IndyStar walks through the closed gardens at Newfields, Friday, April 24, 2020.

Wisconsin AD Barry Alvarez announced his school will not submit waivers for spring-sport seniors to regain a year of eligibility.

Indiana University will move to remote teaching after its scheduled spring break over concerns about the spread of the coronavirus.

USA Today Network will pay tribute to senior high school athletes who did not get to participate in spring sports.

Wisconsin AD Barry Alvarez announced his school will not submit waivers for spring-sport seniors to regain a year of eligibility.

Indiana projects to return more 2019 production than almost any other team in the country.

Plans have been delayed by actions taken to slow the spread of the coronavirus, but Indianapolis restaurant owners have not given up on their dreams.

IndyStar walks through the closed gardens at Newfields, Friday, April 24, 2020.

USA Today Network will pay tribute to senior high school athletes who did not get to participate in spring sports.

The Ottawa River Regulation Planning Board has released its final spring freshet forecast, which predicts a steady decrease in levels.

Smart Spring Yard Care That's Also Stylish

With over 75 million downloads per month, Spring Boot is the most widely used Java framework available. Yet Spring Boot’s simplicity can also be confusing. How do developers learn enough to be productive immediately? This practical book shows you how to use this framework to write successful mission-critical applications. Mark Heckler from VMware, the company behind Spring, guides you through Spring Boot’s architecture and approach, along with topics such as debugging, testing, and deployment.

It’s time to hang your winter jacket in the closet and change your wardrobe to warmer clothes, because “Spring Is Coming” to the Avangate Affiliate Network. Our spring contest will make your sales bloom and may even fulfill your Amazon wishlist. (Feel free to think “beyond the wall” with creative promotions!)

It isn’t surprising that former Springbok tighthead Richard Bands is remembered mainly for one bullocking run for the Springboks in Dunedin in 2003.

The calendar may say May, but that didn't stop Mother Nature from blasting some wintry weather in Muskoka on Friday.

Research Event

Event participants

Maryam Jamshidi, Author, The Future of the Arab Spring: Civic Entrepreneurship in Politics, Art, and Technology Startups
Chair: Leonie Northedge, Research Associate, Middle East and North Africa Programme, Chatham House

• Review of Harmony Korine's Spring Breakers
• Movie Homework: The Seven Year Itch/Bronson/Kirikou and the Sorceress

The COVID-19 pandemic has impacted business activity and supply chains across the globe, with numerous trade fairs and events around the world being postponed or cancelled, depriving many enterprises of business and marketing...

(Yale University) The 2020 Gruber Cosmology Prize recognizes Lars Hernquist, Center for Astrophysics | Harvard & Smithsonian, and Volker Springel, Max Planck Institute for Astrophysics, for their defining contributions to cosmological simulations, a method that tests existing theories of, and inspires new investigations into, the formation of structures at every scale from stars to galaxies to the universe itself.

Baseball season is now on the clock and the Rays are looking to get back to the postseason for the first time since 2014. That quest will begin next week as Spring Training is finally upon us. Here's a primer to get you informed on all you need to know this spring.

When Tyler Glasnow heard the news that the Rays were signing Charlie Morton, he couldn't help but get even more excited for the 2019 season.

The next five weeks will see lots of shuffling on Major League rosters. Here are the most intriguing positional battles on each of the 30 MLB clubs.

While most of the attention will fall on the players who are expected to make the Opening Day roster, manager Kevin Cash and the rest of the organization will be keeping a close eye on some of the players that could find their way to the big leagues at some point within the next year.

Infants born to mothers with obesity have a greater risk for childhood obesity and metabolic diseases; however, the underlying biological mechanisms remain poorly understood. We used a Japanese macaque model to investigate whether maternal obesity combined with a western-style diet (WSD) impairs offspring muscle insulin action. Adult females were fed a control or WSD prior to and during pregnancy through lactation, and offspring subsequently weaned to a control or WSD. Muscle glucose uptake and signaling were measured ex vivo in fetal (n=5-8/group) and juvenile offspring (n=8/group). In vivo signaling was evaluated after an insulin bolus just prior to weaning (n=4-5/group). Maternal WSD reduced insulin-stimulated glucose uptake and impaired insulin signaling at the level of Akt phosphorylation in fetal muscle. In juvenile offspring, insulin-stimulated glucose uptake was similarly reduced by both maternal and post-weaning WSD and corresponded to modest reductions in insulin-stimulated Akt phosphorylation relative to controls. We conclude that maternal WSD leads to a persistent decrease in offspring muscle insulin-stimulated glucose uptake even in the absence of increased offspring adiposity or markers of systemic insulin resistance. Switching offspring to a healthy diet did not reverse the effects of maternal WSD on muscle insulin action suggesting earlier interventions may be warranted.

It's been less than a year since the Giants selected Joey Bart with the second overall pick in the 2018 MLB Draft, but the 22-year-old catcher is already generating plenty of excitement within the organization.

One year after making a pair of high-profile acquisitions in Andrew McCutchen and Evan Longoria, the Giants have experienced a far slower and quieter winter, leaving the club with quite a few question marks as pitchers and catchers reported to Scottsdale, Ariz., for the start of Spring Training on Tuesday.

The next five weeks will see lots of shuffling on Major League rosters. Here are the most intriguing positional battles on each of the 30 MLB clubs.

Here are answers to some of the primary questions you may have as the defending National League East champs prepare to begin Spring Training next week.

Here is a look at 10 Braves players sure to draw attention during this year's Spring Training.

The next five weeks will see lots of shuffling on Major League rosters. Here are the most intriguing positional battles on each of the 30 MLB clubs.

For Brandon Hyde, the days and weeks leading up to Tuesday were filled with phone calls to friends, to former colleagues, to mentors he's made across more than two decades in the game. A constant theme emerged from the ensuing chats: What, exactly, should Hyde expect from his first Spring Training as a big league manager?

As pitchers and catchers reported Tuesday to Ed Smith Stadium, it marked the end to an offseason of overhaul in Baltimore, and the dawn of a new era. The focus will shift even further, from the front office to the field, when the club's first full squad workouts commence on Monday.

The Orioles' cloudy infield picture gained some clarity Saturday when the team signed veteran shortstop Alcides Escobar to a Minor League contract with an invitation to Spring Training.

The next five weeks will see lots of shuffling on Major League rosters. Here are the most intriguing positional battles on each of the 30 MLB clubs.

In holding their first full-squad workout on Monday, the Orioles ushered in the first official phase of a spring set to surprise. Fresh faces flood Ed Smith Stadium. Questions litter the roster. Battles abound at nearly every position.

All eyes were on right-hander Forrest Whitley, MLB Pipeline's top pitching prospect, when he threw in the bullpen for the first time Friday in Major League camp. Astros manager AJ Hinch, assistant general manager Brandon Taubman and director of player development Pete Putila were all watching intently as Whitley threw 21 pitches -- fastballs, changeups and cutters.

The next five weeks will see lots of shuffling on Major League rosters. Here are the most intriguing positional battles on each of the 30 MLB clubs.

G Perseghin
Aug 1, 1999; 48:1600-1606
Articles

Reds Spring Training in Goodyear, Ariz., will feature a new manager in David Bell, a new coaching staff and several new players. Here is what you need to know about 2019 camp.

It wasn't just that there were new faces when Reds camp opened Tuesday with the reporting of pitchers and catchers for physicals, there was a different vibe that could be felt in the hallways and clubhouse.

Reds reliever Michael Lorenzen's top priority in Spring Training will be to get innings and prepare himself to pitch in what could be a multitude of roles. However, Lorenzen's offseason workouts also included outfield work and batting practice -- and that could continue in the spring.

As Reds Spring Training opened with pitchers and catchers reporting for physicals on Tuesday, new manager David Bell was already be tasked with many responsibilities. But there will be one that looms largest. Following five years out of the postseason, including the past four with more than 90 losses, Bell must restore a culture of winning.

The next five weeks will see lots of shuffling on Major League rosters. Here are the most intriguing positional battles on each of the 30 MLB clubs.

The D-backs will open their 22nd Spring Training on Feb. 13 when pitchers and catchers go through their first workout. Here is all you need to know to be ready for the action.

There will be a lot of attention paid to D-backs infielder Jake Lamb when Spring Training gets underway. Lamb, of course, is coming off a season that was almost entirely lost to a left shoulder injury. His healthy return would play a big part in helping the D-backs' offense overcome the departures of Paul Goldschmidt and A.J. Pollock during the offseason.

After watching his pitchers and catchers go through their first workout Wednesday, D-backs manager Torey Lovullo said it was too early to say whether Archie Bradley, Greg Holland or Yoshihisa Hirano would be his closer come Opening Day.

As D-backs pitchers and catchers begin their first official workout of the spring on Wednesday morning, one of the biggest questions facing the organization is who will fill the leadership vacuum.

The next five weeks will see lots of shuffling on Major League rosters. Here are the most intriguing positional battles on each of the 30 MLB clubs.

Autoimmunity against pancreatic β-cell autoantigens is a characteristic of childhood type 1 diabetes (T1D). Autoimmunity usually appears in genetically susceptible children with the development of autoantibodies against (pro)insulin in early childhood. The offspring of mothers with T1D are protected from this process. The aim of this study was to determine whether the protection conferred by maternal T1D is associated with improved neonatal tolerance against (pro)insulin. Consistent with improved neonatal tolerance, the offspring of mothers with T1D had reduced cord blood CD4⁺ T-cell responses to proinsulin and insulin, a reduction in the inflammatory profile of their proinsulin-responsive CD4⁺ T cells, and improved regulation of CD4⁺ T cell responses to proinsulin at 9 months of age, as compared with offspring with a father or sibling with T1D. Maternal T1D was also associated with a modest reduction in CpG methylation of the INS gene in cord blood mononuclear cells from offspring with a susceptible INS genotype. Our findings support the concept that a maternal T1D environment improves neonatal immune tolerance against the autoantigen (pro)insulin.

David J Pettitt
Jan 1, 1993; 16:310-314
Supplement 1: Diabetes in Native Americans