The invention discloses a combined preparation containing IL-10 and rapamycin, able to induce immunosuppression and antigen-specific immune tolerance, and the use thereof in the treatment of diseases involving an excessive, dysfunctional or uncontrolled immune responses mediated by T cells.

Provided herein are novel compounds and novel protected compounds that can be derived from polymyxin, including, e.g., polymyxin A. The novel compounds have antibacterial properties against a diverse range of Gram negative bacteria and reduced toxicity compared to polymyxins such as polymyxin A. Also provided are antibacterial pharmaceutical compositions containing the novel compounds and novel protected compounds, as well as methods for preparing the antibacterial compounds and protected compounds.

Compositions and methods for the treatment of asthma and inflammatory ocular disorders are disclosed.

The invention relates to compositions comprising vasoactive intestinal peptide (VIP) or fragments thereof, and the use of such compositions in the treatment of kidney disease, in particular kidney fibrosis, and other associated conditions.

The present invention relates to novel compounds having a function of a peptide in the amylin family, related nucleic acids, expression constructs, host cells, and processes production of the compounds. The compounds of the invention include one or more amino acid sequence modifications. In addition, methods and compositions are disclosed to treat and prevent metabolic disorders such as obesity, diabetes, and increased cardiovascular risk.

Methods and systems for detecting azetidine-2-carboxylic acid (Aze) in food consumable by humans and animals are provided. Also provided are methods and systems for inactivating Aze in food and byproducts, as well as other methods for the diagnosis, prevention, and treatment of disorders associated with Aze.

The invention relates to compositions comprising vasoactive intestinal peptide (VIP) or fragments thereof, and the use of such compositions in the treatment of aortic fibrosis and other associated conditions.

A method of treating cancer through use of guanosine 3',5'-cyclic monophosphate (cyclic GMP). Cyclic GMP decreases the number of human breast cancer and prostate adenocarcinoma as well as small-cell and squamous lung cells in culture by 30% (1 μM), 84% (1 mM), 31% (1 μM), and 30% (1 μM), respectively. Cyclic GMP decreases DNA synthesis in human pancreatic, breast, and prostate adenocarcinomas as well as small-cell and squamous cell carcinomas of the lung at its 1 μM concentration by 51%, 54%, 56%, 50% and 52%, respectively. Cyclic GMP when infused for one week decreases the tumor volume of human pancreatic adenocarcinomas in athymic mice 95% compared to untreated animals with human pancreatic adenocarcinomas.

A method of treating a disease or condition in which up-regulating GAGs is therapeutically beneficial is disclosed, in particular osteoarthritis and skin diseases. The method comprises locally administering to a subject a therapeutically effective amount of an agent capable of down-regulating activity or expression of a component of the renin-angiotensin system.

Provided herein are novel compounds and novel protected compounds that can be derived from polymyxin, including, e.g., polymyxin A. The novel compounds have antibacterial properties against a diverse range of Gram negative bacteria and reduced toxicity compared to polymyxins such as polymyxin A. Also provided are antibacterial pharmaceutical compositions containing the novel compounds and novel protected compounds, as well as methods for preparing the antibacterial compounds and protected compounds.

A device for reducing sound from an air treatment unit includes, in one embodiment, a wall curb. The air treatment system includes a supply opening and a return opening. The wall curb includes a frame portion defining an interior chamber. A partition divides the interior chamber into a supply plenum in a first portion of the interior chamber and a return plenum in a second portion of the interior chamber. A curb supply opening is formed through the perimeter frame in communication with the supply plenum. A curb return opening is formed through the perimeter frame in communication with the return plenum. The curb return opening is positioned such that airflow through the return plenum is non-linear and a sound absorbing material may be positioned on at least some inside surfaces of the return plenum.

Braid-balls suitable for aneurysm occlusion and/or parent vessel occlusion/sacrifice (e.g., in treating neurovascular defects) are disclosed. Especially for aneurysm treatment, but also for either one of the aforementioned treatments, the form of the ball is very important. In particular, the density of the device is paramount in applications where braid itself is intended to moderate or stop blood flow—allowing thrombosis within a volume formed by the ball.

A system and method of painting parts of large dimensions that present a certain amount of flexibility that makes their shape geometrically unstable in the event of being moved. The surface of a part is moved in front of a paint spray device by an arm of a robot, while the spray device remains stationary relative to the robot and while the part is being deformed. Other elements include a gripper for gripping parts of large dimensions, the gripper being adapted to implement the method; an installation; and a booth for performing surface treatment of parts.

A disclosed thermal treatment apparatus includes a supporting member where plural substrates are supported in the form of shelves; a reaction tube that accommodates the supporting member within the reaction tube, and is provided with plural gas supplying pipes arranged in a side part of the reaction tube, thereby allowing a gas to flow into the reaction tube through the plural gas supplying pipes; and a first heating part that heats the plural substrates supported by the supporting member accommodated within the reaction tube, wherein the first heating part includes a slit that extends from a bottom end to a top end of the first heating part and allows the plural gas supplying pipes to go therethrough, and wherein an entire inner surface, except for the slit, of the heating part faces the side part of the reaction tube.

Provided is a catalyst article for simultaneously remediating the nitrogen oxides (NOx), particulate matter, and gaseous hydrocarbons present in diesel engine exhaust streams. The catalyst article has a soot filter coated with a material effective in the Selective Catalytic Reduction (SCR) of NOx by a reductant, e.g., ammonia.

In one embodiment, a catalyst for ozone oxidation of pollutant components dispersed in a gas is provided. The ozone oxidation catalyst has a porous body formed from a metal body, a ceramic, or polymeric fibers coated with metal. A catalytic noble metal composition is deposited on the surface of the porous body. The catalytic noble metal composition is formed from particles of a noble metal supported by a mesoporous molecular sieve.

Provided are a method for post-treatment of a carbonaceous material using dehydrocyclization, a carbonaceous material post-treated by the method, and a polymer composite material including the carbonaceous material. More particularly, provided are a method for post-treatment of a carbonaceous material using dehydrocyclization, including subjecting the carbonaceous material to dehydrocyclization at room temperature to heal structural defects in the carbonaceous material, while increasing the effective conjugated length of the carbonaceous material to improve the electrical conductivity thereof, as well as a carbonaceous material post-treated by the method and a polymer composite material including the carbonaceous material.

A method of treating an object with radiation that includes generating volumetric image data of an area of interest of an object and emitting a therapeutic radiation beam towards the area of interest of the object in accordance with a reference plan. The method further includes evaluating the volumetric image data and at least one parameter of the therapeutic radiation beam to provide a real-time, on-line or off-line evaluation and on-line or off-line modification of the reference plan.

A cognitive disorder diagnostic system that employs cognitive cubes, gameplay associate with the cognitive cubes, and a data gathering as statistical analysis base device that may be a computer, that communicates the gathered data to a web server host according to a unique ID associated with particular cognitive cubes and further associated with a particular player. Using the statistical data gathered using the gameplay, various cognitive disorders may be successfully diagnosed and treated with higher reliability.

Self controlled method and system for identified, treatment and weaning from computer and Internet addiction. On one embodiment of the invention, the system analyzed user activity on the computer and while surfing the Internet, and presents results of his addictive level visually on user's interface. Supporting the whole information of addictive level to the user, give him the power to fight against the phenomena and prevent to increase it. The user can decide whether he wants treatment and act to have it by personal actions or by involvement of third parties such as parents, therapist, support group or even a specific social website. For weaning from the addiction the system can provide positive feedbacks, special treatment and even presents and prizes if the user reduced dramatically his addictive level.

An aqueous fluid treatment method and system is provided which preferably uses a 3 step electro-chemical oxidation process to remove organic contaminates from water. A high surface area electro-chemical reaction cell can be employed to remove organic particles and precipitate hardness salts from the aqueous solution. Several 3-phase spark arcs generated mixed oxidants and acoustic cavitations to remove dissolved organic compounds and oxidize organic metal compounds in the next step. Finally, a dielectric discharge in aqueous foam is used to eliminate recalcitrant organic compounds such as, but not limited to, polychlorinated aromatics, disinfectants, pesticides, and pharmaceuticals before release to environment or recycled.

A metal material is provided with a bismuth coating which enables the subsequent coating to be accomplished at a high throwing power, and has excellent corrosion resistance, coating adhesion and is able to be produced with reduced damage to the environment. The metal material has a surface and a bismuth-containing layer deposited on at least a part of the surface of the metal material, wherein the percentage of bismuth atoms in the number of atoms in the surface layer of the metal material with a bismuth coating is at least 10%.

The inventive technology includes methods and apparatus for the generation and application of segregated catalytic additives for the pre-combustion treatment of carbonaceous fuel and/or feedstocks. The application of such segregated additives results in the reduction of environmentally harmful emissions during combustion as well as gasification processes. Specifically, pre-combustion treatment of carbonaceous materials with the inventive additives results in the reduction of NOx and/or mercury emissions by least 20% and 40% respectively.

A surface treatment equipment is designed for forming nickel barriers on a plurality of terminals for preventing solder wicking is disclosed. The surface treatment equipment includes a retractable feeding system, a laser engraving system, an image sensor, and a control system. The retractable feeding system is utilized to transmit a strip that has the terminals. The laser engraving system is utilized to ablate the terminals. The image sensor is utilized to collect a plurality of images of the ablated terminals. The control system receives the images to perform image recognition. When a defective terminal is recognized, the control system controls the retractable feeding system to transmit in reverse and controls the laser engraving system to repeatedly ablate the defective terminal. The defective terminals can be automatically recognized by the image sensor accompanying the control system. Thus, the drawback of a human visual inspection is solved.

Provided herein are methods of treating a proliferative disease in a subject, comprising administering to the subject a therapeutically effective amount of AC220 and a nucleoside analog, a topoisomerase inhibitor or an anthracycline, or a combination thereof.

A method and system are presented for enhancing one or more images of an object, so as to increase the visibility within the images of one or more structures within the object. The object may be an anatomical region of a patient, and may include one or more reference structures, for example skeletal structures or vertebral structures, and one or more treatment targets, for example tumors or lesions. An operator, for example a top-hat filter operator, selects at least a first neighborhood and a second neighborhood within the images. The operator selects within each neighborhood one or more pixels having an optimal pixel value, and eliminates the remaining pixels in these neighborhoods. When the operator is applied to the selected neighborhoods, only the pixels having the greatest pixel values remain in the selected neighborhoods, and the remaining pixels are eliminated in the selected neighborhoods. As a result, desired features can be located and enhanced in the images.

A patient wearable, continuously operating extracorporeal pump apparatus which accesses the patient's arterial venous pressure differential by applying external pressure to a subcutaneous graft that has been cannualized to modulate blood flow through an extracorporeal circuit and to drive the pump for delivering a medicament, such as an anticoagulant, to the site of an intravenous cannula to prevent clogging thereof and also to move a dialysate through a circuit, including a dialyzer and a dialysate rejuvenating cartridge, whereby kidney failure can be treated without recourse to prior art hemodialysis machines found in most treatment facilities. With slight modification, the present invention can be used to remove excess fluids from CHF patients, to remove toxins from the blood in those suffering from liver failure and to facilitate administration of insulin to diabetics and/or glucose to those having hypoglycemia.

Systems for treating biomass for the production of ethanol are disclosed. The systems are configured to treat a liquid component separated from biomass to yield sugars available to be fermented into a fermentation product. The systems comprise a filter configured to remove particulate matter to provide a filtered component and an apparatus configured to remove inhibitors from the filtered liquid component provide a treated liquid component comprising sugars available for fermentation. Methods for treating for treating biomass useful in the production of a fermentation product are also disclosed. The methods include the steps of filtering a liquid component to remove particulate matter thereby yielding a filtered liquid component, and treating the filtered liquid component to remove inhibitors thereby yielding a treated liquid component comprising sugars available to be fermented into a fermentation product.

Fluid treatment systems and compositions are provided including (a) at least one material including (1) at least one carboxylic acid functional group and (2) at least one sulfur-containing group selected from the group consisting of sulfonyl functional groups, sulfonate functional groups and mixtures thereof; and (b) at least one friction reducing agent selected from the group consisting of guar gums, polyacrylamides, hydratable cellulosic materials, viscoelastic surfactants, and mixtures thereof. The fluid treatment systems and compositions can be used to treat aqueous systems, for example as fracturing fluids for use in fracturing subterranean formations. Methods for inhibiting formation and/or precipitation of metal oxides in an aqueous composition using the fluid treatment systems or compositions also are provided.

Fluid treatment systems and compositions are provided including (a) at least one material including (1) at least one carboxylic acid functional group and (2) at least one sulfur-containing group selected from the group consisting of sulfonyl functional groups, sulfonate functional groups and mixtures thereof; and (b) at least one scale control agent. The fluid treatment systems and compositions can be used to treat aqueous systems, for example as fracturing fluids for treating aqueous compositions found in subterranean formations. Methods for inhibiting formation and/or precipitation of calcium salts in an aqueous composition using the fluid treatment systems or compositions also are provided.

A tank or bed has a plurality of sidewalls that create a bed cavity and a Fresnel panel frame that includes at least one Fresnel panel. The Fresnel panel frame may be adjacent to the bed cavity and may cover at least a portion of the bed cavity. An amount of sludge may be contained within the bed cavity. When placed in sunlight, the heat enhanced by the Fresnel panels may heat the sludge sufficiently for the sludge to be used as fertilizer.

Disclosed herein is a system comprising an evaporation unit comprising a first heat exchanger in fluid communication with a second heat exchanger; where the first heat exchanger is operative to heat an effluent stream comprising an amine solvent and/or amine byproducts and water and to discharge the effluent stream to the second heat exchanger; where the second heat exchanger is operative to convert the effluent stream into a distillate stream and a concentrate stream; and a reverse osmosis unit in fluid communication with the evaporation unit; where the reverse osmosis unit comprises a first reverse osmosis unit that is operative to receive the distillate stream and to separate water from byproducts of the amine solvent such that the water has a purity of greater than 95%, based on the weight of the distillate stream.

The invention provides a composition for topical treatment of hair loss/alopecia including three natural, active ingredients, caffeine, saw palmetto berry extract, and epigallocatechin-3-gallate (EGCG). The invention also provides methods for using this composition to treat hair loss.

The present invention describes a hair treatment application system, comprising at least one or more hair treatment compositions (15) having a viscosity of from 3,000 cPs to 150,000 cPs and a hair treatment application device (1) comprising a first plate (10) and a second plate (20) positionable in a juxtaposed relationship when said hair treatment application device (1) is in a closed state. The hair treatment application device (1) is characterized by having a first zone comprising at least one absorbent substrate (40) on the internal surface (101) of said at least said first plates (10) and a second zone (50) on said internal surface (101) which is free of said absorbent substrate (40). Said at least one absorbent substrate (40) has a median pore radius of from 300 microns to 3,000 micron. The present invention describes also methods of treating the hair with said hair treatment application system (10) and kit comprising said hair treatment application system.

A surface treatment composition for inkjet media includes: at least one surface sizing agent selected from the group consisting of starch, starch derivatives, polymeric materials, and combinations thereof; and an ink fixative selected from the group consisting of at least one high valence metallic salt, at least one high valence complex poly-salt, and combinations thereof. The ink fixative is present in the surface treatment composition from about 10 weight% to about 50 weight% of the surface treatment composition. The at least one high valence metallic salt and the at least one high valence complex poly-salt have a valence greater than divalent. Additionally included are a method of making and a system for printing the surface treated media; and an inkjet printable paper.

An end treatment portion 1a which treats ends Wa and Wb of an electric wire W and a transfer portion 7 which transfers the electric wire W are provided; a discharge portion 6, which discharges the electric wire W which is subjected to an end treatment by the end treatment portion 1a and transferred by the transfer portion 7, is also provided; the discharge portion 6 includes a discharge beam 11 for securing the electric wire W in a predetermined arrangement pattern; a calculation portion 20, which controls a securing treatment for securing the electric wire W to the discharge beam 11 in the discharge portion 6, is provided; and the predetermined arrangement pattern is set by the calculation portion 20 based on a content of processing the electric wire W at a subsequent process.

Vascular treatment and methods include a plurality of self-expanding bulbs and a hypotube including interspersed patterns of longitudinally spaced rows of kerfs. Joints between woven structures and hypotubes include solder. Woven structures include patterns of radiopaque filaments measureable under x-ray. Structures are heat treated to include at least shapes at different temperatures. A catheter includes a hypotube including interspersed patterns of longitudinally spaced rows of kerfs. Heat treating systems include a detachable flange. Laser cutting systems include a fluid flow system.

Vascular treatment and methods include a plurality of self-expanding bulbs and a hypotube including interspersed patterns of longitudinally spaced rows of kerfs. Joints between woven structures and hypotubes include solder. Woven structures include patterns of radiopaque filaments measurable under x-ray. Structures are heat treated to include at least shapes at different temperatures. A catheter includes a hypotube including interspersed patterns of longitudinally spaced rows of kerfs. Heat treating systems include a detachable flange. Laser cutting systems include a fluid flow system.

Compounds of Formula I, including pharmaceutically acceptable salts, as well as compositions containing these compounds, have activity against hepatitis C virus (HCV) and may be useful in treating those infected with HCV:

The present invention provides treatment apparatus, a fluid application device and methods of removing and applying fluid and relates particularly but not exclusively to an apparatus and method suitable for applying fluid to an elongate object such as a bovine teat or the like and to removing excess fluid. The device includes a holder (28) having a first end (58) and a second end (62) and an interior edge (54) defining a first opening, the first end having a second opening (56); a lower portion (70); and a cassette (30) for insertion into the second opening (56) and including a wiping device (32) having a wiping material (82, 84, 86) extending radially inwardly and extending at least partially across the first opening.

A biomass pyrolysis process is provided in which biomass feedstock is mixed with a heat carrier. The heat carrier at least partly comprises char. The ratio by weight of biomass to char is in the range 1:1 to 1:20. The process may be carried out by in a screw/auger pyrolysis reactor in which the solid feedstock components are conveyed along the reactor by a first screw. A second screw conveys at least a portion of the solid products of the biomass pyrolysis back to a heat transfer medium input port. Thus, the heat transfer medium includes char from the biomass pyrolysis.

A process for heat treatment of a solid, with a coolant solid, in which a stage for mixing the solid with the pre-heated coolant solid is carried out, with the coolant solid being a solid hydrocarbon. The solid hydrocarbon is ground, before the mixing stage with the solid, to obtain a solid hydrocarbon powder with a grain size of between 20 μm and 300 μm. The solid is ground, before the mixing stage with the coolant solid, to obtain solid pellets with a thickness of between 1 mm and 30 mm, a width of between 1 mm and 40 mm, and a length of between 1 mm and 100 mm. The mixing is carried out at a temperature of between 80° C. and 700° C.

A system and process for the recovery of at least one halogenated hydrocarbon from a gas stream. The recovery includes adsorption by exposing the gas stream to an adsorbent with a lattice structure having pore diameters with an average pore opening of between about 5 and about 50 angstroms. The adsorbent is then regenerated by exposing the adsorbent to a purge gas under conditions which efficiently desorb the at least one adsorbed halogenated hydrocarbon from the adsorbent. The at least one halogenated hydrocarbon (and impurities or reaction products) can be condensed from the purge gas and subjected to fractional distillation to provide a recovered halogenated hydrocarbon.

The exhaust gas treatment apparatus has a sealed vessel which is vertically partitioned into two spaces by a partition. A portion of the sealed vessel lower than the partition is an absorbing liquid storage portion, and a portion of the sealed vessel upper than the partition is an exhaust gas introducing portion. The partition is provided with a large number of sparger pipes so that the sparger pipes reach inside an absorbing liquid stored in the absorbing liquid storage portion. The partition is provided with a single gas riser in communication with a space upper than the absorbing liquid in the absorbing liquid storage portion. An upper end of the gas riser passes through a top plate portion of the sealed vessel and protrudes upward.

Disclosed is a water and oil resistant agent comprising a fluorine-containing copolymer obtained by copolymerizing a (meth)acrylate monomer having a polyfluoroalkyl group having 1 to 6 carbon atoms, the agent being able to afford a superior water and oil resistance to a paper. The invention also discloses a composition comprising the water and oil resistant agent, a process for treating a paper thereby and a treated paper thereby.

The invention relates to a method or methods of operating an apparatus for treating material by cutting, soaking and/or washing of the material, wherein the apparatus comprises a receptacle, a discharge element with a vortex generator and a pump arranged to pump fluid and material from the receptacle towards the vortex generator, wherein the vortex generator and the pump in combination are adapted to generate a vortex in the form of a conic helix in the fluid extending into the receptacle.

A blast treatment method capable of performing blast treatment of a treatment subject with a simple structure, with high efficiency, and at low cost, while inhibiting scattering of harmful substances or the like to the outside. The method includes: inside disposing an inside explosive for blasting a treatment subject around the treatment subject; disposing an outside explosive having a detonation velocity greater than that of the inside explosive at a position outside the inside explosive; and detonating the outside explosive using an initiation device, and initiating the inside explosive by detonation of the outside explosive, thereby performing blast treatment of the treatment subject by initiation of the inside explosive. The outside explosive disposing includes arranging a cord-like explosive member containing the outside explosive and having a shape extending in one direction so that a detonation propagation velocity in a specific direction of the inside explosive initiated by the outside explosive is greater than a detonation propagation velocity in the specific direction of the inside explosive.

A blast treatment method capable of more reliably treating an object to be treated which is accommodated in an outer container is provided. The blast treatment method includes: a step for spacing a plurality of blasting explosives (20) from one another at positions on the outer side surface of an outer container (60) in a direction surrounding a central axis (C2) of the outer container (60) and arranging the blasting explosives (20) in such a manner as to extend approximately parallel to the central axis (C2); a step for installing the outer container (60) within a chamber (90); and a step for detonating the blasting explosives (20) within the chamber to perform blast treatment of an object (10) to be treated with the detonation energy, wherein the blasting explosives (20) are detonated at the blast timing at which fragments of the outer container (60) or shock waves, which are generated in the vicinity of the blasting explosives (20) by the detonation energy of the blasting explosives (20), collide with or propagate to a bombshell (10) in less time difference than that in the case in which the plurality of blasting explosives (20) are detonated at the same time.

A steel for heat treatment, which exhibits high strength and high toughness even when the heat treatment (such as quenching and tempering) of the steel is conducted under conventional conditions in an after stage. The steel for heat treatment contains C: 0.10 to 0.70 mass %, Mn: 0.1 to 3.0 mass %, Al: 0.005 to 2.0 mass %, P: 0.050 mass % or less, S: 0.50 mass % or less, O: 0.0030 mass or less, N: 0.0200 mass % or less, and one or more selected from the group consisting of Ti: 0.30 mass % or less and Nb: 0.30 mass or less with the balance being Fe and unavoidable impurities, and has a TH value of 1.0 or above as calculated according to the formula: ({Ti}/48+{Nb}/93) 104 and grain diameters of 10 μm or below. {Ti} and {Nb} refer respectively to the contents of Ti and Nb in precipitates of 5 to 100 nm in size as determined about their respective extraction residues.

A metal material is contacted with a treatment solution containing zirconium and/or titanium compound, and a polyamine compound having a number average molecular weight from 150 to 500,000 and containing from 0.1 mmol to 17 mmol of primary and/or secondary amino group per 1 g of solid content and at least one siloxane unit. Concentration of zirconium and/or titanium compound in the metal surface treatment composition is from 10 ppm to 10,000 ppm with respect to the metal element, and mass ratio of the zirconium and/or titanium element is from 0.1 to 100 with respect to the polyamine compound. The metal material is washed with water after contacted by the treatment solution.