000
ca Eucalyptus smoked Marburg emu fillet, beets, macadamia plus Lilly Pilly and finger lime spritzer By www.abc.net.au Published On :: Mon, 19 Sep 2016 10:34:00 +1000 Delicious Australian dish with fresh Lilly Pilly and finger lime spritzer. Full Article ABC Local brisbane Lifestyle and Leisure:Recipes:All Australia:QLD:Brisbane 4000
ca Calamari and fermented celeriac, barbecued peas and beef fat By www.abc.net.au Published On :: Tue, 20 Sep 2016 12:17:00 +1000 This recipe features on Foodie Tuesday, a weekly segment on 774 Drive with Raf Epstein, 3.30PM, shared by Dan Hunter, chef and owner of Otways' restaurant Brae. Full Article ABC Local melbourne Lifestyle and Leisure:Recipes:All Australia:VIC:Melbourne 3000
ca Duck with scallop and potato salad By www.abc.net.au Published On :: Wed, 21 Sep 2016 14:38:00 +1000 2 duck breast, skin on. 2g five spice 2g dried ground ginger 5g salt flakes 4 scallops, roe on. sweet wasabi dressing potato salad Full Article ABC Local shepparton goulburnmurray Lifestyle and Leisure:Recipes:All Australia:VIC:Shepparton 3630 Australia:VIC:Wodonga 3690
ca BBQ Moreton Bay bugs with asparagus, butter, lemon and capers By www.abc.net.au Published On :: Mon, 10 Oct 2016 10:56:00 +1000 A simple summer seafood dish! Full Article ABC Local brisbane Lifestyle and Leisure:Recipes:All Australia:QLD:Brisbane 4000
ca Bush food macadamia, white chocolate and pepperleaf cookies By www.abc.net.au Published On :: Fri, 21 Oct 2016 13:39:00 +1000 125g butter, softened 1 cup caster sugar 1 egg 1 tsp vanilla essence 1 and 1/2 cups plain flour, sifted 1 tsp baking powder 1/4 tsp. pepper leaf spice, ground 1 cup white chocolate chips 1/3 cup raw macadamia nuts, chopped Full Article ABC Local widebay Lifestyle and Leisure:Recipes:All Australia:QLD:Bundaberg 4670
ca MACADAMIA PESTO POTATO SALAD WITH CRISPY PROSCIUTTO AND MARKET CHERRY TOMATOES By www.abc.net.au Published On :: Tue, 25 Oct 2016 06:24:00 +1100 Love this time of year where our makers are abundant with the sweet aroma of fresh basil . Here is my take on a fancy potato salad of macadamia pesto , crispy prosciutto, sweet cherry tomatoes Full Article ABC Local northcoast Lifestyle and Leisure:Food and Cooking:All Lifestyle and Leisure:Recipes:All Lifestyle and Leisure:Recipes:Main Australia:NSW:Lismore 2480
ca CAULIFLOWER PAKORAS WITH MINTED YOGURT By www.abc.net.au Published On :: Thu, 27 Oct 2016 11:34:00 +1100 These tasty little Indian Fritters will convert a body who has a dislike of cauliflower. Served simply with a minty yogurt they are simply delicious. Full Article ABC Local northcoast Lifestyle and Leisure:Food and Cooking:All Lifestyle and Leisure:Recipes:All Lifestyle and Leisure:Recipes:Main Australia:NSW:Lismore 2480
ca Seared Tasmanian salmon, fennel, caper, parsley By www.abc.net.au Published On :: Mon, 21 Nov 2016 11:28:00 +1000 Salmon and fennel at its best. Full Article ABC Local brisbane Lifestyle and Leisure:Recipes:All Australia:QLD:Brisbane 4000
ca Gateway Chocolate Mud Cake By www.abc.net.au Published On :: Tue, 29 Nov 2016 12:14:00 +1100 This recipe features on Foodie Tuesday, a weekly segment on 774 Drive at 3.30PM. It was shared by Monique Bowley, director of Podcasts at Mamamia Womens Network, and one-time Great Australian Bake Off contestant. Full Article ABC Local melbourne Lifestyle and Leisure:Recipes:All Australia:VIC:Melbourne 3000
ca Upside down local tomato, goats cheese and onion tart By www.abc.net.au Published On :: Thu, 05 Jan 2017 10:24:00 +1100 Always a winner taking advantage of the local summer tomatoes . Who doesn't like flaky puff pastry? Full Article ABC Local northcoast Lifestyle and Leisure:Food and Cooking:All Lifestyle and Leisure:Recipes:All Lifestyle and Leisure:Recipes:Main Australia:NSW:Lismore 2480
ca Lady finger parfait with warm chocolate sauce and crushed Honey Macadamias By www.abc.net.au Published On :: Thu, 19 Jan 2017 06:26:00 +1100 The local lady finger bananas are so sweet and moorish! Full Article ABC Local northcoast Lifestyle and Leisure:Food and Cooking:All Lifestyle and Leisure:Recipes:All Lifestyle and Leisure:Recipes:Main Australia:NSW:Lismore 2480
ca Picante de pescado sauce By www.abc.net.au Published On :: Tue, 07 Feb 2017 12:25:00 +1100 Alejandro Saravia from Pastuso, shared this recipe on Foodie Tuesday, a weekly segment on ABC Radio Melbourne's Drive program at 3.30pm. Full Article ABC Local melbourne Lifestyle and Leisure:Recipes:All Australia:VIC:Melbourne 3000
ca Raw and char-grilled broccoli salad with macadamia and semi-hard goats cheese By www.abc.net.au Published On :: Thu, 16 Feb 2017 10:33:00 +1100 This salad is inspired by a good chef friend of mine who cooked with me last weekend. Such a healthy way to enjoy broccoli which is so delicious at the moment. It's wonderful to utilize the whole vegetable and the added fibre in the stalk which we use in the salad.Feel free to explore with certain quantities in this recipe therefore I encourage you to taste and adjust to your own personal taste. You can also add chopped green olives which add an extra dimension. Full Article ABC Local northcoast Lifestyle and Leisure:Food and Cooking:All Lifestyle and Leisure:Recipes:All Lifestyle and Leisure:Recipes:Main Australia:NSW:Lismore 2480
ca Parmesan and Herby Crumbed Pork Loin with raw cabbage salad and lemon By www.abc.net.au Published On :: Thu, 02 Mar 2017 07:55:00 +1100 4 x 150 x g of pork loin steaks as your butcher to cut 3 x cup (210 g) Panko Breadcrumbs (Japanese bread crumb) 1/2 cup (80g) Plain flour Chopped flat leaf parsley, thyme, rosemary 2 Eggs, lightly beaten 1/2cup (80g) finely grated Parmesan CABBAGE SLAW 500 grams of Cabbage finely shredded Squeezed of Lemon juice 1/4 cup (60 ml) quality cider vinegar add to taste. May need less. 2 Tablespoon of Macadamia Oil 1 Tablespoon chop parsley Aioli just a little bit to bind Sea salt and cracked pepper 100 ml Macadamia oil for cooking 4 juicy lemon wedges to squeeze over Pork Full Article ABC Local northcoast Lifestyle and Leisure:Food and Cooking:All Lifestyle and Leisure:Recipes:All Lifestyle and Leisure:Recipes:Main Australia:NSW:Lismore 2480
ca Autumn roasted vegetables with lemon thyme and a drizzle of macadamia honey By www.abc.net.au Published On :: Thu, 16 Mar 2017 13:45:00 +1100 Nothing beats beautifully roasted vegetables caramelized in their own sugar content to accompany a simple roast dinner or even on their own with a nice salad. The addition of perfumed lemon thyme and macadamia gives a nice touch. Full Article ABC Local northcoast Lifestyle and Leisure:Food and Cooking:All Lifestyle and Leisure:Recipes:All Lifestyle and Leisure:Recipes:Main Australia:NSW:Lismore 2480
ca Chocolate and Hazelnut Cake By www.abc.net.au Published On :: Thu, 30 Mar 2017 12:35:00 +1100 There is nothing more indulgent than a piece of chocolate cake, beautiful with fresh raspberries and a dollop of cream on the side. My partner in crime made this cake last week, its fudgy texture is both delicious and surprisingly not too rich in flavour like chocolate cakes can be. Full Article ABC Local northcoast Lifestyle and Leisure:Food and Cooking:All Lifestyle and Leisure:Recipes:All Lifestyle and Leisure:Recipes:Main Australia:NSW:Lismore 2480
ca Indian cauliflower rice and coriander pesto By www.abc.net.au Published On :: Thu, 20 Apr 2017 12:50:00 +1000 Cauliflower rice: 1 head cauliflower, cut into florets 2 tbsps. ghee Coriander pesto: 1 large bunch coriander 1 garlic clove 1/4 cup cashews 2 tbsps. parmesan, finely grated 1 lime, zested and juiced 3 tbsps. coconut oil Full Article ABC Local widebay Lifestyle and Leisure:Recipes:All Australia:QLD:Bundaberg 4670
ca Roast local pork belly with caramelised pear sauce By www.abc.net.au Published On :: Thu, 27 Apr 2017 06:20:00 +1000 Plenty of pears around at the moment. This sauce is a nice alternative to the traditional apple sauce with pork. Full Article ABC Local northcoast Lifestyle and Leisure:Food and Cooking:All Lifestyle and Leisure:Recipes:All Lifestyle and Leisure:Recipes:Main Australia:NSW:Lismore 2480
ca French salted caramel ganache tart By www.abc.net.au Published On :: Thu, 04 May 2017 13:39:00 +1000 An indulgent French chocolate and salted caramel tart. Decorate with fresh raspberries and pistachio nuts for great colour and a sweet zing. Full Article ABC Local widebay Lifestyle and Leisure:Food and Cooking:All Australia:QLD:Bundaberg 4670
ca Rice and macadamia salad By www.abc.net.au Published On :: Thu, 01 Jun 2017 13:38:00 +1000 This salad is our go-to staple. Everyone loves it. It's healthy, colourful and so, so easy. It can also be made entirely with local ingredients. Full Article ABC Local northcoast Lifestyle and Leisure:Food and Cooking:All Lifestyle and Leisure:Recipes:All Lifestyle and Leisure:Recipes:Main Australia:NSW:Lismore 2480
ca Goat's Curd Bavarois with Cardamom Apples By www.abc.net.au Published On :: Thu, 29 Jun 2017 06:38:00 +1000 Exotic, different, really cool flavours, pared-back dessert and it's not too sweet. Enjoy! Full Article ABC Local northcoast Lifestyle and Leisure:Food and Cooking:All Lifestyle and Leisure:Recipes:All Lifestyle and Leisure:Recipes:Main Australia:NSW:Lismore 2480
ca CASSAVA LEAVES AND UGALI By www.abc.net.au Published On :: Wed, 09 Aug 2017 12:58:00 +1000 Cassava leaves and Ugali - a traditional Congolese dish ... and much, much more. Gigi Mapatano Full Article ABC Local northcoast Lifestyle and Leisure:Food and Cooking:All Lifestyle and Leisure:Recipes:All Lifestyle and Leisure:Recipes:Main Australia:NSW:Lismore 2480
ca Spring chicken & mushroom casserole By www.abc.net.au Published On :: Wed, 11 Oct 2017 12:47:00 +1100 Easy weekend entertaining featuring another great recipe from Geoff Jansz Full Article ABC Local northcoast Lifestyle and Leisure:Food and Cooking:All Lifestyle and Leisure:Recipes:All Lifestyle and Leisure:Recipes:Main Australia:NSW:Lismore 2480
ca As More Migrants from Africa and Asia Arrive in Latin America, Governments Seek Orderly and Controlled Pathways By www.migrationpolicy.org Published On :: Mon, 21 Oct 2019 12:48:50 -0400 Growing numbers of African and Asian migrants are moving through Latin America, many hoping to reach the United States or Canada after expensive, arduous, and often dangerous journeys that can take months or even years. As more extracontinental migrants transit through South and Central America, Colombia, Panama, and Costa Rica have developed the most comprehensive policies to manage these flows, sometimes working in coordination with the U.S. government. Full Article
ca Latin American Responses to the Venezuelan and Nicaraguan Migration Crises By www.migrationpolicy.org Published On :: Mon, 21 Oct 2019 12:56:39 -0400 Leading policymakers and key stakeholders from Latin America, as well as representatives of major international institutions, offer their views on the challenges ahead as Latin American governments seek to chart strategies for responding to large-scale forced migration flows, such as those from Venezuela and Nicaragua. Full Article
ca Respuestas latinoamericanas a las crisis migratorias venezolanas y nicaragüenses By www.migrationpolicy.org Published On :: Fri, 01 Nov 2019 17:38:50 -0400 Responsables de políticos principales y partes interesadas de América Latina, así como representantes de instituciones internacionales claves, ofrecen sus puntos de vista sobre los desafíos futuros mientras gobiernos latinoamericanos buscan establecer las estrategias para responder a flujos migratorios forzados a gran escala, como los de Venezuela y Nicaragua. Full Article
ca Is the Door Closing? Latin American and Caribbean Responses to Venezuelan Migration By www.migrationpolicy.org Published On :: Fri, 31 Jan 2020 16:30:49 -0500 This webinar marks the release of MPI's Latin American and Caribbean Migration Portal that offers up-to-date, authoritative research and data on migration trends and policies, and a report examining the policy responses of 11 countries in Latin America and the Caribbean to increased Venezuelan and Nicaraguan migration. Full Article
ca ¿Se Están Cerrando las Puertas? Respuestas a la Migración Venezolana en América Latina y el Caribe By www.migrationpolicy.org Published On :: Mon, 03 Feb 2020 12:33:28 -0500 MPI llevó a cabo un seminario en línea para marcar el lanzamiento de: Un portal sobre Migración en América Latina y el Caribe; y un informe que examina los efectos de las políticas migratorias y de integración en 11 países en América Latina y el Caribe ante el aumento de la migración venezolana y nicaragüense. Full Article
ca An Uneven Welcome: Latin American and Caribbean Responses to Venezuelan and Nicaraguan Migration By www.migrationpolicy.org Published On :: Mon, 03 Feb 2020 17:19:48 -0500 Large-scale displacement from Venezuela and Nicaragua is reshaping the migration landscape in much of Latin America and the Caribbean. This report, accompanied by the launch of a new Migration Portal offering research and analysis on the region, examines the immigration and integration policy responses of 11 countries, including pathways to legal status and measures to integrate newcomers into schools, health-care systems, and labor markets. Full Article
ca Bienvenidas asimétricas: Respuestas de América Latina y el Caribe a la migración venezolana y nicaragüense By www.migrationpolicy.org Published On :: Mon, 10 Feb 2020 10:44:38 -0500 El gran desplazamiento forzado de personas en Venezuela y Nicaragua está transformando el panorama migratorio en gran parte de América Latina y el Caribe. Este informe examina las respuestas de las políticas de inmigración e integración de once países, incluyendo vías de regularización y medidas para integrar a los recién llegados en las escuelas y mercados laborales. Este informe acompaña el lanzamiento de un Portal Sobre Migración que ofrece investigación y análisis actualizados sobre tendencias y políticas de inmigración en la región. Full Article
ca COVID-19 in Latin America: Tackling Health Care & Other Impacts for Vulnerable Migrant Populations By www.migrationpolicy.org Published On :: Fri, 27 Mar 2020 10:58:29 -0400 This MPI webinar brought together public health and migration experts to analyze the impact that COVID-19 preventative measures will have on vulnerable immigrants and refugees in Latin America, with a particular look at Colombia as a case study. Speakers also discussed how policymakers and international organizations can include migrant populations in their emergency response plans. Full Article
ca Efficacy and Safety of Dapagliflozin in the Elderly: Analysis From the DECLARE-TIMI 58 Study By care.diabetesjournals.org Published On :: 2020-01-20T12:00:30-08:00 OBJECTIVE Data regarding the effects of sodium–glucose cotransporter 2 inhibitors in the elderly (age ≥65 years) and very elderly (age ≥75 years) are limited. RESEARCH DESIGN AND METHODS The Dapagliflozin Effect on Cardiovascular Events (DECLARE)–TIMI 58 assessed cardiac and renal outcomes of dapagliflozin versus placebo in patients with type 2 diabetes. Efficacy and safety outcomes were studied within age subgroups for treatment effect and age-based treatment interaction. RESULTS Of the 17,160 patients, 9,253 were <65 years of age, 6,811 ≥65 to <75 years, and 1,096 ≥75 years. Dapagliflozin reduced the composite of cardiovascular death or hospitalization for heart failure consistently, with a hazard ratio (HR) of 0.88 (95% CI 0.72, 1.07), 0.77 (0.63, 0.94), and 0.94 (0.65, 1.36) in age-groups <65, ≥65 to <75, and ≥75 years, respectively (interaction P value 0.5277). Overall, dapagliflozin did not significantly decrease the rates of major adverse cardiovascular events, with HR 0.93 (95% CI 0.81, 1.08), 0.97 (0.83, 1.13), and 0.84 (0.61, 1.15) in age-groups <65, ≥65 to <75, and ≥75 years, respectively (interaction P value 0.7352). The relative risk reduction for the secondary prespecified cardiorenal composite outcome ranged from 18% to 28% in the different age-groups with no heterogeneity. Major hypoglycemia was less frequent with dapagliflozin versus placebo, with HR 0.97 (95% CI 0.58, 1.64), 0.50 (0.29, 0.84), and 0.68 (0.29, 1.57) in age-groups <65, ≥65 to <75, and ≥75 years, respectively (interaction P value 0.2107). Safety outcomes, including fractures, volume depletion, cancer, urinary tract infections, and amputations were balanced with dapagliflozin versus placebo, and acute kidney injury was reduced, all regardless of age. Genital infections that were serious or led to discontinuation of the study drug and diabetic ketoacidosis were uncommon, yet more frequent with dapagliflozin versus placebo, without heterogeneity (interaction P values 0.1058 and 0.8433, respectively). CONCLUSIONS The overall efficacy and safety of dapagliflozin are consistent regardless of age. Full Article
ca Performance of the ESC 0/1-h and 0/3-h Algorithm for the Rapid Identification of Myocardial Infarction Without ST-Elevation in Patients With Diabetes By care.diabetesjournals.org Published On :: 2020-01-20T12:00:30-08:00 OBJECTIVE Patients with diabetes mellitus (DM) have elevated levels of high-sensitivity cardiac troponin (hs-cTn). We investigated the diagnostic performance of the European Society of Cardiology (ESC) algorithms to rule out or rule in acute myocardial infarction (AMI) without ST-elevation in patients with DM. RESEARCH DESIGN AND METHODS We prospectively enrolled 3,681 patients with suspected AMI and stratified those by the presence of DM. The ESC 0/1-h and 0/3-h algorithms were used to calculate negative and positive predictive values (NPV, PPV). In addition, alternative cutoffs were calculated and externally validated in 2,895 patients. RESULTS In total, 563 patients (15.3%) had DM, and 137 (24.3%) of these had AMI. When the ESC 0/1-h algorithm was used, the NPV was comparable in patients with and without DM (absolute difference [AD] –1.50 [95% CI –5.95, 2.96]). In contrast, the ESC 0/3-h algorithm resulted in a significantly lower NPV in patients with DM (AD –2.27 [95% CI –4.47, –0.07]). The diagnostic performance for rule-in of AMI (PPV) was comparable in both groups: 0/1-h (AD 6.59 [95% CI –19.53, 6.35]) and 0/3-h (AD 1.03 [95% CI –7.63, 9.7]). Alternative cutoffs increased the PPV in both algorithms significantly, while improvements in NPV were only subtle. CONCLUSIONS Application of the ESC 0/1-h algorithm revealed comparable safety to rule out AMI comparing patients with and without DM, while this was not observed with the ESC 0/3-h algorithm. Although alternative cutoffs might be helpful, patients with DM remain a high-risk population in whom identification of AMI is challenging and who require careful clinical evaluation. Full Article
ca Myocardial Ischemic Burden and Differences in Prognosis Among Patients With and Without Diabetes: Results From the Multicenter International REFINE SPECT Registry By care.diabetesjournals.org Published On :: 2020-01-20T12:00:30-08:00 OBJECTIVE Prevalence and prognostic impact of cardiovascular disease differ between patients with or without diabetes. We aimed to explore differences in the prevalence and prognosis of myocardial ischemia by automated quantification of total perfusion deficit (TPD) among patients with and without diabetes. RESEARCH DESIGN AND METHODS Of 20,418 individuals who underwent single-photon emission computed tomography myocardial perfusion imaging, 2,951 patients with diabetes were matched to 2,951 patients without diabetes based on risk factors using propensity score. TPD was categorized as TPD = 0%, 0% < TPD < 1%, 1% ≤ TPD < 5%, 5% ≤ TPD ≤ 10%, and TPD >10%. Major adverse cardiovascular events (MACE) were defined as a composite of all-cause mortality, myocardial infarction, unstable angina, or late revascularization. RESULTS MACE risk was increased in patients with diabetes compared with patients without diabetes at each level of TPD above 0 (P < 0.001 for interaction). In patients with TPD >10%, patients with diabetes had greater than twice the MACE risk compared with patients without diabetes (annualized MACE rate 9.4 [95% CI 6.7–11.6] and 3.9 [95% CI 2.8–5.6], respectively, P < 0.001). Patients with diabetes with even very minimal TPD (0% < TPD < 1%) experienced a higher risk for MACE than those with 0% TPD (hazard ratio 2.05 [95% CI 1.21–3.47], P = 0.007). Patients with diabetes with a TPD of 0.5% had a similar MACE risk as patients without diabetes with a TPD of 8%. CONCLUSIONS For every level of TPD >0%, even a very minimal deficit of 0% < TPD < 1%, the MACE risk was higher in the patients with diabetes compared with patients without diabetes. Patients with diabetes with minimal ischemia had comparable MACE risk as patients without diabetes with significant ischemia. Full Article