Provided herein are pharmaceutical formulations containing exendins, exendin agonists, or exendin analog agonists that are administered at therapeutic plasma concentration levels over a sustained period of time to lower total cholesterol levels; to lower LDL-cholesterol levels; to lower triglyceride levels; to treat dyslipidemia; to treat and slow the progression of atherosclerosis; and to treat, prevent, and reduce the risk of heart attacks and strokes in patients. In the pharmaceutical formulations and methods of the invention, the exendin may be exendin-4, an exendin-4 agonist, or an exendin-4 analog agonist. The pharmaceutical formulations may be polymer-based pharmaceutical formulations that may be administered once weekly. An exemplary pharmaceutical formulation comprises 5% (w/w) of exenatide, about 2% (w/w) of sucrose, and about 93% (w/w) of a poly(lactide-co-glycolide) polymer, wherein the poly(lactide-co-glycolide) polymer is in the form of microspheres encapsulating the exenatide.

A disc drive that includes: a housing configured to receive a tray, a pickup mounted on the tray; a connector installed on the housing for outputting signals obtained from the optical pickup; a ribbon cable that includes a first end which is connected to the connector, including a plurality of wire layers, and a part installed adjacent to a side of a body of the housing; and at least one penetration hole formed in a side of the body of the housing so as to reduce a capacitive coupling between the ribbon cable and the body of the housing.

A The manhole cover is described with a supporting structure device comprising force distribution ribs for supporting a top surface of the manhole cover which can be driven over, and a hollow force distribution cylinder arranged substantially centrally, in particular a circular force distribution cylinder, for supporting the force distribution ribs, characterised by a force distribution plate to relieve the load on the force distribution cylinder, wherein the force distribution plate at least substantially completely covers an underside of the force distribution cylinder in relation to the top surface, and wherein the force distribution ribs transform smoothly into the force distribution plate.

A manhole cover assembly includes a manhole structure, a manhole frame carried by the manhole structure and a manhole frame grout cementing the manhole frame to the manhole structure. The manhole frame grout includes a grout mixture having an epoxy resin, a curing agent and an aggregate. The epoxy resin and the aggregate are present in the grout mixture in an epoxy resin:aggregate weight ratio of about 0.09. A removable manhole cover is carried by the manhole frame. A manhole cover assembly fabrication method is also disclosed.

An LED lamp includes a base, a head connected to the base, an LED mounted on the base and a cover fixed on the base and covering the LED. The cover is made of metal and defines a plurality of through holes therein.

A targeting jig apparatus for targeting interlocking holes of an intramedullary nail. The targeting jig includes a support-arm extending substantially parallel to the intramedullary nail. A targeting mechanism including a pair of targeting mechanism drill-guide orifices is adjustably disposed on the support arm for aligning the targeting mechanism drill-guide orifice with the interlocking holes of the intramedullary nail. The targeting mechanism includes a saddle having a U-shape including a base and parallel legs that are slidable along the support-arm. A connection mechanism includes a horizontal slot on the support-arm aligned with a vertical slot on the targeting mechanism and a pivot screw extending through the slots for facilitating adjustment of the targeting mechanism relative to the support arm.

The present invention relates to a hole-saw assembly includes a hole-saw having at one end a plurality of cutting teeth and with a boss attached to the hole-saw at the other end two shafts. The assembly includes a mandrel coaxially aligned with said hole-saw and including a body having two bores there through coaxially aligned with said shafts. An annulus located on top of the body is coaxially aligned with said mandrel and hole saw and includes two holes, the annulus rotatable around its longitudinal axis from a first to a second position. In the first position the annulus holes are aligned with the bores and shafts allowing the shafts to be freely insertable and removable and in the second position the holes are misaligned to lock the shafts to the annulus. The mandrel further includes a pair of driving pins adapted to engage driving apertures found in hole-saws especially larger ones. Typically the driving pins may be biased to enable the assembly to be used even with those hole-saws that do not include driving apertures and that also enables easier assembly of the device. A compressible O-ring may further facilitate the operation of the assembly. This device avoids the problem of thread stripping. The invention further provides for a boss that can be used with larger hole-saws and includes notches that accommodate driving pains extending on the side of the boss and where appropriate into the driving apertures.

A device and method for creating multiple punch holes during a finishing process of paper sheets and other sheet materials. The improved sheet punch including two rotatable punches set at different angles such that when one intersects the sheet path, the other clears the sheet path. The speed of rotation is controlled such that the non-selected punch intersects the sheet path in a space between pitches.

A method for creating multiple punch holes during a finishing process of paper sheets and other sheet materials. A highlight of the present invention is the ability to select between at least two configurations of punch holes automatically, without manual adjustment, and “on-the-fly” without interruption of the sheet or paper flow. The perforation method utilizes two rotatable punches set at different angles such that when one intersects the sheet path, the other clears the sheet path. The speed of rotation is controlled such that the non-selected punch intersects the sheet path in a space between pitches.

An automatic hole punch is disclosed for creating holes in a sheave of sheet material. The automatic hole punch is preferably user-selectable between punching modes, such as two-hole and three-hole modes. A motor is coupled to a camshaft by a gear train. The cam shaft carries a plurality of cams each having an associated punch. As the camshaft rotates, the cams sequentially drive corresponding punches. However, depending on the selected modality, one or more punches may be idle by not being engaged with their respective cams, thus resulting in varying combinations of driven punches resulting in different hole patterns. Finally, a spacer can be inserted into a material receiving slot for adjusting the relative positioning of the material to the punches to properly position the hole pattern along an edge of the material to be punched.

An improved manufacturing method for the hole-punching assembly of a hole-punching unit is disclosed. The method of the present invention comprises the following steps: (1) forming a plurality of aluminum balancing pieces with a rectangular shape by extrusion, and forming an indentation area on one side of each balancing piece; (2) forming an elongated slot by an application of stamping on the indentation area of each balancing piece; (3) obtaining a plurality of rectangular pieces (the number of which equals that of the balancing pieces), made of iron, and forming a row of holes by a single application of stamping on each rectangular piece; and (4) fitting each of the rectangular pieces onto the indentation area of a balancing piece, and connecting the balancing pieces together by screws or bolts. The manufacturing method can lower the production cost and simplify the production process of the hole-punching assembly.

A pressing structure for a hole-punching unit includes an axle, two wrenching pieces, a pole and two pressing pieces, wherein the axle is axially attached to a case of the hole-punching unit, with one end of the axle axially connecting to a control knob, each wrenching piece connecting to the axle near its end, the pressing piece having a spring coil disposed at its middle and pivotally connected to the pole, and the pressing piece having a pair of lapping portions extending from a first side of the spring coil, and a pair of suppressing portions extending from a second side of the spring coil, the lapping portions leaning against an upper edge of the wrenching piece for the control knob to drive the wrenching piece to move synchronously, so as to let the suppressing portions to press the hole-punching assembly and to fasten the hole-punching assembly.

A sheet hole punching device has a device frame bearing-supporting a plurality of punching members, a driving rotation shaft, a drive motor, a gear mechanism transmitting a rotation of the driving rotation shaft, cam mechanisms converting the rotational movement into vertical movement, and a motor control device. The gearing mechanism includes drive gears fixed on the driving rotation shaft and receiving gears to engage with the drive gears to transmit the rotational movement to the punching members. The cam mechanism includes cylindrical cams formed integrally to the punching members and cam followers fixed to the device frame. The cylindrical cams are provided with V-shaped groove cams to reciprocate the punching members between an upper dead point and a lower dead point. The punching members are rotated in one direction to punch holes in a sheet, and subsequently rotated in a reverse direction to punch holes in a following sheet.

A sheet hole punching device has a device frame; a plurality of punching members arranged in first and second groups, and arranged linearly on the device frame; a driving rotation shaft; a driving motor reciprocally rotating the driving rotation shaft; a gear mechanism transmitting a rotation of the driving rotation shaft; cam mechanisms converting the rotational movement; and a motor control device. The gearing mechanism includes drive gears disposed on the drive rotational shaft, and receiving gears disposed on the punching members to engage with the drive gears. The cam mechanisms include cam followers and cylindrical cams. The cylindrical cam has a V-shaped groove cam to reciprocate each of the punching members between an upper dead point and a lower dead point. The punching members are rotated in one direction to punch holes in first sheets, and subsequently rotated in a reverse direction to punch holes in following sheets.

An apparatus for punching holes is provided. The apparatus may include a base movable from a first position to a second position and first and second punch assemblies attached to and movable with the base. The punch assemblies may each include parallel punches movable relative to the base and having an end. The apparatus may include first and second cams fixed to a rotatable shaft and having an engagement portion for engagement with the ends of the respective punches at a predetermined rotation position of the shaft. When the base is in the first position, rotation of the shaft to the predetermined rotation position may cause movement of only one of the punches relative to the base. When the base is in the second position, rotation of the shaft to the predetermined rotation position may cause movement of only the other punch of the punch assemblies.

Disclosed are novel processing methods for green coffee beans that result in novel green coffee bean products, including products that incorporate whole green coffee beans. Methods include selecting whole coffee beans in their fresh green unroasted state with naturally-occurring levels of phytonutrients, sterilizing and drying them, applying iterative grinding processes and stabilization techniques, all while avoiding high temperatures. Whole green coffee bean products created and defined by these methods have unexpectedly been found to increase focus and concentration in users, and are believed useful in the treatment of attention and concentration deficits and related disorders, such as attention deficit (AD), attention deficit disorder (ADD), attention deficit hyperactivity disorder (ADHD), and various related and/or comorbid disorders.

A method and system for pumping unit with an elastic rod system is applied to maximize fluid production. The maximum stroke of the pump and the shortest cycle time are calculated based on all static and dynamic properties of downhole and surface components without a limitation to angular speed of the prime mover. Limitations of structural and fatigue strength are incorporated into the optimization calculation to ensure safe operation while maximizing pumped volume and minimizing energy consumption. Calculated optimal prime mover speed is applied to the sucker rod pump by means of beam pumping, long stroke or hydraulic pumping unit by controlling velocity, acceleration and torque of the electric prime mover or by controlling pressure and flow rate in hydraulically actuated sucker rod pumping system.

The present invention is directed to a single handle post hole digger. The single handle of the post hole digger includes an outer elongated vertical handle and an inner elongated vertical shaft that is located within the outer handle. The post hole digger includes two blades used to cut into the ground and to loosen soil when open and then used to capture and remove soil when closed. The single handle configuration allows for deeper holes as the holes do not have to accommodate the opening action of the handles as in traditional diggers.

A pick-and-place vacuum nozzle including a a nozzle body, a vacuum chamber within the nozzle body, a cavity formed in a lower surface of the nozzle body below the vacuum chamber, wherein the cavity is shaped to hold a head gimbal assembly, a back pressure relief hole passing through the nozzle body and connected to the vacuum chamber, the back pressure relief hole communicating with an exterior of the nozzle body, wherein a diameter of the back pressure relief hole is between 0.5 mm and 1 mm. The backpressure relief hole prevents light parts from sticking to the nozzle tip after vacuum is no longer applied.

An educational game for teaching addition and subtraction of whole numbers includes a carpet/game board including ten positively numbered spaces from +1 to +10 inclusive a 0 space and negatively numbered spaces from −1 to −10 inclusive and wherein said positive numbered spaces proceed upwardly in a generally zigzag direction from 0 to plus 10 and the negatively numbered spaces proceed downwardly from 0 to minus 10 and an extra space above the plus 10 and an extra space below the minus 10 wherein the extra space above the plus 10 is a win space and the space below the minus 10 is a lose space. The game also includes a single cube shaped die having six faces with an indication of plus 2, minus 2 and no movement on three of the faces and a plus 1, minus 1 and plus 1 plus and additional turn on the sixth face. Further, the game includes six game pieces of separate distinct colors.

A golf hole cup setter for inserting a cylindrical golf hole cup into a golf hole so that its longitudinal axis is in vertical alignment. The cup setter has a base plate having an upper surface and a lower surface. A cup insertion member extends downwardly from the lower surface of the base plate, and is configured to contact the upper rim of the cup. A level is attached to the base plate and is positioned to allow a user to step on the base plate without interference during cup insertion, and to determine whether the longitudinal axis of the golf hole cup inserted into the golf hole by the cup setter is in vertical alignment.

A cleanup device having a first board having a first edge, a second board having a first edge, a first hinge attached to the first edge of the first board and the first edge of the second board, an aperture defined by a portion of the first edge of the first board and a portion of the first edge of the second board, a first plate slidably attached to the first board, wherein the first plate is movable from a first, open position where the aperture is open to a second, closed position where the first plate extends over at least a portion of the aperture, and wherein a top surface of the first board is movable towards a top surface of the second board to form a V-shaped surface for directing dirt or soil off of the first board and the second board.

The invention concerns a drill bit, intended to be used with a down-the-hole drill and comprising a drill head (2) with a front surface provided with drill pins (3) and a shaft (4), whereby the shaft is narrower than the drill head and intended to be inserted in a manner that allows axial sliding into the end of a drill chuck that is a component of a down-the-hole drill and which shaft has a rear end part (6) that is somewhat thickened with a plane striking surface (7) against which a hammer piston (8) that is a component of the down-the-hole hammer drill is arranged to impact, that the drill head when viewed along its axial direction has a cylinder-shaped forward part (20) provided with cuttings channels (22), a rear cylinder-shaped part (21) that is located for the reception of drill cuttings at the same level or somewhat below the bottom (25) of the cuttings channels, whereby the diameter (D1) of the forward part is greater than the diameter (D2) of the rear part. In a drill bit that has high performance and a long useful life, and that is furthermore well-suited to be used for directed drilling, the cylinder-shaped forward part (20) of the drill head (2) has an axial length (L3) from the main plane of the front surface to a shoulder plane (26) located between the drill head (2) and the shaft (4) that is greater than the axial length (L4) of the cylinder-shaped rear part (21) of the drill head.

A drilling apparatus for drilling boreholes in an underground formation includes a tool body that can be positioned in a borehole where drilling is to take place. The apparatus further includes a gas cutting torch having a nozzle, a supply of a cutting gas connected to the gas cutting torch. In some embodiments, the gas cutting torch and supply of cutting gas may be connected by an umbilical link. The tool body may be advanced through the borehole as drilling takes place. In some embodiments, the tool body may be advanced via a tractor device that forms part of the tool body or attached to the tool body.

A method for managing a drilling operation, including generating, by a first sensor and a second sensor of a bottom hole assembly (BHA), a first time based data log and a second time based data log, respectively, representing a borehole parameter along a drilling trajectory, determining, by a computer processor of the BHA and during the drilling operation, a time shift by comparing the first time based data log and the second time based data log, where offsetting the first and second time based data logs by the time shift maximizes a correlation factor of the first and second time based data logs, and determining, within a pre-determined time period from generating the first and second time based data logs, a drilling speed based on the time shift and a pre-determined distance between the first sensor and the second sensor.

Apparatus and method for automated drilling of a borehole in a subsurface formation. In one embodiment, a method includes selecting at least one control variable. A drilling performance objective having a value that is influenced by drilling of the borehole using the at least one control variable is defined. A first interval of the borehole is drilled maintaining the at least one control variable at a first value. A second interval of the borehole is drilled maintaining the at least one control variable at a second value. A third interval of the borehole is drilled maintaining the at least one control variable at a third value. The third value is selected based on a comparison of the values of the drilling performance objective while drilling the first interval and second interval to a predetermined optimal value of the drilling performance objective.

Expandable apparatus for use in subterranean boreholes include at least one member configured to move between a retracted position and an extended position. A latching member disposed in the tubular body may selectively retain the at least one member in the retracted position. Methods of operating an expandable apparatus include securing at least one member of the expandable apparatus in a retracted position by engaging an inner wall of a tubular body with at least one latch member disposed in at least one aperture formed in a latch sleeve.

Expandable apparatus for use in subterranean boreholes include at least one member configured to move between a retracted position and an extended position. Components of the expandable apparatus may include at least one surface for removing debris proximate to the tubular body. Components of the expandable apparatus may be configured to enable the expandable apparatus to increase a diameter of a subterranean borehole by greater than twenty percent. Components of the expandable apparatus may be configured to restrict fluid flow to nozzle assemblies. The expandable apparatus may include a protect sleeve having a push sleeve disposed therein. Methods of operating an expandable apparatus may include removing debris with a surface of the expandable apparatus. Methods of operating an expandable apparatus may also include selectively flowing fluid to nozzle assemblies.

A down-hole hammer comprising a drill bit (10) and a drive collar (11) with an interconnection therebetween for causing rotation of the drill bit upon rotation of the drive collar. The drill bit (10) comprises a drill bit head (13) and a shank (19), the drill bit head (13) defining a cutting face (15) and having a circumferential shoulder section (17) adjacent the cutting face (15). The shank (19) extends from the shoulder section (17) in the direction away from the cutting face (15). The interconnection between the drill bit (10) and the drive collar (11) comprises a spline assembly including at least one spline (43) on the shoulder section (17) for mating engagement with at least one counterpart spline (63) on the drive collar (11) to provide a drive coupling therebetween while also allowing the drill bit (10) to slide axially within the drive collar (11) to perform a percussive action.

A bound system including a plurality of pages and a cover and/or divider including a bound outer edge and a plurality of free outer edges. The cover and/or divider may be bound to the plurality of pages along the bound edge. The cover and/or divider may include one or more discreet tabs extending generally outwardly relative to one of the edges. Each tab may be integrally formed from a single piece of material with the rest of the cover and/or divider. Each tab further may have an opening formed therethrough and is configured to receive at least part of a binding device therethrough to thereby couple the cover and/or divider to the binding device.

The present invention discloses a kind of universal mounting hole means for different tool heads of electric tools, which are disposed on a mounting portion of the tool head, comprising a central hole and a plurality of long and narrow limiting holes which orient radially surrounding the central hole and disposed in distance with each other. Compared with the prior art, the present invention is applicable to various kinds of structures of the mounting seat on electrical tool and is more universal. It takes much convenience to people when changing different tool heads of electric tools, and it is benefit for storing.

The present invention relates to a hole-saw assembly (10) including a hole saw (26) having at one end a plurality of cutting teeth and at the other end two shafts. The assembly includes a mandrel (16) coaxially aligned with said hole-saw and including a body having two bores there through coaxially aligned with said shafts. An annulus (20) located on top of the body is coaxially aligned with said mandrel and hole saw and includes two holes, the annulus rotatable around its longitudinal axis from a first to a second position. In the first position the annulus holes are aligned with the bores and shafts allowing the shafts to be freely insertable and removable and in the second position the holes are misaligned to lock the shafts to the annulus. The mandrel further includes a pair of driving pins (22) adapted to engage driving apertures (24) found in hole saws especially larger ones. Typically the driving pins may biased to enable the assembly to be used even with those hole saws that do not include driving apertures and that also enables easier assembly of the device. A compressible O-ring (42) may further facilitate the operation of the assembly. This device avoids the problem of thread stripping.

Systems and methods for activating a down hole tool in a wellbore. A piston is moveable from a first position to a second position for activating the down hole tool. The piston includes a first side exposed to a first chamber, and a second side exposed to a second chamber. A rupture member has a first side exposed to the first chamber and a second side exposed to a third chamber. The rupture member is configured to rupture when a pressure differential between the first chamber and the third chamber reaches a predetermined threshold value, at which point the rupture member allows fluid communication between the first chamber and the third chamber. When the rupture member is intact, the piston is in the first position, and when the rupture member ruptures, the piston moves to the second position and activates the down hole tool.

Methods are provided for identifying the location and height of induced subterranean formation fractures and the presence of any associated frac-pack or gravel pack material in the vicinity of the borehole using pulsed neutron capture (PNC) logging tools. The proppant/sand used in the fracturing and packing processes is tagged with a thermal neutron absorbing material. When proppant is present, increases in detected PNC formation and/or borehole component cross-sections, combined with decreases in measured count rates, are used to determine the location of the formation fractures and the presence and percent fill of pack material in the borehole region. Changes in measured formation cross-sections relative to changes in other PNC parameters provide a relative indication of the proppant in fractures compared to that in the borehole region.

An apparatus and method for the actuation of down-hole tools are provided. The down-hole tool that may be actuated and controlled using the apparatus and method may include a reamer, an adjustable gauge stabilizer, vertical steerable tools, rotary steerable tools, by-pass valves, packers, whipstocks, down hole valves, latch or release mechanisms and/or anchor mechanisms.

The Invention provided is a hydraulic powered down hole reciprocating pump traveling valve component to provided lifting hydraulics on the down stroke using the derived motion and pressure of petroleum liquids and gasses, such as oil, water and natural gas and also utilizing the frictional traveling forces driven by the surface equipment. Designed to utilize the elements within the pumping apparatus to obtain the hydraulic power within and transfer the energy's force to the exposed bottom end of the pressure locked traveling ball valve adjacent within the ball valve containment cage, providing ultimate lifting power to open the ball valve on the initiation of the down stroke. The component consist of a Hollow Hydraulic Power Shaft, Hollow Pressure Motion House, and a Fluid Cavity Power Drag Plunger.

Neutrally-buoyant tools for seismic data collection are provided that may range from several hundred meters to several kilometers in length and have integrated sensors which move along with the borehole fluid in response to a passing seismic wave. The disclosure also provides methods of deploying neutrally-buoyant tools, which includes using a tractor, adding a weight or both to the tool in order to overcome the difficulty of lowering a neutrally buoyant tool into a borehole, and optionally occasionally clamping the tool to the borehole to alleviate tension in the tool. This disclosure also provides methods of acquiring seismic data, which involves positioning a neutrally-buoyant tool in a borehole such that the tool is able to move relatively freely along with the borehole fluid in response to a seismic wave passing through the fluid, firing a seismic source, and using the sensors to collect seismic data generated thereby.

A receiving housing of a hydraulic tensioning device for a traction mechanism drive in an internal combustion engine, having an opening that extends along a longitudinal axis for receiving a piston that is implemented for deflecting a tensioning rail of the traction mechanism drive. The receiving housing is a cast component, and the opening comprises an inner contour having an inner surface that comprises at least first segments and inclines for removing the workpiece from the mold in the opening. The second segments include surfaces that are directed into the inside of the opening and are aligned in parallel with the longitudinal axis. A sliding core is also provided that has an outer contour that is complementary to the inner contour of the opening of the receiving housing and fits into the opening. A traction mechanism drive and tensioning device having a receiving housing of this type are also included.

A crude oil feedstream is treated to remove or reduce the content of known undesired heteroatomic and polynuclear aromatic compounds containing nitrogen and sulfur by contacting the feedstream with one or more solid adsorbent materials selected from attapulgus clay, alumina, silica gel and activated carbon in a mixing vessel for a time that is sufficient to optimize the adsorption of the undesired compounds from the crude oil, subjecting the mixture to atmospheric flash distillation and then to vacuum flash distillation to recover presorbed boiling ranges of products having a lowered content of the undesired compounds, and preferably regenerating at least a portion of the solid adsorbent material for reuse in the process.

Downhole tool fluid flow control apparatus including a first fluid valve between a first portion of a first flowline and a second portion of a second flowline. The first and second flowlines are adjacent each other. A second fluid valve is between a second portion of the first flowline and a first portion of the second flowline. The first and second fluid valves are controllable to cause fluid flow between the first portion of the first flowline and the second portion of the second flowline or between the first portion of the second flowline and the second portion of the first flowline.

Disclosed are thermite charges for use in well perforation and downhole fracing. The thermite charges have a core, and optionally a case, where at least one of the core and the case includes thermite material.

Clothing iron including a sole (1) having a bottom side with a sliding surface (11) coming into contact with cloth and comprising at least one steam-supplied recess (10), the recess (10) being bounded on its entire periphery by the sliding surface (11) in such a manner that the recess (10) forms a steam diffusion cavity that is surrounded by the sliding surface (11) when the sole (1) is applied to the cloth being ironed, characterized in that the depth of the recess (10) is greater than or equal to 1 mm.

In accordance with embodiments of the present disclosure, systems and methods for sensing and communicating sensed downhole parameters using a hybrid micro-structured fiber optic cable are provided. The micro-structured fiber optic cable may be used to communicate and/or amplify sensor signals indicative of the sensed downhole parameters. These sensed downhole parameters may include one or more of a downhole temperature, pressure, magnetic field, electromagnetic energy, radioactivity, telemetry signal, or some other downhole measurement. The micro-structured fiber optic cable may include opto-electronic circuitry built into the internal structure of the cable for modulating the optical signal based on the sensed parameters. The opto-electronic circuitry may include diodes, triodes, and other components that are communicatively coupled to external sensors used to measure downhole parameters. The opto-electronic circuitry may include an internal sensor in the form of a functional material disposed within the micro-structured fiber optic cable for measuring downhole parameters.

A sewer gas odor absorption apparatus for a manhole having a perforate manhole cover disposed in the manhole which includes an imperforate housing having a seal dimensioned and configured for sealing engagement with the manhole, the housing has a first extremity and a second extremity and a passageway in fluid communication with ambient air above the manhole cover at the first extremity and in fluid communication with sewer gases at the second extremity thereof. A sub-assembly including a porous absorption media and a variable volume device disposed in mutual fluid communication in a subassembly having first and second axial extremities, the first and second extremities of the subassembly being disposed in fluid communication respectively with the first and second extremities of the imperforate housing.

Methods and related systems are described for gamma-ray detection. A gamma-ray detector is made depending on its properties and how those properties are affected by the data analysis. Desirable properties for a downhole detector include; high temperature operation, reliable/robust packaging, good resolution, high countrate capability, high density, high Z, low radioactive background, low neutron cross-section, high light output, single decay time, efficiency, linearity, size availability, etc. Since no single detector has the optimum of all these properties, a downhole tool design preferably picks the best combination of these in existing detectors, which will optimize the performance of the measurement in the required environment and live with the remaining non-optimum properties. A preferable detector choice is one where the required measurement precision (logging speed) is obtained for all of the required inelastic elements and/or minimization of unwanted background signals that complicate the data analysis.

Embodiments of the disclosure encompass methods of amplifying nucleic acid from one or more cells using MALBAC (multiple annealing and looping-based amplification cycles) primers. In particular embodiments, the nucleic acid is amplified as amplicons in a linear manner. Specific embodiments include the removal or effective destruction of nonlinearly produced amplicons.

The present disclosure provides robust, high-throughput, and clinically applicable methods for simultaneously separating and quantifying the biologically active forms of Vitamin B1 (TPP) and Vitamin B6 (PLP) from human whole blood.

Together with a team of volunteers — including the Street Royalty Motorcycle Club — popular pitmaster Matt Horn prepared and served 600 pork and chicken sandwiches to feed the entire staff at Valley Children's Hospital in Fresno.

Rather than lament the delayed opening of his eagerly awaited Horn Barbecue brick-and-mortar restaurant in the heart of Oakland, last month the pitmaster created a philanthropic project, the Horn Initiative, which has since mid-March facilitated the making and serving of over 4,000 meals to frontline workers and others in need.…

IT is the Winchester watering hole that brings in “thousands of tourists” each year.

IT IS the popular pub that has a whole new look.