mo

[ASAP] Bromo-spiroisoxazoline Alkaloids, Including an Isoserine Peptide, from the Caribbean Marine Sponge <italic toggle="yes">Aplysina lacunosa</italic>

Journal of Natural Products
DOI: 10.1021/acs.jnatprod.9b01286




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[ASAP] Effect of Temperature on <sup>1</sup>H NMR Spectra, Antitrypanosomal Activity, Conformational Analysis, and Molecular Docking of Curine Derivatives from <italic toggle="yes">Berberis brevissima</italic>

Journal of Natural Products
DOI: 10.1021/acs.jnatprod.9b00397




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[ASAP] Inhibitory Effect of Cannabidiol on the Activation of NLRP3 Inflammasome Is Associated with Its Modulation of the P2X7 Receptor in Human Monocytes

Journal of Natural Products
DOI: 10.1021/acs.jnatprod.0c00138




mo

Highlight.js 10, Node 14, and modern React in 20 minutes

#485 — April 24, 2020

Unsubscribe  :  Read on the Web

JavaScript Weekly

Introducing Crank.js: A New JSX-Driven Framework — A new framework for creating JSX-driven components with functions, promises and generators. If you haven’t got time to read the creator’s lengthy (but well worth reading!) rationale for creating another framework, check out the GitHub repo or jump straight into a CodeSandbox example. I hope to see a lot more about this in the near future.

Brian Kim

The Cost of JavaScript Frameworks — Using data from the HTTP Archive, Tim explores the performance cost of using various popular frameworks as a starting point. Some good analysis here.

Tim Kadlec

You Hacked the Gibson? Yeah, They Built Their Own Login — Don't let Crash Override pwn your app. FusionAuth adds secure login, registration and user management to your app in minutes not months. Download our community edition for free.

FusionAuth sponsor

Node.js 14 Released — v14 now becomes the current ‘release’ line with it becoming a LTS (Long Term Support) release in October. Diagnostic reports are now a stable feature, it now uses V8 8.1, there's an experimental Async Local Storage API, and more.

Michael Dawson and Bethany Griggs

Vidact: A Compiler to Convert React-like Apps to Vanilla JS — Compiles pure React-compatible JavaScript (JSX) to vanilla JavaScript with no virtual DOM.. think similar to Svelte, but without introducing a new syntax. A curious idea.

Mohamad Mohebifar

Highlight.js 10.0: The Web Syntax Highlighter Library — I always laugh when I see a big release of a popular library and saw we last linked it 5 years ago ???? Nonetheless, this is a big release and Highlight.js continues to be a fantastic library for syntax highlighting code.

highlight.js

???? Jobs

Senior Full-stack Developer (Malmö/Sweden) — Every day is different from the next. Join our upbeat Team and work on exciting, major projects using a modern JavaScript stack.

Ortelius AB

Find a Job Through Vettery — Vettery specializes in tech roles and is completely free for job seekers. Create a profile to get started.

Vettery

???? Tutorials

▶  React: The Basics in 20 Minutes — A well presented, up to date (yep, it covers hooks) tutorial that doesn’t hang around, whether you’re new to React or just want a refresher.

Devistry

Creating Web Apps via TypeScript and webpack — The example app doesn’t use any front-end framework, just vanilla DOM APIs. Some knowledge of TypeScript, webpack, and npm are required, but this is a neat way to bring together a bunch of tools.

Axel Rauschmayer

What Is The toJSON() Function? — If an object has a toJSON function, JSON.stringify() calls toJSON() and serializes the return value from toJSON() instead.

Valeri Karpov

A Much Faster Way to Debug Code Than with Breakpoints or console.log — Move forward and backwards through your code to understand what led to a specific bug, view runtime values, edit-and-continue, and more.

Wallaby.js sponsor

How Does TypeScript Work? A Bird’s Eye View — Dr. Axel goes into depth on the structure of a typical TypeScript project, what gets compiled, and how can an IDE be used to write TypeScript. Aimed at people who haven’t yet picked TypeScript up.

Axel Rauschmayer

10 Lesser Known Angular Features You've Probably Never Used

W3Radar

You Might Not Need switch — Using an object of outcomes instead of switch suits many use cases, though take care over readability.

Valentino Gagliardi

???? Upcoming Online Events

  • Pick JS (May 8) — Aimed at intermediate to expert JS developers rather than beginners.
  • JavaScript Remote Conf 2020 (May 14-15) — Speakers lined up already include Douglas Crockford, Aimee Knight and Christian Heilmann.
  • ESNEXT CONF 2020 (May 18-22) — From the Pika folks (of Snowpack fame). 12 speakers over 5 days so it's a gradual pace.
  • ForwardJS (May 26-29) — A real world event (ForwardJS Ottawa) that has now become a virtual event.
  • CascadiaJS 2020 (September 1-2) — This upcoming online conference is set to take place in September, and the CFP is open now through May 15.

???? Code & Tools

Phelia: A Reactive Slack Application Framework — If you think Slack apps were all about text bots, think again.. you can now create apps complete with in-app UIs. Phelia brings the React approach to the task.

Max Chehab

Marked.js 1.0: A Fast Markdown Parser and Compiler — Got Markdown to render? Marked.js to the rescue. While the project is years old, 1.0 has dropped just this week. Here’s a live demo.

Christopher Jeffrey

Stream Chat API & JavaScript SDK for Custom Chat Apps — Build real-time chat in less time. Rapidly ship in-app messaging with our highly reliable chat infrastructure.

Stream sponsor

Alpine.js: A Minimal Framework for Composing JS Behavior in Your Markup — We only gave Alpine a brief link when it first dropped but with new versions coming out thick and fast, we think it’s well worth a look. Billed as “like Tailwind for JavaScript”, Alpine lets you keep the HTML you know and love and just pepper it with JavaScript as and where appropriate.

Alpine.js

enroute: A React Router with a Small Footprint for Modern Browsers

TJ Holowaychuk

Rosetta: A General Purpose Internationalization Library in 292 Bytes — Less than 300 bytes, but does have a few dependencies. Aims to be very simple and is targeted at basic string use cases.

Luke Edwards

NAB 2020 May Be Canceled, But The Full Bitmovin Experience Is Not

Bitmovin Inc. sponsor

Hotkey 1.4: Trigger an Action on an Element When a 'Hotkey' is Pressed — Use Hotkey, set the data-hotkey attribute on your elements, and you get keyboard shortcuts. GitHub built and uses it (look for the data-hotkey attributes on their pages).

GitHub

web-worker: Consistent Web Workers for the Browser and Node — In Node it works as a web-compatible Worker implementation atop worker_threads. In the browser it’s an alias for Worker.

Jason Miller




mo

New tax structure will leave more cash in the hands of people: Revenue Secy

He said the Budget gives an option to individuals to migrate to a new regime by foregoing their existing exemptions and deductions for a lower tax rate




mo

Budget 2020: Rs 2,500 cr not enough for tourism promotion, says industry

Tourism bodies say Indians spending Rs 9,000 cr abroad abroad due to poor domestic infra, which cannot be improved with this allocation




mo

No timeline to remove income tax exemptions, says Nirmala Sitharaman

"We have not made up our minds as yet (on the removal of all exemptions)... We are trying step by step, move forward and no particular timeline given," she said




mo

Understanding Depression and Distress Among Medical Students

Interview with Laura Weiss Roberts, MD, MA, author of Understanding Depression and Distress Among Medical Students




mo

Substituted Interests and Best Judgments: An Integrated Model of Surrogate Decision Making

Interview with Daniel P. Sulmasy, MD, PhD, author of Substituted Interests and Best Judgments: An Integrated Model of Surrogate Decision Making




mo

Biosafety Concerns Involving Genetically Modified Mosquitoes to Combat Malaria and Dengue in Developing Countries

Interview with Lawrence O. Gostin, JD, author of Biosafety Concerns Involving Genetically Modified Mosquitoes to Combat Malaria and Dengue in Developing Countries




mo

Quality of Life, Burnout, Educational Debt, and Medical Knowledge Among Internal Medicine Residents

Interview with Colin P. West, MD, PhD, author of Quality of Life, Burnout, Educational Debt, and Medical Knowledge Among Internal Medicine Residents




mo

Prevalence and Outcomes of Same-Day Discharge After Elective Percutaneous Coronary Intervention Among Older Patients

Interview with Sunil V. Rao, MD, author of Prevalence and Outcomes of Same-Day Discharge After Elective Percutaneous Coronary Intervention Among Older Patients




mo

Use of Electron-Beam Sterilized Hemodialysis Membranes and Risk of Thrombocytopenia

Interview with Mercedeh Kiaii, MD, author of Use of Electron-Beam Sterilized Hemodialysis Membranes and Risk of Thrombocytopenia




mo

National and Regional Trends in Heart Failure Hospitalization and Mortality Rates for Medicare Beneficiaries, 1998-2008

Interview with Jersey Chen, MD, MPH, author of National and Regional Trends in Heart Failure Hospitalization and Mortality Rates for Medicare Beneficiaries, 1998-2008




mo

Identification of Chronic Obstructive Pulmonary Disease in Lung Cancer Screening Computed Tomographic Scans

Interview with Pim A. de Jong, MD, PhD, author of Identification of Chronic Obstructive Pulmonary Disease in Lung Cancer Screening Computed Tomographic Scans




mo

Moderate Alcohol Consumption During Adult Life, Drinking Patterns, and Breast Cancer Risk

Interview with Wendy Y. Chen, MD, MPH, author of Moderate Alcohol Consumption During Adult Life, Drinking Patterns, and Breast Cancer Risk




mo

Effect of Intracoronary Delivery of Autologous Bone Marrow Mononuclear Cells 2 to 3 Weeks Following Acute Myocardial Infarction on Left Ventricular Function: The LateTIME Randomized Trial

Interview with Jay H. Traverse, MD, author of Effect of Intracoronary Delivery of Autologous Bone Marrow Mononuclear Cells 2 to 3 Weeks Following Acute Myocardial Infarction on Left Ventricular Function: The LateTIME Randomized Trial




mo

Effects of the CETP Inhibitor Evacetrapib Administered as Monotherapy or in Combination With Statins on HDL and LDL Cholesterol: A Randomized Controlled Trial

Interview with Steven E. Nissen, MD, author of Effects of the CETP Inhibitor Evacetrapib Administered as Monotherapy or in Combination With Statins on HDL and LDL Cholesterol: A Randomized Controlled Trial




mo

Association Between Valvular Surgery and Mortality Among Patients With Infective Endocarditis Complicated by Heart

Interview with Andrew Wang, MD, author of Association Between Valvular Surgery and Mortality Among Patients With Infective Endocarditis Complicated by Heart Failure




mo

Association of Antenatal Corticosteroids With Mortality and Neurodevelopmental Outcomes Among Infants Born at 22 to 25 Weeks' Gestation

Interview with Waldemar A. Carlo, MD, author of Association of Antenatal Corticosteroids With Mortality and Neurodevelopmental Outcomes Among Infants Born at 22 to 25 Weeks' Gestation




mo

Causes of Death Among Stillbirths

Interview with Robert M. Silver, MD, author of Causes of Death Among Stillbirths




mo

Association Between Marijuana Exposure and Pulmonary Function Over 20 Years

Interview with Stefan Kertesz, MD, author of Association Between Marijuana Exposure and Pulmonary Function Over 20 Years




mo

Moderate to Vigorous Physical Activity and Sedentary Time and Cardiometabolic Risk Factors in Children and Adolescents

Interview with Ulf Ekelund, PhD, author of Moderate to Vigorous Physical Activity and Sedentary Time and Cardiometabolic Risk Factors in Children and Adolescents




mo

Amoxicillin for Acute Rhinosinusitis: A Randomized Controlled Trial

Interview with Jay F. Piccirillo, MD, author of Amoxicillin for Acute Rhinosinusitis: A Randomized Controlled Trial




mo

Association of Age and Sex With Myocardial Infarction Symptom Presentation and In-Hospital Mortality

Interview with John G. Canto, MD, MSPH, author of Association of Age and Sex With Myocardial Infarction Symptom Presentation and In-Hospital Mortality




mo

Association of Hospital Spending Intensity With Mortality and Readmission Rates in Ontario Hospitals

Interview with Therese A. Stukel, PhD, author of Association of Hospital Spending Intensity With Mortality and Readmission Rates in Ontario Hospitals




mo

Out-of-Pocket Medication Costs and Use of Medications and Health Care Services Among Children With Asthma

Interview with Dana P. Goldman, PhD, author of Out-of-Pocket Medication Costs and Use of Medications and Health Care Services Among Children With Asthma




mo

Detection of Breast Cancer With Addition of Annual Screening Ultrasound or a Single Screening MRI to Mammography in Women With Elevated Breast Cancer Risk

Interview with Wendie A. Berg, MD, PhD, author of Detection of Breast Cancer With Addition of Annual Screening Ultrasound or a Single Screening MRI to Mammography in Women With Elevated Breast Cancer Risk




mo

Association Between Treatment With Brachytherapy vs Whole-Breast Irradiation and Subsequent Mastectomy, Complications, and Survival Among Older Women With Invasive Breast Cancer

Interview with Benjamin D. Smith, MD, author of Association Between Treatment With Brachytherapy vs Whole-Breast Irradiation and Subsequent Mastectomy, Complications, and Survival Among Older Women With Invasive Breast Cancer




mo

HIV Development Assistance and Adult Mortality in Africa

Interview with Eran Bendavid, MD, MS, author of HIV Development Assistance and Adult Mortality in Africa




mo

Effect of Telephone-Administered vs Face-to-face Cognitive Behavioral Therapy on Adherence to Therapy and Depression Outcomes Among Primary Care Patients: A Randomized Trial

Interview with David C. Mohr, PhD, author of Effect of Telephone-Administered vs Face-to-face Cognitive Behavioral Therapy on Adherence to Therapy and Depression Outcomes Among Primary Care Patients: A Randomized Trial




mo

Association Between Vaccination for Herpes Zoster and Risk of Herpes Zoster Infection Among Older Patients With Selected Immune-Mediated Diseases: Herpes Zoster and Immune-Mediated Diseases

Interview with Jeffrey R. Curtis, MD, MS, author of Association Between Vaccination for Herpes Zoster and Risk of Herpes Zoster Infection Among Older Patients With Selected Immune-Mediated Diseases: Herpes Zoster and Immune-Mediated Diseases




mo

Trends in Serum Lipids Among US Youths Aged 6 to 19 Years, 1988-2010

Interview with Brian K. Kit, MD, MPH, author of Trends in Serum Lipids Among US Youths Aged 6 to 19 Years, 1988-2010




mo

Effect of Biolimus-Eluting Stents With Biodegradable Polymer vs Bare-Metal Stents on Cardiovascular Events Among Patients With Acute Myocardial Infarction: The COMFORTABLE AMI Randomized Trial

Interview with Stephan Windecker, MD, author of Effect of Biolimus-Eluting Stents With Biodegradable Polymer vs Bare-Metal Stents on Cardiovascular Events Among Patients With Acute Myocardial Infarction: The COMFORTABLE AMI Randomized Trial




mo

Total Knee Arthroplasty Volume, Utilization, and Outcomes Among Medicare Beneficiaries, 1991-2010

Interview with Peter Cram, MD, MBA, author of Total Knee Arthroplasty Volume, Utilization, and Outcomes Among Medicare Beneficiaries, 1991-2010




mo

Association of Public Reporting for Percutaneous Coronary Intervention With Utilization and Outcomes Among Medicare Beneficiaries With Acute Myocardial Infarction

Interview with Karen E. Joynt, MD, MPH, author of Association of Public Reporting for Percutaneous Coronary Intervention With Utilization and Outcomes Among Medicare Beneficiaries With Acute Myocardial Infarction




mo

Hospitalizations and Mortality Associated With Norovirus Outbreaks in Nursing Homes, 2009-2010

Interview with Tarak K. Trivedi, BS, author of Hospitalizations and Mortality Associated With Norovirus Outbreaks in Nursing Homes, 2009-2010




mo

Effect of a Protected Sleep Period on Hours Slept During Extended Overnight In-hospital Duty Hours Among Medical Interns: A Randomized Trial

Interview with Kevin G. Volpp, MD, PhD, author of Effect of a Protected Sleep Period on Hours Slept During Extended Overnight In-hospital Duty Hours Among Medical Interns: A Randomized Trial




mo

General Medicine vs Subspecialty Career Plans Among Internal Medicine Residents

Interview with Colin P. West, MD, PhD, author of General Medicine vs Subspecialty Career Plans Among Internal Medicine Residents




mo

Association of Clopidogrel Pretreatment With Mortality, Cardiovascular Events, and Major Bleeding Among Patients Undergoing Percutaneous Coronary Intervention: A Systematic Review and Meta-analysis

Interview with Gilles Montalescot, MD, PhD, author of Association of Clopidogrel Pretreatment With Mortality, Cardiovascular Events, and Major Bleeding Among Patients Undergoing Percutaneous Coronary Intervention: A Systematic Review and Meta-analysis




mo

Prevalence of and Risk Factors for Autopsy-Determined Atherosclerosis Among US Service Members, 2001-2011

Interview with Bryant J. Webber, MD, author of Prevalence of and Risk Factors for Autopsy-Determined Atherosclerosis Among US Service Members, 2001-2011




mo

Association of All-Cause Mortality With Overweight and Obesity Using Standard Body Mass Index Categories: A Systematic Review and Meta-analysis

Interview with Katherine M. Flegal, PhD, author of Association of All-Cause Mortality With Overweight and Obesity Using Standard Body Mass Index Categories: A Systematic Review and Meta-analysis




mo

Diagnoses and Timing of 30-Day Readmissions After Hospitalization for Heart Failure, Acute Myocardial Infarction, or Pneumonia

Interview with Harlan M. Krumholz, MD, SM, author of Diagnoses and Timing of 30-Day Readmissions After Hospitalization for Heart Failure, Acute Myocardial Infarction, or Pneumonia




mo

Robotically Assisted vs Laparoscopic Hysterectomy Among Women With Benign Gynecologic Disease

Interview with Jason D. Wright, MD, author of Robotically Assisted vs Laparoscopic Hysterectomy Among Women With Benign Gynecologic Disease




mo

Association Between the Initiation of Anti-Tumor Necrosis Factor Therapy and the Risk of Herpes Zoster

Interview with Kevin L Winthrop, MD, MPH, author of Association Between the Initiation of Anti-Tumor Necrosis Factor Therapy and the Risk of Herpes Zoster




mo

Association of Smoking Cessation and Weight Change With Cardiovascular Disease Among People With and Without Diabetes

Interview with James B. Meigs, MD, MPH, author of Association of Smoking Cessation and Weight Change With Cardiovascular Disease Among People With and Without Diabetes




mo

Long-term Mortality After Stroke Among Adults Aged 18 to 50 Years

Interview with Frank-Erik de Leeuw, MD, PhD and Loes C. A. Rutten-Jacobs, MSc, authors of Long-term Mortality After Stroke Among Adults Aged 18 to 50 Years




mo

Effect of Duloxetine on Pain, Function, and Quality of Life Among Patients With Chemotherapy-Induced Painful Peripheral Neuropathy: A Randomized Clinical Trial

Interview with Ellen M. Lavoie Smith, PhD, author of Effect of Duloxetine on Pain, Function, and Quality of Life Among Patients With Chemotherapy-Induced Painful Peripheral Neuropathy: A Randomized Clinical Trial




mo

Prevalence of a Healthy Lifestyle Among Individuals With Cardiovascular Disease in High-, Middle- and Low-Income Countries: The Prospective Urban Rural Epidemiology (PURE) Studyterview

Interview with Koon Teo, MB, PhD, author of Prevalence of a Healthy Lifestyle Among Individuals With Cardiovascular Disease in High-, Middle- and Low-Income Countries: The Prospective Urban Rural Epidemiology (PURE) Study




mo

Short-term vs Conventional Glucocorticoid Therapy in Acute Exacerbations of Chronic Obstructive Pulmonary Disease: The REDUCE Randomized Clinical Trial

Interview with Jonas Rutishauser, MD, author of Short-term vs Conventional Glucocorticoid Therapy in Acute Exacerbations of Chronic Obstructive Pulmonary Disease: The REDUCE Randomized Clinical Trial