Disclosed herein is a method for determining a trajectory for a transfer of a spacecraft from a starting space body to a target space body with respect to a given central space body, wherein the determined trajectory is optimal with respect to a given space mission requirement to be met by the transfer of the spacecraft. The method comprises providing, according to the Pontryagin maximum principle, a physical-mathematical model relating model quantities and physical quantities representing the transfer of the spacecraft with respect to the given central space body.

Systems and methods for subsurface secondary and/or tertiary oil recovery optimization based on either a short term, medium term or long term optimization analysis of selected zones, wells, patterns/clusters and/or fields.

A system for intelligent monitoring and management of an electrical system is disclosed. The system includes a data acquisition component, a power analytics server and a client terminal. The data acquisition component acquires real-time data output from the electrical system. The power analytics server is comprised of a real-time energy pricing engine, virtual system modeling engine, an analytics engine, a machine learning engine and a schematic user interface creator engine. The real-time energy pricing engine generates real-time utility power pricing data. The virtual system modeling engine generates predicted data output for the electrical system. The analytics engine monitors real-time data output and predicted data output of the electrical system. The machine learning engine stores acid processes patterns observed from the real-time data output and the predicted data output to forecast an aspect of the electrical system.

Methods for creating and using space-time surrogate models of subsurface regions, such as subsurface regions containing at least one hydrocarbon formation. The created surrogate models are explicit models that may be created from implicit models, such as computationally intensive full-physics models. The space-time surrogate models are parametric with respect to preselected variables, such as space, state, and/or design variables, while also indicating responsiveness of the preselected variables with respect to time. In some embodiments, the space-time surrogate model may be parametric with respect to preselected variables as well as to time. Methods for updating and evolving models of subsurface regions are also disclosed.

A retractable screw-type stimulation or defibrillation intracardiac lead is disclosed. According to one embodiment, the lead comprises a flexible hollow sheath (12) having at its distal end a lead head (10) and a connector (66) at its proximal end. The connector comprises a pin (62) connected to a lead head electrode (18). The lead head comprises a tubular body (28), at least one electrode (18, 20) for stimulation or defibrillation, a moving element translationally and rotationally moving within the tubular body in a helical motion, an anchoring screw (24) axially moving with respect to the tubular body, and a deployment mechanism (22) to deploy the anchoring screw out of the tubular body (28). The lead is a co-radial type, and the moving element (26) secured to the anchoring screw is connected to the tubular body (28) by a helical guide (46) and a coupling finger (56) protruding between two successive turns of the helical guide (46) for transforming a rotary movement imparted to the lead body in a deployment or retraction movement of the moving element (26). The helical guide (46) is resiliently compressible, with a free end (52) with a flat area (54) facing a flange (38) in vis-à-vis, so as to pinch the coupling finger (56) and to perform the function of a clutch limiting the torque transmitted to the anchoring screw by the rotation of the lead body, even in case of continuation of this rotation.

The present invention relates to a system and method for using the system. In particular, the present invention relates to an application, executable by a processing device to assess the organization of a non-nutritive suck (NNS) pattern of a patient and to entrain an organized NNS pattern in the patient. The software system receives data from an orofacial stimulation appliance to assess the patient's natural NNS pattern and generates a precise therapeutic pulse profile that is actuated as a tactile stimulus via the orofacial stimulation appliance to entrain an organized NNS pattern.

The portable, wearable, proximal Alzheimer's disease treatment invention is based upon creating an RF field of particular frequencies and intensities that are applied to the patient's head. To accomplish the aforementioned disease treatment functionality, a system was invented comprising a network of antennas connected to an RF generator via a feedline connector. The invention also provides methods for using measurements to monitor and manage the effectiveness of an ongoing disease treatment regimen, and databases which contain information about measurements, variables, and their relationships to clinical outcome.

Embodiments of the present invention include an apparatus and method for treatment of pain by a device that provides transcutaneous electrical nerve stimulation. The device includes an applicator equipped with an electric pulse provider that sends an electric pulse to a set of electrodes disposed in an applicator head. The device is placed onto the skin of a patient's body at the point where the patient experiences pain and such that the electrodes of the device contact the skin of the patient while an insulating land area between the electrodes compresses the nerve during transmittal of the electric pulse through the electrodes and into the patient's body.

A textile for providing traditional Chinese medicine therapy to a wearer using electronic stimulation includes at least two conductive paths that are made from conductive textile material, the conductive paths are separated by nonconductive textile material, at least one pair of electrodes attach to the conductive paths corresponding to specific part of body or acupoints according to traditional Chinese medicine theory, and an electronic stimulation signal controller configured to conduct electronic stimulation signals to the electrodes via the conductive paths.

One or more temporal stimulation parameters of vagus nerve stimulation (VNS) are selected to substantially modulate one or more target physiological functions without substantially modulating one or more non-target physiological functions. In one embodiment, a stimulation duty cycle is selected such that VNS is delivered to the cervical vagus nerve trunk to modulate a cardiovascular function without causing laryngeal muscle contractions.

Methods and devices for determining optimal Atrial to Ventricular (AV) pacing intervals and Ventricular to Ventricular (VV) delay intervals in order to optimize cardiac output. Impedance, preferably sub-threshold impedance, is measured across the heart at selected cardiac cycle times as a measure of chamber expansion or contraction. One embodiment measures impedance over a long AV interval to obtain the minimum impedance, indicative of maximum ventricular expansion, in order to set the AV interval. Another embodiment measures impedance change over a cycle and varies the AV pace interval in a binary search to converge on the AV interval causing maximum impedance change indicative of maximum ventricular output. Another method varies the right ventricle to left ventricle (VV) interval to converge on an impedance maximum indicative of minimum cardiac volume at end systole. Another embodiment varies the VV interval to maximize impedance change.

A housing for an electrostimulation device comprising a charger plug and a stimulation plug, designed to receive respectively a connector linked to a charger and a connector linked to a stimulation electrode, characterized in that it comprises a mobile locking element designed to alternately lock the charger plug or the stimulation plug.

The present invention provides a closed-loop system for treating neurological disorders, such as epilepsy. In one embodiment the system comprises an input assembly that is adapted to receive one or more signals from a patient that are indicative of a patient's neurological state. The input assembly processes the one or more signals to generate one or more control input signals. An output assembly receives the one or more control input signals from the input assembly and generate a neuromodulation signal that is a function of the patient's neurological state. An electrode array is configured to deliver the neuromodulation signal to a patient's peripheral nerve, such as the vagus nerve.

Bioelectrical signals may be sensed within a brain of a patient with a plurality of sense electrode combinations. A stimulation electrode combination for delivering stimulation to the patient to manage a patient condition may be selected based on the frequency band characteristics of the sensed signals. In some examples, a stimulation electrode combination associated with the sense electrode combination that sensed a bioelectrical brain signal having a relatively highest relative beta band power level may be selected to deliver stimulation therapy to the patient. Other frequency bands characteristics may also be used to select the stimulation electrode combination.

Bioelectrical signals may be sensed within a brain of a patient with a plurality of sense electrode combinations. A stimulation electrode combination for delivering stimulation to the patient to manage a patient condition may be selected based on the frequency band characteristics of the sensed signals. In some examples, a stimulation electrode combination associated with the sense electrode combination that sensed a bioelectrical brain signal having a relatively highest relative beta band power level may be selected to deliver stimulation therapy to the patient. Other frequency bands characteristics may also be used to select the stimulation electrode combination.

An implantable head-mounted unibody peripheral neurostimulation system is provided for implantation in the head for the purpose of treating chronic head pain, including migraine. The system may include an implantable pulse generator (IPG) from which multiple stimulating leads may extend sufficient to allow for adequate stimulation over multiple regions of the head, preferably including the frontal, parietal and occipital regions. A lead may include an extended body, along which may be disposed a plurality of surface metal electrodes, which may be sub-divided into a plurality of electrode arrays. A plurality of internal metal wires may run a portion of its length and connect the IPG's internal circuit to the surface metal electrodes. The IPG may include a rechargeable battery, an antenna, and an application specific integrated circuit. The IPG may be capable of functional connection with an external radiofrequency unit for purposes that may include recharging, diagnostic evaluation, and programming.

A lead for providing electrical stimulation of patient tissue includes a distal lead element, at least two proximal lead elements, and a junction coupling the distal lead element to each of the at least two proximal lead elements. The distal lead element includes a plurality of electrodes and a plurality of conductive wires coupled to the plurality of electrodes and extending along a longitudinal axis of the distal lead element. Each of the at least two proximal lead elements includes a plurality of terminals and a plurality of conductive wires coupled to the plurality of terminals and extending along a longitudinal axis of the proximal lead element. The junction includes a circuit arrangement electrically coupling each of the conductive wires of the distal lead element to at least one of the conductive wires of at least one of the at least two proximal lead elements.

An electronic musical instrument having a number of keys, having tone generators capable of simultaneous tone production, the tone generators being smaller in number than the number of keys. The instrument forms an operation for synthesizing a desired waveform, the operation for synthesizing a desired waveform being performed in a repeating cyclic order with an operation cycle and in which the waveform is transferred to the tone generators and read out therefrom at a rate in accordance with the note of a key being depressed to obtain a desired musical waveform. The device includes a number-of-depressed keys detecting device which counts the number of keys which are actuating the tone generator upon depression. A cycle altering device is provided for changing the operation cycle, as a whole, on the basis of the number of depressed keys, counted by the number-of-depressed keys detecting device. The construction allows for a waveform of a smooth temporal variation to be produced.

One embodiment may include an automotive timing chain system component (10, 12) such as a tensioner arm (10) or a chain guide (12) that, during use, bears directly or indirectly against a chain (22) of an automotive timing chain system (14). The component (10, 12) may have an elongated body (16, 116) made into a generally hollow shape by a hydroforming process. The body may have a first open free end (26, 126) and a second open free end (28, 128).

The present invention relates to the field of organic chemistry and in particular to organic free radicals used as polarizing agents in the technique of Dynamic Nuclear Polarization (DNP), which involves transferring the polarization of electron spins to the nuclei of a compound whose Nuclear Magnetic Resonance (NMR) is being observed. It concerns Dinitroxide-type Biradical polarizing agents characterized by a rigid linkage between the aminoxyl groups of said nitroxide units. This particular structure enables, at low temperatures and high fields, optimal transfer of polarization and optimal enhancement of NMR/MAS signals of the polarized nuclei of the compound studied.

A micro device includes a substrate and a structure configured to bind to an object or a material, or not to bind to an object or material. The structure has a roughness based on a roughness of the object or material. For example, a microarray includes a substrate and a well positioned in the substrate and configured to bind to a type of bead. The well has a roughness based on a roughness of the type of bead to which the well is configured to bind. The roughness of the well is controlled by controlling a position and number of striations in the side of the well. In another example, a moveable component of a micro device may have a roughness different from a roughness of an adjacent component, to reduce the likelihood of the moveable component sticking to the adjacent component.

An estimation device is configured to estimate a feature value of a specific component contained in a sample and includes: a spectral estimation parameter storage module; a calibration parameter storage module; a multiband image acquirer; an optical spectrum operator configured to compute an optical spectrum from a multiband image using a spectral estimation parameter; and a calibration processor configured to compute the feature value from the optical spectrum using a calibration parameter.

A ring mechanism has an elongate housing and rings for holding loose-leaf pages. Each ring has ring members mounted on pivoting hinge plates for movement between open and closed positions. An actuator has opening and closing arms extending from an actuator body for opening and closing the rings. The mechanism has a travel bar moveable between a locked position in which a locking element blocks pivoting movement of the hinge plates and an unlocked position. The actuator has a flexible arm positioned to push the travel bar toward the locked position when the actuator closes the rings. At least a portion of the flexible arm is adapted to deform during closing in a manner that includes rotation in a first direction relative to the body of the actuator. Movement of the actuator to close the rings includes rotation of the actuator in the first direction relative to the housing.

A system for providing an accumulated phase to an interpolator of a read channel, the interpolator configured to provide a digital clock signal. A frequency accumulator is configured to generate a frequency offset based on a difference between the digital clock signal and a desired clock signal. A zero phase start module is configured to, during a zero phase start, output an incremental phase jump. A phase accumulator is configured to generate the accumulated phase based on the difference between the digital clock signal and the desired clock signal, and, during the zero phase start, the incremental phase jump output by the zero phase start module, or the frequency offset generated by the frequency accumulator or a predetermined frequency offset.

Aspects of the disclosure provide a sync mark detector. The sync mark detector includes a first unit configured to decay over time a value indicating a length of a bit format, a second unit configured to compare the decayed value with a detected length of the bit format to determine a new length, and a third unit configured to detect a sync mark based on the detected length and the new length.

The present disclosure describes the manufacture and use of soft surfaces such as fabrics bearing surface-grafted antimicrobial polymers.

A hydrogel tissue adhesive having decreased gelation time and decreased degradation time is described. The hydrogel tissue adhesive is formed by reacting an oxidized polysaccharide containing aldehyde groups with a water-dispersible, multi-arm amine in the presence of a thiol additive. The thiol additive accelerates the process to form the hydrogel and accelerates the degradation of the hydrogel formed. The hydrogel may be useful as a tissue adhesive or sealant for medical applications, such as a hemostat sealant or to prevent undesired tissue-to-tissue adhesions resulting from trauma or surgery.

A method, apparatus, and computer program product for generating a social network data structure, the method comprising: receiving a corpus comprising one or more communication indications for one or more customers, each communication indication indicating start time and end time of a communication of the customer; and generating a social network data structure indicating connections between customers based upon the start time and end time indications of communication indication comprised in the communication indications.

A device for generating limit torque with a function of yielding a torque change in real time includes a spring, a rotating portion having a cam surface formed therein, a transmitting portion transmitting an elastic force of the spring to the cam surface, a fixed portion with respect to which the relative rotation of the rotating portion is generated, and a limit-torque control portion provided to the fixed portion so as to control limit torque of the rotating portion by adjusting the elastic force of the spring. In the device, the limit-torque control portion controls the limit torque of the spring by changing the elastic force of the spring in real time.

A phase control apparatus in a variable cam timing (VCT) system of an engine is described herein. The phase control apparatus includes a locking pin coupled to a vane, the locking pin extending into a locking pin recess in a cover plate in a locked configuration, the locking pin and locking pin recess having a backlash and a housing at least partially enclosing the vane and spaced away from the vane forming a gap in the locked configuration.

A valve timing control device includes: a vane rotor having a plurality of vanes; a housing having the vane rotor inside so that an advance chamber is formed on one side of each vane and a retard chamber is formed on the other side; a lock pin inserted in a cylinder provided in the vane and moves to a lock position and to an unlock position; and a feeding passage for feeding oil into the cylinder from the retard chamber adjacent to the vane provided with the cylinder to make the lock pin move to the unlock position, and controls an oil supplying unit to supply oil to each retard chamber, wherein a flow passage cross sectional area of the branch passage connected with the retard chamber linking with the cylinder is larger than a flow passage cross sectional area of the branch passage connected with the other retard chamber.

In an electrically-driven valve timing control apparatus employing a housing and a cover member axially opposed to each other, a cylindrical-hollow motor output shaft is installed in the housing, and configured to rotate relative to the housing by electricity-feeding to the electric motor, and also configured such that lubricating oil is supplied into the motor output shaft. A plug is fitted to the inner periphery of an axial opening end of the motor output shaft for suppressing a leakage of lubricating oil from the motor output shaft to the outside. One of two opposing faces of the cover member and the plug is formed with a protruding portion configured to prevent the plug's slipping out of the axial opening end. A part of the inside face of the cover member, opposed to the plug, is formed integral with the protruding portion partially disposed within the axial opening end.

A system and methods are provided for controlling a motor of a rod pumping system using previous RPMs of the motor and predicting an RPM of the motor; correcting a power factor of a motor of a rod pumping system; allocating energy consumption and allocating energy generation for a set of wells connected to an electricity meter using an amount of energy generated by each well; and generating an alert if a set of data is beyond a threshold for the set of data.

Monitoring and optimizing a state of an electrical grid are provided. An approach for synchronizing state information and context information, associated with one or more electrical devices on an electrical grid, with time information is provided. The state information is from one or more phasor measurement units (PMUs) associated with the one or more electrical devices, and the context information is from one or more third party servers. The approach further includes notifying one or more subscribing devices of the synchronized state information and the synchronized context information such that the one or more subscribing devices monitors and controls the one or more electrical devices based on the synchronized state information and the synchronized context information.

A method for design of a fuel assembly for nuclear reactors, including structural components made from zirconium alloy: the mean uniaxial tensile or compressive stress to which the components are subjected during the assembly life is calculated, the zirconium alloy of which the components are made is selected according to the following criteria: those components subjected to an axial or transverse compressive stress of between −10 et −20 MPa are made from an alloy with a content of Sn between Sn=(=0.025σ−0.25)% and Sn=−0.05σ%: those components subjected to such a stress of between 0 et −10 MPa are made from an alloy the Sn content of which is between Sn=traces and Sn=(0.05σ+1)%: those components subjected to such a stress of between 0 and +10 MPa are made from an alloy the Sn content of which is between Sn=0.05% and Sn=(0.07σ+1)%: and those components subjected to such a stress of between +10 and +20 MPa are made from an alloy the content of SN of which is between 0.05% and 1.70%. A fuel assembly made according to the method.

The present disclosure describes antibodies that target HM1.24. In various aspects, the antibodies have specific CDR, variable, or full length sequences, have modifications with the parent antibody, or include at least one modification relative to a parent antibody that alters affinity to an FcγR or alters effector function as compared to the parent antibody. Nucleic acids encoding the antibodies and methods of using the antibodies are also disclosed.

The present invention relates to a compound which is a polysaccharide derivative of GCSF, or of a GCSF like protein, wherein the polysaccharide is anionic and comprises between 2 and 200 saccharide units. The present invention also relates to pharmaceutical compositions comprising the novel compounds, and methods for making the novel compounds.

A remote time shift buffer system with shadow tuning. The remote time shift buffer system includes a client in communication with a remote video recorder. The client tunes to a channel from a television signal source and sends the channel content to a television. When a channel change occurs at the client, the remote video recorder tunes to the same channel as the client and buffers the content. When a pause live television (PLTV) function is initiated, the remote video recorder generates an independent RTSB content stream using the buffered content. Once the RTSB content stream is available, the client switches inputs and displays the RTSB content stream from the remote video recorder. Manipulating the position within the RTSB content stream does not affect buffering of the live content. The remote time shift buffer system provides pause live television functionality with minimal loss of content.

A method includes receiving, at a multimedia device, a data stream representing multimedia content, the data stream comprising first timing information for the multimedia content, and metadata representing interactive event information associated with the multimedia content, the metadata comprising second timing information for the interactive event information. During the playback of the multimedia content, a first user interactive event is identified that is associated with a first time point in the playback of the multimedia content based on the interactive event information, and the first user interactive event is performed concurrent with the first time point in the playback of the multimedia content.

A method of providing information including providing a communication session of at least one of audio and video media and applying automatic recognition to media transferred on the communication session. An advertisement is selected by a processor, based on the automatic recognition and non-advertisement information is selected by the processor, responsive to the automatic recognition. The selected advertisements and the selected non-advertisement information, are presented during the communication session.

A method for virtual channel management is provided. The method includes the following steps. In response to a command, a control unit of a network-based multimedia reproduction system determines whether the command is associated with virtual channel switching. When the command is associated with virtual channel switching, the control unit checks whether a channel value corresponding to the command exists in an application virtual channel table. When the channel value exists in the application virtual channel table, the control unit determines an application corresponding to the channel number from the application virtual channel table, and executes the application. According to a first operation parameter set corresponding to the application, the control unit sets the executed application to retrieve digital contents through a network unit of the network-based multimedia reproduction system.

The invention relates to a glass item, at least one of the surfaces thereof having antimicrobial properties that are resistant to a temperature treatment, especially a temperature treatment in preparation of the subsequent tempering thereof. The glass item especially comprises an antimicrobial agent beneath the surface of the glass, and nanoparticles that are partially and/or totally incorporated into the mass of the glass close to said surface and consist of at least one inorganic component.

A method and transmission control unit configured to improve shift event performance in a vehicle with an automatic transmission by determining a vent time for release of a clutch assembly in a transmission of a vehicle. The vehicle must be stopped and a gear selector in the vehicle must be set to a drive condition. If these conditions are met, the clutch assembly is vented. The vent time from when venting begins to when a turbine (or input shift) speed of the transmission rises is tracked. Once the turbine speed of the transmission rises, the clutch assembly is reapplied. The clutch assembly vent time is set based on the tracked vent time.

A transmission controller increases an indicated hydraulic pressure to a starting frictional engagement element to a normal hydraulic pressure, causes a hydraulic piston to stroke and executes a learning control of the indicated hydraulic pressure so that a time until the starting frictional engagement element starts generating a transmission capacity after the range is switched from the neutral range to the drive range becomes a target time when a range is switched from a neutral range to a drive range. The transmission controller further detects a driver's starting intention and increases the indicated hydraulic pressure to the starting frictional engagement element to a starting time hydraulic pressure higher than the normal hydraulic pressure and prohibits the learning control if the starting intention is detected before the starting frictional engagement element starts generating the transmission capacity.

A method for optimized launch of a vehicle is provided wherein a driveline of the vehicle at least includes an engine, an automatic transmission, a system for exhaust gas recirculation, which are controlled by a driveline management system, wherein the management system is able to determine the mass of the vehicle, and whereby a launching gear of the transmission is calculated dependent at least on the determined mass of the vehicle, whereby a launching gear is chosen dependent of the power loss caused by the EGR and wherein the power loss caused by the EGR is determined, the available power to launch the vehicle is determined, and the launching gear is recalculated dependent of the available power, and selecting said recalculated launching gear before launch of the vehicle, launch the vehicle with the recalculated launching gear.

An agricultural combine has a threshing assembly for threshing a crop to produce chaff and grain, a cleaning assembly for removing the chaff from the grain, and a control system. The threshing assembly and the cleaning assembly operate at threshing and cleaning settings, respectively, for tending to produce a balance between a threshing load applied across the threshing assembly and a cleaning load applied across the cleaning assembly that tends to have a favorable influence on grain loss. The control system is for sensing an imbalance between the threshing load and the cleaning load tending to have an unfavorable influence on grain loss, and for concurrently adjusting the threshing and cleaning settings of the threshing and cleaning assemblies, respectively, for tending to convert the imbalance between the threshing and cleaning loads to a balance between the threshing and cleaning loads tending to have a favorable influence on grain loss.

In one embodiment, a system includes a robotic accessor for transporting media between multiple storage slots and one or more data storage drives; a controller for controlling the robotic accessor; a memory in communication with and/or integrated with the controller for storing information about the media and the storage slots, the information including data corresponding to a physical distribution of the media in the storage slots; and logic integrated with and/or executable by the controller, the logic being adapted to: position the robotic accessor at a computed optimal position during an idle period of the robotic accessor, the computed optimal position being based at least in part on the physical distribution of the media in the storage slots.

The techniques described herein implement an operating system that can reliably process time sensitive information in non real-time manner. Thus, the operating system described herein is capable of processing an instance of time sensitive input during a time period after the instance of time sensitive input is received (e.g., at a future point in time). To accomplish this, the techniques timestamp each instance of time sensitive input when it is received at a device. The techniques then store the timestamped instance of time sensitive input in a temporary queue, and make the timestamped instance available to the operating system at a time period after the time period when it is received, as indicated by the timestamp. Additional techniques described herein prioritize the activation of a driver configured to receive the time sensitive information during a boot sequence or a reboot sequence.

Systems and methods for retrieving service request messages stored in a messaging queue and received by a queue in real-time. The service request messages are retrieved using a plurality of threads that comprise at least one retrieval criteria. Service request messages may be retrieved from the message queue or retrieved as they are received by the message queue in real-time using criteria in addition to or instead of the arrival time of the service request message which may also be referred to as the put-time. Service request messages may be requested and retrieved in an iterative process wherein multiple threads execute consecutively, concurrently, or a combination of both, in order to retrieve service request messages requested by an application.

Disclosed are various embodiments for automated service interface optimization. In one embodiment, a service client and/or a service provider is reconfigured to use an optimized version of a data transfer interface, where the optimized version transfers fewer data items from the service provider to the service client. In another embodiment, service calls from a service client for multiple different data objects are aggregated into an aggregated service call for a data object. In yet another embodiment, an optimized data object is provided to a service client in response to a request for an unoptimized data object. If the service client attempts to use a data item excluded from the optimized data object, the excluded data item is then provided to the service client.