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Protein misfolding and amyloid nucleation through liquid–liquid phase separation

Chem. Soc. Rev., 2024, Advance Article
DOI: 10.1039/D3CS01065A, Review Article
Semanti Mukherjee, Manisha Poudyal, Kritika Dave, Pradeep Kadu, Samir K. Maji
Protein misfolding and amyloid aggregation, linked to neurodegenerative diseases, can result from liquid–liquid phase separation (LLPS) and a subsequent liquid-to-solid transition. This represents LLPS as a generic mechanism in amyloid nucleation.
To cite this article before page numbers are assigned, use the DOI form of citation above.
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Jagan declared the winner after dead-heat in Pro-Stock 165cc Open




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India beats Australia in men’s hockey; first win in an Olympics since 1972

Goalkeeper P.R. Sreejesh stood between the Australian players and goal post like a pillar.




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Paris Olympics: Men’s hockey team peaking at right time, faces Great Britain in quarterfinals

Harmanpreet Singh-led outfit has lifted its game steadily in the Olympics and is likely to throw a different challenge against Great Britain




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Men’s hockey: 10-man India beats Great Britain to enter semifinals at Paris Olympics

Harmanpreet, Sukhjeet, Lalit Upadhyay and Raj Kumar Pal scored for India in the shootout, which had more drama in store than one expects in pure action.




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India vs Great Britain Olympics quarterfinal: Everyone gathered around and worked on the tactics, says Craig Fulton

“Sreejesh is a legend, he is one of the best we have. He is saving us from day one. But when you ask him, he will say it was a team effort, so team first, then individuals,” said Harmanpreet.




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India vs Great Britain quarterfinal: Sreejesh was God of hockey today, says Dilip Tirkey

Dilip Tirkey, who was present at the stadium to witness the match, praised the Indian team for defending well after Amit Rohidas’ expulsion owing to a foul early in the second quarter.




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India defeats Spain 2-1 to clinch second consecutive bronze medal at Paris Olympics

The bronze medal was indeed a fitting farewell for the goalkeeper P.R. Sreejesh. India wins back-to-back medals in hockey after 52 years.




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Hero Asian Champions Trophy: India beats Korea; registers fourth consecutive win

Paris Olympics bronze medallist India had already defeated China 3-0, Japan 5-0 before thrashing last year's runner-up Malaysia 8-1.




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Asian Champions Trophy: India beats Pakistan 2-1, ends league campaign on unbeaten note

India is the only team to remain unbeaten in the Asian Champions Trophy.




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Asian Champions Trophy: India beats South Korea 4-1 to enter final

India will take on hosts China in the final on September 17, 2024.




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Karnataka gets the better of NCOE; Railways beats Maharashtra; Photo: Velankanni Raj

NCOE came to the tournament with a reputation to defend, having won the Lakshmi Ammal memorial tournament in Kovilpatti in June. It hasn’t done well so far, losing two of its three ties




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IOC beats Odisha, secures semifinal berth; Army downs Tamil Nadu




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HOCKEY | IOC weathers Army’s sustained challenge to make the title clash

MCC-MURUGAPPA GOLD CUP | Defending champion Railways blanks Odisha thanks to Joginder’s hat-trick




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Indian hockey team beats world champions Germany 5-3 in second Test, but loses series in shoot-out

India turned the table in the second half, with goals from Sukhjeet Singh (34th and 48th), skipper Harmanpreet Singh (42nd and 43rd) and Abhishek (45th) to level the two-match series.




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Karnataka defeats Chandigarh, makes the last-eight stage




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Great War at Sea: Prizes of War

During the Great War, British naval planners worried that French or Russian dreadnoughts could fall into German hands, and wondered if they might buy or seize them themselves. Prizes of War is a new downloadable supplement for the Great War at Sea game series. You can download it right now -- 70 new ship pieces, 21 (yes, twenty-one!) scenarios and ship data -- no pre-orders, no waiting!




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RTE seats lie vacant in districts

Ramanathapuram tops southern districts in enrolment




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Special children at their creative best

French artist Matthieu Charbonneau guides Satya Special School children to express themselves




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Creativity labs in schools soon

KITCO proposes Creativity and Innovation Lab@School in government schools across the State




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The Great Lakes : our freshwater treasure / by Barb Rosenstock ; illustrated by Jamey Christoph

Rosenstock, Barb, author




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How to spacewalk : step-by-step with shuttle astronauts / created by Kathryn D. Sullivan, the first American woman to walk in space, and Michael J. Rosen ; illustrated with images from NASA and drawings by Michael J. Rosen

Sullivan, Kathy, 1951- author




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The leaf detective : how Margaret Lowman uncovered secrets in the rainforest / Heather Lang ; illustrated by Jana Christy

Lang, Heather, 1966- author




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Minnow : the girl who became part fish / created by Willie Poll and Bailey Macabre

Poll, Willie, author




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The next scientist : the unexpected beginnings and unwritten future of the world's great scientists / by Kate Messner ; illustrated by Julia Kuo

Messner, Kate, author




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Weather / by Christina Earley

Earley, Christina, author




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The boy, the cloud and the very tall tale / Heather Smith

Smith, Heather, 1968- author




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Extreme weather for kids : lessons and activities all about hurricanes, tornadoes, blizzards, and more! / Matthew Cappucci ; illustrated by Stephanie Hathaway

Cappucci, Matthew, author




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Founders, authors are birds of the same feather

Why writing a book is not that different from becoming a first-generation entrepreneur




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Start-ups cut out for meat delivery

Backed by marquee investors, online delivery platforms sharpen knives to carve out a slice of India’s juicy meat business




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Innovate for wealth creation

How sector-agnostic funder Inflection Point Ventures prioritises returns for investors




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IoT on tap: Defeating drought through data analysis

Bengaluru start-up digitises water infrastructure of industries, smart cities to halt wastage




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Bond investment 101: Create a login ID

Higher interest. Bond investment platforms buzz with users drawn by the user-friendly interface, zero cost, jargon-free guidance




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Axial oxygen-bridged FeN4O/NC produced by ultrafast joule heating for efficient oxygen reduction reaction

Chem. Commun., 2024, Accepted Manuscript
DOI: 10.1039/D4CC05604C, Communication
Feng Liu, Xinyu Guo, Yan Zhong, Shaqi Fu, Jingsha Li, Chunmei Zhang, Heng Zhang, Fenghui Ye, Shuai Yuan, Chuangang Hu, Chunxian Guo
Herein, we report an atomically dispersed Fe-N-C catalyst with axial oxygen ligands (FeN4O/NC) firstly synthesized by ultrafast joule heating. The formation of oxygen species between FeN4 and graphene, which offers...
The content of this RSS Feed (c) The Royal Society of Chemistry




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May you eat in M.I.P

For a dash of Punjabi cuisine and hospitality, head straight towards Made In Punjab




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In the creative universe of Raghu Rai

The internationally-acclaimed photographer tells us how he enjoys his work and food




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Eating out? Leave your cash at home

From your local chaiwalla discovering digital wallets to restaurants setting up tabs for regulars, SHONALI MUTHALALY looks at how demonetisation has affected the food industry




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In Auroville, try a mac and ‘sheeze’ as vegan chefs set up cafes and create healthy alternatives to meat

We sample inventive menus across the lush, experimental township, which draws visitors from across the world



  • Life & Style

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Chances of infection: food safety squad continues aggressive checking in eateries

Nearly 70 shops dealing with food-based business inspected; flash inspections conducted considering the crowd turnout for Kerala State School Kalolsavam




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Karupatti aappam in Madurai: Meet a streetside vendor who makes this sweet treat

MG Vedhavathi has been making soft karupatti aappams on Kamarajar Salai for over a decade




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Creating a JavaScript promise from scratch, Part 7: Unhandled rejection tracking

When promises were introduced in ECMAScript 2015, they had an interesting flaw: if a promise didn’t have a rejection handler and was later rejected, you would have no idea. The rejection silently occurred behind the scenes and, therefore, could easily be missed. The best practice of always attaching rejection handlers to promises emerged due to...




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Qualities of great men




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Mystery of creation




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Hallmarks of great works




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A heat-resistant explosive featuring an N,N'-ethylene bridged 1,2,4-1H-triazole fused ring

New J. Chem., 2024, Advance Article
DOI: 10.1039/D4NJ00898G, Communication
Shaoqing Wang, Congcong Li, Shaojia Li, Hongquan Yin, Qing Ma, Fu-Xue Chen
A high thermal stability explosive with a fused-ring structure was formed by N,N'-ethylene bridging, exhibiting decomposition temperatures comparable to traditional HNS.
To cite this article before page numbers are assigned, use the DOI form of citation above.
The content of this RSS Feed (c) The Royal Society of Chemistry




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Ambient temperature-prepared BiOBr-supported zero-pretreatment coal gasification fine slag for organic pollutant removal

New J. Chem., 2024, 48,7256-7264
DOI: 10.1039/D3NJ05906E, Paper
Hele Hua, Jing Yang, Rui Li, Yunfang Wang, Caimei Fan, Jianxin Liu, Yawen Wang
The BiOBr/CGFS photocatalysts were synthesized at ambient temperature by a simple hydrolysis method with zero pre-treatment of CGFS. CGFS led to the improvement of the quantum efficiency of BiOBr and further promoted the photocatalytic performance.
The content of this RSS Feed (c) The Royal Society of Chemistry




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For the TEAtotaller

Tea is just more than a few leaves in hot water. Startup, Teabox, which ships Indian and Nepalese tea to over 95 countries, has shown what a good cup of the brew can do




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Tamil theatre’s new voice: Chennai audiences cheer for fresh ideas and new faces

Tamil contemporary theatre in the city sees a promising resurgence as new faces debut on stage with fresh scripts and creative ideas




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Bengaluru’s Christmas treats




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Creativity in clutter

The founders of Studio Clutter from Chennai talk about their journey as pet furniture makers and teaching about working with wood



  • Homes and gardens